SENP1_MOUSE - dbPTM
SENP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SENP1_MOUSE
UniProt AC P59110
Protein Name Sentrin-specific protease 1
Gene Name Senp1
Organism Mus musculus (Mouse).
Sequence Length 640
Subcellular Localization Nucleus . Cytoplasm. Shuttles between cytoplasm and nucleus..
Protein Description Protease that catalyzes two essential functions in the SUMO pathway. [PubMed: 15923632]
Protein Sequence MDDTADGVKMDAGEVTLVNHGSTFRTHRPPQSGFPEEQLLLSDQQSLPFRQGTLDGSFTCSTRSPAYRPDYHSDNPSSDSFLGSGDVRTFGQSANGQWRNSTPASGSAPQKPRNSRSLCLETRKTSSGLSNTFVGKSNHHCHMSAYEKSFPIKPAPSPSWSGSCRRSLLSPKKTQRRHFSTAEETVQEEEKEIYRQLLQMVTGKQFCVAKPTTHFPLRLSRCLSSNKNSLKDSLLRNGNSCASHVIGSDTSSSGSASILTAQEQLSHSAHSLSSGTPDVAFGSKDSDPHHHLAAPHQPNSLPASNTQSEGSDSVILLKVKESQTPASSPTFFQAELWIKELTSVYDSRARERLRRIEEQKALALQLQNQRLQEQEHAVLDSVELHLRVPLEKEIPVTAAQETRKKSHQLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGFPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRRKSITYYDSMGGINNEACRILLQYLKQESVDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
53PhosphorylationSLPFRQGTLDGSFTC
CCCCCCCCCCCCEEE		17.2122006019
57PhosphorylationRQGTLDGSFTCSTRS
CCCCCCCCEEECCCC		19.6325266776
59PhosphorylationGTLDGSFTCSTRSPA
CCCCCCEEECCCCCC		13.7728066266
61PhosphorylationLDGSFTCSTRSPAYR
CCCCEEECCCCCCCC		24.6528066266
64PhosphorylationSFTCSTRSPAYRPDY
CEEECCCCCCCCCCC		17.6125777480
67PhosphorylationCSTRSPAYRPDYHSD
ECCCCCCCCCCCCCC		26.5125777480
71PhosphorylationSPAYRPDYHSDNPSS
CCCCCCCCCCCCCCC		13.1025777480
73PhosphorylationAYRPDYHSDNPSSDS
CCCCCCCCCCCCCCC		32.6225777480
77PhosphorylationDYHSDNPSSDSFLGS
CCCCCCCCCCCCCCC		53.7025777480
78PhosphorylationYHSDNPSSDSFLGSG
CCCCCCCCCCCCCCC		38.2325777480
80PhosphorylationSDNPSSDSFLGSGDV
CCCCCCCCCCCCCCC		25.0725777480
84PhosphorylationSSDSFLGSGDVRTFG
CCCCCCCCCCCEECC		33.6925777480
101PhosphorylationANGQWRNSTPASGSA
CCCCCCCCCCCCCCC		27.4828066266
102PhosphorylationNGQWRNSTPASGSAP
CCCCCCCCCCCCCCC		26.8228066266
115PhosphorylationAPQKPRNSRSLCLET
CCCCCCCCCCEEECE		25.2429514104
117PhosphorylationQKPRNSRSLCLETRK
CCCCCCCCEEECEEC		24.2124453211
125PhosphorylationLCLETRKTSSGLSNT
EEECEECCCCCCCCC		25.4928833060
126PhosphorylationCLETRKTSSGLSNTF
EECEECCCCCCCCCC		25.9928833060
127PhosphorylationLETRKTSSGLSNTFV
ECEECCCCCCCCCCC		49.3228833060
130PhosphorylationRKTSSGLSNTFVGKS
ECCCCCCCCCCCCCC		37.0328833060
132PhosphorylationTSSGLSNTFVGKSNH
CCCCCCCCCCCCCCC		19.13-
157PhosphorylationFPIKPAPSPSWSGSC
CCCCCCCCCCCCCCH		33.4028725479
159PhosphorylationIKPAPSPSWSGSCRR
CCCCCCCCCCCCHHH		37.9125159016
161PhosphorylationPAPSPSWSGSCRRSL
CCCCCCCCCCHHHHH		25.7625159016
163PhosphorylationPSPSWSGSCRRSLLS
CCCCCCCCHHHHHCC		10.0325159016
167PhosphorylationWSGSCRRSLLSPKKT
CCCCHHHHHCCCHHH		17.8218846507
170PhosphorylationSCRRSLLSPKKTQRR
CHHHHHCCCHHHHHH		39.7124453211
233PhosphorylationNKNSLKDSLLRNGNS
CCCHHHHHHHHCCCC		27.9324719451
322PhosphorylationILLKVKESQTPASSP
EEEEEECCCCCCCCC		33.3726643407
324PhosphorylationLKVKESQTPASSPTF
EEEECCCCCCCCCCE		30.0626643407
327PhosphorylationKESQTPASSPTFFQA
ECCCCCCCCCCEEEH		37.7526643407
328PhosphorylationESQTPASSPTFFQAE
CCCCCCCCCCEEEHH		30.0226643407
330PhosphorylationQTPASSPTFFQAELW
CCCCCCCCEEEHHHH		38.7426643407
360AcetylationLRRIEEQKALALQLQ
HHHHHHHHHHHHHHH		48.9623236377
392AcetylationHLRVPLEKEIPVTAA
EEECCCCCCCCCCCC		69.4923806337
406PhosphorylationAQETRKKSHQLTDSE
CHHHHHHHHCCCCCC		21.3625159016
410PhosphorylationRKKSHQLTDSEDEFP
HHHHHCCCCCCCCCH		30.8025159016
412PhosphorylationKSHQLTDSEDEFPEI
HHHCCCCCCCCCHHH		41.5325159016
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SENP1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SENP1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SENP1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SUMO2_HUMANSUMO2physical
17428805
SUMO3_HUMANSUMO3physical
17428805
SUMO1_HUMANSUMO1physical
17428805
HIF1A_MOUSEHif1aphysical
17981124
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SENP1_MOUSE

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Related Literatures of Post-Translational Modification

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