dbPTM

TCOF_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TCOF_MOUSE
UniProt AC	O08784
Protein Name	Treacle protein
Gene Name	Tcof1
Organism	Mus musculus (Mouse).
Sequence Length	1320
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification..
Protein Sequence	MAEARKRRELLPLIYHHLLQAGYVRAAREVKEQSGQKSFLTQPVTLLDIYTHWQQTSELGQKQKAEDDETLQAKKSRVSDPVSSSESSDQEKEEEAATERAKATPRPTPVNSATAALPSKVKEKGKTKTANKTVNSVSHPGSGKTVVHLLSGKSPKKSAEPLANTVLASETEEEGNAQALGPTAKSGTVSAGQGSSSSEDSSISSDETDVEVKSPAKPAQAKASAAPAKDPPARTAPGPTKLGNVAPTPAKPARAAAAAAAAAVAAAAAAAAEESESSEEDSDSEDEAPAGLPSQVKASGKGPHVRADSVSAKGISGKGPILATPGKTGPAATQAKAERPEKDSETSSEDDSDSEDEMPVTVNTPQARTSGKSPRARGTSAPAKESSQKGAPAVTPGKARPVAAQAGKPEAKSSEESESDSGETPAAATLTTSPAKVKPLGKSSQVRPVSTVTPGSSGKGANLPCPGKVGSAALRVQMVKKEDVSESSSAELDSDGPGSPAKAKASLALPQKVRPVATQVKTDRGKGHSGSSEESSDSEEEAAPAASAAQAKPALEKQMKASSRKGTPASATGASTSSHCKAGAVTSSASLSSPALAKGTQRSDVDSSSESESEGAAPSTPRVQGKSGGKGLQGKAALGQGVAPVHTQKTGPSVKAMAQEDSESLEEDSSSEEEDETPAQATPLGRLPQAKANPPPTKTPPASASGKAVAAPTKGKPPVPNSTVSARGQRSVPAAGKAGAPATQAQKGPVAGTGEDSESSSKEESDSEEETPAQIKPVGKTSQVRAASAPAKESPKKGAHPGTPGKTGSSATQAQPGKTEDSDSSSEESDSDTEMPSAQAIKSPPVSVNRNSSPAVPAPTPEGVQAVNTTKKASGTTAQSSSSESEDGDEDLIPATQPSTYALRTSVTTPAALSRAASQPSKSEQSSRMPKGKKAKAAASAQTSSAVETLPMMPPQSAPIQPKATNKLGKSKLPEKQQLAPGYPKAPRSSEDSSDTSSEDEEDAKRPQMPKSAHRLDPDPSQKETVVEETPTESSEDEMVAPSQSLLSGYMTPGLTVANSQASKATPRPDSNSLASSAPATKDNPDGKQKSKSQHAADTALPKTGRKEASSGSTPQKPKKLKKSTSSSPAPTQTLPNSITQRLLEQAWPLSEAQVQASVVKVLTELLEQERLKATEAIKESGKKSQKRKLSGDLEAGAPKNKKKKEQPVPRASAVSPEKAPMTSKAKSKLDKGSAGGKGKGSPGPQGAKEKPDGELLGIKLESGEQSDPKSKSKKKKSLKKKKDKEKKEKKKGKKSLAKDSASPIQKKKKKKKKSAEPAV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	ETLQAKKSRVSDPVS HHHHHHHHHCCCCCC	36.89	30635358
79	Phosphorylation	QAKKSRVSDPVSSSE HHHHHHCCCCCCCCC	34.78	25619855
83	Phosphorylation	SRVSDPVSSSESSDQ HHCCCCCCCCCCCHH	33.27	23684622
84	Phosphorylation	RVSDPVSSSESSDQE HCCCCCCCCCCCHHH	38.06	23684622
85	Phosphorylation	VSDPVSSSESSDQEK CCCCCCCCCCCHHHH	33.71	23684622
87	Phosphorylation	DPVSSSESSDQEKEE CCCCCCCCCHHHHHH	40.96	23684622
88	Phosphorylation	PVSSSESSDQEKEEE CCCCCCCCHHHHHHH	38.98	23684622
98	Phosphorylation	EKEEEAATERAKATP HHHHHHHHHHHHCCC	32.81	25619855
104	Phosphorylation	ATERAKATPRPTPVN HHHHHHCCCCCCCCC	21.08	25266776
108	Phosphorylation	AKATPRPTPVNSATA HHCCCCCCCCCHHHH	40.94	25266776
112	Phosphorylation	PRPTPVNSATAALPS CCCCCCCHHHHCCCH	27.51	28066266
114	Phosphorylation	PTPVNSATAALPSKV CCCCCHHHHCCCHHH	16.57	28066266
132	Acetylation	GKTKTANKTVNSVSH CCCCCCCCCCCCCCC	51.92	23806337
144	Acetylation	VSHPGSGKTVVHLLS CCCCCCCCEEEECCC	39.58	23806337
151	Phosphorylation	KTVVHLLSGKSPKKS CEEEECCCCCCCCCC	51.00	28725479
153	Acetylation	VVHLLSGKSPKKSAE EEECCCCCCCCCCCC	61.27	23806337
154	Phosphorylation	VHLLSGKSPKKSAEP EECCCCCCCCCCCCC	45.54	26824392
158	Phosphorylation	SGKSPKKSAEPLANT CCCCCCCCCCCHHCC	43.95	27087446
165	Phosphorylation	SAEPLANTVLASETE CCCCHHCCHHCCCCC	15.99	24925903
169	Phosphorylation	LANTVLASETEEEGN HHCCHHCCCCCCCCC	40.67	27087446
171	Phosphorylation	NTVLASETEEEGNAQ CCHHCCCCCCCCCCC	46.32	24925903
183	Phosphorylation	NAQALGPTAKSGTVS CCCCCCCCCCCCCEE	44.94	25619855
186	Phosphorylation	ALGPTAKSGTVSAGQ CCCCCCCCCCEECCC	36.91	25293948
188	Phosphorylation	GPTAKSGTVSAGQGS CCCCCCCCEECCCCC	20.55	25293948
190	Phosphorylation	TAKSGTVSAGQGSSS CCCCCCEECCCCCCC	26.90	25293948
195	Phosphorylation	TVSAGQGSSSSEDSS CEECCCCCCCCCCCC	21.11	25293948
196	Phosphorylation	VSAGQGSSSSEDSSI EECCCCCCCCCCCCC	44.71	25293948
197	Phosphorylation	SAGQGSSSSEDSSIS ECCCCCCCCCCCCCC	39.17	25293948
198	Phosphorylation	AGQGSSSSEDSSISS CCCCCCCCCCCCCCC	47.58	25293948
201	Phosphorylation	GSSSSEDSSISSDET CCCCCCCCCCCCCCC	26.06	25293948
202	Phosphorylation	SSSSEDSSISSDETD CCCCCCCCCCCCCCC	38.52	25293948
204	Phosphorylation	SSEDSSISSDETDVE CCCCCCCCCCCCCCE	33.41	26525534
205	Phosphorylation	SEDSSISSDETDVEV CCCCCCCCCCCCCEE	37.48	25293948
208	Phosphorylation	SSISSDETDVEVKSP CCCCCCCCCCEECCC	50.78	25293948
214	Phosphorylation	ETDVEVKSPAKPAQA CCCCEECCCCCHHHH	34.95	26370283
241	Acetylation	RTAPGPTKLGNVAPT CCCCCCCCCCCCCCC	58.49	23236377
248	Phosphorylation	KLGNVAPTPAKPARA CCCCCCCCCCHHHHH	26.58	24453211
275	Phosphorylation	AAAAAEESESSEEDS HHHHHHHHHCCCCCC	33.99	29895711
277	Phosphorylation	AAAEESESSEEDSDS HHHHHHHCCCCCCCC	52.94	25293948
278	Phosphorylation	AAEESESSEEDSDSE HHHHHHCCCCCCCCC	40.74	25293948
282	Phosphorylation	SESSEEDSDSEDEAP HHCCCCCCCCCCCCC	46.44	25293948
284	Phosphorylation	SSEEDSDSEDEAPAG CCCCCCCCCCCCCCC	51.39	29895711
294	Phosphorylation	EAPAGLPSQVKASGK CCCCCCCHHHHCCCC	53.28	25293948
301	Acetylation	SQVKASGKGPHVRAD HHHHCCCCCCCCCCC	67.77	-
309	Phosphorylation	GPHVRADSVSAKGIS CCCCCCCCCCCCCCC	19.58	24453211
311	Phosphorylation	HVRADSVSAKGISGK CCCCCCCCCCCCCCC	28.37	25266776
318	Acetylation	SAKGISGKGPILATP CCCCCCCCCCEECCC	55.51	23806337
324	Phosphorylation	GKGPILATPGKTGPA CCCCEECCCCCCCCC	29.18	26824392
327	Acetylation	PILATPGKTGPAATQ CEECCCCCCCCCHHH	52.06	23806337
328	Phosphorylation	ILATPGKTGPAATQA EECCCCCCCCCHHHH	55.07	25168779
344	Phosphorylation	AERPEKDSETSSEDD HCCCCCCCCCCCCCC	54.57	27149854
346	Phosphorylation	RPEKDSETSSEDDSD CCCCCCCCCCCCCCC	41.32	27149854
347	Phosphorylation	PEKDSETSSEDDSDS CCCCCCCCCCCCCCC	27.90	27149854
348	Phosphorylation	EKDSETSSEDDSDSE CCCCCCCCCCCCCCC	53.09	27149854
352	Phosphorylation	ETSSEDDSDSEDEMP CCCCCCCCCCCCCCC	56.19	27149854
354	Phosphorylation	SSEDDSDSEDEMPVT CCCCCCCCCCCCCEE	51.39	27149854
361	Phosphorylation	SEDEMPVTVNTPQAR CCCCCCEEECCCCHH	11.36	30635358
364	Phosphorylation	EMPVTVNTPQARTSG CCCEEECCCCHHCCC	16.67	19854140
379	Phosphorylation	KSPRARGTSAPAKES CCCCCCCCCCCCCHH	19.03	30635358
380	Phosphorylation	SPRARGTSAPAKESS CCCCCCCCCCCCHHH	34.77	26239621
386	Phosphorylation	TSAPAKESSQKGAPA CCCCCCHHHCCCCCC	37.04	26239621
387	Phosphorylation	SAPAKESSQKGAPAV CCCCCHHHCCCCCCC	36.68	26239621
395	Phosphorylation	QKGAPAVTPGKARPV CCCCCCCCCCCCCCC	28.56	26239621
413	Phosphorylation	AGKPEAKSSEESESD CCCCCCCCCCCCCCC	50.45	22802335
414	Phosphorylation	GKPEAKSSEESESDS CCCCCCCCCCCCCCC	44.68	22942356
417	Phosphorylation	EAKSSEESESDSGET CCCCCCCCCCCCCCC	38.05	27087446
419	Phosphorylation	KSSEESESDSGETPA CCCCCCCCCCCCCCC	46.48	27087446
421	Phosphorylation	SEESESDSGETPAAA CCCCCCCCCCCCCCE	48.05	27087446
424	Phosphorylation	SESDSGETPAAATLT CCCCCCCCCCCEEEE	23.04	27087446
429	Phosphorylation	GETPAAATLTTSPAK CCCCCCEEEECCCCC	21.65	29119230
431	Phosphorylation	TPAAATLTTSPAKVK CCCCEEEECCCCCCC	22.37	21149613
432	Phosphorylation	PAAATLTTSPAKVKP CCCEEEECCCCCCCC	35.51	21149613
433	Phosphorylation	AAATLTTSPAKVKPL CCEEEECCCCCCCCC	20.02	21149613
443	Phosphorylation	KVKPLGKSSQVRPVS CCCCCCCCCCEECCE	24.97	25619855
444	Phosphorylation	VKPLGKSSQVRPVST CCCCCCCCCEECCEE	35.86	25619855
450	Phosphorylation	SSQVRPVSTVTPGSS CCCEECCEEECCCCC	21.60	25619855
451	Phosphorylation	SQVRPVSTVTPGSSG CCEECCEEECCCCCC	28.74	25619855
453	Phosphorylation	VRPVSTVTPGSSGKG EECCEEECCCCCCCC	23.24	25619855
456	Phosphorylation	VSTVTPGSSGKGANL CEEECCCCCCCCCCC	36.80	22942356
457	Phosphorylation	STVTPGSSGKGANLP EEECCCCCCCCCCCC	50.90	25619855
459	Acetylation	VTPGSSGKGANLPCP ECCCCCCCCCCCCCC	57.72	23806337
465	Glutathionylation	GKGANLPCPGKVGSA CCCCCCCCCCCCCCH	8.59	24333276
468	Malonylation	ANLPCPGKVGSAALR CCCCCCCCCCCHHHE	28.68	26320211
485	Phosphorylation	MVKKEDVSESSSAEL EEEHHHCCCCCCCCC	44.05	24759943
487	Phosphorylation	KKEDVSESSSAELDS EHHHCCCCCCCCCCC	23.30	24759943
488	Phosphorylation	KEDVSESSSAELDSD HHHCCCCCCCCCCCC	29.52	28285833
489	Phosphorylation	EDVSESSSAELDSDG HHCCCCCCCCCCCCC	34.73	20531401
494	Phosphorylation	SSSAELDSDGPGSPA CCCCCCCCCCCCCHH	58.03	21149613
499	Phosphorylation	LDSDGPGSPAKAKAS CCCCCCCCHHHHHHH	25.47	21149613
521	Acetylation	RPVATQVKTDRGKGH CCCEEEEECCCCCCC	34.59	-
529	Phosphorylation	TDRGKGHSGSSEESS CCCCCCCCCCCCCCC	49.38	29895711
531	Phosphorylation	RGKGHSGSSEESSDS CCCCCCCCCCCCCCC	37.28	29895711
532	Phosphorylation	GKGHSGSSEESSDSE CCCCCCCCCCCCCCH	49.24	29895711
535	Phosphorylation	HSGSSEESSDSEEEA CCCCCCCCCCCHHHH	35.08	29895711
536	Phosphorylation	SGSSEESSDSEEEAA CCCCCCCCCCHHHHH	48.73	25338131
538	Phosphorylation	SSEESSDSEEEAAPA CCCCCCCCHHHHHHH	49.18	29895711
547	Phosphorylation	EEAAPAASAAQAKPA HHHHHHHHHHHHHHH	26.66	20531401
562	Phosphorylation	LEKQMKASSRKGTPA HHHHHHHHCCCCCCC	25.76	25168779
563	Phosphorylation	EKQMKASSRKGTPAS HHHHHHHCCCCCCCC	42.76	25168779
567	Phosphorylation	KASSRKGTPASATGA HHHCCCCCCCCCCCC	20.79	29895711
570	Phosphorylation	SRKGTPASATGASTS CCCCCCCCCCCCCCC	27.80	29550500
572	Phosphorylation	KGTPASATGASTSSH CCCCCCCCCCCCCCC	30.68	25168779
575	Phosphorylation	PASATGASTSSHCKA CCCCCCCCCCCCCCC	30.11	25168779
576	Phosphorylation	ASATGASTSSHCKAG CCCCCCCCCCCCCCC	33.44	25168779
577	Phosphorylation	SATGASTSSHCKAGA CCCCCCCCCCCCCCC	18.65	25168779
578	Phosphorylation	ATGASTSSHCKAGAV CCCCCCCCCCCCCCC	32.75	25168779
586	Phosphorylation	HCKAGAVTSSASLSS CCCCCCCCCCCCCCC	19.21	25619855
587	Phosphorylation	CKAGAVTSSASLSSP CCCCCCCCCCCCCCH	19.80	25168779
588	Phosphorylation	KAGAVTSSASLSSPA CCCCCCCCCCCCCHH	16.71	25168779
590	Phosphorylation	GAVTSSASLSSPALA CCCCCCCCCCCHHHH	30.63	27087446
592	Phosphorylation	VTSSASLSSPALAKG CCCCCCCCCHHHHCC	31.61	22942356
593	Phosphorylation	TSSASLSSPALAKGT CCCCCCCCHHHHCCC	21.34	27087446
600	Phosphorylation	SPALAKGTQRSDVDS CHHHHCCCCHHCCCC	21.80	29895711
603	Phosphorylation	LAKGTQRSDVDSSSE HHCCCCHHCCCCCCC	31.97	28833060
607	Phosphorylation	TQRSDVDSSSESESE CCHHCCCCCCCCCCC	35.30	28833060
608	Phosphorylation	QRSDVDSSSESESEG CHHCCCCCCCCCCCC	33.39	28833060
609	Phosphorylation	RSDVDSSSESESEGA HHCCCCCCCCCCCCC	49.44	28833060
611	Phosphorylation	DVDSSSESESEGAAP CCCCCCCCCCCCCCC	48.66	28833060
613	Phosphorylation	DSSSESESEGAAPST CCCCCCCCCCCCCCC	51.08	28833060
619	Phosphorylation	ESEGAAPSTPRVQGK CCCCCCCCCCCCCCC	46.44	28833060
620	Phosphorylation	SEGAAPSTPRVQGKS CCCCCCCCCCCCCCC	17.66	28833060
626	Acetylation	STPRVQGKSGGKGLQ CCCCCCCCCCCCCCC	28.92	23806337
630	Acetylation	VQGKSGGKGLQGKAA CCCCCCCCCCCHHHH	61.03	23806337
655	Acetylation	QKTGPSVKAMAQEDS CCCCHHHHHHHHHCH	36.46	-
662	Phosphorylation	KAMAQEDSESLEEDS HHHHHHCHHHHCCCC	28.47	29895711
664	Phosphorylation	MAQEDSESLEEDSSS HHHHCHHHHCCCCCC	45.06	29895711
669	Phosphorylation	SESLEEDSSSEEEDE HHHHCCCCCCCCCCC	38.76	29895711
670	Phosphorylation	ESLEEDSSSEEEDET HHHCCCCCCCCCCCC	54.83	29895711
671	Phosphorylation	SLEEDSSSEEEDETP HHCCCCCCCCCCCCC	53.64	29895711
677	Phosphorylation	SSEEEDETPAQATPL CCCCCCCCCCCCCCC	35.92	25293948
682	Phosphorylation	DETPAQATPLGRLPQ CCCCCCCCCCCCCCH	13.63	20531401
697	Phosphorylation	AKANPPPTKTPPASA HHCCCCCCCCCCCCC	54.01	25159016
699	Phosphorylation	ANPPPTKTPPASASG CCCCCCCCCCCCCCC	36.66	25159016
703	Phosphorylation	PTKTPPASASGKAVA CCCCCCCCCCCCCCC	28.83	28066266
705	Phosphorylation	KTPPASASGKAVAAP CCCCCCCCCCCCCCC	38.03	25159016
722	Phosphorylation	GKPPVPNSTVSARGQ CCCCCCCCCCCCCCC	24.90	29176673
723	Phosphorylation	KPPVPNSTVSARGQR CCCCCCCCCCCCCCC	25.72	29176673
725	Phosphorylation	PVPNSTVSARGQRSV CCCCCCCCCCCCCCC	16.61	29176673
753	Phosphorylation	QKGPVAGTGEDSESS CCCCCCCCCCCCCCC	27.88	29895711
757	Phosphorylation	VAGTGEDSESSSKEE CCCCCCCCCCCCCCC	34.77	29895711
759	Phosphorylation	GTGEDSESSSKEESD CCCCCCCCCCCCCCC	43.81	22802335
760	Phosphorylation	TGEDSESSSKEESDS CCCCCCCCCCCCCCC	41.18	22802335
761	Phosphorylation	GEDSESSSKEESDSE CCCCCCCCCCCCCCC	54.06	22802335
765	Phosphorylation	ESSSKEESDSEEETP CCCCCCCCCCCCCCC	47.75	23684622
767	Phosphorylation	SSKEESDSEEETPAQ CCCCCCCCCCCCCCC	57.07	23684622
771	Phosphorylation	ESDSEEETPAQIKPV CCCCCCCCCCCCCCC	27.49	29472430
788	Phosphorylation	TSQVRAASAPAKESP HHHHEECCCCCCCCC	33.53	25159016
794	Phosphorylation	ASAPAKESPKKGAHP CCCCCCCCCCCCCCC	41.11	26824392
803	Phosphorylation	KKGAHPGTPGKTGSS CCCCCCCCCCCCCCC	33.06	25266776
819	Phosphorylation	TQAQPGKTEDSDSSS CCCCCCCCCCCCCCC	51.44	30635358
822	Phosphorylation	QPGKTEDSDSSSEES CCCCCCCCCCCCCCC	32.91	30635358
824	Phosphorylation	GKTEDSDSSSEESDS CCCCCCCCCCCCCCC	39.45	30635358
825	Phosphorylation	KTEDSDSSSEESDSD CCCCCCCCCCCCCCC	46.92	30635358
826	Phosphorylation	TEDSDSSSEESDSDT CCCCCCCCCCCCCCC	49.70	30635358
829	Phosphorylation	SDSSSEESDSDTEMP CCCCCCCCCCCCCCC	38.06	30635358
831	Phosphorylation	SSSEESDSDTEMPSA CCCCCCCCCCCCCCC	56.57	30635358
833	Phosphorylation	SEESDSDTEMPSAQA CCCCCCCCCCCCCHH	37.83	30635358
837	Phosphorylation	DSDTEMPSAQAIKSP CCCCCCCCCHHCCCC	31.53	30635358
843	Phosphorylation	PSAQAIKSPPVSVNR CCCHHCCCCCCCCCC	28.46	23684622
847	Phosphorylation	AIKSPPVSVNRNSSP HCCCCCCCCCCCCCC	21.32	25159016
852	Phosphorylation	PVSVNRNSSPAVPAP CCCCCCCCCCCCCCC	34.17	25521595
853	Phosphorylation	VSVNRNSSPAVPAPT CCCCCCCCCCCCCCC	22.04	25521595
860	Phosphorylation	SPAVPAPTPEGVQAV CCCCCCCCCCCCEEE	35.76	27087446
869	Phosphorylation	EGVQAVNTTKKASGT CCCEEEECCCCCCCC	33.13	25619855
870	Phosphorylation	GVQAVNTTKKASGTT CCEEEECCCCCCCCC	25.91	25619855
874	Phosphorylation	VNTTKKASGTTAQSS EECCCCCCCCCCCCC	45.62	30635358
876	Phosphorylation	TTKKASGTTAQSSSS CCCCCCCCCCCCCCC	19.23	30635358
877	Phosphorylation	TKKASGTTAQSSSSE CCCCCCCCCCCCCCC	26.65	30635358
880	Phosphorylation	ASGTTAQSSSSESED CCCCCCCCCCCCCCC	29.71	30635358
881	Phosphorylation	SGTTAQSSSSESEDG CCCCCCCCCCCCCCC	26.29	30635358
882	Phosphorylation	GTTAQSSSSESEDGD CCCCCCCCCCCCCCC	43.29	30635358
883	Phosphorylation	TTAQSSSSESEDGDE CCCCCCCCCCCCCCC	47.27	30635358
885	Phosphorylation	AQSSSSESEDGDEDL CCCCCCCCCCCCCCC	42.82	30635358
896	Phosphorylation	DEDLIPATQPSTYAL CCCCCCCCCCCCEEC	35.34	30635358
899	Phosphorylation	LIPATQPSTYALRTS CCCCCCCCCEECCCC	25.00	19854140
900	Phosphorylation	IPATQPSTYALRTSV CCCCCCCCEECCCCC	21.35	19854140
901	Phosphorylation	PATQPSTYALRTSVT CCCCCCCEECCCCCC	14.15	19854140
905	Phosphorylation	PSTYALRTSVTTPAA CCCEECCCCCCCHHH	28.53	28833060
906	Phosphorylation	STYALRTSVTTPAAL CCEECCCCCCCHHHH	15.84	28833060
908	Phosphorylation	YALRTSVTTPAALSR EECCCCCCCHHHHHH	27.16	28833060
909	Phosphorylation	ALRTSVTTPAALSRA ECCCCCCCHHHHHHH	14.58	28833060
914	Phosphorylation	VTTPAALSRAASQPS CCCHHHHHHHHHCCC	18.36	28066266
918	Phosphorylation	AALSRAASQPSKSEQ HHHHHHHHCCCCCHH	41.46	27149854
922	Acetylation	RAASQPSKSEQSSRM HHHHCCCCCHHHHCC	65.77	23806337
945	Phosphorylation	AASAQTSSAVETLPM HHHHCCCCHHHHCCC	39.46	28285833
976	Acetylation	GKSKLPEKQQLAPGY CCCCCCHHHCCCCCC	41.21	23806337
989	Phosphorylation	GYPKAPRSSEDSSDT CCCCCCCCCCCCCCC	36.70	30635358
990	Phosphorylation	YPKAPRSSEDSSDTS CCCCCCCCCCCCCCC	46.86	30635358
993	Phosphorylation	APRSSEDSSDTSSED CCCCCCCCCCCCCCC	26.51	30635358
994	Phosphorylation	PRSSEDSSDTSSEDE CCCCCCCCCCCCCCH	58.17	30635358
996	Phosphorylation	SSEDSSDTSSEDEED CCCCCCCCCCCCHHH	35.78	30635358
997	Phosphorylation	SEDSSDTSSEDEEDA CCCCCCCCCCCHHHH	36.40	30635358
998	Phosphorylation	EDSSDTSSEDEEDAK CCCCCCCCCCHHHHH	51.68	30635358
1021	Phosphorylation	HRLDPDPSQKETVVE HCCCCCHHHCCEEEE	62.35	26370283
1025	Phosphorylation	PDPSQKETVVEETPT CCHHHCCEEEEECCC	36.57	21743459
1030	Phosphorylation	KETVVEETPTESSED CCEEEEECCCCCCCC	23.23	21743459
1032	Phosphorylation	TVVEETPTESSEDEM EEEEECCCCCCCCCC	56.79	21743459
1034	Phosphorylation	VEETPTESSEDEMVA EEECCCCCCCCCCCC	41.32	21743459
1035	Phosphorylation	EETPTESSEDEMVAP EECCCCCCCCCCCCC	42.72	21743459
1066	Phosphorylation	NSQASKATPRPDSNS CCCCCCCCCCCCCCC	24.46	25263469
1071	Phosphorylation	KATPRPDSNSLASSA CCCCCCCCCCCHHCC	30.88	29514104
1073	Phosphorylation	TPRPDSNSLASSAPA CCCCCCCCCHHCCCC	29.30	29472430
1076	Phosphorylation	PDSNSLASSAPATKD CCCCCCHHCCCCCCC	32.12	29472430
1077	Phosphorylation	DSNSLASSAPATKDN CCCCCHHCCCCCCCC	32.44	29472430
1081	Phosphorylation	LASSAPATKDNPDGK CHHCCCCCCCCCCCC	37.56	29472430
1110	Phosphorylation	KTGRKEASSGSTPQK CCCCCCCCCCCCCCC	36.00	25159016
1111	Phosphorylation	TGRKEASSGSTPQKP CCCCCCCCCCCCCCC	43.76	25159016
1113	Phosphorylation	RKEASSGSTPQKPKK CCCCCCCCCCCCCCC	38.57	25159016
1114	Phosphorylation	KEASSGSTPQKPKKL CCCCCCCCCCCCCCC	33.01	26824392
1124	Phosphorylation	KPKKLKKSTSSSPAP CCCCCCCCCCCCCCC	31.75	27087446
1125	Phosphorylation	PKKLKKSTSSSPAPT CCCCCCCCCCCCCCC	41.32	22942356
1126	Phosphorylation	KKLKKSTSSSPAPTQ CCCCCCCCCCCCCCC	35.59	27087446
1127	Phosphorylation	KLKKSTSSSPAPTQT CCCCCCCCCCCCCCC	40.19	27087446
1128	Phosphorylation	LKKSTSSSPAPTQTL CCCCCCCCCCCCCCC	25.50	25521595
1132	Phosphorylation	TSSSPAPTQTLPNSI CCCCCCCCCCCCCHH	35.97	22942356
1134	Phosphorylation	SSPAPTQTLPNSITQ CCCCCCCCCCCHHHH	46.81	25168779
1138	Phosphorylation	PTQTLPNSITQRLLE CCCCCCCHHHHHHHH	25.69	25619855
1140	Phosphorylation	QTLPNSITQRLLEQA CCCCCHHHHHHHHHH	13.88	25619855
1161	Ubiquitination	QVQASVVKVLTELLE HHHHHHHHHHHHHHH	29.39	-
1181	Phosphorylation	ATEAIKESGKKSQKR HHHHHHHHCHHHHHH	51.41	28066266
1189	Acetylation	GKKSQKRKLSGDLEA CHHHHHHHHCCCCCC	54.78	7720263
1191	Phosphorylation	KSQKRKLSGDLEAGA HHHHHHHCCCCCCCC	33.04	27087446
1213	Phosphorylation	EQPVPRASAVSPEKA CCCCCCHHCCCCCCC	30.40	22942356
1216	Phosphorylation	VPRASAVSPEKAPMT CCCHHCCCCCCCCCC	27.36	27087446
1223	Phosphorylation	SPEKAPMTSKAKSKL CCCCCCCCHHHHHHC	26.47	25619855
1224	Phosphorylation	PEKAPMTSKAKSKLD CCCCCCCHHHHHHCC	25.10	25619855
1240	Acetylation	GSAGGKGKGSPGPQG CCCCCCCCCCCCCCC	60.75	7495849
1242	Phosphorylation	AGGKGKGSPGPQGAK CCCCCCCCCCCCCCC	30.12	27087446
1249	Acetylation	SPGPQGAKEKPDGEL CCCCCCCCCCCCCCE	73.44	-
1263	Phosphorylation	LLGIKLESGEQSDPK EEEEEECCCCCCCCC	59.05	28833060
1267	Phosphorylation	KLESGEQSDPKSKSK EECCCCCCCCCCHHH	52.13	28833060
1301	Phosphorylation	KKSLAKDSASPIQKK HHHHHCCCCCHHHHH	29.91	22802335
1303	Phosphorylation	SLAKDSASPIQKKKK HHHCCCCCHHHHHHH	26.87	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TCOF_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TCOF_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TCOF_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TCOF_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TCOF_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; THR-171; SER-593AND SER-1216, AND MASS SPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-908 AND SER-1191, ANDMASS SPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-757; SER-759; SER-760;SER-761; SER-765; SER-767; SER-794; SER-1191 AND SER-1242, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169 AND THR-171, ANDMASS SPECTROMETRY.	17242355 [Abstract]
"A differential phosphoproteomic analysis of retinoic acid-treated P19cells."; Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.; J. Proteome Res. 6:3174-3186(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-84; SER-85;SER-87; SER-88; SER-344; THR-346; SER-347; SER-348; SER-352; SER-354;SER-413; SER-414; SER-417; SER-419; SER-421; SER-433; SER-485;SER-487; SER-488; SER-489; SER-494; SER-499; SER-529; SER-531;SER-532; SER-535; SER-536; SER-538; THR-600; SER-603; SER-607;SER-608; SER-609; THR-753; SER-757; SER-759; SER-760; SER-761;SER-765; SER-767; SER-993; SER-994; THR-996; SER-997 AND SER-998, ANDMASS SPECTROMETRY.	17622165 [Abstract]
"Identification of phosphoproteins and their phosphorylation sites inthe WEHI-231 B lymphoma cell line."; Shu H., Chen S., Bi Q., Mumby M., Brekken D.L.; Mol. Cell. Proteomics 3:279-286(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1191, AND MASSSPECTROMETRY.	14729942 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-171, AND MASSSPECTROMETRY.	15345747 [Abstract]