UniProt ID | TCOF_MOUSE | |
---|---|---|
UniProt AC | O08784 | |
Protein Name | Treacle protein | |
Gene Name | Tcof1 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 1320 | |
Subcellular Localization | Nucleus, nucleolus . | |
Protein Description | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.. | |
Protein Sequence | MAEARKRRELLPLIYHHLLQAGYVRAAREVKEQSGQKSFLTQPVTLLDIYTHWQQTSELGQKQKAEDDETLQAKKSRVSDPVSSSESSDQEKEEEAATERAKATPRPTPVNSATAALPSKVKEKGKTKTANKTVNSVSHPGSGKTVVHLLSGKSPKKSAEPLANTVLASETEEEGNAQALGPTAKSGTVSAGQGSSSSEDSSISSDETDVEVKSPAKPAQAKASAAPAKDPPARTAPGPTKLGNVAPTPAKPARAAAAAAAAAVAAAAAAAAEESESSEEDSDSEDEAPAGLPSQVKASGKGPHVRADSVSAKGISGKGPILATPGKTGPAATQAKAERPEKDSETSSEDDSDSEDEMPVTVNTPQARTSGKSPRARGTSAPAKESSQKGAPAVTPGKARPVAAQAGKPEAKSSEESESDSGETPAAATLTTSPAKVKPLGKSSQVRPVSTVTPGSSGKGANLPCPGKVGSAALRVQMVKKEDVSESSSAELDSDGPGSPAKAKASLALPQKVRPVATQVKTDRGKGHSGSSEESSDSEEEAAPAASAAQAKPALEKQMKASSRKGTPASATGASTSSHCKAGAVTSSASLSSPALAKGTQRSDVDSSSESESEGAAPSTPRVQGKSGGKGLQGKAALGQGVAPVHTQKTGPSVKAMAQEDSESLEEDSSSEEEDETPAQATPLGRLPQAKANPPPTKTPPASASGKAVAAPTKGKPPVPNSTVSARGQRSVPAAGKAGAPATQAQKGPVAGTGEDSESSSKEESDSEEETPAQIKPVGKTSQVRAASAPAKESPKKGAHPGTPGKTGSSATQAQPGKTEDSDSSSEESDSDTEMPSAQAIKSPPVSVNRNSSPAVPAPTPEGVQAVNTTKKASGTTAQSSSSESEDGDEDLIPATQPSTYALRTSVTTPAALSRAASQPSKSEQSSRMPKGKKAKAAASAQTSSAVETLPMMPPQSAPIQPKATNKLGKSKLPEKQQLAPGYPKAPRSSEDSSDTSSEDEEDAKRPQMPKSAHRLDPDPSQKETVVEETPTESSEDEMVAPSQSLLSGYMTPGLTVANSQASKATPRPDSNSLASSAPATKDNPDGKQKSKSQHAADTALPKTGRKEASSGSTPQKPKKLKKSTSSSPAPTQTLPNSITQRLLEQAWPLSEAQVQASVVKVLTELLEQERLKATEAIKESGKKSQKRKLSGDLEAGAPKNKKKKEQPVPRASAVSPEKAPMTSKAKSKLDKGSAGGKGKGSPGPQGAKEKPDGELLGIKLESGEQSDPKSKSKKKKSLKKKKDKEKKEKKKGKKSLAKDSASPIQKKKKKKKKSAEPAV | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
76 | Phosphorylation | ETLQAKKSRVSDPVS HHHHHHHHHCCCCCC | 36.89 | 30635358 | |
79 | Phosphorylation | QAKKSRVSDPVSSSE HHHHHHCCCCCCCCC | 34.78 | 25619855 | |
83 | Phosphorylation | SRVSDPVSSSESSDQ HHCCCCCCCCCCCHH | 33.27 | 23684622 | |
84 | Phosphorylation | RVSDPVSSSESSDQE HCCCCCCCCCCCHHH | 38.06 | 23684622 | |
85 | Phosphorylation | VSDPVSSSESSDQEK CCCCCCCCCCCHHHH | 33.71 | 23684622 | |
87 | Phosphorylation | DPVSSSESSDQEKEE CCCCCCCCCHHHHHH | 40.96 | 23684622 | |
88 | Phosphorylation | PVSSSESSDQEKEEE CCCCCCCCHHHHHHH | 38.98 | 23684622 | |
98 | Phosphorylation | EKEEEAATERAKATP HHHHHHHHHHHHCCC | 32.81 | 25619855 | |
104 | Phosphorylation | ATERAKATPRPTPVN HHHHHHCCCCCCCCC | 21.08 | 25266776 | |
108 | Phosphorylation | AKATPRPTPVNSATA HHCCCCCCCCCHHHH | 40.94 | 25266776 | |
112 | Phosphorylation | PRPTPVNSATAALPS CCCCCCCHHHHCCCH | 27.51 | 28066266 | |
114 | Phosphorylation | PTPVNSATAALPSKV CCCCCHHHHCCCHHH | 16.57 | 28066266 | |
132 | Acetylation | GKTKTANKTVNSVSH CCCCCCCCCCCCCCC | 51.92 | 23806337 | |
144 | Acetylation | VSHPGSGKTVVHLLS CCCCCCCCEEEECCC | 39.58 | 23806337 | |
151 | Phosphorylation | KTVVHLLSGKSPKKS CEEEECCCCCCCCCC | 51.00 | 28725479 | |
153 | Acetylation | VVHLLSGKSPKKSAE EEECCCCCCCCCCCC | 61.27 | 23806337 | |
154 | Phosphorylation | VHLLSGKSPKKSAEP EECCCCCCCCCCCCC | 45.54 | 26824392 | |
158 | Phosphorylation | SGKSPKKSAEPLANT CCCCCCCCCCCHHCC | 43.95 | 27087446 | |
165 | Phosphorylation | SAEPLANTVLASETE CCCCHHCCHHCCCCC | 15.99 | 24925903 | |
169 | Phosphorylation | LANTVLASETEEEGN HHCCHHCCCCCCCCC | 40.67 | 27087446 | |
171 | Phosphorylation | NTVLASETEEEGNAQ CCHHCCCCCCCCCCC | 46.32 | 24925903 | |
183 | Phosphorylation | NAQALGPTAKSGTVS CCCCCCCCCCCCCEE | 44.94 | 25619855 | |
186 | Phosphorylation | ALGPTAKSGTVSAGQ CCCCCCCCCCEECCC | 36.91 | 25293948 | |
188 | Phosphorylation | GPTAKSGTVSAGQGS CCCCCCCCEECCCCC | 20.55 | 25293948 | |
190 | Phosphorylation | TAKSGTVSAGQGSSS CCCCCCEECCCCCCC | 26.90 | 25293948 | |
195 | Phosphorylation | TVSAGQGSSSSEDSS CEECCCCCCCCCCCC | 21.11 | 25293948 | |
196 | Phosphorylation | VSAGQGSSSSEDSSI EECCCCCCCCCCCCC | 44.71 | 25293948 | |
197 | Phosphorylation | SAGQGSSSSEDSSIS ECCCCCCCCCCCCCC | 39.17 | 25293948 | |
198 | Phosphorylation | AGQGSSSSEDSSISS CCCCCCCCCCCCCCC | 47.58 | 25293948 | |
201 | Phosphorylation | GSSSSEDSSISSDET CCCCCCCCCCCCCCC | 26.06 | 25293948 | |
202 | Phosphorylation | SSSSEDSSISSDETD CCCCCCCCCCCCCCC | 38.52 | 25293948 | |
204 | Phosphorylation | SSEDSSISSDETDVE CCCCCCCCCCCCCCE | 33.41 | 26525534 | |
205 | Phosphorylation | SEDSSISSDETDVEV CCCCCCCCCCCCCEE | 37.48 | 25293948 | |
208 | Phosphorylation | SSISSDETDVEVKSP CCCCCCCCCCEECCC | 50.78 | 25293948 | |
214 | Phosphorylation | ETDVEVKSPAKPAQA CCCCEECCCCCHHHH | 34.95 | 26370283 | |
241 | Acetylation | RTAPGPTKLGNVAPT CCCCCCCCCCCCCCC | 58.49 | 23236377 | |
248 | Phosphorylation | KLGNVAPTPAKPARA CCCCCCCCCCHHHHH | 26.58 | 24453211 | |
275 | Phosphorylation | AAAAAEESESSEEDS HHHHHHHHHCCCCCC | 33.99 | 29895711 | |
277 | Phosphorylation | AAAEESESSEEDSDS HHHHHHHCCCCCCCC | 52.94 | 25293948 | |
278 | Phosphorylation | AAEESESSEEDSDSE HHHHHHCCCCCCCCC | 40.74 | 25293948 | |
282 | Phosphorylation | SESSEEDSDSEDEAP HHCCCCCCCCCCCCC | 46.44 | 25293948 | |
284 | Phosphorylation | SSEEDSDSEDEAPAG CCCCCCCCCCCCCCC | 51.39 | 29895711 | |
294 | Phosphorylation | EAPAGLPSQVKASGK CCCCCCCHHHHCCCC | 53.28 | 25293948 | |
301 | Acetylation | SQVKASGKGPHVRAD HHHHCCCCCCCCCCC | 67.77 | - | |
309 | Phosphorylation | GPHVRADSVSAKGIS CCCCCCCCCCCCCCC | 19.58 | 24453211 | |
311 | Phosphorylation | HVRADSVSAKGISGK CCCCCCCCCCCCCCC | 28.37 | 25266776 | |
318 | Acetylation | SAKGISGKGPILATP CCCCCCCCCCEECCC | 55.51 | 23806337 | |
324 | Phosphorylation | GKGPILATPGKTGPA CCCCEECCCCCCCCC | 29.18 | 26824392 | |
327 | Acetylation | PILATPGKTGPAATQ CEECCCCCCCCCHHH | 52.06 | 23806337 | |
328 | Phosphorylation | ILATPGKTGPAATQA EECCCCCCCCCHHHH | 55.07 | 25168779 | |
344 | Phosphorylation | AERPEKDSETSSEDD HCCCCCCCCCCCCCC | 54.57 | 27149854 | |
346 | Phosphorylation | RPEKDSETSSEDDSD CCCCCCCCCCCCCCC | 41.32 | 27149854 | |
347 | Phosphorylation | PEKDSETSSEDDSDS CCCCCCCCCCCCCCC | 27.90 | 27149854 | |
348 | Phosphorylation | EKDSETSSEDDSDSE CCCCCCCCCCCCCCC | 53.09 | 27149854 | |
352 | Phosphorylation | ETSSEDDSDSEDEMP CCCCCCCCCCCCCCC | 56.19 | 27149854 | |
354 | Phosphorylation | SSEDDSDSEDEMPVT CCCCCCCCCCCCCEE | 51.39 | 27149854 | |
361 | Phosphorylation | SEDEMPVTVNTPQAR CCCCCCEEECCCCHH | 11.36 | 30635358 | |
364 | Phosphorylation | EMPVTVNTPQARTSG CCCEEECCCCHHCCC | 16.67 | 19854140 | |
379 | Phosphorylation | KSPRARGTSAPAKES CCCCCCCCCCCCCHH | 19.03 | 30635358 | |
380 | Phosphorylation | SPRARGTSAPAKESS CCCCCCCCCCCCHHH | 34.77 | 26239621 | |
386 | Phosphorylation | TSAPAKESSQKGAPA CCCCCCHHHCCCCCC | 37.04 | 26239621 | |
387 | Phosphorylation | SAPAKESSQKGAPAV CCCCCHHHCCCCCCC | 36.68 | 26239621 | |
395 | Phosphorylation | QKGAPAVTPGKARPV CCCCCCCCCCCCCCC | 28.56 | 26239621 | |
413 | Phosphorylation | AGKPEAKSSEESESD CCCCCCCCCCCCCCC | 50.45 | 22802335 | |
414 | Phosphorylation | GKPEAKSSEESESDS CCCCCCCCCCCCCCC | 44.68 | 22942356 | |
417 | Phosphorylation | EAKSSEESESDSGET CCCCCCCCCCCCCCC | 38.05 | 27087446 | |
419 | Phosphorylation | KSSEESESDSGETPA CCCCCCCCCCCCCCC | 46.48 | 27087446 | |
421 | Phosphorylation | SEESESDSGETPAAA CCCCCCCCCCCCCCE | 48.05 | 27087446 | |
424 | Phosphorylation | SESDSGETPAAATLT CCCCCCCCCCCEEEE | 23.04 | 27087446 | |
429 | Phosphorylation | GETPAAATLTTSPAK CCCCCCEEEECCCCC | 21.65 | 29119230 | |
431 | Phosphorylation | TPAAATLTTSPAKVK CCCCEEEECCCCCCC | 22.37 | 21149613 | |
432 | Phosphorylation | PAAATLTTSPAKVKP CCCEEEECCCCCCCC | 35.51 | 21149613 | |
433 | Phosphorylation | AAATLTTSPAKVKPL CCEEEECCCCCCCCC | 20.02 | 21149613 | |
443 | Phosphorylation | KVKPLGKSSQVRPVS CCCCCCCCCCEECCE | 24.97 | 25619855 | |
444 | Phosphorylation | VKPLGKSSQVRPVST CCCCCCCCCEECCEE | 35.86 | 25619855 | |
450 | Phosphorylation | SSQVRPVSTVTPGSS CCCEECCEEECCCCC | 21.60 | 25619855 | |
451 | Phosphorylation | SQVRPVSTVTPGSSG CCEECCEEECCCCCC | 28.74 | 25619855 | |
453 | Phosphorylation | VRPVSTVTPGSSGKG EECCEEECCCCCCCC | 23.24 | 25619855 | |
456 | Phosphorylation | VSTVTPGSSGKGANL CEEECCCCCCCCCCC | 36.80 | 22942356 | |
457 | Phosphorylation | STVTPGSSGKGANLP EEECCCCCCCCCCCC | 50.90 | 25619855 | |
459 | Acetylation | VTPGSSGKGANLPCP ECCCCCCCCCCCCCC | 57.72 | 23806337 | |
465 | Glutathionylation | GKGANLPCPGKVGSA CCCCCCCCCCCCCCH | 8.59 | 24333276 | |
468 | Malonylation | ANLPCPGKVGSAALR CCCCCCCCCCCHHHE | 28.68 | 26320211 | |
485 | Phosphorylation | MVKKEDVSESSSAEL EEEHHHCCCCCCCCC | 44.05 | 24759943 | |
487 | Phosphorylation | KKEDVSESSSAELDS EHHHCCCCCCCCCCC | 23.30 | 24759943 | |
488 | Phosphorylation | KEDVSESSSAELDSD HHHCCCCCCCCCCCC | 29.52 | 28285833 | |
489 | Phosphorylation | EDVSESSSAELDSDG HHCCCCCCCCCCCCC | 34.73 | 20531401 | |
494 | Phosphorylation | SSSAELDSDGPGSPA CCCCCCCCCCCCCHH | 58.03 | 21149613 | |
499 | Phosphorylation | LDSDGPGSPAKAKAS CCCCCCCCHHHHHHH | 25.47 | 21149613 | |
521 | Acetylation | RPVATQVKTDRGKGH CCCEEEEECCCCCCC | 34.59 | - | |
529 | Phosphorylation | TDRGKGHSGSSEESS CCCCCCCCCCCCCCC | 49.38 | 29895711 | |
531 | Phosphorylation | RGKGHSGSSEESSDS CCCCCCCCCCCCCCC | 37.28 | 29895711 | |
532 | Phosphorylation | GKGHSGSSEESSDSE CCCCCCCCCCCCCCH | 49.24 | 29895711 | |
535 | Phosphorylation | HSGSSEESSDSEEEA CCCCCCCCCCCHHHH | 35.08 | 29895711 | |
536 | Phosphorylation | SGSSEESSDSEEEAA CCCCCCCCCCHHHHH | 48.73 | 25338131 | |
538 | Phosphorylation | SSEESSDSEEEAAPA CCCCCCCCHHHHHHH | 49.18 | 29895711 | |
547 | Phosphorylation | EEAAPAASAAQAKPA HHHHHHHHHHHHHHH | 26.66 | 20531401 | |
562 | Phosphorylation | LEKQMKASSRKGTPA HHHHHHHHCCCCCCC | 25.76 | 25168779 | |
563 | Phosphorylation | EKQMKASSRKGTPAS HHHHHHHCCCCCCCC | 42.76 | 25168779 | |
567 | Phosphorylation | KASSRKGTPASATGA HHHCCCCCCCCCCCC | 20.79 | 29895711 | |
570 | Phosphorylation | SRKGTPASATGASTS CCCCCCCCCCCCCCC | 27.80 | 29550500 | |
572 | Phosphorylation | KGTPASATGASTSSH CCCCCCCCCCCCCCC | 30.68 | 25168779 | |
575 | Phosphorylation | PASATGASTSSHCKA CCCCCCCCCCCCCCC | 30.11 | 25168779 | |
576 | Phosphorylation | ASATGASTSSHCKAG CCCCCCCCCCCCCCC | 33.44 | 25168779 | |
577 | Phosphorylation | SATGASTSSHCKAGA CCCCCCCCCCCCCCC | 18.65 | 25168779 | |
578 | Phosphorylation | ATGASTSSHCKAGAV CCCCCCCCCCCCCCC | 32.75 | 25168779 | |
586 | Phosphorylation | HCKAGAVTSSASLSS CCCCCCCCCCCCCCC | 19.21 | 25619855 | |
587 | Phosphorylation | CKAGAVTSSASLSSP CCCCCCCCCCCCCCH | 19.80 | 25168779 | |
588 | Phosphorylation | KAGAVTSSASLSSPA CCCCCCCCCCCCCHH | 16.71 | 25168779 | |
590 | Phosphorylation | GAVTSSASLSSPALA CCCCCCCCCCCHHHH | 30.63 | 27087446 | |
592 | Phosphorylation | VTSSASLSSPALAKG CCCCCCCCCHHHHCC | 31.61 | 22942356 | |
593 | Phosphorylation | TSSASLSSPALAKGT CCCCCCCCHHHHCCC | 21.34 | 27087446 | |
600 | Phosphorylation | SPALAKGTQRSDVDS CHHHHCCCCHHCCCC | 21.80 | 29895711 | |
603 | Phosphorylation | LAKGTQRSDVDSSSE HHCCCCHHCCCCCCC | 31.97 | 28833060 | |
607 | Phosphorylation | TQRSDVDSSSESESE CCHHCCCCCCCCCCC | 35.30 | 28833060 | |
608 | Phosphorylation | QRSDVDSSSESESEG CHHCCCCCCCCCCCC | 33.39 | 28833060 | |
609 | Phosphorylation | RSDVDSSSESESEGA HHCCCCCCCCCCCCC | 49.44 | 28833060 | |
611 | Phosphorylation | DVDSSSESESEGAAP CCCCCCCCCCCCCCC | 48.66 | 28833060 | |
613 | Phosphorylation | DSSSESESEGAAPST CCCCCCCCCCCCCCC | 51.08 | 28833060 | |
619 | Phosphorylation | ESEGAAPSTPRVQGK CCCCCCCCCCCCCCC | 46.44 | 28833060 | |
620 | Phosphorylation | SEGAAPSTPRVQGKS CCCCCCCCCCCCCCC | 17.66 | 28833060 | |
626 | Acetylation | STPRVQGKSGGKGLQ CCCCCCCCCCCCCCC | 28.92 | 23806337 | |
630 | Acetylation | VQGKSGGKGLQGKAA CCCCCCCCCCCHHHH | 61.03 | 23806337 | |
655 | Acetylation | QKTGPSVKAMAQEDS CCCCHHHHHHHHHCH | 36.46 | - | |
662 | Phosphorylation | KAMAQEDSESLEEDS HHHHHHCHHHHCCCC | 28.47 | 29895711 | |
664 | Phosphorylation | MAQEDSESLEEDSSS HHHHCHHHHCCCCCC | 45.06 | 29895711 | |
669 | Phosphorylation | SESLEEDSSSEEEDE HHHHCCCCCCCCCCC | 38.76 | 29895711 | |
670 | Phosphorylation | ESLEEDSSSEEEDET HHHCCCCCCCCCCCC | 54.83 | 29895711 | |
671 | Phosphorylation | SLEEDSSSEEEDETP HHCCCCCCCCCCCCC | 53.64 | 29895711 | |
677 | Phosphorylation | SSEEEDETPAQATPL CCCCCCCCCCCCCCC | 35.92 | 25293948 | |
682 | Phosphorylation | DETPAQATPLGRLPQ CCCCCCCCCCCCCCH | 13.63 | 20531401 | |
697 | Phosphorylation | AKANPPPTKTPPASA HHCCCCCCCCCCCCC | 54.01 | 25159016 | |
699 | Phosphorylation | ANPPPTKTPPASASG CCCCCCCCCCCCCCC | 36.66 | 25159016 | |
703 | Phosphorylation | PTKTPPASASGKAVA CCCCCCCCCCCCCCC | 28.83 | 28066266 | |
705 | Phosphorylation | KTPPASASGKAVAAP CCCCCCCCCCCCCCC | 38.03 | 25159016 | |
722 | Phosphorylation | GKPPVPNSTVSARGQ CCCCCCCCCCCCCCC | 24.90 | 29176673 | |
723 | Phosphorylation | KPPVPNSTVSARGQR CCCCCCCCCCCCCCC | 25.72 | 29176673 | |
725 | Phosphorylation | PVPNSTVSARGQRSV CCCCCCCCCCCCCCC | 16.61 | 29176673 | |
753 | Phosphorylation | QKGPVAGTGEDSESS CCCCCCCCCCCCCCC | 27.88 | 29895711 | |
757 | Phosphorylation | VAGTGEDSESSSKEE CCCCCCCCCCCCCCC | 34.77 | 29895711 | |
759 | Phosphorylation | GTGEDSESSSKEESD CCCCCCCCCCCCCCC | 43.81 | 22802335 | |
760 | Phosphorylation | TGEDSESSSKEESDS CCCCCCCCCCCCCCC | 41.18 | 22802335 | |
761 | Phosphorylation | GEDSESSSKEESDSE CCCCCCCCCCCCCCC | 54.06 | 22802335 | |
765 | Phosphorylation | ESSSKEESDSEEETP CCCCCCCCCCCCCCC | 47.75 | 23684622 | |
767 | Phosphorylation | SSKEESDSEEETPAQ CCCCCCCCCCCCCCC | 57.07 | 23684622 | |
771 | Phosphorylation | ESDSEEETPAQIKPV CCCCCCCCCCCCCCC | 27.49 | 29472430 | |
788 | Phosphorylation | TSQVRAASAPAKESP HHHHEECCCCCCCCC | 33.53 | 25159016 | |
794 | Phosphorylation | ASAPAKESPKKGAHP CCCCCCCCCCCCCCC | 41.11 | 26824392 | |
803 | Phosphorylation | KKGAHPGTPGKTGSS CCCCCCCCCCCCCCC | 33.06 | 25266776 | |
819 | Phosphorylation | TQAQPGKTEDSDSSS CCCCCCCCCCCCCCC | 51.44 | 30635358 | |
822 | Phosphorylation | QPGKTEDSDSSSEES CCCCCCCCCCCCCCC | 32.91 | 30635358 | |
824 | Phosphorylation | GKTEDSDSSSEESDS CCCCCCCCCCCCCCC | 39.45 | 30635358 | |
825 | Phosphorylation | KTEDSDSSSEESDSD CCCCCCCCCCCCCCC | 46.92 | 30635358 | |
826 | Phosphorylation | TEDSDSSSEESDSDT CCCCCCCCCCCCCCC | 49.70 | 30635358 | |
829 | Phosphorylation | SDSSSEESDSDTEMP CCCCCCCCCCCCCCC | 38.06 | 30635358 | |
831 | Phosphorylation | SSSEESDSDTEMPSA CCCCCCCCCCCCCCC | 56.57 | 30635358 | |
833 | Phosphorylation | SEESDSDTEMPSAQA CCCCCCCCCCCCCHH | 37.83 | 30635358 | |
837 | Phosphorylation | DSDTEMPSAQAIKSP CCCCCCCCCHHCCCC | 31.53 | 30635358 | |
843 | Phosphorylation | PSAQAIKSPPVSVNR CCCHHCCCCCCCCCC | 28.46 | 23684622 | |
847 | Phosphorylation | AIKSPPVSVNRNSSP HCCCCCCCCCCCCCC | 21.32 | 25159016 | |
852 | Phosphorylation | PVSVNRNSSPAVPAP CCCCCCCCCCCCCCC | 34.17 | 25521595 | |
853 | Phosphorylation | VSVNRNSSPAVPAPT CCCCCCCCCCCCCCC | 22.04 | 25521595 | |
860 | Phosphorylation | SPAVPAPTPEGVQAV CCCCCCCCCCCCEEE | 35.76 | 27087446 | |
869 | Phosphorylation | EGVQAVNTTKKASGT CCCEEEECCCCCCCC | 33.13 | 25619855 | |
870 | Phosphorylation | GVQAVNTTKKASGTT CCEEEECCCCCCCCC | 25.91 | 25619855 | |
874 | Phosphorylation | VNTTKKASGTTAQSS EECCCCCCCCCCCCC | 45.62 | 30635358 | |
876 | Phosphorylation | TTKKASGTTAQSSSS CCCCCCCCCCCCCCC | 19.23 | 30635358 | |
877 | Phosphorylation | TKKASGTTAQSSSSE CCCCCCCCCCCCCCC | 26.65 | 30635358 | |
880 | Phosphorylation | ASGTTAQSSSSESED CCCCCCCCCCCCCCC | 29.71 | 30635358 | |
881 | Phosphorylation | SGTTAQSSSSESEDG CCCCCCCCCCCCCCC | 26.29 | 30635358 | |
882 | Phosphorylation | GTTAQSSSSESEDGD CCCCCCCCCCCCCCC | 43.29 | 30635358 | |
883 | Phosphorylation | TTAQSSSSESEDGDE CCCCCCCCCCCCCCC | 47.27 | 30635358 | |
885 | Phosphorylation | AQSSSSESEDGDEDL CCCCCCCCCCCCCCC | 42.82 | 30635358 | |
896 | Phosphorylation | DEDLIPATQPSTYAL CCCCCCCCCCCCEEC | 35.34 | 30635358 | |
899 | Phosphorylation | LIPATQPSTYALRTS CCCCCCCCCEECCCC | 25.00 | 19854140 | |
900 | Phosphorylation | IPATQPSTYALRTSV CCCCCCCCEECCCCC | 21.35 | 19854140 | |
901 | Phosphorylation | PATQPSTYALRTSVT CCCCCCCEECCCCCC | 14.15 | 19854140 | |
905 | Phosphorylation | PSTYALRTSVTTPAA CCCEECCCCCCCHHH | 28.53 | 28833060 | |
906 | Phosphorylation | STYALRTSVTTPAAL CCEECCCCCCCHHHH | 15.84 | 28833060 | |
908 | Phosphorylation | YALRTSVTTPAALSR EECCCCCCCHHHHHH | 27.16 | 28833060 | |
909 | Phosphorylation | ALRTSVTTPAALSRA ECCCCCCCHHHHHHH | 14.58 | 28833060 | |
914 | Phosphorylation | VTTPAALSRAASQPS CCCHHHHHHHHHCCC | 18.36 | 28066266 | |
918 | Phosphorylation | AALSRAASQPSKSEQ HHHHHHHHCCCCCHH | 41.46 | 27149854 | |
922 | Acetylation | RAASQPSKSEQSSRM HHHHCCCCCHHHHCC | 65.77 | 23806337 | |
945 | Phosphorylation | AASAQTSSAVETLPM HHHHCCCCHHHHCCC | 39.46 | 28285833 | |
976 | Acetylation | GKSKLPEKQQLAPGY CCCCCCHHHCCCCCC | 41.21 | 23806337 | |
989 | Phosphorylation | GYPKAPRSSEDSSDT CCCCCCCCCCCCCCC | 36.70 | 30635358 | |
990 | Phosphorylation | YPKAPRSSEDSSDTS CCCCCCCCCCCCCCC | 46.86 | 30635358 | |
993 | Phosphorylation | APRSSEDSSDTSSED CCCCCCCCCCCCCCC | 26.51 | 30635358 | |
994 | Phosphorylation | PRSSEDSSDTSSEDE CCCCCCCCCCCCCCH | 58.17 | 30635358 | |
996 | Phosphorylation | SSEDSSDTSSEDEED CCCCCCCCCCCCHHH | 35.78 | 30635358 | |
997 | Phosphorylation | SEDSSDTSSEDEEDA CCCCCCCCCCCHHHH | 36.40 | 30635358 | |
998 | Phosphorylation | EDSSDTSSEDEEDAK CCCCCCCCCCHHHHH | 51.68 | 30635358 | |
1021 | Phosphorylation | HRLDPDPSQKETVVE HCCCCCHHHCCEEEE | 62.35 | 26370283 | |
1025 | Phosphorylation | PDPSQKETVVEETPT CCHHHCCEEEEECCC | 36.57 | 21743459 | |
1030 | Phosphorylation | KETVVEETPTESSED CCEEEEECCCCCCCC | 23.23 | 21743459 | |
1032 | Phosphorylation | TVVEETPTESSEDEM EEEEECCCCCCCCCC | 56.79 | 21743459 | |
1034 | Phosphorylation | VEETPTESSEDEMVA EEECCCCCCCCCCCC | 41.32 | 21743459 | |
1035 | Phosphorylation | EETPTESSEDEMVAP EECCCCCCCCCCCCC | 42.72 | 21743459 | |
1066 | Phosphorylation | NSQASKATPRPDSNS CCCCCCCCCCCCCCC | 24.46 | 25263469 | |
1071 | Phosphorylation | KATPRPDSNSLASSA CCCCCCCCCCCHHCC | 30.88 | 29514104 | |
1073 | Phosphorylation | TPRPDSNSLASSAPA CCCCCCCCCHHCCCC | 29.30 | 29472430 | |
1076 | Phosphorylation | PDSNSLASSAPATKD CCCCCCHHCCCCCCC | 32.12 | 29472430 | |
1077 | Phosphorylation | DSNSLASSAPATKDN CCCCCHHCCCCCCCC | 32.44 | 29472430 | |
1081 | Phosphorylation | LASSAPATKDNPDGK CHHCCCCCCCCCCCC | 37.56 | 29472430 | |
1110 | Phosphorylation | KTGRKEASSGSTPQK CCCCCCCCCCCCCCC | 36.00 | 25159016 | |
1111 | Phosphorylation | TGRKEASSGSTPQKP CCCCCCCCCCCCCCC | 43.76 | 25159016 | |
1113 | Phosphorylation | RKEASSGSTPQKPKK CCCCCCCCCCCCCCC | 38.57 | 25159016 | |
1114 | Phosphorylation | KEASSGSTPQKPKKL CCCCCCCCCCCCCCC | 33.01 | 26824392 | |
1124 | Phosphorylation | KPKKLKKSTSSSPAP CCCCCCCCCCCCCCC | 31.75 | 27087446 | |
1125 | Phosphorylation | PKKLKKSTSSSPAPT CCCCCCCCCCCCCCC | 41.32 | 22942356 | |
1126 | Phosphorylation | KKLKKSTSSSPAPTQ CCCCCCCCCCCCCCC | 35.59 | 27087446 | |
1127 | Phosphorylation | KLKKSTSSSPAPTQT CCCCCCCCCCCCCCC | 40.19 | 27087446 | |
1128 | Phosphorylation | LKKSTSSSPAPTQTL CCCCCCCCCCCCCCC | 25.50 | 25521595 | |
1132 | Phosphorylation | TSSSPAPTQTLPNSI CCCCCCCCCCCCCHH | 35.97 | 22942356 | |
1134 | Phosphorylation | SSPAPTQTLPNSITQ CCCCCCCCCCCHHHH | 46.81 | 25168779 | |
1138 | Phosphorylation | PTQTLPNSITQRLLE CCCCCCCHHHHHHHH | 25.69 | 25619855 | |
1140 | Phosphorylation | QTLPNSITQRLLEQA CCCCCHHHHHHHHHH | 13.88 | 25619855 | |
1161 | Ubiquitination | QVQASVVKVLTELLE HHHHHHHHHHHHHHH | 29.39 | - | |
1181 | Phosphorylation | ATEAIKESGKKSQKR HHHHHHHHCHHHHHH | 51.41 | 28066266 | |
1189 | Acetylation | GKKSQKRKLSGDLEA CHHHHHHHHCCCCCC | 54.78 | 7720263 | |
1191 | Phosphorylation | KSQKRKLSGDLEAGA HHHHHHHCCCCCCCC | 33.04 | 27087446 | |
1213 | Phosphorylation | EQPVPRASAVSPEKA CCCCCCHHCCCCCCC | 30.40 | 22942356 | |
1216 | Phosphorylation | VPRASAVSPEKAPMT CCCHHCCCCCCCCCC | 27.36 | 27087446 | |
1223 | Phosphorylation | SPEKAPMTSKAKSKL CCCCCCCCHHHHHHC | 26.47 | 25619855 | |
1224 | Phosphorylation | PEKAPMTSKAKSKLD CCCCCCCHHHHHHCC | 25.10 | 25619855 | |
1240 | Acetylation | GSAGGKGKGSPGPQG CCCCCCCCCCCCCCC | 60.75 | 7495849 | |
1242 | Phosphorylation | AGGKGKGSPGPQGAK CCCCCCCCCCCCCCC | 30.12 | 27087446 | |
1249 | Acetylation | SPGPQGAKEKPDGEL CCCCCCCCCCCCCCE | 73.44 | - | |
1263 | Phosphorylation | LLGIKLESGEQSDPK EEEEEECCCCCCCCC | 59.05 | 28833060 | |
1267 | Phosphorylation | KLESGEQSDPKSKSK EECCCCCCCCCCHHH | 52.13 | 28833060 | |
1301 | Phosphorylation | KKSLAKDSASPIQKK HHHHHCCCCCHHHHH | 29.91 | 22802335 | |
1303 | Phosphorylation | SLAKDSASPIQKKKK HHHCCCCCHHHHHHH | 26.87 | 25521595 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TCOF_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TCOF_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TCOF_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of TCOF_MOUSE !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; THR-171; SER-593AND SER-1216, AND MASS SPECTROMETRY. | |
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-908 AND SER-1191, ANDMASS SPECTROMETRY. | |
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-757; SER-759; SER-760;SER-761; SER-765; SER-767; SER-794; SER-1191 AND SER-1242, AND MASSSPECTROMETRY. | |
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169 AND THR-171, ANDMASS SPECTROMETRY. | |
"A differential phosphoproteomic analysis of retinoic acid-treated P19cells."; Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.; J. Proteome Res. 6:3174-3186(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-84; SER-85;SER-87; SER-88; SER-344; THR-346; SER-347; SER-348; SER-352; SER-354;SER-413; SER-414; SER-417; SER-419; SER-421; SER-433; SER-485;SER-487; SER-488; SER-489; SER-494; SER-499; SER-529; SER-531;SER-532; SER-535; SER-536; SER-538; THR-600; SER-603; SER-607;SER-608; SER-609; THR-753; SER-757; SER-759; SER-760; SER-761;SER-765; SER-767; SER-993; SER-994; THR-996; SER-997 AND SER-998, ANDMASS SPECTROMETRY. | |
"Identification of phosphoproteins and their phosphorylation sites inthe WEHI-231 B lymphoma cell line."; Shu H., Chen S., Bi Q., Mumby M., Brekken D.L.; Mol. Cell. Proteomics 3:279-286(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1191, AND MASSSPECTROMETRY. | |
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-171, AND MASSSPECTROMETRY. |