TCOF_MOUSE - dbPTM
TCOF_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TCOF_MOUSE
UniProt AC O08784
Protein Name Treacle protein
Gene Name Tcof1
Organism Mus musculus (Mouse).
Sequence Length 1320
Subcellular Localization Nucleus, nucleolus .
Protein Description Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification..
Protein Sequence MAEARKRRELLPLIYHHLLQAGYVRAAREVKEQSGQKSFLTQPVTLLDIYTHWQQTSELGQKQKAEDDETLQAKKSRVSDPVSSSESSDQEKEEEAATERAKATPRPTPVNSATAALPSKVKEKGKTKTANKTVNSVSHPGSGKTVVHLLSGKSPKKSAEPLANTVLASETEEEGNAQALGPTAKSGTVSAGQGSSSSEDSSISSDETDVEVKSPAKPAQAKASAAPAKDPPARTAPGPTKLGNVAPTPAKPARAAAAAAAAAVAAAAAAAAEESESSEEDSDSEDEAPAGLPSQVKASGKGPHVRADSVSAKGISGKGPILATPGKTGPAATQAKAERPEKDSETSSEDDSDSEDEMPVTVNTPQARTSGKSPRARGTSAPAKESSQKGAPAVTPGKARPVAAQAGKPEAKSSEESESDSGETPAAATLTTSPAKVKPLGKSSQVRPVSTVTPGSSGKGANLPCPGKVGSAALRVQMVKKEDVSESSSAELDSDGPGSPAKAKASLALPQKVRPVATQVKTDRGKGHSGSSEESSDSEEEAAPAASAAQAKPALEKQMKASSRKGTPASATGASTSSHCKAGAVTSSASLSSPALAKGTQRSDVDSSSESESEGAAPSTPRVQGKSGGKGLQGKAALGQGVAPVHTQKTGPSVKAMAQEDSESLEEDSSSEEEDETPAQATPLGRLPQAKANPPPTKTPPASASGKAVAAPTKGKPPVPNSTVSARGQRSVPAAGKAGAPATQAQKGPVAGTGEDSESSSKEESDSEEETPAQIKPVGKTSQVRAASAPAKESPKKGAHPGTPGKTGSSATQAQPGKTEDSDSSSEESDSDTEMPSAQAIKSPPVSVNRNSSPAVPAPTPEGVQAVNTTKKASGTTAQSSSSESEDGDEDLIPATQPSTYALRTSVTTPAALSRAASQPSKSEQSSRMPKGKKAKAAASAQTSSAVETLPMMPPQSAPIQPKATNKLGKSKLPEKQQLAPGYPKAPRSSEDSSDTSSEDEEDAKRPQMPKSAHRLDPDPSQKETVVEETPTESSEDEMVAPSQSLLSGYMTPGLTVANSQASKATPRPDSNSLASSAPATKDNPDGKQKSKSQHAADTALPKTGRKEASSGSTPQKPKKLKKSTSSSPAPTQTLPNSITQRLLEQAWPLSEAQVQASVVKVLTELLEQERLKATEAIKESGKKSQKRKLSGDLEAGAPKNKKKKEQPVPRASAVSPEKAPMTSKAKSKLDKGSAGGKGKGSPGPQGAKEKPDGELLGIKLESGEQSDPKSKSKKKKSLKKKKDKEKKEKKKGKKSLAKDSASPIQKKKKKKKKSAEPAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
76PhosphorylationETLQAKKSRVSDPVS
HHHHHHHHHCCCCCC
36.8930635358
79PhosphorylationQAKKSRVSDPVSSSE
HHHHHHCCCCCCCCC
34.7825619855
83PhosphorylationSRVSDPVSSSESSDQ
HHCCCCCCCCCCCHH
33.2723684622
84PhosphorylationRVSDPVSSSESSDQE
HCCCCCCCCCCCHHH
38.0623684622
85PhosphorylationVSDPVSSSESSDQEK
CCCCCCCCCCCHHHH
33.7123684622
87PhosphorylationDPVSSSESSDQEKEE
CCCCCCCCCHHHHHH
40.9623684622
88PhosphorylationPVSSSESSDQEKEEE
CCCCCCCCHHHHHHH
38.9823684622
98PhosphorylationEKEEEAATERAKATP
HHHHHHHHHHHHCCC
32.8125619855
104PhosphorylationATERAKATPRPTPVN
HHHHHHCCCCCCCCC
21.0825266776
108PhosphorylationAKATPRPTPVNSATA
HHCCCCCCCCCHHHH
40.9425266776
112PhosphorylationPRPTPVNSATAALPS
CCCCCCCHHHHCCCH
27.5128066266
114PhosphorylationPTPVNSATAALPSKV
CCCCCHHHHCCCHHH
16.5728066266
132AcetylationGKTKTANKTVNSVSH
CCCCCCCCCCCCCCC
51.9223806337
144AcetylationVSHPGSGKTVVHLLS
CCCCCCCCEEEECCC
39.5823806337
151PhosphorylationKTVVHLLSGKSPKKS
CEEEECCCCCCCCCC
51.0028725479
153AcetylationVVHLLSGKSPKKSAE
EEECCCCCCCCCCCC
61.2723806337
154PhosphorylationVHLLSGKSPKKSAEP
EECCCCCCCCCCCCC
45.5426824392
158PhosphorylationSGKSPKKSAEPLANT
CCCCCCCCCCCHHCC
43.9527087446
165PhosphorylationSAEPLANTVLASETE
CCCCHHCCHHCCCCC
15.9924925903
169PhosphorylationLANTVLASETEEEGN
HHCCHHCCCCCCCCC
40.6727087446
171PhosphorylationNTVLASETEEEGNAQ
CCHHCCCCCCCCCCC
46.3224925903
183PhosphorylationNAQALGPTAKSGTVS
CCCCCCCCCCCCCEE
44.9425619855
186PhosphorylationALGPTAKSGTVSAGQ
CCCCCCCCCCEECCC
36.9125293948
188PhosphorylationGPTAKSGTVSAGQGS
CCCCCCCCEECCCCC
20.5525293948
190PhosphorylationTAKSGTVSAGQGSSS
CCCCCCEECCCCCCC
26.9025293948
195PhosphorylationTVSAGQGSSSSEDSS
CEECCCCCCCCCCCC
21.1125293948
196PhosphorylationVSAGQGSSSSEDSSI
EECCCCCCCCCCCCC
44.7125293948
197PhosphorylationSAGQGSSSSEDSSIS
ECCCCCCCCCCCCCC
39.1725293948
198PhosphorylationAGQGSSSSEDSSISS
CCCCCCCCCCCCCCC
47.5825293948
201PhosphorylationGSSSSEDSSISSDET
CCCCCCCCCCCCCCC
26.0625293948
202PhosphorylationSSSSEDSSISSDETD
CCCCCCCCCCCCCCC
38.5225293948
204PhosphorylationSSEDSSISSDETDVE
CCCCCCCCCCCCCCE
33.4126525534
205PhosphorylationSEDSSISSDETDVEV
CCCCCCCCCCCCCEE
37.4825293948
208PhosphorylationSSISSDETDVEVKSP
CCCCCCCCCCEECCC
50.7825293948
214PhosphorylationETDVEVKSPAKPAQA
CCCCEECCCCCHHHH
34.9526370283
241AcetylationRTAPGPTKLGNVAPT
CCCCCCCCCCCCCCC
58.4923236377
248PhosphorylationKLGNVAPTPAKPARA
CCCCCCCCCCHHHHH
26.5824453211
275PhosphorylationAAAAAEESESSEEDS
HHHHHHHHHCCCCCC
33.9929895711
277PhosphorylationAAAEESESSEEDSDS
HHHHHHHCCCCCCCC
52.9425293948
278PhosphorylationAAEESESSEEDSDSE
HHHHHHCCCCCCCCC
40.7425293948
282PhosphorylationSESSEEDSDSEDEAP
HHCCCCCCCCCCCCC
46.4425293948
284PhosphorylationSSEEDSDSEDEAPAG
CCCCCCCCCCCCCCC
51.3929895711
294PhosphorylationEAPAGLPSQVKASGK
CCCCCCCHHHHCCCC
53.2825293948
301AcetylationSQVKASGKGPHVRAD
HHHHCCCCCCCCCCC
67.77-
309PhosphorylationGPHVRADSVSAKGIS
CCCCCCCCCCCCCCC
19.5824453211
311PhosphorylationHVRADSVSAKGISGK
CCCCCCCCCCCCCCC
28.3725266776
318AcetylationSAKGISGKGPILATP
CCCCCCCCCCEECCC
55.5123806337
324PhosphorylationGKGPILATPGKTGPA
CCCCEECCCCCCCCC
29.1826824392
327AcetylationPILATPGKTGPAATQ
CEECCCCCCCCCHHH
52.0623806337
328PhosphorylationILATPGKTGPAATQA
EECCCCCCCCCHHHH
55.0725168779
344PhosphorylationAERPEKDSETSSEDD
HCCCCCCCCCCCCCC
54.5727149854
346PhosphorylationRPEKDSETSSEDDSD
CCCCCCCCCCCCCCC
41.3227149854
347PhosphorylationPEKDSETSSEDDSDS
CCCCCCCCCCCCCCC
27.9027149854
348PhosphorylationEKDSETSSEDDSDSE
CCCCCCCCCCCCCCC
53.0927149854
352PhosphorylationETSSEDDSDSEDEMP
CCCCCCCCCCCCCCC
56.1927149854
354PhosphorylationSSEDDSDSEDEMPVT
CCCCCCCCCCCCCEE
51.3927149854
361PhosphorylationSEDEMPVTVNTPQAR
CCCCCCEEECCCCHH
11.3630635358
364PhosphorylationEMPVTVNTPQARTSG
CCCEEECCCCHHCCC
16.6719854140
379PhosphorylationKSPRARGTSAPAKES
CCCCCCCCCCCCCHH
19.0330635358
380PhosphorylationSPRARGTSAPAKESS
CCCCCCCCCCCCHHH
34.7726239621
386PhosphorylationTSAPAKESSQKGAPA
CCCCCCHHHCCCCCC
37.0426239621
387PhosphorylationSAPAKESSQKGAPAV
CCCCCHHHCCCCCCC
36.6826239621
395PhosphorylationQKGAPAVTPGKARPV
CCCCCCCCCCCCCCC
28.5626239621
413PhosphorylationAGKPEAKSSEESESD
CCCCCCCCCCCCCCC
50.4522802335
414PhosphorylationGKPEAKSSEESESDS
CCCCCCCCCCCCCCC
44.6822942356
417PhosphorylationEAKSSEESESDSGET
CCCCCCCCCCCCCCC
38.0527087446
419PhosphorylationKSSEESESDSGETPA
CCCCCCCCCCCCCCC
46.4827087446
421PhosphorylationSEESESDSGETPAAA
CCCCCCCCCCCCCCE
48.0527087446
424PhosphorylationSESDSGETPAAATLT
CCCCCCCCCCCEEEE
23.0427087446
429PhosphorylationGETPAAATLTTSPAK
CCCCCCEEEECCCCC
21.6529119230
431PhosphorylationTPAAATLTTSPAKVK
CCCCEEEECCCCCCC
22.3721149613
432PhosphorylationPAAATLTTSPAKVKP
CCCEEEECCCCCCCC
35.5121149613
433PhosphorylationAAATLTTSPAKVKPL
CCEEEECCCCCCCCC
20.0221149613
443PhosphorylationKVKPLGKSSQVRPVS
CCCCCCCCCCEECCE
24.9725619855
444PhosphorylationVKPLGKSSQVRPVST
CCCCCCCCCEECCEE
35.8625619855
450PhosphorylationSSQVRPVSTVTPGSS
CCCEECCEEECCCCC
21.6025619855
451PhosphorylationSQVRPVSTVTPGSSG
CCEECCEEECCCCCC
28.7425619855
453PhosphorylationVRPVSTVTPGSSGKG
EECCEEECCCCCCCC
23.2425619855
456PhosphorylationVSTVTPGSSGKGANL
CEEECCCCCCCCCCC
36.8022942356
457PhosphorylationSTVTPGSSGKGANLP
EEECCCCCCCCCCCC
50.9025619855
459AcetylationVTPGSSGKGANLPCP
ECCCCCCCCCCCCCC
57.7223806337
465GlutathionylationGKGANLPCPGKVGSA
CCCCCCCCCCCCCCH
8.5924333276
468MalonylationANLPCPGKVGSAALR
CCCCCCCCCCCHHHE
28.6826320211
485PhosphorylationMVKKEDVSESSSAEL
EEEHHHCCCCCCCCC
44.0524759943
487PhosphorylationKKEDVSESSSAELDS
EHHHCCCCCCCCCCC
23.3024759943
488PhosphorylationKEDVSESSSAELDSD
HHHCCCCCCCCCCCC
29.5228285833
489PhosphorylationEDVSESSSAELDSDG
HHCCCCCCCCCCCCC
34.7320531401
494PhosphorylationSSSAELDSDGPGSPA
CCCCCCCCCCCCCHH
58.0321149613
499PhosphorylationLDSDGPGSPAKAKAS
CCCCCCCCHHHHHHH
25.4721149613
521AcetylationRPVATQVKTDRGKGH
CCCEEEEECCCCCCC
34.59-
529PhosphorylationTDRGKGHSGSSEESS
CCCCCCCCCCCCCCC
49.3829895711
531PhosphorylationRGKGHSGSSEESSDS
CCCCCCCCCCCCCCC
37.2829895711
532PhosphorylationGKGHSGSSEESSDSE
CCCCCCCCCCCCCCH
49.2429895711
535PhosphorylationHSGSSEESSDSEEEA
CCCCCCCCCCCHHHH
35.0829895711
536PhosphorylationSGSSEESSDSEEEAA
CCCCCCCCCCHHHHH
48.7325338131
538PhosphorylationSSEESSDSEEEAAPA
CCCCCCCCHHHHHHH
49.1829895711
547PhosphorylationEEAAPAASAAQAKPA
HHHHHHHHHHHHHHH
26.6620531401
562PhosphorylationLEKQMKASSRKGTPA
HHHHHHHHCCCCCCC
25.7625168779
563PhosphorylationEKQMKASSRKGTPAS
HHHHHHHCCCCCCCC
42.7625168779
567PhosphorylationKASSRKGTPASATGA
HHHCCCCCCCCCCCC
20.7929895711
570PhosphorylationSRKGTPASATGASTS
CCCCCCCCCCCCCCC
27.8029550500
572PhosphorylationKGTPASATGASTSSH
CCCCCCCCCCCCCCC
30.6825168779
575PhosphorylationPASATGASTSSHCKA
CCCCCCCCCCCCCCC
30.1125168779
576PhosphorylationASATGASTSSHCKAG
CCCCCCCCCCCCCCC
33.4425168779
577PhosphorylationSATGASTSSHCKAGA
CCCCCCCCCCCCCCC
18.6525168779
578PhosphorylationATGASTSSHCKAGAV
CCCCCCCCCCCCCCC
32.7525168779
586PhosphorylationHCKAGAVTSSASLSS
CCCCCCCCCCCCCCC
19.2125619855
587PhosphorylationCKAGAVTSSASLSSP
CCCCCCCCCCCCCCH
19.8025168779
588PhosphorylationKAGAVTSSASLSSPA
CCCCCCCCCCCCCHH
16.7125168779
590PhosphorylationGAVTSSASLSSPALA
CCCCCCCCCCCHHHH
30.6327087446
592PhosphorylationVTSSASLSSPALAKG
CCCCCCCCCHHHHCC
31.6122942356
593PhosphorylationTSSASLSSPALAKGT
CCCCCCCCHHHHCCC
21.3427087446
600PhosphorylationSPALAKGTQRSDVDS
CHHHHCCCCHHCCCC
21.8029895711
603PhosphorylationLAKGTQRSDVDSSSE
HHCCCCHHCCCCCCC
31.9728833060
607PhosphorylationTQRSDVDSSSESESE
CCHHCCCCCCCCCCC
35.3028833060
608PhosphorylationQRSDVDSSSESESEG
CHHCCCCCCCCCCCC
33.3928833060
609PhosphorylationRSDVDSSSESESEGA
HHCCCCCCCCCCCCC
49.4428833060
611PhosphorylationDVDSSSESESEGAAP
CCCCCCCCCCCCCCC
48.6628833060
613PhosphorylationDSSSESESEGAAPST
CCCCCCCCCCCCCCC
51.0828833060
619PhosphorylationESEGAAPSTPRVQGK
CCCCCCCCCCCCCCC
46.4428833060
620PhosphorylationSEGAAPSTPRVQGKS
CCCCCCCCCCCCCCC
17.6628833060
626AcetylationSTPRVQGKSGGKGLQ
CCCCCCCCCCCCCCC
28.9223806337
630AcetylationVQGKSGGKGLQGKAA
CCCCCCCCCCCHHHH
61.0323806337
655AcetylationQKTGPSVKAMAQEDS
CCCCHHHHHHHHHCH
36.46-
662PhosphorylationKAMAQEDSESLEEDS
HHHHHHCHHHHCCCC
28.4729895711
664PhosphorylationMAQEDSESLEEDSSS
HHHHCHHHHCCCCCC
45.0629895711
669PhosphorylationSESLEEDSSSEEEDE
HHHHCCCCCCCCCCC
38.7629895711
670PhosphorylationESLEEDSSSEEEDET
HHHCCCCCCCCCCCC
54.8329895711
671PhosphorylationSLEEDSSSEEEDETP
HHCCCCCCCCCCCCC
53.6429895711
677PhosphorylationSSEEEDETPAQATPL
CCCCCCCCCCCCCCC
35.9225293948
682PhosphorylationDETPAQATPLGRLPQ
CCCCCCCCCCCCCCH
13.6320531401
697PhosphorylationAKANPPPTKTPPASA
HHCCCCCCCCCCCCC
54.0125159016
699PhosphorylationANPPPTKTPPASASG
CCCCCCCCCCCCCCC
36.6625159016
703PhosphorylationPTKTPPASASGKAVA
CCCCCCCCCCCCCCC
28.8328066266
705PhosphorylationKTPPASASGKAVAAP
CCCCCCCCCCCCCCC
38.0325159016
722PhosphorylationGKPPVPNSTVSARGQ
CCCCCCCCCCCCCCC
24.9029176673
723PhosphorylationKPPVPNSTVSARGQR
CCCCCCCCCCCCCCC
25.7229176673
725PhosphorylationPVPNSTVSARGQRSV
CCCCCCCCCCCCCCC
16.6129176673
753PhosphorylationQKGPVAGTGEDSESS
CCCCCCCCCCCCCCC
27.8829895711
757PhosphorylationVAGTGEDSESSSKEE
CCCCCCCCCCCCCCC
34.7729895711
759PhosphorylationGTGEDSESSSKEESD
CCCCCCCCCCCCCCC
43.8122802335
760PhosphorylationTGEDSESSSKEESDS
CCCCCCCCCCCCCCC
41.1822802335
761PhosphorylationGEDSESSSKEESDSE
CCCCCCCCCCCCCCC
54.0622802335
765PhosphorylationESSSKEESDSEEETP
CCCCCCCCCCCCCCC
47.7523684622
767PhosphorylationSSKEESDSEEETPAQ
CCCCCCCCCCCCCCC
57.0723684622
771PhosphorylationESDSEEETPAQIKPV
CCCCCCCCCCCCCCC
27.4929472430
788PhosphorylationTSQVRAASAPAKESP
HHHHEECCCCCCCCC
33.5325159016
794PhosphorylationASAPAKESPKKGAHP
CCCCCCCCCCCCCCC
41.1126824392
803PhosphorylationKKGAHPGTPGKTGSS
CCCCCCCCCCCCCCC
33.0625266776
819PhosphorylationTQAQPGKTEDSDSSS
CCCCCCCCCCCCCCC
51.4430635358
822PhosphorylationQPGKTEDSDSSSEES
CCCCCCCCCCCCCCC
32.9130635358
824PhosphorylationGKTEDSDSSSEESDS
CCCCCCCCCCCCCCC
39.4530635358
825PhosphorylationKTEDSDSSSEESDSD
CCCCCCCCCCCCCCC
46.9230635358
826PhosphorylationTEDSDSSSEESDSDT
CCCCCCCCCCCCCCC
49.7030635358
829PhosphorylationSDSSSEESDSDTEMP
CCCCCCCCCCCCCCC
38.0630635358
831PhosphorylationSSSEESDSDTEMPSA
CCCCCCCCCCCCCCC
56.5730635358
833PhosphorylationSEESDSDTEMPSAQA
CCCCCCCCCCCCCHH
37.8330635358
837PhosphorylationDSDTEMPSAQAIKSP
CCCCCCCCCHHCCCC
31.5330635358
843PhosphorylationPSAQAIKSPPVSVNR
CCCHHCCCCCCCCCC
28.4623684622
847PhosphorylationAIKSPPVSVNRNSSP
HCCCCCCCCCCCCCC
21.3225159016
852PhosphorylationPVSVNRNSSPAVPAP
CCCCCCCCCCCCCCC
34.1725521595
853PhosphorylationVSVNRNSSPAVPAPT
CCCCCCCCCCCCCCC
22.0425521595
860PhosphorylationSPAVPAPTPEGVQAV
CCCCCCCCCCCCEEE
35.7627087446
869PhosphorylationEGVQAVNTTKKASGT
CCCEEEECCCCCCCC
33.1325619855
870PhosphorylationGVQAVNTTKKASGTT
CCEEEECCCCCCCCC
25.9125619855
874PhosphorylationVNTTKKASGTTAQSS
EECCCCCCCCCCCCC
45.6230635358
876PhosphorylationTTKKASGTTAQSSSS
CCCCCCCCCCCCCCC
19.2330635358
877PhosphorylationTKKASGTTAQSSSSE
CCCCCCCCCCCCCCC
26.6530635358
880PhosphorylationASGTTAQSSSSESED
CCCCCCCCCCCCCCC
29.7130635358
881PhosphorylationSGTTAQSSSSESEDG
CCCCCCCCCCCCCCC
26.2930635358
882PhosphorylationGTTAQSSSSESEDGD
CCCCCCCCCCCCCCC
43.2930635358
883PhosphorylationTTAQSSSSESEDGDE
CCCCCCCCCCCCCCC
47.2730635358
885PhosphorylationAQSSSSESEDGDEDL
CCCCCCCCCCCCCCC
42.8230635358
896PhosphorylationDEDLIPATQPSTYAL
CCCCCCCCCCCCEEC
35.3430635358
899PhosphorylationLIPATQPSTYALRTS
CCCCCCCCCEECCCC
25.0019854140
900PhosphorylationIPATQPSTYALRTSV
CCCCCCCCEECCCCC
21.3519854140
901PhosphorylationPATQPSTYALRTSVT
CCCCCCCEECCCCCC
14.1519854140
905PhosphorylationPSTYALRTSVTTPAA
CCCEECCCCCCCHHH
28.5328833060
906PhosphorylationSTYALRTSVTTPAAL
CCEECCCCCCCHHHH
15.8428833060
908PhosphorylationYALRTSVTTPAALSR
EECCCCCCCHHHHHH
27.1628833060
909PhosphorylationALRTSVTTPAALSRA
ECCCCCCCHHHHHHH
14.5828833060
914PhosphorylationVTTPAALSRAASQPS
CCCHHHHHHHHHCCC
18.3628066266
918PhosphorylationAALSRAASQPSKSEQ
HHHHHHHHCCCCCHH
41.4627149854
922AcetylationRAASQPSKSEQSSRM
HHHHCCCCCHHHHCC
65.7723806337
945PhosphorylationAASAQTSSAVETLPM
HHHHCCCCHHHHCCC
39.4628285833
976AcetylationGKSKLPEKQQLAPGY
CCCCCCHHHCCCCCC
41.2123806337
989PhosphorylationGYPKAPRSSEDSSDT
CCCCCCCCCCCCCCC
36.7030635358
990PhosphorylationYPKAPRSSEDSSDTS
CCCCCCCCCCCCCCC
46.8630635358
993PhosphorylationAPRSSEDSSDTSSED
CCCCCCCCCCCCCCC
26.5130635358
994PhosphorylationPRSSEDSSDTSSEDE
CCCCCCCCCCCCCCH
58.1730635358
996PhosphorylationSSEDSSDTSSEDEED
CCCCCCCCCCCCHHH
35.7830635358
997PhosphorylationSEDSSDTSSEDEEDA
CCCCCCCCCCCHHHH
36.4030635358
998PhosphorylationEDSSDTSSEDEEDAK
CCCCCCCCCCHHHHH
51.6830635358
1021PhosphorylationHRLDPDPSQKETVVE
HCCCCCHHHCCEEEE
62.3526370283
1025PhosphorylationPDPSQKETVVEETPT
CCHHHCCEEEEECCC
36.5721743459
1030PhosphorylationKETVVEETPTESSED
CCEEEEECCCCCCCC
23.2321743459
1032PhosphorylationTVVEETPTESSEDEM
EEEEECCCCCCCCCC
56.7921743459
1034PhosphorylationVEETPTESSEDEMVA
EEECCCCCCCCCCCC
41.3221743459
1035PhosphorylationEETPTESSEDEMVAP
EECCCCCCCCCCCCC
42.7221743459
1066PhosphorylationNSQASKATPRPDSNS
CCCCCCCCCCCCCCC
24.4625263469
1071PhosphorylationKATPRPDSNSLASSA
CCCCCCCCCCCHHCC
30.8829514104
1073PhosphorylationTPRPDSNSLASSAPA
CCCCCCCCCHHCCCC
29.3029472430
1076PhosphorylationPDSNSLASSAPATKD
CCCCCCHHCCCCCCC
32.1229472430
1077PhosphorylationDSNSLASSAPATKDN
CCCCCHHCCCCCCCC
32.4429472430
1081PhosphorylationLASSAPATKDNPDGK
CHHCCCCCCCCCCCC
37.5629472430
1110PhosphorylationKTGRKEASSGSTPQK
CCCCCCCCCCCCCCC
36.0025159016
1111PhosphorylationTGRKEASSGSTPQKP
CCCCCCCCCCCCCCC
43.7625159016
1113PhosphorylationRKEASSGSTPQKPKK
CCCCCCCCCCCCCCC
38.5725159016
1114PhosphorylationKEASSGSTPQKPKKL
CCCCCCCCCCCCCCC
33.0126824392
1124PhosphorylationKPKKLKKSTSSSPAP
CCCCCCCCCCCCCCC
31.7527087446
1125PhosphorylationPKKLKKSTSSSPAPT
CCCCCCCCCCCCCCC
41.3222942356
1126PhosphorylationKKLKKSTSSSPAPTQ
CCCCCCCCCCCCCCC
35.5927087446
1127PhosphorylationKLKKSTSSSPAPTQT
CCCCCCCCCCCCCCC
40.1927087446
1128PhosphorylationLKKSTSSSPAPTQTL
CCCCCCCCCCCCCCC
25.5025521595
1132PhosphorylationTSSSPAPTQTLPNSI
CCCCCCCCCCCCCHH
35.9722942356
1134PhosphorylationSSPAPTQTLPNSITQ
CCCCCCCCCCCHHHH
46.8125168779
1138PhosphorylationPTQTLPNSITQRLLE
CCCCCCCHHHHHHHH
25.6925619855
1140PhosphorylationQTLPNSITQRLLEQA
CCCCCHHHHHHHHHH
13.8825619855
1161UbiquitinationQVQASVVKVLTELLE
HHHHHHHHHHHHHHH
29.39-
1181PhosphorylationATEAIKESGKKSQKR
HHHHHHHHCHHHHHH
51.4128066266
1189AcetylationGKKSQKRKLSGDLEA
CHHHHHHHHCCCCCC
54.787720263
1191PhosphorylationKSQKRKLSGDLEAGA
HHHHHHHCCCCCCCC
33.0427087446
1213PhosphorylationEQPVPRASAVSPEKA
CCCCCCHHCCCCCCC
30.4022942356
1216PhosphorylationVPRASAVSPEKAPMT
CCCHHCCCCCCCCCC
27.3627087446
1223PhosphorylationSPEKAPMTSKAKSKL
CCCCCCCCHHHHHHC
26.4725619855
1224PhosphorylationPEKAPMTSKAKSKLD
CCCCCCCHHHHHHCC
25.1025619855
1240AcetylationGSAGGKGKGSPGPQG
CCCCCCCCCCCCCCC
60.757495849
1242PhosphorylationAGGKGKGSPGPQGAK
CCCCCCCCCCCCCCC
30.1227087446
1249AcetylationSPGPQGAKEKPDGEL
CCCCCCCCCCCCCCE
73.44-
1263PhosphorylationLLGIKLESGEQSDPK
EEEEEECCCCCCCCC
59.0528833060
1267PhosphorylationKLESGEQSDPKSKSK
EECCCCCCCCCCHHH
52.1328833060
1301PhosphorylationKKSLAKDSASPIQKK
HHHHHCCCCCHHHHH
29.9122802335
1303PhosphorylationSLAKDSASPIQKKKK
HHHCCCCCHHHHHHH
26.8725521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TCOF_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TCOF_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TCOF_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TCOF_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TCOF_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; THR-171; SER-593AND SER-1216, AND MASS SPECTROMETRY.
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-908 AND SER-1191, ANDMASS SPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-757; SER-759; SER-760;SER-761; SER-765; SER-767; SER-794; SER-1191 AND SER-1242, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169 AND THR-171, ANDMASS SPECTROMETRY.
"A differential phosphoproteomic analysis of retinoic acid-treated P19cells.";
Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.;
J. Proteome Res. 6:3174-3186(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-84; SER-85;SER-87; SER-88; SER-344; THR-346; SER-347; SER-348; SER-352; SER-354;SER-413; SER-414; SER-417; SER-419; SER-421; SER-433; SER-485;SER-487; SER-488; SER-489; SER-494; SER-499; SER-529; SER-531;SER-532; SER-535; SER-536; SER-538; THR-600; SER-603; SER-607;SER-608; SER-609; THR-753; SER-757; SER-759; SER-760; SER-761;SER-765; SER-767; SER-993; SER-994; THR-996; SER-997 AND SER-998, ANDMASS SPECTROMETRY.
"Identification of phosphoproteins and their phosphorylation sites inthe WEHI-231 B lymphoma cell line.";
Shu H., Chen S., Bi Q., Mumby M., Brekken D.L.;
Mol. Cell. Proteomics 3:279-286(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1191, AND MASSSPECTROMETRY.
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-171, AND MASSSPECTROMETRY.

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