TDRD3_MOUSE - dbPTM
TDRD3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TDRD3_MOUSE
UniProt AC Q91W18
Protein Name Tudor domain-containing protein 3
Gene Name Tdrd3
Organism Mus musculus (Mouse).
Sequence Length 743
Subcellular Localization Cytoplasm. Nucleus. Predominantly cytoplasmic. Associated with actively translating polyribosomes and with mRNA stress granules (By similarity)..
Protein Description Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins (By similarity)..
Protein Sequence MAEVSGAALSQAGWYLSDEGVEACTSSPGKGSINDIILIALNTDLRTIGKKFLPSDINGGKVEKLEGPCVLQIQKVRNVAAPKDNEESQAAPRMLRVQMTDGHTSCTAVEFSYISKISLNTPPGTKVKLSGTVDIKNGFLLLSDSNTTVLGGEVEHLIDKWALQRSLLKHNRSNIGAEGGPPPFLPFGQKCASNVQVDSRELDRRKTLQVSLPAKPANDNDEFEKQRTAAIAEVAKSKETKTFGGGGGGARSNLNIGAAGHRNREVLQKEKASKSESKNEGVYRELVDEKALKHITEMGFSKEASRQALMDNANNLEAALNVLLNSSKQKPAVGPPARGRGKGRGRGRSEDEEDLGTARPSAPSTLFDFLESKMGTLNVEEPKSQPQHLHQGQHRGWNAEQNGMKDGTQSRHLPRNDTRQPRNERPPRFQKDTPTSKSTVENSVLSRNRGSERPSSSSGSDVWAEERIKCDRPYSRYDRTKDASHPLGLQHNDGAFKKRENSMQNRPGRGPLYAEAKENPLPPEFVDYNNQRRGRRENQTGHPDHCYERKPRTMNSEAVSGLKIEKHFSVNTDYPRPVQSNSLGVPNGETAPPLKGRRVGPIKSAGPVTAVPYDDKIFYNSGPKRRSGPIKPEKVIESSIPVEYAKVWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVVKFTDYGNYEEVLLSNIKPVQTEAWEEEGTYDHTIEFRRGGDGQPRRSTRPTQQFYQPPRARN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25PhosphorylationDEGVEACTSSPGKGS
CCCCCHHCCCCCCCC		39.0126643407
26PhosphorylationEGVEACTSSPGKGSI
CCCCHHCCCCCCCCH		34.1326643407
27PhosphorylationGVEACTSSPGKGSIN
CCCHHCCCCCCCCHH		21.3726643407
173PhosphorylationSLLKHNRSNIGAEGG
HHHHCCHHCCCCCCC		37.8128285833
228PhosphorylationDEFEKQRTAAIAEVA
HHHHHHHHHHHHHHH		20.2529514104
237UbiquitinationAIAEVAKSKETKTFG
HHHHHHHCCCCCCCC		26.4527667366
283PhosphorylationESKNEGVYRELVDEK
CCCCHHHHHHHHCHH		14.8229514104
301PhosphorylationHITEMGFSKEASRQA
HHHHCCCCHHHHHHH		24.6929514104
308UbiquitinationSKEASRQALMDNANN
CHHHHHHHHHHCHHH		12.0727667366
330UbiquitinationLLNSSKQKPAVGPPA
HHHCCCCCCCCCCCC		38.3927667366
349PhosphorylationKGRGRGRSEDEEDLG
CCCCCCCCCCHHHHC		52.8326824392
357PhosphorylationEDEEDLGTARPSAPS
CCHHHHCCCCCCCCH		27.1323984901
361PhosphorylationDLGTARPSAPSTLFD
HHCCCCCCCCHHHHH		47.4623984901
364PhosphorylationTARPSAPSTLFDFLE
CCCCCCCHHHHHHHH		37.1426745281
365PhosphorylationARPSAPSTLFDFLES
CCCCCCHHHHHHHHH		30.3126745281
405UbiquitinationNAEQNGMKDGTQSRH
CHHHCCCCCCCCCCC		55.1722790023
418PhosphorylationRHLPRNDTRQPRNER
CCCCCCCCCCCCCCC		34.45-
438PhosphorylationKDTPTSKSTVENSVL
CCCCCCHHHHHHHHH		37.1425521595
439PhosphorylationDTPTSKSTVENSVLS
CCCCCHHHHHHHHHH		35.2622871156
451PhosphorylationVLSRNRGSERPSSSS
HHHCCCCCCCCCCCC		27.4823684622
455PhosphorylationNRGSERPSSSSGSDV
CCCCCCCCCCCCCCC		49.4230635358
456PhosphorylationRGSERPSSSSGSDVW
CCCCCCCCCCCCCCC		31.0725266776
457PhosphorylationGSERPSSSSGSDVWA
CCCCCCCCCCCCCCH		42.9530635358
458PhosphorylationSERPSSSSGSDVWAE
CCCCCCCCCCCCCHH		44.2430635358
460PhosphorylationRPSSSSGSDVWAEER
CCCCCCCCCCCHHHH		30.8230635358
474PhosphorylationRIKCDRPYSRYDRTK
HHCCCCCCCCCCCCC		13.4829514104
513PhosphorylationRPGRGPLYAEAKENP
CCCCCCCHHHHCCCC		12.9125367039
547PhosphorylationTGHPDHCYERKPRTM
CCCCCCCCCCCCCCC		18.4929514104
574PhosphorylationHFSVNTDYPRPVQSN
CEECCCCCCCCCCCC		10.0929514104
604PhosphorylationRRVGPIKSAGPVTAV
CCCCCCCCCCCCEEE		38.9029514104
613PhosphorylationGPVTAVPYDDKIFYN
CCCEEECCCCCCCCC		30.1229514104
619PhosphorylationPYDDKIFYNSGPKRR
CCCCCCCCCCCCCCC		16.3429514104
621PhosphorylationDDKIFYNSGPKRRSG
CCCCCCCCCCCCCCC		45.1329514104
627PhosphorylationNSGPKRRSGPIKPEK
CCCCCCCCCCCCHHH		53.6125263469
644PhosphorylationESSIPVEYAKVWKPG
ECCCCCEEEEECCCC		16.3829514104
711PhosphorylationAWEEEGTYDHTIEFR
CCCCCCCCCCEEEEE		19.3118563927
736PhosphorylationTRPTQQFYQPPRARN
CCCCCCCCCCCCCCC		18.7729514104
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TDRD3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TDRD3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TDRD3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TDRD3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TDRD3_MOUSE

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Related Literatures of Post-Translational Modification

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