GASP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GASP1_MOUSE
• UniProt AC: Q5U4C1
• Protein Name: G-protein coupled receptor-associated sorting protein 1
• Gene Name: Gprasp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1347
• Subcellular Localization: Cytoplasm.
• Protein Description: Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2..
• Protein Sequence: MTRAEVEPGAQAKAENKPGDENANAAEVEPEAPLVVRPKVRTQIMTGARPKVKPKGTPGARPKGETSTPGGAYAKCKPKAIPIARSKHDAQVWAPNKFRGESMSKMGKQCQISAADPPLLSNDSGMVAQAKCLPVDRELANMDTESIPKKANSPAGFQPSYGSEEGTNMGSWYRARPVPKGEAYENSDFKWADKPSGSPSFWNRDEASTRFRPRKSMKANNRFRHMAKQEANTMPRHKNKQEFYNISSSDSEDESGKTPWFWPKDKTKVWSKPKEEPNSRSWFRSKKEVRVESTSGSECENPTKSLFWSGEEAKSRSKPRARKGVNMRARQQAKREACSDAMSGAIDTNKKESWFLPEEKANVFSKSKTKKEPRTRAVPKEEVKTKARASTKQEARPEEEVLVGAWFWDTQESTMADRISIKTTFVEEEPIVGDWFWSEEEASVDSETCHTSRPRAKEEQVSSFCLGSGKKSSMESGPKATSKSMPVAKEDEVVIGSWFWADDEEINLQADDESIFGSWFWGTGENSLRSVGVNCEKMPKAGEKEVTDSWFWAGDVNTEAEVEEQARSASTKATIFVPWFWSEKQPNMDLGSEPCSDIMAGAEEEPIIGPWFWAKVDNSVEAEVNSKSSLEDEEEPIRSPWFGAREQTDMKYAAGIRYKPMAEAEDANKKSCVWAKEPCLYPTNRECLKSTLGEKEDTVDPWLWSNNYPRTKTITGSWLWAAEEGNIDDETGEKIKLPTLEDNAFNSWFWKENEESIVEAPKREEFRPEAEEEDIIGSWFWAGDEDRFEPAAKINEENKIASEDEDTVGSWFWGNEEASLEAVRRGTFESAPGIKEEKVTGSWFWTDKAKVGAGSQTVETGSETEEEAIFESLIWAAKKDSIQAGVKRVSKPKDDGNIAVGSWLWSSDKATKEAKTLIVSEASPENGKESVVKFGSRAKDEVINKTGSGDNCKHSTEAETIVGAWFWEGDEASFESNPVPVCKAVCEPESSAEHEPDPSRRPQSWDEVTVQFKAGPWGKAGFPPMNPFRFPKEAASLFAEMFGGKPKLVEVGPEREPEPQFPFQYDPSYRSVREIREHLKARESAQPENWSCNCIQCELRIGSEEFEELLLLMDRNRDPFIHEISKIAMGMRGASQFTRDFIRNSGVVSLIEALLNYPSSRVRTRFLENMVRMAPPYPDLNMIETYVCQICEDTFDYDLDSPDQLSGLTMITHLTATSDYHKVVVNYLAGFFYLLNSGNTKTRFHVLKLLLNLSENLVMTKRLLVTDSVSEFMDLINREESDENIQIVLAIFETISKHIQKEALFSDDDDDDEEEDAVNLEPFISAFREAEKIAKELKRKPGNQKAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTRAEVEPG ------CCCCCCCCC	50.30	25521595
42	Phosphorylation	VVRPKVRTQIMTGAR EECHHHCCEECCCCC	25.99	25338131
46	Phosphorylation	KVRTQIMTGARPKVK HHCCEECCCCCCCCC	29.35	25338131
102	Phosphorylation	PNKFRGESMSKMGKQ CCCCCCCHHHHHCCC	31.05	22324799
153	Phosphorylation	SIPKKANSPAGFQPS CCCCCCCCCCCCCCC	22.46	24759943
163	Phosphorylation	GFQPSYGSEEGTNMG CCCCCCCCCCCCCCC	25.00	29899451
196	Phosphorylation	FKWADKPSGSPSFWN CCCCCCCCCCCCCCC	58.61	28066266
198	Phosphorylation	WADKPSGSPSFWNRD CCCCCCCCCCCCCCC	23.00	28066266
200	Phosphorylation	DKPSGSPSFWNRDEA CCCCCCCCCCCCCHH	44.59	28066266
293	Phosphorylation	KKEVRVESTSGSECE CCEEEEEECCCCCCC	25.64	25521595
294	Phosphorylation	KEVRVESTSGSECEN CEEEEEECCCCCCCC	24.49	25521595
295	Phosphorylation	EVRVESTSGSECENP EEEEEECCCCCCCCC	49.99	25521595
297	Phosphorylation	RVESTSGSECENPTK EEEECCCCCCCCCCC	38.55	22324799
303	Phosphorylation	GSECENPTKSLFWSG CCCCCCCCCCCCCCH	44.86	22324799
309	Phosphorylation	PTKSLFWSGEEAKSR CCCCCCCCHHHHHHC	29.06	25521595
339	Phosphorylation	QAKREACSDAMSGAI HHHHHHHHHHHCCCC	35.14	-
343	Phosphorylation	EACSDAMSGAIDTNK HHHHHHHCCCCCCCC	27.13	-
438	Phosphorylation	IVGDWFWSEEEASVD CCCCCCCCHHHCCCC	26.17	19060867
473	Phosphorylation	LGSGKKSSMESGPKA CCCCCCCCCCCCCCC	35.13	29899451
619	Phosphorylation	FWAKVDNSVEAEVNS EEEECCCCEEEEECC	19.51	22817900
626	Phosphorylation	SVEAEVNSKSSLEDE CEEEEECCCCCCCCC	38.81	25521595
628	Phosphorylation	EAEVNSKSSLEDEEE EEEECCCCCCCCCCC	39.72	19060867
629	Phosphorylation	AEVNSKSSLEDEEEP EEECCCCCCCCCCCC	39.24	25521595
639	Phosphorylation	DEEEPIRSPWFGARE CCCCCCCCCCCCCHH	27.48	28066266
756	Phosphorylation	FWKENEESIVEAPKR CCCCCHHHHCCCCCC	26.25	22817900
802	Phosphorylation	NEENKIASEDEDTVG CCCCCCCCCCCCCCC	49.40	29899451
807	Phosphorylation	IASEDEDTVGSWFWG CCCCCCCCCCCCCCC	25.39	29899451
827	Phosphorylation	LEAVRRGTFESAPGI HHHHHHCCCCCCCCC	23.55	28066266
830	Phosphorylation	VRRGTFESAPGIKEE HHHCCCCCCCCCCCC	35.26	28066266
838	Ubiquitination	APGIKEEKVTGSWFW CCCCCCCCCCCCEEE	46.30	22790023
855	Phosphorylation	KAKVGAGSQTVETGS CCCCCCCCCEECCCC	23.34	26643407
857	Phosphorylation	KVGAGSQTVETGSET CCCCCCCEECCCCCC	23.23	26643407
860	Phosphorylation	AGSQTVETGSETEEE CCCCEECCCCCCHHH	41.49	24759943
862	Phosphorylation	SQTVETGSETEEEAI CCEECCCCCCHHHHH	49.08	24759943
864	Phosphorylation	TVETGSETEEEAIFE EECCCCCCHHHHHHH	50.85	26643407
872	Phosphorylation	EEEAIFESLIWAAKK HHHHHHHHHHHHHHH	17.88	20415495
881	Phosphorylation	IWAAKKDSIQAGVKR HHHHHHHHHHHHCCC	26.02	29899451
920	Phosphorylation	EAKTLIVSEASPENG HHCEEEEEECCCCCC	22.05	28066266
923	Phosphorylation	TLIVSEASPENGKES EEEEEECCCCCCCCC	28.79	28066266
1045	Ubiquitination	FAEMFGGKPKLVEVG HHHHHCCCCCEEEEC	39.08	22790023
1047	Ubiquitination	EMFGGKPKLVEVGPE HHHCCCCCEEEECCC	69.52	22790023
1126	Ubiquitination	PFIHEISKIAMGMRG HHHHHHHHHHHHHCC	39.90	22790023
1254	Phosphorylation	LKLLLNLSENLVMTK HHHHHHCCCCHHCCC	24.30	21659604
1260	Phosphorylation	LSENLVMTKRLLVTD CCCCHHCCCEEEECC	12.92	21659604
1261	Ubiquitination	SENLVMTKRLLVTDS CCCHHCCCEEEECCC	23.97	22790023
1306	Phosphorylation	IQKEALFSDDDDDDE HHHHHHCCCCCCCCC	40.77	22817900
1339	Dimethylation	KIAKELKRKPGNQKA HHHHHHHCCCCCCCC	64.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GASP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GASP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GASP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GASP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.