| UniProt ID | KEAP1_MOUSE | |
|---|---|---|
| UniProt AC | Q9Z2X8 | |
| Protein Name | Kelch-like ECH-associated protein 1 | |
| Gene Name | Keap1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 624 | |
| Subcellular Localization | Cytoplasm . Nucleus . Shuttles between cytoplasm and nucleus.. | |
| Protein Description | Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).. | |
| Protein Sequence | MQPEPKLSGAPRSSQFLPLWSKCPEGAGDAVMYASTECKAEVTPSQDGNRTFSYTLEDHTKQAFGVMNELRLSQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLVQIFQELTLHKPTQAVPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MQPEPKLSGAPRSSQ CCCCCCCCCCCCCHH | 38.75 | 24719451 | |
| 13 | Phosphorylation | KLSGAPRSSQFLPLW CCCCCCCCHHCHHHH | 27.68 | 29472430 | |
| 14 | Phosphorylation | LSGAPRSSQFLPLWS CCCCCCCHHCHHHHH | 26.65 | 29472430 | |
| 38 | Succinylation | VMYASTECKAEVTPS EEEEECEEEEEECCC | 5.25 | 22014577 | |
| 43 | Phosphorylation | TECKAEVTPSQDGNR CEEEEEECCCCCCCE | 14.55 | 25521595 | |
| 85 | Phosphorylation | DVTLQVKYEDIPAAQ CEEEEEECCCCCHHH | 21.70 | 22448038 | |
| 131 | Acetylation | SIEGIHPKVMERLIE EEECCCHHHHHHHHH | 39.80 | 23236377 | |
| 141 | Phosphorylation | ERLIEFAYTASISVG HHHHHHHHHCCCCCC | 14.25 | 22817900 | |
| 151 | Succinylation | SISVGEKCVLHVMNG CCCCCCCEEEEECCC | 3.24 | 22014577 | |
| 151 | S-nitrosylation | SISVGEKCVLHVMNG CCCCCCCEEEEECCC | 3.24 | 20956331 | |
| 151 | Other | SISVGEKCVLHVMNG CCCCCCCEEEEECCC | 3.24 | - | |
| 196 | Glutathionylation | NFAEQIGCTELHQRA HHHHHHCCHHHHHHH | 2.60 | 24333276 | |
| 241 | Succinylation | RDDLNVRCESEVFHA CCCCCCCCCHHHHHH | 6.17 | 22014577 | |
| 257 | Other | IDWVKYDCPQRRFYV HHHHCCCCCCHHHHH | 2.54 | - | |
| 273 | Other | ALLRAVRCHALTPRF HHHHHHHHHHCCHHH | 1.44 | - | |
| 288 | Other | LQTQLQKCEILQADA HHHHHHHCCHHHCCH | 2.25 | - | |
| 288 | Succinylation | LQTQLQKCEILQADA HHHHHHHCCHHHCCH | 2.25 | 22014577 | |
| 319 | Succinylation | KPTQAVPCRAPKVGR CCCCCCCCCCCCCCE | 4.69 | 22014577 | |
| 434 | Other | AVGGSHGCIHHSSVE EECCCCCCCCCCCCC | 1.93 | 20498371 | |
| 613 | Succinylation | VAVTMEPCRKQIDQQ EEEEEHHHHHHCHHC | 5.60 | 22014577 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KEAP1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KEAP1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KEAP1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NF2L2_HUMAN | NFE2L2 | physical | 9887101 | |
| NF2L2_MOUSE | Nfe2l2 | physical | 18512965 | |
| NF2L2_MOUSE | Nfe2l2 | physical | 17591699 | |
| NF2L2_MOUSE | Nfe2l2 | physical | 17420218 | |
| CUL3_MOUSE | Cul3 | physical | 19279002 | |
| RBX1_MOUSE | Rbx1 | physical | 19279002 | |
| NF2L2_MOUSE | Nfe2l2 | physical | 19279002 | |
| PTMA_HUMAN | PTMA | physical | 19279002 | |
| BPTF_HUMAN | BPTF | physical | 19279002 | |
| PTMA_MOUSE | Ptma | physical | 19279002 | |
| NF2L2_MOUSE | Nfe2l2 | physical | 16785233 | |
| KEAP1_MOUSE | Keap1 | physical | 20133743 | |
| NF2L2_MOUSE | Nfe2l2 | physical | 22688683 | |
| NF2L2_MOUSE | Nfe2l2 | physical | 16507366 | |
| SQSTM_MOUSE | Sqstm1 | physical | 20173742 | |
| NF2L2_MOUSE | Nfe2l2 | physical | 20173742 | |
| ATG7_MOUSE | Atg7 | genetic | 20173742 | |
| KEAP1_MOUSE | Keap1 | physical | 12145307 | |
| NF2L2_MOUSE | Nfe2l2 | physical | 17785452 | |
| NF2L2_MOUSE | Nfe2l2 | physical | 24366543 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
