PTMA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTMA_MOUSE
• UniProt AC: P26350
• Protein Name: Prothymosin alpha
• Gene Name: Ptma
• Organism: Mus musculus (Mouse).
• Sequence Length: 111
• Subcellular Localization: Nucleus.
• Protein Description: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections..
• Protein Sequence: MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAQNEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAEAPTGKRVAEDDEDDDVDTKKQKTEEDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MSDAAVDT -------CCCCCCCC	8.05	-
2	Acetylation	------MSDAAVDTS ------CCCCCCCCC	35.64	23806337
2	Phosphorylation	------MSDAAVDTS ------CCCCCCCCC	35.64	23527152
8	Phosphorylation	MSDAAVDTSSEITTK CCCCCCCCCCCCCHH	27.79	26824392
9	Phosphorylation	SDAAVDTSSEITTKD CCCCCCCCCCCCHHH	22.85	23527152
10	Phosphorylation	DAAVDTSSEITTKDL CCCCCCCCCCCHHHH	34.80	26824392
13	Phosphorylation	VDTSSEITTKDLKEK CCCCCCCCHHHHHHH	24.60	27742792
14	Phosphorylation	DTSSEITTKDLKEKK CCCCCCCHHHHHHHH	28.37	27742792
15	Acetylation	TSSEITTKDLKEKKE CCCCCCHHHHHHHHH	53.03	23806337
15	Succinylation	TSSEITTKDLKEKKE CCCCCCHHHHHHHHH	53.03	-
15	Malonylation	TSSEITTKDLKEKKE CCCCCCHHHHHHHHH	53.03	26320211
15	Succinylation	TSSEITTKDLKEKKE CCCCCCHHHHHHHHH	53.03	23806337
20	Ubiquitination	TTKDLKEKKEVVEEA CHHHHHHHHHHHHHH	53.28	-
21	Ubiquitination	TKDLKEKKEVVEEAE HHHHHHHHHHHHHHH	57.75	-
102	Phosphorylation	DEDDDVDTKKQKTEE CCCCCCCHHHHHCCC	39.73	29514104
103	Ubiquitination	EDDDVDTKKQKTEED CCCCCCHHHHHCCCC	49.06	-
103	Acetylation	EDDDVDTKKQKTEED CCCCCCHHHHHCCCC	49.06	23806337
103	Succinylation	EDDDVDTKKQKTEED CCCCCCHHHHHCCCC	49.06	23954790
104	Acetylation	DDDVDTKKQKTEEDD CCCCCHHHHHCCCCC	60.15	70365
104	Ubiquitination	DDDVDTKKQKTEEDD CCCCCHHHHHCCCCC	60.15	-
106	Ubiquitination	DVDTKKQKTEEDD-- CCCHHHHHCCCCC--	67.78	-
107	Phosphorylation	VDTKKQKTEEDD--- CCHHHHHCCCCC---	41.96	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTMA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTMA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTMA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KEAP1_MOUSE	Keap1	physical	19279002
NF2L2_MOUSE	Nfe2l2	physical	19279002
CUL3_MOUSE	Cul3	physical	19279002
RBX1_MOUSE	Rbx1	physical	19279002

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.