ATG7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATG7_MOUSE
• UniProt AC: Q9D906
• Protein Name: Ubiquitin-like modifier-activating enzyme ATG7
• Gene Name: Atg7
• Organism: Mus musculus (Mouse).
• Sequence Length: 698
• Subcellular Localization: Cytoplasm. Preautophagosomal structure. Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.
• Protein Description: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation..
• Protein Sequence: MGDPGLAKLQFAPFNSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLPTRLTLEFSAFDMSASTPAHCCPAMGTLHNTNTLEAFKTADKKLLLEQSANEIWEAIKSGAALENPMLLNKFLLLTFADLKKYHFYYWFCCPALCLPESIPLIRGPVSLDQRLSPKQIQALEHAYDDLCRAEGVTALPYFLFKYDDDTVLVSLLKHYSDFFQGQRTKITVGVYDPCNLAQYPGWPLRNFLVLAAHRWSGSFQSVEVLCFRDRTMQGARDVTHSIIFEVKLPEMAFSPDCPKAVGWEKNQKGGMGPRMVNLSGCMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGVRHVTFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAAERLQKIFPGVNARGFNMSIPMPGHPVNFSDVTMEQARRDVEQLEQLIDNHDVIFLLMDTRESRWLPTVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPSHLVAPADLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEGGYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSPKVLDQYEREGFTFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDEETV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
291	Phosphorylation	KLPEMAFSPDCPKAV ECCCCCCCCCCCCCC	15.41	22817900
419	Ubiquitination	AAAERLQKIFPGVNA HHHHHHHHHCCCCCC	51.40	-
476	Phosphorylation	LLMDTRESRWLPTVI EEEECCHHHCHHHHH	26.01	-
486	Phosphorylation	LPTVIAASKRKLVIN HHHHHHHCCCHHHHH	24.79	-
520	Glutathionylation	QQGAGDLCPSHLVAP CCCCCCCCHHHCCCC	3.75	24333276
546	Phosphorylation	PGYKLGCYFCNDVVA CCCCEEEEEECCEEC	14.90	-
693	Phosphorylation	AAEIWDMSDEETV-- HHHHHCCCCCCCC--	39.12	23984901
697	Phosphorylation	WDMSDEETV------ HCCCCCCCC------	29.48	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATG7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATG7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATG7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATG3_MOUSE	Atg3	physical	22170151
ATG7_MOUSE	Atg7	physical	22170151
ATG7_MOUSE	Atg7	physical	22055190
ATG3_MOUSE	Atg3	physical	22055190

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.