dbPTM

MA7D1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MA7D1_MOUSE
UniProt AC	A2AJI0
Protein Name	MAP7 domain-containing protein 1
Gene Name	Map7d1
Organism	Mus musculus (Mouse).
Sequence Length	846
Subcellular Localization	Cytoplasm, cytoskeleton, spindle.
Protein Description
Protein Sequence	MESGPRVEPGPGAPAAVLARIPQEPRPSPEGDPSPPPPPTPMSALVPDTPPDTPPALKTATNPKQLPLEPGNPTGQISPQPAPPQEECPSSEAKSRGPTPTATGPREAKPSRRSSQPSPTTVPASDSPPAKQDVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGRKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGSGPGRRPTRARAGASLAPGPHPDRTHPSAAVPVCPRSASASPLTPCSAPRSAHRCTPSGERPERRKPGAGGSPALARRRLEATPVQKKEKKDKERENEKEKSALARERNLKKRQSLPASIRPRLSTGSELSPKSKARPSSPSTTWHRPASPCPSPGPGHALPPKPPSPRGTTASPKGRVRRKEEAKESPSPSGPEDKNHRKSRAAEEKEPAAPASPAPSPVPSPTPAQPQKEQSSTQIPAETAVPAVPAAPTAPPTAAPSVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERKLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRQEREKHFQKEEQERQERRKRLEEIMKRTRKSEAAETKKQDAKETAANNSGPDPVKAVETRPSGLQKDSMQKEELAPQEPQWSLPSKEMPGSLVNGLQPLPAHQENGFSPKGTAGDKSLGRTAEGLLPFAEAEAFLKKAVVQPPQVTEVL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	IPQEPRPSPEGDPSP CCCCCCCCCCCCCCC	36.54	26824392
34	Phosphorylation	PSPEGDPSPPPPPTP CCCCCCCCCCCCCCC	55.57	27180971
40	Phosphorylation	PSPPPPPTPMSALVP CCCCCCCCCHHHCCC	37.08	24453211
43	Phosphorylation	PPPPTPMSALVPDTP CCCCCCHHHCCCCCC	21.47	22817900
49	Phosphorylation	MSALVPDTPPDTPPA HHHCCCCCCCCCCCC	30.56	26745281
53	Phosphorylation	VPDTPPDTPPALKTA CCCCCCCCCCCCCCC	36.62	26745281
74	Phosphorylation	PLEPGNPTGQISPQP CCCCCCCCCCCCCCC	45.80	26824392
78	Phosphorylation	GNPTGQISPQPAPPQ CCCCCCCCCCCCCCC	15.03	25521595
90	Phosphorylation	PPQEECPSSEAKSRG CCCHHCCCHHHHHCC	53.09	25619855
91	Phosphorylation	PQEECPSSEAKSRGP CCHHCCCHHHHHCCC	27.07	25619855
95	Phosphorylation	CPSSEAKSRGPTPTA CCCHHHHHCCCCCCC	49.90	25521595
99	Phosphorylation	EAKSRGPTPTATGPR HHHHCCCCCCCCCCC	35.77	25521595
101	Phosphorylation	KSRGPTPTATGPREA HHCCCCCCCCCCCCC	39.05	25521595
103	Phosphorylation	RGPTPTATGPREAKP CCCCCCCCCCCCCCC	50.63	25159016
111	Phosphorylation	GPREAKPSRRSSQPS CCCCCCCCCCCCCCC	39.35	29472430
114	Phosphorylation	EAKPSRRSSQPSPTT CCCCCCCCCCCCCCC	32.01	24925903
115	Phosphorylation	AKPSRRSSQPSPTTV CCCCCCCCCCCCCCC	44.28	25521595
118	Phosphorylation	SRRSSQPSPTTVPAS CCCCCCCCCCCCCCC	27.52	25521595
120	Phosphorylation	RSSQPSPTTVPASDS CCCCCCCCCCCCCCC	44.77	25521595
121	Phosphorylation	SSQPSPTTVPASDSP CCCCCCCCCCCCCCC	28.07	25521595
125	Phosphorylation	SPTTVPASDSPPAKQ CCCCCCCCCCCCCHH	32.33	24925903
127	Phosphorylation	TTVPASDSPPAKQDV CCCCCCCCCCCHHHH	30.23	25521595
210	Ubiquitination	RQKLEKNKERYEAAI HHHHHHHHHHHHHHH	55.42	22790023
234	Phosphorylation	EIRQQRWSWAGALHH HHHHHHHCHHHHHCC	14.83	20415495
242	Phosphorylation	WAGALHHSSPGRKTS HHHHHCCCCCCCCCC	27.72	29233185
243	Phosphorylation	AGALHHSSPGRKTSG HHHHCCCCCCCCCCC	27.32	21082442
248	Phosphorylation	HSSPGRKTSGSRCSV CCCCCCCCCCCCCEE	36.64	22210690
249	Phosphorylation	SSPGRKTSGSRCSVS CCCCCCCCCCCCEEE	37.49	22210690
251	Phosphorylation	PGRKTSGSRCSVSAV CCCCCCCCCCEEEEC	29.85	21183079
254	Phosphorylation	KTSGSRCSVSAVNLP CCCCCCCEEEECCCC	20.28	26745281
256	Phosphorylation	SGSRCSVSAVNLPKH CCCCCEEEECCCCHH	15.37	25521595
266	Phosphorylation	NLPKHVDSIINKRLS CCCHHHHHHHHHHCC	25.03	22324799
273	Phosphorylation	SIINKRLSKSSATLW HHHHHHCCCCCCCCC	34.23	19060867
274	Ubiquitination	IINKRLSKSSATLWN HHHHHCCCCCCCCCC	53.69	22790023
275	Phosphorylation	INKRLSKSSATLWNS HHHHCCCCCCCCCCC	23.10	25521595
276	Phosphorylation	NKRLSKSSATLWNSP HHHCCCCCCCCCCCC	29.07	21082442
278	Phosphorylation	RLSKSSATLWNSPSR HCCCCCCCCCCCCCC	33.96	22324799
282	Phosphorylation	SSATLWNSPSRNRSL CCCCCCCCCCCCCCC	16.81	26643407
284	Phosphorylation	ATLWNSPSRNRSLQL CCCCCCCCCCCCCCH	41.84	28066266
288	Phosphorylation	NSPSRNRSLQLSAWE CCCCCCCCCCHHHHH	24.82	29899451
296	Phosphorylation	LQLSAWESSIVDRLM CCHHHHHHHHHHHHH	18.05	-
304	Phosphorylation	SIVDRLMTPTLSFLA HHHHHHHCHHHHHHH	20.08	29514104
306	Phosphorylation	VDRLMTPTLSFLARS HHHHHCHHHHHHHHC	26.35	23608596
308	Phosphorylation	RLMTPTLSFLARSRS HHHCHHHHHHHHCCC	22.23	29514104
313	Phosphorylation	TLSFLARSRSAVTLP HHHHHHHCCCCEECC	25.61	26745281
315	Phosphorylation	SFLARSRSAVTLPRN HHHHHCCCCEECCCC	28.47	26824392
318	Phosphorylation	ARSRSAVTLPRNGRD HHCCCCEECCCCCCC	30.66	26745281
344	Phosphorylation	TRARAGASLAPGPHP CCCCCCCCCCCCCCC	24.93	25266776
354	Phosphorylation	PGPHPDRTHPSAAVP CCCCCCCCCCCCCCC	45.58	30165576
357	Phosphorylation	HPDRTHPSAAVPVCP CCCCCCCCCCCCCCC	22.66	30165576
366	Phosphorylation	AVPVCPRSASASPLT CCCCCCCCCCCCCCC	16.24	23527152
368	Phosphorylation	PVCPRSASASPLTPC CCCCCCCCCCCCCCC	30.44	25521595
370	Phosphorylation	CPRSASASPLTPCSA CCCCCCCCCCCCCCC	20.25	27149854
373	Phosphorylation	SASASPLTPCSAPRS CCCCCCCCCCCCCCC	26.15	25619855
375	S-nitrosylation	SASPLTPCSAPRSAH CCCCCCCCCCCCCCC	4.58	21278135
375	S-nitrosocysteine	SASPLTPCSAPRSAH CCCCCCCCCCCCCCC	4.58	-
376	Phosphorylation	ASPLTPCSAPRSAHR CCCCCCCCCCCCCCC	42.38	25619855
385	Phosphorylation	PRSAHRCTPSGERPE CCCCCCCCCCCCCCC	22.05	29899451
395	Ubiquitination	GERPERRKPGAGGSP CCCCCCCCCCCCCCH	54.76	22790023
401	Phosphorylation	RKPGAGGSPALARRR CCCCCCCCHHHHHHH	13.19	27087446
412	Phosphorylation	ARRRLEATPVQKKEK HHHHHHCCCCCCHHH	18.02	29514104
444	Phosphorylation	RNLKKRQSLPASIRP HCHHHHHCCCCHHCC	40.11	26824392
448	Phosphorylation	KRQSLPASIRPRLST HHHCCCCHHCCCCCC	19.72	28066266
454	Phosphorylation	ASIRPRLSTGSELSP CHHCCCCCCCCCCCC	31.81	25521595
455	Phosphorylation	SIRPRLSTGSELSPK HHCCCCCCCCCCCCC	49.68	26824392
457	Phosphorylation	RPRLSTGSELSPKSK CCCCCCCCCCCCCCC	35.14	22942356
460	Phosphorylation	LSTGSELSPKSKARP CCCCCCCCCCCCCCC	26.65	26824392
468	Phosphorylation	PKSKARPSSPSTTWH CCCCCCCCCCCCCCC	49.69	29233185
469	Phosphorylation	KSKARPSSPSTTWHR CCCCCCCCCCCCCCC	26.08	29233185
471	Phosphorylation	KARPSSPSTTWHRPA CCCCCCCCCCCCCCC	40.18	29472430
472	Phosphorylation	ARPSSPSTTWHRPAS CCCCCCCCCCCCCCC	36.97	29472430
473	Phosphorylation	RPSSPSTTWHRPASP CCCCCCCCCCCCCCC	24.50	21183079
479	Phosphorylation	TTWHRPASPCPSPGP CCCCCCCCCCCCCCC	29.71	29233185
483	Phosphorylation	RPASPCPSPGPGHAL CCCCCCCCCCCCCCC	49.56	22817900
496	Phosphorylation	ALPPKPPSPRGTTAS CCCCCCCCCCCCCCC	35.44	21659605
503	Phosphorylation	SPRGTTASPKGRVRR CCCCCCCCCCCCCCC	25.67	27149854
517	Phosphorylation	RKEEAKESPSPSGPE CHHHHHCCCCCCCCC	29.94	26824392
519	Phosphorylation	EEAKESPSPSGPEDK HHHHCCCCCCCCCCC	40.76	25521595
521	Phosphorylation	AKESPSPSGPEDKNH HHCCCCCCCCCCCCH	71.91	29550500
531	Phosphorylation	EDKNHRKSRAAEEKE CCCCHHHHHHHHHHC	27.40	26745281
544	Phosphorylation	KEPAAPASPAPSPVP HCCCCCCCCCCCCCC	22.12	18388127
548	Phosphorylation	APASPAPSPVPSPTP CCCCCCCCCCCCCCC	40.41	18388127
552	Phosphorylation	PAPSPVPSPTPAQPQ CCCCCCCCCCCCCCC	41.46	25521595
554	Phosphorylation	PSPVPSPTPAQPQKE CCCCCCCCCCCCCCC	35.28	27087446
759	Phosphorylation	KAVETRPSGLQKDSM CHHHCCCCCCCCCCC	49.17	27841257
805	Phosphorylation	AHQENGFSPKGTAGD CCCCCCCCCCCCCCC	27.40	25168779
809	Phosphorylation	NGFSPKGTAGDKSLG CCCCCCCCCCCHHCC	33.33	23984901
818	Phosphorylation	GDKSLGRTAEGLLPF CCHHCCCCHHCCCCH	27.54	-
834	Ubiquitination	EAEAFLKKAVVQPPQ HHHHHHHHHHCCCCC	48.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
275	S	Phosphorylation	Kinase	DCLK1	Q9JLM8	GPS
308	S	Phosphorylation	Kinase	DCLK1	Q9JLM8	GPS
315	S	Phosphorylation	Kinase	DCLK1	Q9JLM8	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MA7D1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MA7D1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MA7D1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MA7D1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-544, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401; SER-544 ANDSER-548, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276; SER-544; SER-548AND SER-552, AND MASS SPECTROMETRY.	17242355 [Abstract]