DYST_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DYST_MOUSE
• UniProt AC: Q91ZU6
• Protein Name: Dystonin
• Gene Name: Dst
• Organism: Mus musculus (Mouse).
• Sequence Length: 7393
• Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, axon . Associates with axonal microtubules at the growing distal tip and intermediate filaments, but not with actin cytoskeleton, in sensory neurons (By similarity). Associates with intermediate filaments, ac
• Protein Description: Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1.; Isoform 5: plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; Isoform 6: required for bundling actin filaments around the nucleus..
• Protein Sequence: MAGYLSPAAYMYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGVRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVVTMSERTFPNNPLELKALYNQYLQFKEKEIPPKEMEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLDMLQQIATRVQRDSVSCEDKLILARNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRMLTTEQTKLMISGITQSLNSGFAQTLHPSLNSGLTQSLTPSLTSSSVTSGLSSGMTSRLTPSVTPVYAPGFPSVVAPNFSLGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEVNMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLSYTDKLHRLESQYAKLLNTSRNQERHLDTLHNFVTRATNELIWLNEKEESEVAYDWSERNSSVARKKSYHAELMRELEQKEESIKAVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIQENSAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEKEELLQYRSVVAGLMGRAKTVVQLKPRNPDNPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDFANRIEQQYQSVLTLWHESHINMKSVVSWHYLVNEIDRIRASNVASIKTMLPGEHQQVLSNLQSRLEDFLEDSQESQIFSGSDISQLEKEVSVCRKYYQELLKSAEREEQEESVYNLYISEVRNIRLRLESCEDRLIRQIRTPLERDDLHESMLRITEQEKLKKELDRLKDDLGTITNKCEEFFSQAADSPSVPALRSELSVVIQSLSQIYSMSSTYIEKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLMSTLKQWRSEVDEKREVFHALEDELQKAKAISDEMFKTHKERDLDFDWHKEKADQLVERWQSVHVQIDNRLRDLEGIGKSLKHYRDSYHPLDDWIQHIETTQRKIQENQPENSKALALQLNQQKMLVSEIEVKQSKMDECQKYSEQYSAAVKDYELQTMTYRAMVESQQKSPVKRRRIQSSADLVIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLDEEKKQHIEKAKELQKWVSNISKTLGDGEKAGKPLFSKQQMSSKEISTKKEQFSEALQTTQIFLAKHGDKLTEEERSDLEKQVKTLQEGYNLLFSESLKQQELQPSGESKVPEKPDKVIAGTINQTTGEVLSVFQAVLRGLIDYETGIRLLEAQLVITGLISPELRKCFDLRDAESHGLIDEQVLRQLKELNRAKQLISTASPTSIPVLDSLAQGMVSESMAIRVLEILLSAGPLLVPATGEHLTLQQAFQQNLISSALFSKVLERQDTCKDLIDPCTSEKVSLTDMVQRSILQENTRMWLLPVRPQEAGRITLKCGRSVSILRAAHEGLIDRETMFRLLGAQLLSGGLIDCNSGQKMTVEEAVAEGVIDRDTASSILTYQVQTGGIVHSNPAKRLTVDEAVQCELITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELASKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASVLKSVTLPDKMPDLGDLEDCKNAKRWLSFCKLQPSTVHDYRQEEGGSDGEEPVTAQSSEQTKKLFLSYLMVNSYMDAHTGQRLLLYDGDLDEAVGMLLESCGTELGADTSTRESLSVLTIPDAFPDCALSEEKHECSAAAAGPDKCHYSHPGHKESLENAKWDMNEAFCKMGNNDSNGELPRPENLADTTVVQKGSESPSRVRVPKPTSSSTQPEGSVLRPESGSILKGCKSQSEPVTKKYPDGANHSHFLTSETSRPCDSNEREDEENIQKGPSVFDYSPRLSALLSHDELRQSQGRFSDTSTPQNTGYLCEASTLSPSDQRVLADQSTREKFQDQFLGIAAISVSLQGAPCGQKPVDTECSSSQVHYHSEESMSDASAESGATRQTDESEKTGSKVEDNSCTMVPGGGSRNDNTSDCGPLSHKGAIDAGDYETSLLAGQQSDTATDSDSDDYFYDTPLFEDEDHDSLILQGDDRDCLQPEDYDTSLQEENDRTPPPDDIFYDVMKEKENPEFPHGGMDESLGVENKVCCPQGFPVGIEKPELYLAGEKEFNSGGSEQLVESVSESENPPGLWDSESDSLTEGEIIGRKERLGASLTPDGHWRGDREECDTSRESQSDTDGVGSIQSSESYRPYMSDGSDLDEEDNGGRSSEDSGDGRGGQGVADEGGEPQYQADPTQLYTAIRKEHGGETQNVSDMIPLDKTHSYSPLETQHGAGVFQPESAGRGGWDTERSSHPELTTEADEEDEASLSTHMATKGVSLSNAEGTASEEIRLVQGPDSTGILKAEDLENVSPEISPSSDNIVRSEAELGGGASEDGHLSFTGSDRDQQGPGRGLVKGRDGQSDKLVDETSIREMGFQKEGVLMSSPEEGGEEERDLEPFPNGSATESLNMGKSQVPPLLTHTEELSHRGAPHTTTMTTTMTLEGEAKNVQTGLTESPVLLETLAEIFDTPASKVTRADLTSAVTASEMKSQVKEDSLTGGPEKETGPCTSLGHCDKCIHVDMLEPNEHTPSCALVAPPTVKDNLCSVNNAGEKSVRPQEDWPPAAEVRLSDACVEESISEGKAGILQFTPENSDSTLSRLPHQSVAGWGKSADSVQARLPVSGVRHTSADTLDVGCPQLESSREKASAEEEPHRERALSLKPQEREHHMLGFVEDGRSILKSSLDKVHMNLQEVGDPSAGTGTKISIQNLIRRAILSELPNEVSNVPSHGISPISNSSEVRAESGGDPFCITSFLHLLKQNQPPQETPGISELAKVLTQMDCDPEQRGLGSELLPPQLKNAFYKLLFDGYATEKDQAEALGQTSCAVPKMAEEKPHVCSDLRNKEGHHCPLNPQAVGEAEVEPFSVHIAALPGGEKLGELCSEPPEHSESTSGSKERSSDSSSKEKCSNGLQQCLQHTEKMHEYLVLLQDMKPPLDNQASVESSLEALKSQLKQLEAFELGLAPIAVFLRKDLKLAEEFLKSFPSDLPRRHHEELSKSHQRLQNAFSSLSSVSSERMKLIKLAINSEMSKLAVRHEDFLHKLTSYSDWVSEKSRSVKAIQTVNVQDTELVKNSVKFLKNVLADLSHTKMQLETTAFDVQSFISDYAQDLSPSQSRQLLRLLNTTQKGFLDLQELVTTEADRLEALLQLEQELGHQKVVAERQQEYREKLQGLCDLLTQTENRLISNQEAFVIGDGTVELQKYQSKQEELQRDMQGSTQAMEEIVRNTELFLKESGDELSQADRALIEQKLNEVKMKCAQLNLKAEQSRKELDKAVTTALKEETEKVAAVRQLEESKTKIENLLNWLSNVEEDSEGVWTKHTQPMEQNGTYLHEGDSKLGAGEEDEVNGNLLETDAEGHSEATKGNLNQQYEKVKAQHGKIMAQHQAVLLATQSAQVLLEKQGHYLSPEEKEKLQKNTQELKVHYEKVLAECEKKVKLTHSLQEELEKFDTDYSEFEHWLQQSEQELANLEAGADDLSGLMDKLTRQKSFSEDVISHKGDLRYITISGNRVIDAAKSCSKRDSDRIGKDSVETSATHREVQTKLDQVTDRFRSLYSKCSVLGNNLKDLVDQYQQYEDASCGLLSGLQACEAKASKHLREPIALDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDAKGSLLPAKNDIQKTLDDIVGRYDDLSKCVNERNEKLQITLTRSLSVQDALDEMLDWMGSVESSLVKPGQVPLNSTALQDLISKDTMLEQDITGRQSSINAMNEKVKTFIETTDPSTASSLQAKMKDLSARFSEASQKHKEKLAKMVELKAKVEQFEKLSDKLQTFLETQSQALTEVAMPGKDVPELSQHMQESTAKFLEHRKDLEALHSLLKEISSHGLPGDKALVFEKTNNLSRKFKEMEDTIQEKKDALSSCQEQLSAFQTLAQSLKTWIKETTKQVPVVKPSLGTEDLRKSLEETKKLQEKWNLKAPEIHKANNSGVSLCNLLSALISPAKAIAAAKSGGVILNGEGTDTNTQDFLANKGLTSIKKDMTDISHSYEDLGLLLKDKIVELNTKLSKLQKAQEESSAMMQWLEKMNKTASRWRQTPTPADTESVKLQVEQNKSFEAELKQNVNKVQELKDKLSELLEENPEAPEAQSWKQALAEMDTKWQELNQLTMDRQQKLEESSNNLTQFQTTEAQLKQWLMEKELMVSVLGPLSIDPNMLNTQKQQVQILLQEFDTRKPQYEQLTAAGQGILSRPGEDPSLHGIVNEQLEAVTQKWDNLTGQLRDRCDWIDQAIVKSTQYQSLLRSLSGTLTELDDKLSSGLTSGALPDAVNQQLEAAQRLKQEIEQQAPKIKEAQEVCEDLSALVKEEYLKAELSRQLEGILKSFKDIEQKTENHVQHLQSACASSHQFQQMSKDFQAWLDAKKEEQRDSPPISAKLDVLESLLNSQKDFGKTFTEQSNIYEKTISEGENLLLKTQGAEKAALQLQLNTMKTDWDRFRKQVKEREEKLKDSLEKALKYREQVETLRPWIDRCQHSLDGVTFSLDPTESESSIAELKSLQKEMDHHFGMLELLNNTANSLLSVCEVDKEAVTEENQSLMEKVNRVTEQLQSKTVSLENMAQKFKEFQEVSRDTQRQLQDTKEQLEVHHSLGPQAYSNKHLSVLQAQQKSLQTLKQQVDEAKRLAQDLVVEAADSKGTSDVLLQAETLAEEHSELSQQVDEKCSFLETKLQGLGHFQNTIREMFSQFTECDDELDGMAPVGRDAETLRKQKACMQTFLKKLEALMASNDSANRTCKMMLATEETSPDLIGVKRDLEALSKQCNKLLDRAKTREEQVDGATEKLEEFHRKLEEFSTLLQKAEEHEESQGPVGTETETINQQLDVFKVFQKEEIEPLQVKQQDVNWLGQGLIQSAAANTCTQGLEHDLDSVNSRWKTLNKKVAQRTSQLQEALLHCGRFQDALESLLSWMADTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLEDRKSTVEVIKREGEKIAASAEPADRVKLTRQLSLLDSRWEALLSRAEARNRQLEGISVVAQEFHETLEPLNEWLTAVEKKLANSEPIGTQAPKLEEQISQHKALQEDILLRKQSVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSADVAKTLEHALQLAGQLQSMHKELCNWLDKVEVELLSYETQGLKGEAASQVQERQKELKNEVRSNKALVDSLNEVSSALLELVPWRAREGLEKTIAEDNERYRLVSDTITQKVEEIDAAILRSQQFEQAADAELSWITETQKKLMSLGDIRLEQDQTSAQLQVQKAFTMDILRHKDIIDELVTSGHKIMTTSSEEEKQSMKKKLDKVLKKYDAVCQINSERHLQLERAQSLVSQFWETYEELWPWLTETQRIISQLPAPALEYETLRRQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPKEGIYIQEKYVAADTLYSQIKEDVKKRAVVLDEAISQSTQFHDKIDQILESLERIAERLRQPPSISAEVEKIKEQIGENKSVSVDMEKLQPLYETLRQRGEEMIARSEGTEKDVSARAVQDKLDQMVFIWGSIHTLVEEREAKLLDVMELAEKFWCDHMSLVVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAEAIREEIDGLQEELDMVITLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRVDRLEEAMQAAVQYQDGLQGIFDWVDIAGNKLATMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEEADKHTVQDPLMELKLIWDSLDERIVSRQHKLEGALLALGQFQHALDELLAWLTHTKGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSEGEEASNLQYKLRILNQRWQDILEKTDQRKQQLDSALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNAHMEVCTAFAIKEETYKSLMLRGQQMLARCPRSAETNIDQDITNLKEKWESVKSKLNEKKTKLEEALHLAMNFHNSLQDFINWLTQAEQTLNVASRPSLILDTILFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDEARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKAQLVQHKEFQKSLGGKHSVYDTTNRTGRSLKEKTSLADDNLKLDNMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKVFQKELGKRTSSVQALKRSARELIEGSRDDSSWVRVQMQELSTRWETVCALSISKQTRLESALQQAEEFHSVVHTLLEWLAEAEQTLRFHGALPDDEDALRTLIEQHKEFMKRLEEKRAELSKATGMGDALLAVCHPDSITTIKHWITIIQARFEEVLAWAKQHQQRLAGALAGLIAKQELLETLLAWLQWAETTLTEKDKEVIPQEIEEVKTLIAEHQTFMEEMTRKQPDVDKVTKTYKRRATDPPSLQSHIPVLDKGRAGRKRFPASGFYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHHGSKMLRSESNSSITATQPTLAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSASSHACQAASPPVPAAASTPKGTPIQGSKLRLPGYLSGKGFHSGEDSALITTAAARVRTQFAESRKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPVPRAGSRPSTAKPSKIPTPQRRSPASKLDKSSKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29 (in isoform 8)	Phosphorylation	-	17.26	26643407
30 (in isoform 8)	Phosphorylation	-	60.37	27742792
48 (in isoform 8)	Phosphorylation	-	24.33	23737553
54 (in isoform 8)	Phosphorylation	-	55.69	23375375
55 (in isoform 8)	Phosphorylation	-	17.04	23737553
59 (in isoform 6)	Phosphorylation	-	4.21	29899451
77 (in isoform 6)	Phosphorylation	-	39.54	25521595
106 (in isoform 6)	Phosphorylation	-	44.02	25159016
109	Malonylation	YLKRRQVKLVNIRND HHHHCCCEEEEECCC	38.08	26320211
110 (in isoform 6)	Phosphorylation	-	3.61	25159016
111 (in isoform 6)	Phosphorylation	-	4.66	28066266
130 (in isoform 8)	Phosphorylation	-	2.64	26370283
140 (in isoform 6)	Phosphorylation	-	21.52	25521595
141 (in isoform 6)	Phosphorylation	-	36.32	25521595
146 (in isoform 6)	Phosphorylation	-	35.03	29899451
146 (in isoform 8)	Phosphorylation	-	35.03	25195567
149 (in isoform 6)	Phosphorylation	-	54.13	30635358
151 (in isoform 6)	Phosphorylation	-	3.54	30635358
152 (in isoform 6)	Phosphorylation	-	48.81	30635358
153 (in isoform 6)	Phosphorylation	-	15.87	30635358
157 (in isoform 6)	Phosphorylation	-	4.90	25521595
163 (in isoform 6)	Phosphorylation	-	42.76	28066266
166 (in isoform 6)	Phosphorylation	-	53.90	25521595
168 (in isoform 6)	Phosphorylation	-	8.24	30372032
170 (in isoform 6)	Phosphorylation	-	10.02	29233185
176 (in isoform 6)	Phosphorylation	-	2.53	20415495
181 (in isoform 8)	Phosphorylation	-	44.97	23737553
182 (in isoform 8)	Phosphorylation	-	33.79	23737553
183 (in isoform 8)	Phosphorylation	-	21.71	23737553
195 (in isoform 6)	Phosphorylation	-	37.36	28066266
205 (in isoform 8)	Phosphorylation	-	5.80	25521595
208 (in isoform 8)	Phosphorylation	-	26.53	23737553
236	Phosphorylation	DPEDVDVSSPDEKSV CHHHCCCCCCCHHHH	31.52	25521595
237	Phosphorylation	PEDVDVSSPDEKSVI HHHCCCCCCCHHHHH	35.90	25521595
481	Phosphorylation	MALRNECSSVYSKGR HHHHHHHHHHHCCCC	19.36	-
482	Phosphorylation	ALRNECSSVYSKGRM HHHHHHHHHHCCCCC	36.41	-
721	Phosphorylation	WLNEKEESEVAYDWS ECCCCCCCCCCCCHH	38.16	22807455
725	Phosphorylation	KEESEVAYDWSERNS CCCCCCCCCHHHCCC	24.11	22807455
739	Phosphorylation	SSVARKKSYHAELMR CHHHHHHHHHHHHHH	24.41	24899341
833	Phosphorylation	DAIQRKYSCDRSSSI HHHHHHHCCCCCCHH	16.75	23375375
888	Phosphorylation	PDNPLKTSIPIKAIC CCCCCCCCCCHHHCC	25.44	28059163
1080	Phosphorylation	NIRLRLESCEDRLIR HHHHHHHHHHHHHHH	27.65	24899341
1128 (in isoform 5)	Phosphorylation	-	34.08	-
1260 (in isoform 5)	Phosphorylation	-	57.57	21183079
1261 (in isoform 5)	Phosphorylation	-	40.36	21183079
1294	Phosphorylation	IGKSLKHYRDSYHPL HHHHHHHHHHCCCCH	17.96	30635358
1297	Phosphorylation	SLKHYRDSYHPLDDW HHHHHHHCCCCHHHH	19.15	30635358
1298	Phosphorylation	LKHYRDSYHPLDDWI HHHHHHCCCCHHHHH	16.25	30635358
1310	Phosphorylation	DWIQHIETTQRKIQE HHHHHHHHHHHHHHH	27.85	30635358
1311	Phosphorylation	WIQHIETTQRKIQEN HHHHHHHHHHHHHHC	17.37	30635358
1377	Phosphorylation	TYRAMVESQQKSPVK HHHHHHHHHCCCCCH	26.88	21454597
1380	Acetylation	AMVESQQKSPVKRRR HHHHHHCCCCCHHHH	49.44	6567261
1381	Phosphorylation	MVESQQKSPVKRRRI HHHHHCCCCCHHHHH	30.50	26824392
1406	Phosphorylation	FMDLRTRYTALVTLM HHHHHHHHHHHHHHH	8.85	24759943
1414	Phosphorylation	TALVTLMTQYIKFAG HHHHHHHHHHHHHHH	22.72	24759943
1416	Phosphorylation	LVTLMTQYIKFAGDS HHHHHHHHHHHHHHH	9.27	24759943
1457	Acetylation	KWVSNISKTLGDGEK HHHHHHHHHHCCCHH	43.93	15612673
1457 (in isoform 5)	Phosphorylation	-	43.93	29514104
1467	Acetylation	GDGEKAGKPLFSKQQ CCCHHCCCCCCCHHH	43.33	15612679
1517 (in isoform 5)	Phosphorylation	-	8.29	28507225
1527 (in isoform 5)	Phosphorylation	-	3.85	-
1531	Phosphorylation	YNLLFSESLKQQELQ HHHHCCHHHHCCCCC	39.40	23140645
1555 (in isoform 5)	Phosphorylation	-	18.92	-
1561 (in isoform 5)	Phosphorylation	-	22.91	-
1725	Phosphorylation	LTDMVQRSILQENTR HHHHHHHHHHCCCCC	15.57	21183079
1755	Phosphorylation	LKCGRSVSILRAAHE EECCCCHHHHHHHHC	19.70	23737553
1886 (in isoform 5)	Phosphorylation	-	45.68	30165576
1890 (in isoform 5)	Phosphorylation	-	29.92	30165576
1958	Phosphorylation	SFCKLQPSTVHDYRQ HHCCCCCCCCCCCCC	32.07	23737553
1959	Phosphorylation	FCKLQPSTVHDYRQE HCCCCCCCCCCCCCC	28.66	23737553
1963	Phosphorylation	QPSTVHDYRQEEGGS CCCCCCCCCCCCCCC	10.18	23737553
1970	Phosphorylation	YRQEEGGSDGEEPVT CCCCCCCCCCCCCCC	53.98	27087446
1977	Phosphorylation	SDGEEPVTAQSSEQT CCCCCCCCCCCHHHH	29.69	26643407
1980	Phosphorylation	EEPVTAQSSEQTKKL CCCCCCCCHHHHHHH	33.12	25619855
2121	Phosphorylation	VVQKGSESPSRVRVP EEECCCCCCCCEECC	37.60	23375375
2202	Phosphorylation	KGPSVFDYSPRLSAL CCCCHHCCCHHHHHH	20.39	22871156
2203	Phosphorylation	GPSVFDYSPRLSALL CCCHHCCCHHHHHHH	19.67	24899341
2207	Phosphorylation	FDYSPRLSALLSHDE HCCCHHHHHHHCHHH	32.31	27180971
2211	Phosphorylation	PRLSALLSHDELRQS HHHHHHHCHHHHHHC	31.86	24899341
2233	Phosphorylation	STPQNTGYLCEASTL CCCCCCCEEEEEEEC	13.95	25619855
2238	Phosphorylation	TGYLCEASTLSPSDQ CCEEEEEEECCHHHH	42.89	25619855
2239	Phosphorylation	GYLCEASTLSPSDQR CEEEEEEECCHHHHH	43.63	25619855
2241	Phosphorylation	LCEASTLSPSDQRVL EEEEEECCHHHHHHC	30.33	25619855
2243	Phosphorylation	EASTLSPSDQRVLAD EEEECCHHHHHHCCC	4.78	25619855
2318 (in isoform 5)	Phosphorylation	-	56.16	-
2325 (in isoform 5)	Phosphorylation	-	25.53	-
2333 (in isoform 5)	Phosphorylation	-	45.06	-
2340	Phosphorylation	GSRNDNTSDCGPLSH CCCCCCCCCCCCCCC	5.20	-
2346	Phosphorylation	TSDCGPLSHKGAIDA CCCCCCCCCCCCCCC	5.20	-
2355 (in isoform 5)	Phosphorylation	-	5.05	29895711
2359 (in isoform 5)	Phosphorylation	-	33.72	29895711
2363 (in isoform 5)	Phosphorylation	-	36.38	29895711
2410	Phosphorylation	QPEDYDTSLQEENDR CCCCCCCCCHHCCCC	43.22	21149613
2418	Phosphorylation	LQEENDRTPPPDDIF CHHCCCCCCCCCCHH	38.37	27180971
2487 (in isoform 5)	Phosphorylation	-	58.30	26060331
2519	Phosphorylation	RKERLGASLTPDGHW CHHHCCCCCCCCCCC	24.38	27180971
2521	Phosphorylation	ERLGASLTPDGHWRG HHCCCCCCCCCCCCC	16.10	27180971
2560	Phosphorylation	ESYRPYMSDGSDLDE CCCCCCCCCCCCCCC	10.79	25338131
2563	Phosphorylation	RPYMSDGSDLDEEDN CCCCCCCCCCCCCCC	57.34	25338131
2627	Phosphorylation	DMIPLDKTHSYSPLE HCCCCCCCCCCCCCC	26.44	27742792
2629	Phosphorylation	IPLDKTHSYSPLETQ CCCCCCCCCCCCCCC	50.21	27742792
2630	Phosphorylation	PLDKTHSYSPLETQH CCCCCCCCCCCCCCC	33.28	27742792
2631	Phosphorylation	LDKTHSYSPLETQHG CCCCCCCCCCCCCCC	24.52	26824392
2635	Phosphorylation	HSYSPLETQHGAGVF CCCCCCCCCCCCCCC	25.93	27742792
2646	Phosphorylation	AGVFQPESAGRGGWD CCCCCCCCCCCCCCC	23.67	25777480
2686	Phosphorylation	ATKGVSLSNAEGTAS CCCCCCCCCCCCCCC	20.65	25338131
2717	Phosphorylation	AEDLENVSPEISPSS HHHHCCCCCCCCCCC	43.44	27180971
2721	Phosphorylation	ENVSPEISPSSDNIV CCCCCCCCCCCCCCC	36.28	22006019
2723	Phosphorylation	VSPEISPSSDNIVRS CCCCCCCCCCCCCCC	7.45	30635358
2724	Phosphorylation	SPEISPSSDNIVRSE CCCCCCCCCCCCCCC	25.61	30635358
2790	Phosphorylation	QKEGVLMSSPEEGGE CCCCEECCCCCCCCC	47.34	21743459
2791	Phosphorylation	KEGVLMSSPEEGGEE CCCEECCCCCCCCCC	42.28	21743459
2857	Phosphorylation	GEAKNVQTGLTESPV CCEECCCCCCCCCHH	18.31	23984901
2860	Phosphorylation	KNVQTGLTESPVLLE ECCCCCCCCCHHHHH	3.98	23984901
2862	Phosphorylation	VQTGLTESPVLLETL CCCCCCCCHHHHHHH	37.30	27180971
2868	Phosphorylation	ESPVLLETLAEIFDT CCHHHHHHHHHHHCC	6.87	23984901
2886	Phosphorylation	KVTRADLTSAVTASE HCCHHHHHHHHCHHH	9.26	19854140
2995	Phosphorylation	KAGILQFTPENSDST CCEEEEECCCCCCCC	58.17	22006019
3033	Phosphorylation	PVSGVRHTSADTLDV CCCCCCCCCCCCCCC	5.31	23984901
3034	Phosphorylation	VSGVRHTSADTLDVG CCCCCCCCCCCCCCC	36.53	27742792
3037	Phosphorylation	VRHTSADTLDVGCPQ CCCCCCCCCCCCCCC	1.63	23984901
3065	Phosphorylation	PHRERALSLKPQERE CHHHHHHCCCCCHHH	69.44	26824392
3088	Phosphorylation	DGRSILKSSLDKVHM CHHHHHHHHHHHHCC	5.31	25338131
3089	Phosphorylation	GRSILKSSLDKVHMN HHHHHHHHHHHHCCC	12.73	29514104
3134	Phosphorylation	NEVSNVPSHGISPIS CCHHCCCCCCCCCCC	31.91	25338131
3138	Phosphorylation	NVPSHGISPISNSSE CCCCCCCCCCCCCHH	22.53	25338131
3288	Phosphorylation	EKLGELCSEPPEHSE CHHHHHCCCCCCCCC	42.51	24719451
3304	Phosphorylation	TSGSKERSSDSSSKE CCCCCCCCCCCCCHH	50.81	24719451
3309	Phosphorylation	ERSSDSSSKEKCSNG CCCCCCCCHHHHHHH	45.03	24719451
3417	Phosphorylation	NAFSSLSSVSSERMK HHHHHCHHCCHHHHH	29.50	28059163
3419	Phosphorylation	FSSLSSVSSERMKLI HHHCHHCCHHHHHHH	53.97	28059163
3435	Phosphorylation	LAINSEMSKLAVRHE HHHCHHHHHHHHHCH	23.13	23882026
3655	Acetylation	DRALIEQKLNEVKMK HHHHHHHHHHHHHHH	26.85	-
3655	Acetylation	DRALIEQKLNEVKMK HHHHHHHHHHHHHHH	26.85	23806337
3812	Phosphorylation	EKQGHYLSPEEKEKL HHCCCCCCHHHHHHH	63.38	-
3821	Succinylation	EEKEKLQKNTQELKV HHHHHHHHHHHHHHH	5.16	23954790
3894	Phosphorylation	DKLTRQKSFSEDVIS HHHHCCCCCCCHHHC	4.20	25521595
3896	Phosphorylation	LTRQKSFSEDVISHK HHCCCCCCCHHHCCC	20.99	25521595
4154	Phosphorylation	AMNEKVKTFIETTDP HHHHHHHHHHHCCCH	32.87	29895711
4158	Phosphorylation	KVKTFIETTDPSTAS HHHHHHHCCCHHHHH	35.63	29895711
4159	Phosphorylation	VKTFIETTDPSTASS HHHHHHCCCHHHHHH	11.06	29895711
4162	Phosphorylation	FIETTDPSTASSLQA HHHCCCHHHHHHHHH	5.49	29895711
4163	Phosphorylation	IETTDPSTASSLQAK HHCCCHHHHHHHHHH	40.67	29895711
4175	Phosphorylation	QAKMKDLSARFSEAS HHHHHHHHHHHHHHH	50.02	25521595
4378	Phosphorylation	NLLSALISPAKAIAA HHHHHHHCHHHHHHH	2.36	24759943
4400	Phosphorylation	LNGEGTDTNTQDFLA ECCCCCCCCHHHHHH	5.09	21454597
4613	Phosphorylation	FDTRKPQYEQLTAAG HCCCCCHHHHHHHCC	20.42	19854140
4625	Phosphorylation	AAGQGILSRPGEDPS HCCCCHHCCCCCCCC	43.96	19854140
4652	Phosphorylation	TQKWDNLTGQLRDRC HHHHHHHHHHHHHHC	65.24	18779572
4678	Phosphorylation	QYQSLLRSLSGTLTE HHHHHHHHHHCCHHH	3.90	27087446
4680	Phosphorylation	QSLLRSLSGTLTELD HHHHHHHHCCHHHHH	54.00	25521595
4682	Phosphorylation	LLRSLSGTLTELDDK HHHHHHCCHHHHHHH	44.78	24899341
4684	Phosphorylation	RSLSGTLTELDDKLS HHHHCCHHHHHHHHH	50.35	26160508
4691	Phosphorylation	TELDDKLSSGLTSGA HHHHHHHHHCCCCCC	27.41	26160508
4692	Phosphorylation	ELDDKLSSGLTSGAL HHHHHHHHCCCCCCC	26.37	26160508
4695	Phosphorylation	DKLSSGLTSGALPDA HHHHHCCCCCCCCHH	27.29	26160508
4696	Phosphorylation	KLSSGLTSGALPDAV HHHHCCCCCCCCHHH	65.09	26160508
4748	Phosphorylation	EYLKAELSRQLEGIL HHHHHHHHHHHHHHH	38.84	25619855
4987	Phosphorylation	QLQSKTVSLENMAQK HHHHHCCCHHHHHHH	22.46	27841257
5033	Phosphorylation	AYSNKHLSVLQAQQK HHCCHHHHHHHHHHH	37.97	26060331
5175	Phosphorylation	MMLATEETSPDLIGV HHHCCCCCCHHHHCH	8.53	28576409
5190	Phosphorylation	KRDLEALSKQCNKLL HHHHHHHHHHHHHHH	59.04	30352176
5225	Phosphorylation	HRKLEEFSTLLQKAE HHHHHHHHHHHHHHH	58.70	23649490
5393	Phosphorylation	EGEKIAASAEPADRV HCCCEECCCCCHHHH	67.62	19854140
5407	Phosphorylation	VKLTRQLSLLDSRWE HHHHHHHHHHHHHHH	34.61	25521595
5411	Phosphorylation	RQLSLLDSRWEALLS HHHHHHHHHHHHHHH	2.79	23984901
5488	Phosphorylation	DILLRKQSVDQALLN HHHHHCCCHHHHHHH	2.95	27180971
5529	Phosphorylation	YKDITKLSADVAKTL HHHHHHHCHHHHHHH	54.19	23140645
5635	Phosphorylation	NERYRLVSDTITQKV CHHHHCCHHHHHHHH	24.67	20139300
5637	Phosphorylation	RYRLVSDTITQKVEE HHHCCHHHHHHHHHH	50.67	20139300
5639	Phosphorylation	RLVSDTITQKVEEID HCCHHHHHHHHHHHH	54.78	20139300
5731 (in isoform 4)	Acetylation	-	60.96	-
5735	Acetylation	SMKKKLDKVLKKYDA HHHHHHHHHHHHCHH	44.17	23201123
5739	Acetylation	KLDKVLKKYDAVCQI HHHHHHHHCHHHHHC	1.95	-
5739	Acetylation	KLDKVLKKYDAVCQI HHHHHHHHCHHHHHC	1.95	22826441
5794	Phosphorylation	APALEYETLRRQQEE CCHHHHHHHHHHHHH	48.08	30352176
5924	Phosphorylation	MEKLQPLYETLRQRG HHHHHHHHHHHHHHH	31.41	-
6014	Phosphorylation	EDPGIDPSVVKQQQE CCCCCCHHHHHHHHH	38.28	26824392
6305	Phosphorylation	QRKQQLDSALRQAKG HHHHHHHHHHHHHHC	48.56	28059163
6561	Ubiquitination	EIANDPDKIKAQLVQ HHCCCHHHHHHHHHH	36.84	22790023
6561	Ubiquitination	EIANDPDKIKAQLVQ HHCCCHHHHHHHHHH	36.84	-
6592	Phosphorylation	TTNRTGRSLKEKTSL CCCCCCCCHHHHCCC	41.65	25619855
6597	Phosphorylation	GRSLKEKTSLADDNL CCCHHHHCCCCCCCC	51.10	25619855
6598	Phosphorylation	RSLKEKTSLADDNLK CCHHHHCCCCCCCCC	57.67	25619855
6619	Phosphorylation	ELRDKWDTICGKSVE HHHHHHHHHCCHHHH	47.09	23970565
6624	Phosphorylation	WDTICGKSVERQNKL HHHHCCHHHHHHHHH	37.59	23970565
6722	Phosphorylation	RVQMQELSTRWETVC HHHHHHHHHHHHHHH	28.24	25338131
6723	Phosphorylation	VQMQELSTRWETVCA HHHHHHHHHHHHHHH	17.58	25338131
6916	Phosphorylation	QPDVDKVTKTYKRRA CCCHHHHHHHHHHHC	40.41	25338131
6924	Phosphorylation	KTYKRRATDPPSLQS HHHHHHCCCCCCHHH	44.41	26370283
6949	Phosphorylation	GRKRFPASGFYPSGS CCCCCCCCCCCCCCC	29.92	23140645
6952	Phosphorylation	RFPASGFYPSGSQTQ CCCCCCCCCCCCCCE	34.10	23140645
6954	Phosphorylation	PASGFYPSGSQTQIE CCCCCCCCCCCCEEE	32.96	23140645
6956	Phosphorylation	SGFYPSGSQTQIETK CCCCCCCCCCEEEEC	9.13	23140645
6958	Phosphorylation	FYPSGSQTQIETKNP CCCCCCCCEEEECCC	37.44	23140645
7132 (in isoform 3)	Phosphorylation	-	24.72	25338131
7182	Phosphorylation	HHHGSKMLRSESNSS ECCCCCCCCCCCCCC	43.17	17114649
7184	Phosphorylation	HGSKMLRSESNSSIT CCCCCCCCCCCCCCC	32.18	23737553
7186	Phosphorylation	SKMLRSESNSSITAT CCCCCCCCCCCCCCC	2.81	25521595
7188	Phosphorylation	MLRSESNSSITATQP CCCCCCCCCCCCCCC	11.54	25521595
7189	Phosphorylation	LRSESNSSITATQPT CCCCCCCCCCCCCCC	26.82	25521595
7191	Phosphorylation	SESNSSITATQPTLA CCCCCCCCCCCCCCC	25.65	28066266
7193	Phosphorylation	SNSSITATQPTLAKG CCCCCCCCCCCCCCC	6.20	28066266
7196	Phosphorylation	SITATQPTLAKGRTN CCCCCCCCCCCCCCC	35.72	20415495
7199	Acetylation	ATQPTLAKGRTNMEL CCCCCCCCCCCCHHH	22.14	6566115
7224 (in isoform 3)	Phosphorylation	-	34.38	29514104
7230	Phosphorylation	FRPRGRRSRPSSRGA CCCCCCCCCCCCCCC	37.10	29899451
7230 (in isoform 4)	Phosphorylation	-	37.10	29514104
7233	Phosphorylation	RGRRSRPSSRGASPN CCCCCCCCCCCCCCC	22.24	29514104
7234	Phosphorylation	GRRSRPSSRGASPNR CCCCCCCCCCCCCCC	26.07	29899451
7238	Phosphorylation	RPSSRGASPNRSTSA CCCCCCCCCCCCCCC	33.30	26160508
7242	Phosphorylation	RGASPNRSTSASSHA CCCCCCCCCCCCCCH	20.79	26160508
7243	Phosphorylation	GASPNRSTSASSHAC CCCCCCCCCCCCCHH	20.73	26160508
7244	Phosphorylation	ASPNRSTSASSHACQ CCCCCCCCCCCCHHH	32.02	26160508
7244 (in isoform 3)	Phosphorylation	-	32.02	29514104
7246	Phosphorylation	PNRSTSASSHACQAA CCCCCCCCCCHHHHC	2.07	26160508
7247	Phosphorylation	NRSTSASSHACQAAS CCCCCCCCCHHHHCC	40.52	26160508
7250 (in isoform 4)	Phosphorylation	-	32.52	29514104
7254	Phosphorylation	SHACQAASPPVPAAA CCHHHHCCCCCCCCC	23.19	29233185
7272	Phosphorylation	KGTPIQGSKLRLPGY CCCCCCCCCCCCCCC	5.82	-
7279	Phosphorylation	SKLRLPGYLSGKGFH CCCCCCCCCCCCCCC	55.84	20469934
7281	Phosphorylation	LRLPGYLSGKGFHSG CCCCCCCCCCCCCCC	4.76	28066266
7286 (in isoform 3)	Phosphorylation	-	42.61	29514104
7287	Phosphorylation	LSGKGFHSGEDSALI CCCCCCCCCCCHHHH	22.22	29899451
7291	Phosphorylation	GFHSGEDSALITTAA CCCCCCCHHHHHHHH	15.95	20469934
7292 (in isoform 4)	Phosphorylation	-	13.80	29514104
7295	Phosphorylation	GEDSALITTAAARVR CCCHHHHHHHHHHHH	14.19	20469934
7296	Phosphorylation	EDSALITTAAARVRT CCHHHHHHHHHHHHH	17.45	20469934
7308	Phosphorylation	VRTQFAESRKTPSRP HHHHHHHHCCCCCCC	31.23	29514104
7311	Phosphorylation	QFAESRKTPSRPGSR HHHHHCCCCCCCCCC	49.83	23737553
7313	Phosphorylation	AESRKTPSRPGSRAG HHHCCCCCCCCCCCC	22.95	23737553
7317	Phosphorylation	KTPSRPGSRAGSKAG CCCCCCCCCCCCCCC	20.53	23737553
7328	Phosphorylation	SKAGSRASSRRGSDA CCCCCCCCCCCCCCC	28.86	29899451
7329	Phosphorylation	KAGSRASSRRGSDAS CCCCCCCCCCCCCCC	28.35	29899451
7333	Phosphorylation	RASSRRGSDASDFDI CCCCCCCCCCCCCCH	47.13	26824392
7336	Phosphorylation	SRRGSDASDFDISEI CCCCCCCCCCCHHHH	3.93	26824392
7341	Phosphorylation	DASDFDISEIQSVCS CCCCCCHHHHHHHHC	30.65	25619855
7345	Phosphorylation	FDISEIQSVCSDVET CCHHHHHHHHCCCCC	36.83	25619855
7348	Phosphorylation	SEIQSVCSDVETVPQ HHHHHHHCCCCCCCC	37.02	14576348
7352	Phosphorylation	SVCSDVETVPQTHRP HHHCCCCCCCCCCCC	17.49	25619855
7356	Phosphorylation	DVETVPQTHRPVPRA CCCCCCCCCCCCCCC	5.16	25619855
7368	Phosphorylation	PRAGSRPSTAKPSKI CCCCCCCCCCCCCCC	38.09	29899451
7382	Phosphorylation	IPTPQRRSPASKLDK CCCCCCCCCCHHCCC	63.91	24719451
7385	Phosphorylation	PQRRSPASKLDKSSK CCCCCCCHHCCCCCC	68.04	27149854

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DYST_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DYST_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DYST_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DYST_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7182, AND MASSSPECTROMETRY.
PubMed: 17114649