UNC79_MOUSE - dbPTM
UNC79_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UNC79_MOUSE
UniProt AC Q0KK59
Protein Name Protein unc-79 homolog
Gene Name Unc79
Organism Mus musculus (Mouse).
Sequence Length 2596
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability..
Protein Sequence MSTKAEQFASKIRYLQEYHNRVLHNIYPVPSGTDIANTLKYFSQTLLSILSRTGKKENQDASNLTVPMTMCLFPVPFPLTPSLRPQVSSINPTVTRSLLYSVLRDAPSERGPQSRDAQLSDYPSLDYQGLYVTLVTLLDLVPLLQHGQHDLGQSIFYTTTCLLPFLNDDVLSTLPYTMISTLATFPPFLHKDIIEYLSTSFLPMAILGSSGREGVPAHVNLSASSMLMIAMQYTSNPVYHCQLLECLMKYKQEVWKDLLYVIAYGPSQVKPPAVQMLFHYWPNLKPPGAISEYRGLQYTAWNPIHCQHIECHNAINKPAVKMCIDPSLSVALGDKPPPLYLCEECSERISGDHSEWLIDVLLPQAEISAICQKKNCSSHVRRAVVTCFSAGCCGRHGNRPVRYCKRCHSNHHSNEVGATAETHLYQTSPPPINTRECGAEELVCAVEAVISLLKEAEFHAEQREHELNRRRQLGLSSSHHSLDNTDFDNKDDDKHDQRLLSQFGIWFLVSLCTPSENTPTESLARLVAMVFQWFHSTAYMMDDEVGSLVEKLKPQFVTKWLKTVCDVRFDVMVMCLLPKPMEFARVGGYWDKSCSTVTQLKEGLNRILCLIPYNVISQSVWECIMPEWLEAIRTEVPDNQLKEFREVLSKMFDIELCPLPFSMEEMFGFISCRFTGYPSTVQEQALLWLHVLSELDITVPLQLLISMFSDGVNSVKELANQRKSRANELAGNLASRRVSVASDPGRRGQHNTLSPFHSPFQSPFRSPMRSPFRSPFKNFGHPGGRTIDFDCEDDDMNLNCFILMFDLLLKQMELQDDGITMGLEHSLSKDIISIINNVFQAPWGGSHSCQKDKKATECNLCQSSILCYQLACELLERLAPKEESRLVEPTDSLEDSLLSSRPEFILGPEGEEEENPAAKHGENPGNRTVPSEHAAIKNDTERKFCYQQLPVTLRLIYTIFQEMAKFEEPDILFNMLNCLKILCLHGECLYTARKDHPQFLAYIQDHMLIASLWRVVKSEFSQLSSLAVPLLLHALSLPHGADIFWTIINGNFNSKDWKMRFEAVEKVAVICRFLDIHSVTKNHLLKYSLAHAFCCFLTAVEDVNPAVATRAGLLLDTIKRPALQGLCLCLDFQFDTVVKDRPTILSKLLLLHFLKQDIPALSWEFFVNRFETLSLEAQLHLDCNKEFPFPTTITAVRTNVANLSDAALWKIKRARFARNRQKSVRSLRDSVKGPAESKRALSLPETLTSKIRQQSPENDNTIKDLLPEDAGIDHQTVHQLITVLMKFMARDESSAESDISSAKAFNTVKRHLYVLLGYDQQEGCFMIAPQKMRLSTCFNAFIAGIAQVMDYNINLGKHLLPLVVQVLKYCSCPQLRHYFQQPPRCSLWSLKPHIRQMWLKALLVILYKYPYRDCDVSKTLLHLIHITVNTLNAQYHSCKPHATAGPLYTDNSNISRYSEKEKGEIELAEYRETGALQDSVLHCVREESIQKKKLRSLKQKSLDIGNADSLLFTLDEHRRKSCIDRCDIDKPPAQAAYISQRQNDHHGRSRQNSATRPDNTEIPKNPGTEGFQEIRRPVIPEVRLNCMETFEVRVDSPGKPAPREDLDLIDLSSDSTSGPEKHSILSTSDSDSLVFEPLPPLRIVESDEEEEMMNQGNGGALGNNAASSPSIPSQPSVLSLSTTPLVQVSVEDCSKDFSSKDSGNHQSASNEDSTIAALDDLTDSEELSKSEELREFASGSPLTLKQKRDLLQKSSAVPEMSVDYNPEPSPAEEKPGQTPTSGVKTVLLKVPEDGENLIESEKPNTSAESDTEQNPERKVEEDGAEESEFKIQIVPRQRKQRKIAVSAIQREYLDISFNILDKLGEQKDPDPSAKGLSTLEMPRESSSAPTLEAGAPETSSHSSISKQIQPGKRQCNVPMCLNPDLEGQPLRTRGATKSSLLSAPSIASMFVPAPEEFTEEQPTVMADKCHDCGAILEEYDEETLGLAIVVLSTFIHLSPDLAAPLLLDIMQSVGRLASSTTFSNQAESMMVPGNAAGVAKQFLRCIFHQLAPNGIFPQLFQSAIKDGTFLRTLATSLMDFNELSSIAALSQLLEGLNNKKNLPAGGAMIRCLENIATFMEALPMDSPSSLWTTISNQFQTFFAKLPCVLPLKCSLDSSLRIMICLLKIPSTNATRSLLEPFSKLLSFVIQNAVFTLAYLVELCGLCYRAFTKERDKFYLSRSVVLELLQALKLKSPLPDTNLLLLVQFICADAGTKLAESTILSKQMIASVPGCGTAAMECIRQYVSEVLEFMADMHTLTKLKSHMKTCSQPLHEDTFGGHLKVGLAQIAAMEISRGNHRDNKAVIRYLPWLYHPPSAMQQGPKEFIECVSHIRLLSWLLLGSLTHNAVCPNASSPCLPIPLDAGSHIADHLIVILIGFPEQSKTCVLHMCSLFHAFIFAQLWTVYCEQSAVATNVQNQNEFSFTAILTALEFWSRVTPSILQLMAHNKVMVEMVCLHVISLMEALQECNSTIFVKLIPMWLPMIQSNTKHLSAGLQLRLQAIQNNVNHHSLRTLPGSGQSSAGLAALRKWLQCTQFKMAQVEIQSSEAASQFYPL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
481PhosphorylationGLSSSHHSLDNTDFD
CCCCCCCCCCCCCCC		31.8127841257
739PhosphorylationNLASRRVSVASDPGR
HHHHCCEECCCCCCC		15.3422324799
742PhosphorylationSRRVSVASDPGRRGQ
HCCEECCCCCCCCCC		42.0322324799
752PhosphorylationGRRGQHNTLSPFHSP
CCCCCCCCCCCCCCC		26.8729899451
754PhosphorylationRGQHNTLSPFHSPFQ
CCCCCCCCCCCCCCC		24.3919060867
758PhosphorylationNTLSPFHSPFQSPFR
CCCCCCCCCCCCCCC		27.9919060867
762PhosphorylationPFHSPFQSPFRSPMR
CCCCCCCCCCCCCCC		26.7819060867
766PhosphorylationPFQSPFRSPMRSPFR
CCCCCCCCCCCCCCC		24.35-
896PhosphorylationPTDSLEDSLLSSRPE
CCCCHHHHHHHCCCC		23.1029899451
899PhosphorylationSLEDSLLSSRPEFIL
CHHHHHHHCCCCCCC		29.6029899451
946PhosphorylationDTERKFCYQQLPVTL
CCCCCHHHHHHHHHH		11.48-
952PhosphorylationCYQQLPVTLRLIYTI
HHHHHHHHHHHHHHH		12.29-
1088PhosphorylationKNHLLKYSLAHAFCC
HHHHHHHHHHHHHHH		19.93-
1223PhosphorylationFARNRQKSVRSLRDS
HHHHHHHHHHHHHHH		17.9022324799
1226PhosphorylationNRQKSVRSLRDSVKG
HHHHHHHHHHHHCCC		26.1222324799
1230PhosphorylationSVRSLRDSVKGPAES
HHHHHHHHCCCCHHH		21.2129899451
1242PhosphorylationAESKRALSLPETLTS
HHHHHHHCCCHHHHH		40.6729899451
1255PhosphorylationTSKIRQQSPENDNTI
HHHHHHCCCCCCCCH		26.3322324799
1488PhosphorylationLHCVREESIQKKKLR
HHHHCHHHHHHHHHH		26.1029899451
1501PhosphorylationLRSLKQKSLDIGNAD
HHHHHHHCCCCCCHH		28.8719060867
1521PhosphorylationLDEHRRKSCIDRCDI
CCHHHHHHCHHHCCC		17.9429899451
1553PhosphorylationHGRSRQNSATRPDNT
CCCCCCCCCCCCCCC		23.7629899451
1560PhosphorylationSATRPDNTEIPKNPG
CCCCCCCCCCCCCCC		42.5529899451
1596PhosphorylationTFEVRVDSPGKPAPR
EEEEEECCCCCCCCH		32.4725521595
1738PhosphorylationEELREFASGSPLTLK
HHHHHHHCCCCCCHH		45.1628066266
1740PhosphorylationLREFASGSPLTLKQK
HHHHHCCCCCCHHHH		17.7822817900
1743PhosphorylationFASGSPLTLKQKRDL
HHCCCCCCHHHHHHH		34.9828066266
1805PhosphorylationIESEKPNTSAESDTE
CCCCCCCCCCCCCCC		37.5329899451
1809PhosphorylationKPNTSAESDTEQNPE
CCCCCCCCCCCCCCC		49.9329899451
1811PhosphorylationNTSAESDTEQNPERK
CCCCCCCCCCCCCCC		49.0729899451
1877PhosphorylationDPSAKGLSTLEMPRE
CCCCCCCCCCCCCCC		39.3523527152
2478PhosphorylationLEFWSRVTPSILQLM
HHHHHHCCHHHHHHH		15.3721082442
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UNC79_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UNC79_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UNC79_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of UNC79_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UNC79_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1242, AND MASSSPECTROMETRY.

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