ABLM3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABLM3_MOUSE
• UniProt AC: Q69ZX8
• Protein Name: Actin-binding LIM protein 3
• Gene Name: Ablim3
• Organism: Mus musculus (Mouse).
• Sequence Length: 682
• Subcellular Localization: Cytoplasm.
• Protein Description: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity..
• Protein Sequence: MNTSIPYQQSPYSPRGGSNVIQCYRCGDTCKGEVVRVHNNHFHIRCFTCQVCGCGLAQSGFFFKNQEYICTQDYQQLYGTRCDSCRDFITGEVISALGRTYHPKCFVCSLCRKPFPIGDKVTFSGKECVCQTCSQSMTSSKPIKIRGPSHCAGCKEEIKHGQSLLALDKQWHVSCFKCQTCSVILTGEYISKDGVPYCESDYHSQFGIKCETCDRYISGRVLEAGGKHYHPTCARCVRCHQMFTEGEEMYLTGSEVWHPICKQAARAEKKLKHRRTSETSISPPGSSIGSPNRVICAKVDNEILNYKDLAALPKVKSIYEVQRPDLISYEPHSRYTSDEMLERCGYGESLGTLSPYSQDIYENLDLRQRRASSPGYIDSPTYSRQGMSPTFSRSPHYYRSGPESGRSSPYHSQLDVRSSTPTSYQAPKHFHIPAGESNIYRKPPIYKRHGDLSTATKSKTSEDISQASKYSPAYSPDPYYASESEYWTYHGSPKVPRARRFSSGGEEEDFDRSMHKLQSGIGRLILKEEMKARSSSYADPWTPPRSSTSSREALHTTGYEMSFNGSPRSHYLADSDPLISKSASLPAYRRNGLHRTPSADLFHYDSMNAVNWGMREYKIYPYELLLVTTRGRNRLPKDVDRTRLERHLSQEEFYQVFGMTISEFERLALWKRNELKKQARLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNTSIPYQ -------CCCCCCCC	12.77	-
4	Phosphorylation	----MNTSIPYQQSP ----CCCCCCCCCCC	19.30	29472430
10	Phosphorylation	TSIPYQQSPYSPRGG CCCCCCCCCCCCCCC	15.41	29472430
12	Phosphorylation	IPYQQSPYSPRGGSN CCCCCCCCCCCCCCC	36.23	29472430
13	Phosphorylation	PYQQSPYSPRGGSNV CCCCCCCCCCCCCCC	16.11	29472430
163	Phosphorylation	EEIKHGQSLLALDKQ HHHHCCCCEEHHCCC	29.91	27180971
276	Phosphorylation	KKLKHRRTSETSISP HHHHCCCCCCCCCCC	30.76	25521595
277	Phosphorylation	KLKHRRTSETSISPP HHHCCCCCCCCCCCC	36.75	25521595
279	Phosphorylation	KHRRTSETSISPPGS HCCCCCCCCCCCCCC	31.00	24925903
280	Phosphorylation	HRRTSETSISPPGSS CCCCCCCCCCCCCCC	19.60	25521595
282	Phosphorylation	RTSETSISPPGSSIG CCCCCCCCCCCCCCC	25.47	25521595
286	Phosphorylation	TSISPPGSSIGSPNR CCCCCCCCCCCCCCC	25.26	25521595
287	Phosphorylation	SISPPGSSIGSPNRV CCCCCCCCCCCCCCE	36.56	25521595
290	Phosphorylation	PPGSSIGSPNRVICA CCCCCCCCCCCEEEE	19.82	24925903
317	Phosphorylation	AALPKVKSIYEVQRP HHCCCCEEEEEECCC	33.13	29899451
335	Phosphorylation	SYEPHSRYTSDEMLE CCCCCCCCCCHHHHH	17.38	22324799
336	Phosphorylation	YEPHSRYTSDEMLER CCCCCCCCCHHHHHH	28.70	22324799
337	Phosphorylation	EPHSRYTSDEMLERC CCCCCCCCHHHHHHC	23.73	27180971
372	Phosphorylation	DLRQRRASSPGYIDS CHHHHHCCCCCCCCC	34.94	25521595
373	Phosphorylation	LRQRRASSPGYIDSP HHHHHCCCCCCCCCC	22.74	25521595
376	Phosphorylation	RRASSPGYIDSPTYS HHCCCCCCCCCCCCC	12.63	22324799
379	Phosphorylation	SSPGYIDSPTYSRQG CCCCCCCCCCCCCCC	15.02	25521595
381	Phosphorylation	PGYIDSPTYSRQGMS CCCCCCCCCCCCCCC	37.77	22324799
382	Phosphorylation	GYIDSPTYSRQGMSP CCCCCCCCCCCCCCC	12.77	23984901
383	Phosphorylation	YIDSPTYSRQGMSPT CCCCCCCCCCCCCCC	22.17	23737553
383	O-linked_Glycosylation	YIDSPTYSRQGMSPT CCCCCCCCCCCCCCC	22.17	19458039
388	Phosphorylation	TYSRQGMSPTFSRSP CCCCCCCCCCCCCCC	27.84	25521595
390	Phosphorylation	SRQGMSPTFSRSPHY CCCCCCCCCCCCCCC	27.25	23737553
392	Phosphorylation	QGMSPTFSRSPHYYR CCCCCCCCCCCCCCC	34.03	23984901
394	Phosphorylation	MSPTFSRSPHYYRSG CCCCCCCCCCCCCCC	18.16	22817900
400	Phosphorylation	RSPHYYRSGPESGRS CCCCCCCCCCCCCCC	42.45	30372032
404	Phosphorylation	YYRSGPESGRSSPYH CCCCCCCCCCCCCCC	42.51	24899341
407	Phosphorylation	SGPESGRSSPYHSQL CCCCCCCCCCCCCCC	38.91	24899341
408	Phosphorylation	GPESGRSSPYHSQLD CCCCCCCCCCCCCCC	28.28	24899341
410	Phosphorylation	ESGRSSPYHSQLDVR CCCCCCCCCCCCCCC	18.95	51457531
412	Phosphorylation	GRSSPYHSQLDVRSS CCCCCCCCCCCCCCC	26.96	16221785
417	Methylation	YHSQLDVRSSTPTSY CCCCCCCCCCCCCCC	25.26	-
418	Phosphorylation	HSQLDVRSSTPTSYQ CCCCCCCCCCCCCCC	38.11	29899451
419	O-linked_Glycosylation	SQLDVRSSTPTSYQA CCCCCCCCCCCCCCC	28.04	19458039
419	Phosphorylation	SQLDVRSSTPTSYQA CCCCCCCCCCCCCCC	28.04	29899451
420	Phosphorylation	QLDVRSSTPTSYQAP CCCCCCCCCCCCCCC	31.65	24899341
422	Phosphorylation	DVRSSTPTSYQAPKH CCCCCCCCCCCCCCC	39.91	29895711
423	Phosphorylation	VRSSTPTSYQAPKHF CCCCCCCCCCCCCCC	19.22	29895711
423	O-linked_Glycosylation	VRSSTPTSYQAPKHF CCCCCCCCCCCCCCC	19.22	19458039
424	Phosphorylation	RSSTPTSYQAPKHFH CCCCCCCCCCCCCCC	15.92	29895711
458	Phosphorylation	DLSTATKSKTSEDIS CCCCCCCCCCHHHHH	36.49	29899451
460	Phosphorylation	STATKSKTSEDISQA CCCCCCCCHHHHHHH	44.43	25195567
461	Phosphorylation	TATKSKTSEDISQAS CCCCCCCHHHHHHHH	36.69	25195567
468	Phosphorylation	SEDISQASKYSPAYS HHHHHHHHHCCCCCC	25.21	25195567
471	Phosphorylation	ISQASKYSPAYSPDP HHHHHHCCCCCCCCC	13.54	19060867
475	Phosphorylation	SKYSPAYSPDPYYAS HHCCCCCCCCCCCCC	25.57	21183079
479	Phosphorylation	PAYSPDPYYASESEY CCCCCCCCCCCHHHC	21.02	23984901
480	Phosphorylation	AYSPDPYYASESEYW CCCCCCCCCCHHHCE	14.72	23984901
482	Phosphorylation	SPDPYYASESEYWTY CCCCCCCCHHHCEEE	26.07	23984901
484	Phosphorylation	DPYYASESEYWTYHG CCCCCCHHHCEEECC	33.23	19060867
486	Phosphorylation	YYASESEYWTYHGSP CCCCHHHCEEECCCC	16.60	23984901
488	Phosphorylation	ASESEYWTYHGSPKV CCHHHCEEECCCCCC	12.53	29472430
489	Phosphorylation	SESEYWTYHGSPKVP CHHHCEEECCCCCCC	7.05	21183079
492	Phosphorylation	EYWTYHGSPKVPRAR HCEEECCCCCCCCCC	14.29	27180971
502	Phosphorylation	VPRARRFSSGGEEED CCCCCCCCCCCCHHH	26.68	25521595
503	Phosphorylation	PRARRFSSGGEEEDF CCCCCCCCCCCHHHH	48.37	25521595
534	Phosphorylation	KEEMKARSSSYADPW HHHHHHCCCCCCCCC	28.61	29472430
534	O-linked_Glycosylation	KEEMKARSSSYADPW HHHHHHCCCCCCCCC	28.61	19458039
535	Phosphorylation	EEMKARSSSYADPWT HHHHHCCCCCCCCCC	23.09	30834945
536	Phosphorylation	EMKARSSSYADPWTP HHHHCCCCCCCCCCC	26.11	19060867
537	Phosphorylation	MKARSSSYADPWTPP HHHCCCCCCCCCCCC	19.57	29472430
542	Phosphorylation	SSYADPWTPPRSSTS CCCCCCCCCCCCCCC	28.89	27180971
546	O-linked_Glycosylation	DPWTPPRSSTSSREA CCCCCCCCCCCCCHH	43.68	19458039
546	Phosphorylation	DPWTPPRSSTSSREA CCCCCCCCCCCCCHH	43.68	23984901
547	Phosphorylation	PWTPPRSSTSSREAL CCCCCCCCCCCCHHH	33.32	23984901
547	O-linked_Glycosylation	PWTPPRSSTSSREAL CCCCCCCCCCCCHHH	33.32	19458039
548	Phosphorylation	WTPPRSSTSSREALH CCCCCCCCCCCHHHH	31.78	23984901
549	Phosphorylation	TPPRSSTSSREALHT CCCCCCCCCCHHHHH	29.37	23984901
550	Phosphorylation	PPRSSTSSREALHTT CCCCCCCCCHHHHHC	33.94	23984901
556	Phosphorylation	SSREALHTTGYEMSF CCCHHHHHCCCEEEC	23.83	23984901
557	Phosphorylation	SREALHTTGYEMSFN CCHHHHHCCCEEECC	27.33	23984901
559	Phosphorylation	EALHTTGYEMSFNGS HHHHHCCCEEECCCC	13.33	23984901
566	Phosphorylation	YEMSFNGSPRSHYLA CEEECCCCCCCEECC	20.46	27180971
569	Phosphorylation	SFNGSPRSHYLADSD ECCCCCCCEECCCCC	21.62	23984901
571	Phosphorylation	NGSPRSHYLADSDPL CCCCCCEECCCCCCC	12.58	22817900
575	Phosphorylation	RSHYLADSDPLISKS CCEECCCCCCCCCCC	35.20	27180971
580	Phosphorylation	ADSDPLISKSASLPA CCCCCCCCCCCCCCC	28.39	29472430
580	O-linked_Glycosylation	ADSDPLISKSASLPA CCCCCCCCCCCCCCC	28.39	69005179
582	Phosphorylation	SDPLISKSASLPAYR CCCCCCCCCCCCCHH	19.12	29472430
584	Phosphorylation	PLISKSASLPAYRRN CCCCCCCCCCCHHHC	41.81	27180971
596	Phosphorylation	RRNGLHRTPSADLFH HHCCCCCCCCCCCCC	15.73	19060867
598	Phosphorylation	NGLHRTPSADLFHYD CCCCCCCCCCCCCHH	33.53	27180971
604	Phosphorylation	PSADLFHYDSMNAVN CCCCCCCHHHCCCCC	11.46	23984901
606	Phosphorylation	ADLFHYDSMNAVNWG CCCCCHHHCCCCCCC	13.53	22817900
620	Phosphorylation	GMREYKIYPYELLLV CCCCCEECCEEEEEE	8.80	-
622	Phosphorylation	REYKIYPYELLLVTT CCCEECCEEEEEEEC	11.39	-
628	Phosphorylation	PYELLLVTTRGRNRL CEEEEEEECCCCCCC	15.67	-
629	Phosphorylation	YELLLVTTRGRNRLP EEEEEEECCCCCCCC	24.52	-
630	Methylation	ELLLVTTRGRNRLPK EEEEEECCCCCCCCC	32.48	24129315

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABLM3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABLM3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABLM3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ABLM3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502, AND MASSSPECTROMETRY.
PubMed: 19367708

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277; SER-280; SER-373AND SER-502, AND MASS SPECTROMETRY.
PubMed: 17242355

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282, AND MASSSPECTROMETRY.
PubMed: 17114649