dbPTM

MYPT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MYPT1_MOUSE
UniProt AC	Q9DBR7
Protein Name	Protein phosphatase 1 regulatory subunit 12A
Gene Name	Ppp1r12a {ECO:0000312\|MGI:MGI:1309528}
Organism	Mus musculus (Mouse).
Sequence Length	1029
Subcellular Localization	Cytoplasm . Along actomyosin filaments and stress fibers.
Protein Description	Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity (By similarity)..
Protein Sequence	MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERVMLRDARQWLNSGHISDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMETVNKVGQTAFDVADEDILGYLEELQKKQTLLHSEKRDKKSPLIESTANMENNQPQKAFKNKETLIIEPEKNASRIESLEHEKADEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPMASVSNAHTSSTQAAPAAVTAPTLSSNQGTPTSPVKKFPISTTKISPKEEERKDESPASWRLGLRKTGSYGALAEISASKEAQKEKDTAGVMRSASSPRLSSSLDNKEKEKDNKGTRLAYVTPTIPRRLASTSDIEEKENRESSSLRTSSSYTRRKWEDDLKKNSSINEGSTYHRSCSFGRRQDDLISCSVPSTTSTPTVTSAAGLQRSLPSSTSTAAKTPPGSSSAGTQSSTSNRLWAEDSTEKEKDSAPTAVTIPVAPTVVNAAAPSTTTLTTTTAGTVSEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESEASREDEYKQKYSRTYDETYTRYRPVSTSSSSAPSSSSLSTLGSTLYASSQLNRPNSLVGITSAYSRGLAKENEREGEKKEEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQERQSDTEDGSSKRETQTDSVSRYDSSSTSSSDRYDSLLGRSASYSYLEDRKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSQLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	QLKRWIGSETDLEPP HHHHHHCCCCCCCCC	28.34	29899451
22	Phosphorylation	KRWIGSETDLEPPVV HHHHCCCCCCCCCCC	47.81	26525534
67	Hydroxylation	LHRGADINYANVDGL HHCCCCCCCCCCCHH	30.34	-
100	Hydroxylation	VENGANINQPDNEGW HHCCCCCCCCCCCCC	47.33	-
198	Phosphorylation	SDVRHAKSGGTALHV CCCCCCCCCCCHHHH	43.15	25338131
226	Hydroxylation	IQAGYDVNIKDYDGW HHCCCCCCCCCCCCC	32.47	-
285	Ubiquitination	GYLEELQKKQTLLHS HHHHHHHHHHHHHCC	60.52	-
286	Ubiquitination	YLEELQKKQTLLHSE HHHHHHHHHHHHCCC	35.24	-
299	Phosphorylation	SEKRDKKSPLIESTA CCCCCCCCCCCHHHC	30.58	25521595
304	Phosphorylation	KKSPLIESTANMENN CCCCCCHHHCCCCCC	26.31	25521595
305	Phosphorylation	KSPLIESTANMENNQ CCCCCHHHCCCCCCC	14.84	25521595
320	Acetylation	PQKAFKNKETLIIEP CCHHHCCCCCEEECC	53.30	23806337
320	Ubiquitination	PQKAFKNKETLIIEP CCHHHCCCCCEEECC	53.30	22790023
336	Phosphorylation	KNASRIESLEHEKAD CCHHHHHHHHHHCCH	36.36	29514104
353	Phosphorylation	EEGKKDESSCSSEED HCCCCCCCCCCCCCC	46.94	21659604
354	Phosphorylation	EGKKDESSCSSEEDE CCCCCCCCCCCCCCC	18.90	25195567
356	Phosphorylation	KKDESSCSSEEDEED CCCCCCCCCCCCCCC	42.61	25195567
357	Phosphorylation	KDESSCSSEEDEEDD CCCCCCCCCCCCCCC	49.70	27357545
365	Phosphorylation	EEDEEDDSESEAETD CCCCCCCCHHHHCCC	56.17	25195567
367	Phosphorylation	DEEDDSESEAETDKT CCCCCCHHHHCCCCC	46.16	25195567
371	Phosphorylation	DSESEAETDKTKPMA CCHHHHCCCCCCCCC	50.25	21659604
374	Phosphorylation	SEAETDKTKPMASVS HHHCCCCCCCCCCCC	43.09	18846507
379	Phosphorylation	DKTKPMASVSNAHTS CCCCCCCCCCCCCCC	21.59	18846507
381	O-linked_Glycosylation	TKPMASVSNAHTSST CCCCCCCCCCCCCCC	26.29	30059200
381	Phosphorylation	TKPMASVSNAHTSST CCCCCCCCCCCCCCC	26.29	18846507
385	Phosphorylation	ASVSNAHTSSTQAAP CCCCCCCCCCCCCCC	23.20	18846507
386	O-linked_Glycosylation	SVSNAHTSSTQAAPA CCCCCCCCCCCCCCC	22.86	30059200
386	Phosphorylation	SVSNAHTSSTQAAPA CCCCCCCCCCCCCCC	22.86	18846507
387	Phosphorylation	VSNAHTSSTQAAPAA CCCCCCCCCCCCCCE	26.20	18846507
388	Phosphorylation	SNAHTSSTQAAPAAV CCCCCCCCCCCCCEE	23.22	18846507
396	Phosphorylation	QAAPAAVTAPTLSSN CCCCCEEECCCCCCC	23.38	18846507
399	Phosphorylation	PAAVTAPTLSSNQGT CCEEECCCCCCCCCC	36.49	26643407
401	Phosphorylation	AVTAPTLSSNQGTPT EEECCCCCCCCCCCC	29.71	26643407
402	Phosphorylation	VTAPTLSSNQGTPTS EECCCCCCCCCCCCC	35.96	26643407
406	Phosphorylation	TLSSNQGTPTSPVKK CCCCCCCCCCCCCCC	17.40	25266776
408	Phosphorylation	SSNQGTPTSPVKKFP CCCCCCCCCCCCCCC	45.56	26643407
409	Phosphorylation	SNQGTPTSPVKKFPI CCCCCCCCCCCCCCC	28.97	25266776
417	Phosphorylation	PVKKFPISTTKISPK CCCCCCCCCCCCCCC	30.20	25293948
418	Phosphorylation	VKKFPISTTKISPKE CCCCCCCCCCCCCCH	32.59	25777480
419	Phosphorylation	KKFPISTTKISPKEE CCCCCCCCCCCCCHH	21.42	27600695
422	Phosphorylation	PISTTKISPKEEERK CCCCCCCCCCHHHCC	31.32	26824392
432	Phosphorylation	EEERKDESPASWRLG HHHCCCCCCCHHHHH	35.58	28066266
443	Phosphorylation	WRLGLRKTGSYGALA HHHHCCCCCCHHHHE	25.56	25521595
445	Phosphorylation	LGLRKTGSYGALAEI HHCCCCCCHHHHEEH	26.14	24925903
446	Phosphorylation	GLRKTGSYGALAEIS HCCCCCCHHHHEEHH	14.04	25521595
453	Phosphorylation	YGALAEISASKEAQK HHHHEEHHCCHHHHH	20.28	25619855
464	Phosphorylation	EAQKEKDTAGVMRSA HHHHHCCCHHHHHCC	36.06	18779572
470	Phosphorylation	DTAGVMRSASSPRLS CCHHHHHCCCCCCCH	17.88	22324799
472	Phosphorylation	AGVMRSASSPRLSSS HHHHHCCCCCCCHHC	41.96	26824392
473	Phosphorylation	GVMRSASSPRLSSSL HHHHCCCCCCCHHCC	17.47	26745281
477	Phosphorylation	SASSPRLSSSLDNKE CCCCCCCHHCCCCHH	21.11	26643407
478	Phosphorylation	ASSPRLSSSLDNKEK CCCCCCHHCCCCHHH	39.24	22324799
479	Phosphorylation	SSPRLSSSLDNKEKE CCCCCHHCCCCHHHH	36.04	22324799
496	Phosphorylation	NKGTRLAYVTPTIPR CCCCEEEEECCCCCC	14.95	29472430
498	Phosphorylation	GTRLAYVTPTIPRRL CCEEEEECCCCCCCC	11.31	26824392
500	Phosphorylation	RLAYVTPTIPRRLAS EEEEECCCCCCCCCC	33.96	26745281
507	Phosphorylation	TIPRRLASTSDIEEK CCCCCCCCCCCHHHH	32.79	25521595
508	Phosphorylation	IPRRLASTSDIEEKE CCCCCCCCCCHHHHH	25.47	25521595
509	Phosphorylation	PRRLASTSDIEEKEN CCCCCCCCCHHHHHH	33.81	26824392
521	Phosphorylation	KENRESSSLRTSSSY HHHHCCCCCCCCCHH	31.02	-
525	Phosphorylation	ESSSLRTSSSYTRRK CCCCCCCCCHHHHHH	15.74	18779572
526	Phosphorylation	SSSLRTSSSYTRRKW CCCCCCCCHHHHHHH	27.10	18779572
527	Phosphorylation	SSLRTSSSYTRRKWE CCCCCCCHHHHHHHH	30.23	18779572
528	Phosphorylation	SLRTSSSYTRRKWED CCCCCCHHHHHHHHH	13.25	29514104
541	Phosphorylation	EDDLKKNSSINEGST HHHHHHCCCCCCCCH	41.28	21743459
542	Phosphorylation	DDLKKNSSINEGSTY HHHHHCCCCCCCCHH	38.53	29176673
547	Phosphorylation	NSSINEGSTYHRSCS CCCCCCCCHHCCCCC	21.44	18846507
548	Phosphorylation	SSINEGSTYHRSCSF CCCCCCCHHCCCCCC	33.92	18846507
549	Phosphorylation	SINEGSTYHRSCSFG CCCCCCHHCCCCCCC	9.27	29514104
552	Phosphorylation	EGSTYHRSCSFGRRQ CCCHHCCCCCCCCCC	10.78	26643407
554	Phosphorylation	STYHRSCSFGRRQDD CHHCCCCCCCCCCCC	31.79	23737553
564	O-linked_Glycosylation	RRQDDLISCSVPSTT CCCCCEEEEECCCCC	13.98	30059200
564	Phosphorylation	RRQDDLISCSVPSTT CCCCCEEEEECCCCC	13.98	26643407
566	O-linked_Glycosylation	QDDLISCSVPSTTST CCCEEEEECCCCCCC	30.21	30059200
566	Phosphorylation	QDDLISCSVPSTTST CCCEEEEECCCCCCC	30.21	26643407
569	Phosphorylation	LISCSVPSTTSTPTV EEEEECCCCCCCCCC	42.01	26643407
570	O-linked_Glycosylation	ISCSVPSTTSTPTVT EEEECCCCCCCCCCC	20.78	30059200
570	Phosphorylation	ISCSVPSTTSTPTVT EEEECCCCCCCCCCC	20.78	26643407
571	O-linked_Glycosylation	SCSVPSTTSTPTVTS EEECCCCCCCCCCCC	34.63	30059200
571	Phosphorylation	SCSVPSTTSTPTVTS EEECCCCCCCCCCCC	34.63	26643407
572	Phosphorylation	CSVPSTTSTPTVTSA EECCCCCCCCCCCCC	32.26	26643407
573	Phosphorylation	SVPSTTSTPTVTSAA ECCCCCCCCCCCCCC	22.38	26643407
577	O-linked_Glycosylation	TTSTPTVTSAAGLQR CCCCCCCCCCCCCCC	18.35	30059200
578	O-linked_Glycosylation	TSTPTVTSAAGLQRS CCCCCCCCCCCCCCC	16.28	30059200
585	Phosphorylation	SAAGLQRSLPSSTST CCCCCCCCCCCCCCC	31.50	25619855
588	Phosphorylation	GLQRSLPSSTSTAAK CCCCCCCCCCCCCCC	52.09	25619855
589	Phosphorylation	LQRSLPSSTSTAAKT CCCCCCCCCCCCCCC	25.16	25619855
590	Phosphorylation	QRSLPSSTSTAAKTP CCCCCCCCCCCCCCC	34.14	25619855
591	Phosphorylation	RSLPSSTSTAAKTPP CCCCCCCCCCCCCCC	20.28	25619855
592	Phosphorylation	SLPSSTSTAAKTPPG CCCCCCCCCCCCCCC	30.62	25619855
596	Phosphorylation	STSTAAKTPPGSSSA CCCCCCCCCCCCCCC	29.95	27149854
600	Phosphorylation	AAKTPPGSSSAGTQS CCCCCCCCCCCCCCC	27.22	25619855
601	Phosphorylation	AKTPPGSSSAGTQSS CCCCCCCCCCCCCCC	30.07	25619855
602	Phosphorylation	KTPPGSSSAGTQSST CCCCCCCCCCCCCCC	32.20	25619855
605	Phosphorylation	PGSSSAGTQSSTSNR CCCCCCCCCCCCCCC	25.62	25619855
607	Phosphorylation	SSSAGTQSSTSNRLW CCCCCCCCCCCCCCC	35.11	25619855
608	Phosphorylation	SSAGTQSSTSNRLWA CCCCCCCCCCCCCCC	26.49	23984901
609	Phosphorylation	SAGTQSSTSNRLWAE CCCCCCCCCCCCCCC	34.96	23984901
610	Phosphorylation	AGTQSSTSNRLWAED CCCCCCCCCCCCCCC	23.15	25619855
618	Phosphorylation	NRLWAEDSTEKEKDS CCCCCCCCCCCCCCC	29.94	20415495
619	Phosphorylation	RLWAEDSTEKEKDSA CCCCCCCCCCCCCCC	64.50	20415495
666	Phosphorylation	EVRERRRSYLTPVRD HHHHHHHHHCCCCCC	23.76	23737553
667	Phosphorylation	VRERRRSYLTPVRDE HHHHHHHHCCCCCCC	16.88	23737553
669	Phosphorylation	ERRRSYLTPVRDEES HHHHHHCCCCCCCCC	16.11	19060867
676	Phosphorylation	TPVRDEESESQRKAR CCCCCCCCHHHHHHH	40.26	29550500
690	Phosphorylation	RSRQARQSRRSTQGV HHHHHHHHHHHCCCC	24.90	-
693	Phosphorylation	QARQSRRSTQGVTLT HHHHHHHHCCCCCHH	24.79	25521595
694	Phosphorylation	ARQSRRSTQGVTLTD HHHHHHHCCCCCHHH	27.77	25521595
698	Phosphorylation	RRSTQGVTLTDLQEA HHHCCCCCHHHHHHH	30.66	25619855
700	Phosphorylation	STQGVTLTDLQEAEK HCCCCCHHHHHHHHH	25.87	25619855
708	Phosphorylation	DLQEAEKTIGRSRST HHHHHHHHHCCCHHH	21.85	26370283
756	Phosphorylation	EDEYKQKYSRTYDET HHHHHHHHCCCCCCC	10.82	20116462
757	Phosphorylation	DEYKQKYSRTYDETY HHHHHHHCCCCCCCC	25.78	24719451
759	Phosphorylation	YKQKYSRTYDETYTR HHHHHCCCCCCCCCE	29.41	25367039
760	Phosphorylation	KQKYSRTYDETYTRY HHHHCCCCCCCCCEE	15.63	25367039
763	Phosphorylation	YSRTYDETYTRYRPV HCCCCCCCCCEEECC	27.56	25367039
764	Phosphorylation	SRTYDETYTRYRPVS CCCCCCCCCEEECCC	6.28	20116462
765	Phosphorylation	RTYDETYTRYRPVST CCCCCCCCEEECCCC	28.75	25367039
767	Phosphorylation	YDETYTRYRPVSTSS CCCCCCEEECCCCCC	16.09	20116462
771	Phosphorylation	YTRYRPVSTSSSSAP CCEEECCCCCCCCCC	25.84	30635358
772	Phosphorylation	TRYRPVSTSSSSAPS CEEECCCCCCCCCCC	32.63	30635358
773	Phosphorylation	RYRPVSTSSSSAPSS EEECCCCCCCCCCCC	22.25	30635358
774	Phosphorylation	YRPVSTSSSSAPSSS EECCCCCCCCCCCCC	28.53	30635358
775	Phosphorylation	RPVSTSSSSAPSSSS ECCCCCCCCCCCCCC	30.22	30635358
776	Phosphorylation	PVSTSSSSAPSSSSL CCCCCCCCCCCCCCC	46.26	30635358
779	Phosphorylation	TSSSSAPSSSSLSTL CCCCCCCCCCCCHHH	42.44	30635358
780	Phosphorylation	SSSSAPSSSSLSTLG CCCCCCCCCCCHHHH	23.92	30635358
781	Phosphorylation	SSSAPSSSSLSTLGS CCCCCCCCCCHHHHH	39.37	30635358
782	Phosphorylation	SSAPSSSSLSTLGST CCCCCCCCCHHHHHH	28.43	30635358
784	Phosphorylation	APSSSSLSTLGSTLY CCCCCCCHHHHHHHH	24.43	23984901
785	Phosphorylation	PSSSSLSTLGSTLYA CCCCCCHHHHHHHHH	40.19	23984901
788	Phosphorylation	SSLSTLGSTLYASSQ CCCHHHHHHHHHHHC	20.53	23984901
789	Phosphorylation	SLSTLGSTLYASSQL CCHHHHHHHHHHHCC	23.22	25367039
791	Phosphorylation	STLGSTLYASSQLNR HHHHHHHHHHHCCCC	12.43	23984901
793	Phosphorylation	LGSTLYASSQLNRPN HHHHHHHHHCCCCCC	12.69	23984901
794	Phosphorylation	GSTLYASSQLNRPNS HHHHHHHHCCCCCCC	30.43	23984901
801	Phosphorylation	SQLNRPNSLVGITSA HCCCCCCCCHHHHHH	27.41	19060867
806	Phosphorylation	PNSLVGITSAYSRGL CCCCHHHHHHHHHCH	11.02	23984901
807	Phosphorylation	NSLVGITSAYSRGLA CCCHHHHHHHHHCHH	24.24	23984901
809	Phosphorylation	LVGITSAYSRGLAKE CHHHHHHHHHCHHHH	9.92	23984901
810	Phosphorylation	VGITSAYSRGLAKEN HHHHHHHHHCHHHHH	21.42	23984901
815	Ubiquitination	AYSRGLAKENEREGE HHHHCHHHHHHHCCC	67.14	22790023
834	Phosphorylation	EKEGEDKSQPKSIRE HHCCCCCCCCHHHHH	65.13	19854140
838	Phosphorylation	EDKSQPKSIRERRRP CCCCCCHHHHHHCCC	33.29	18779572
851	Phosphorylation	RPREKRRSTGVSFWT CCHHHHHHCCCCCCC	33.28	25521595
852	Phosphorylation	PREKRRSTGVSFWTQ CHHHHHHCCCCCCCC	39.53	24925903
855	Phosphorylation	KRRSTGVSFWTQDSD HHHHCCCCCCCCCCC	19.19	24925903
858	Phosphorylation	STGVSFWTQDSDENE HCCCCCCCCCCCCCH	22.08	27087446
861	Phosphorylation	VSFWTQDSDENEQER CCCCCCCCCCCHHHH	36.69	25521595
870	Phosphorylation	ENEQERQSDTEDGSS CCHHHHHHCCCCCCC	53.36	24925903
872	Phosphorylation	EQERQSDTEDGSSKR HHHHHHCCCCCCCCC	41.02	27087446
876	Phosphorylation	QSDTEDGSSKRETQT HHCCCCCCCCCCCCC	45.03	23429704
877	Phosphorylation	SDTEDGSSKRETQTD HCCCCCCCCCCCCCC	41.06	24925903
891	Phosphorylation	DSVSRYDSSSTSSSD CCCCCCCCCCCCCHH	19.77	29514104
892	Phosphorylation	SVSRYDSSSTSSSDR CCCCCCCCCCCCHHH	34.44	23984901
893	Phosphorylation	VSRYDSSSTSSSDRY CCCCCCCCCCCHHHH	35.94	23984901
894	Phosphorylation	SRYDSSSTSSSDRYD CCCCCCCCCCHHHHH	34.28	23984901
895	Phosphorylation	RYDSSSTSSSDRYDS CCCCCCCCCHHHHHH	29.77	23984901
896	Phosphorylation	YDSSSTSSSDRYDSL CCCCCCCCHHHHHHH	36.02	23984901
897	Phosphorylation	DSSSTSSSDRYDSLL CCCCCCCHHHHHHHH	26.35	23984901
900	Phosphorylation	STSSSDRYDSLLGRS CCCCHHHHHHHHCCC	18.18	19060867
902	Phosphorylation	SSSDRYDSLLGRSAS CCHHHHHHHHCCCCC	19.29	27149854
907	Phosphorylation	YDSLLGRSASYSYLE HHHHHCCCCCCHHHC	21.55	26824392
909	Phosphorylation	SLLGRSASYSYLEDR HHHCCCCCCHHHCCC	18.83	25521595
910	Phosphorylation	LLGRSASYSYLEDRK HHCCCCCCHHHCCCC	10.89	25619855
911	Phosphorylation	LGRSASYSYLEDRKP HCCCCCCHHHCCCCC	22.27	25619855
912	Phosphorylation	GRSASYSYLEDRKPY CCCCCCHHHCCCCCC	13.08	25619855
919	Phosphorylation	YLEDRKPYSSRLEKD HHCCCCCCCHHCCCC	23.47	25367039
920	Phosphorylation	LEDRKPYSSRLEKDD HCCCCCCCHHCCCCC	19.94	25367039
921	Phosphorylation	EDRKPYSSRLEKDDS CCCCCCCHHCCCCCC	34.73	25367039
925	Acetylation	PYSSRLEKDDSTDFK CCCHHCCCCCCHHHH	72.00	23806337
952	Phosphorylation	LKAQLHDTNMELTDL HHHHHHHCCHHHHHH	26.22	23984901
957	Phosphorylation	HDTNMELTDLKLQLE HHCCHHHHHHHHHHH	26.44	23984901
994	Phosphorylation	RALERRISEMEEELK HHHHHHHHHHHHHHH	29.13	25521595
1014	Ubiquitination	KADNQRLKDENGALI HHHHHHHCCCCCHHH	66.25	22790023
1025	Phosphorylation	GALIRVISKLSK--- CHHHHHHHHHCC---	25.37	21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
445	S	Phosphorylation	Kinase	NUAK1	Q641K5	Uniprot
472	S	Phosphorylation	Kinase	NUAK1	Q641K5	Uniprot
473	S	Phosphorylation	Kinase	CDK1	P11440	Uniprot
690	S	Phosphorylation	Kinase	PKG	-	Uniprot
690	S	Phosphorylation	Kinase	PKA	-	Uniprot
693	S	Phosphorylation	Kinase	PKG	-	Uniprot
693	S	Phosphorylation	Kinase	PKA	-	Uniprot
694	T	Phosphorylation	Kinase	DAPK3	O54784	Uniprot
694	T	Phosphorylation	Kinase	CDC42BP	-	Uniprot
694	T	Phosphorylation	Kinase	MRCK-SUBFAMILY	-	GPS
694	T	Phosphorylation	Kinase	ROCK2	P70336	Uniprot
694	T	Phosphorylation	Kinase	ROCK1	P70335	Uniprot
694	T	Phosphorylation	Kinase	ROCK1	Q13464	PSP
694	T	Phosphorylation	Kinase	RAF1	Q99N57	Uniprot
851	S	Phosphorylation	Kinase	ROCK2	P70336	Uniprot
852	T	Phosphorylation	Kinase	ROCK2	O75116	PSP
852	T	Phosphorylation	Kinase	ROCK1	Q13464	PSP
909	S	Phosphorylation	Kinase	NUAK1	Q641K5	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
445	S	Phosphorylation	17242355
Phosphorylation at Ser-445, Ser-472 and Ser-909 by NUAK1 promotes interaction with 14-3-3, leading to inhibit interaction with myosin light chain MLC2, preventing dephosphorylation of MLC2.
472	S	Phosphorylation	-
Phosphorylation at Ser-445, Ser-472 and Ser-909 by NUAK1 promotes interaction with 14-3-3, leading to inhibit interaction with myosin light chain MLC2, preventing dephosphorylation of MLC2.
473	S	Phosphorylation	-
Phosphorylated at Ser-473 by CDK1 during mitosis, creating docking sites for the POLO box domains of PLK1.
693	S	Phosphorylation	-
In vitro, phosphorylation of Ser-693 by PKA and PKG appears to prevent phosphorylation of the inhibitory site Thr-694, probably mediated by PRKG1.
694	T	Phosphorylation	-
In vitro, phosphorylation of Ser-693 by PKA and PKG appears to prevent phosphorylation of the inhibitory site Thr-694, probably mediated by PRKG1.
694	T	Phosphorylation	-
May be phosphorylated at Thr-694 by DMPK; may inhibit the myosin phosphatase activity (By similarity).
694	T	Phosphorylation	-
Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-694 (By similarity).
909	S	Phosphorylation	-
Phosphorylation at Ser-445, Ser-472 and Ser-909 by NUAK1 promotes interaction with 14-3-3, leading to inhibit interaction with myosin light chain MLC2, preventing dephosphorylation of MLC2.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MYPT1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PP1G_MOUSE	Ppp1cc	physical	22544752
MYL9_MOUSE	Myl9	physical	22544752

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MYPT1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-507 AND SER-666, ANDMASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-443; SER-445; SER-870AND SER-909, AND MASS SPECTROMETRY.	17242355 [Abstract]

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