MYL9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYL9_MOUSE
• UniProt AC: Q9CQ19
• Protein Name: Myosin regulatory light polypeptide 9
• Gene Name: Myl9
• Organism: Mus musculus (Mouse).
• Sequence Length: 172
• Protein Description: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion..
• Protein Sequence: MSSKRAKAKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDEYLEGMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEASGFIHEDHLRELLTTMGDRFTDEEVDEMYREAPIDKKGNFNYVEFTRILKHGAKDKDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSKRAKAK ------CCCHHHHCC	44.56	-
19	Phosphorylation	KKRPQRATSNVFAMF CCCCHHHHHHHHHHC	24.03	27087446
20	Phosphorylation	KRPQRATSNVFAMFD CCCHHHHHHHHHHCC	29.97	27087446
29	Phosphorylation	VFAMFDQSQIQEFKE HHHHCCHHHHHHHHH	30.97	24925903
51	Ubiquitination	NRDGFIDKEDLHDML CCCCCCCHHHHHHHH	48.59	-
135	Phosphorylation	TTMGDRFTDEEVDEM HHHHCCCCHHHHHHH	43.31	17242355
150	Ubiquitination	YREAPIDKKGNFNYV HHHCCCCCCCCCCCC	64.40	27667366
151	Ubiquitination	REAPIDKKGNFNYVE HHCCCCCCCCCCCCH	56.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
19	T	Phosphorylation	Kinase	CIT	P49025	Uniprot
19	T	Phosphorylation	Kinase	DAPK3	O43293	PSP
19	T	Phosphorylation	Kinase	MYLK	P11799	GPS
19	T	Phosphorylation	Kinase	ROCK2	P70336	Uniprot
19	T	Phosphorylation	Kinase	MLCK	-	Uniprot
20	S	Phosphorylation	Kinase	CIT	P49025	Uniprot
20	S	Phosphorylation	Kinase	DAPK1	Q80YE7	Uniprot
20	S	Phosphorylation	Kinase	DAPK2	Q8VDF3	Uniprot
20	S	Phosphorylation	Kinase	DAPK3	O43293	PSP
20	S	Phosphorylation	Kinase	DAPK3	O54784	Uniprot
20	S	Phosphorylation	Kinase	MYLK	P11799	GPS
20	S	Phosphorylation	Kinase	PAK1	O88643	Uniprot
20	S	Phosphorylation	Kinase	ROCK1	P70335	Uniprot
20	S	Phosphorylation	Kinase	ROCK2	P70336	Uniprot
20	S	Phosphorylation	Kinase	CDC42BP	-	Uniprot
20	S	Phosphorylation	Kinase	MLCK	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYL9_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYL9_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MYL9_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-19; SER-20; SER-29 ANDTHR-135, AND MASS SPECTROMETRY.
PubMed: 17242355

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-19 AND SER-20, AND MASSSPECTROMETRY.
PubMed: 19367708