dbPTM

AKA12_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AKA12_MOUSE
UniProt AC	Q9WTQ5
Protein Name	A-kinase anchor protein 12
Gene Name	Akap12
Organism	Mus musculus (Mouse).
Sequence Length	1684
Subcellular Localization	Cytoplasm, cytoskeleton. Membrane Lipid-anchor .
Protein Description	Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC)..
Protein Sequence	MGAGSSTEQRSPEQPAESDTPSELELSGHGPAAEASGAAGDPADADPATKLPQKNGQLSAVNGVAEQEDVHVQEESQDGQEEEVTVEDVGQRESEDVKEKDRAKEMAASSTVVEDITKDEQEETPEIIEQIPASESNVEEMAQAAESQANDVGFKKVFKFVGFKFTVKKDKNEKSDTVQLLTVKKDEGEGAEASVGAGDHQEPGVETVGESASKESELKQSTEKQEGTLKQAQSSTEIPLQAESGQGTEEEAAKDGEENREKEPTKPLESPTSPVSNETTSSFKKFFTHGWAGWRKKTSFKKPKEDDLETSEKRKEQEAEKVDEEEGEKTEPAPAEEQEPAEGTDQARLSADYEKVELPLEDQVGDLEALSEKCAPLATEVFDEKTEAHQEVVAEVHVSTVEKMTKGQGGAEVEGDVVVEGSGESLPPEKLAETQEVPQEAEPVEELMKTKEVCVSGGDHTQLTDLSPEEKMLPKHPEGIVSEVEMLSSQERIKVQGSPLKKLFSSSGLKKLSGKKQKGKRGGGGGDEEPGEYQHIQTESPESADEQKGESSASSPEEPEEIACLEKGPSEAPQEAEAEEGATSDGEKKREGITPWASFKKMVTPKKRVRRPSESDKEEELDKVKSATLSSTESTASGMQDEVRAVGEEQRSEEPKRRVDTSVSWEALICVGSSKKRARKASSSDDEGGPRTLGGDGHRAEEASKDKEADALPASTQEQDQAHGSSSPEPAGSPSEGEGVSTWESFKRLVTPRKKSKSKLEERAEDSGAEQLASEIEPSREESWVSIKKFIPGRRKKRADGKQEQAAVEDSGPGEINEDDPDVPAVVPLSEYDAVEREKLEAQRAQENVELPQLKGAVYVSEELSKTLVHTVSVAVIDGTRAVTSAEERSPSWISASMTEPLEHAEGVATPPVGEVTEKDITAEATPALAQTLPGGKDAHDDIVTSEVDFTSEAVTAAETTEALRAEELTEASGAEETTDMVSAVSQLSDSPDTTEEATPVQEVEGGMLDTEEQERQTQAVLQAVADKVKEDSQVPATQTLQRAGPKALEKVEEVEEDSEVLATEKEKDVVPEGPVQEAETEHLAQGSETVQATPESLEVPEVTEDVDRATTCQVIKHQQLMEQAVAPESSETLTDSETNGSTPLADSDTPNGTQQDETVDSQDSNAIAAVKQSQVTEEEAAAAQTEGPSTPSSFPAQEEHREKPGRDVLEPTQALAAGAVPILAKAEVGQEGEAGQFDGEKVKDGQCVKELEVPVHTGPNSQKTADLTRDSEVMEVARCQETESNEEQSISPEKREMGTDVEKEETETKTEQASEEHEQETAAPEHEGTHPKPVLTADMPHSERGKALGSLEGSPSLPDQDKADCIEVQVQSSDTPVTQTTEAVKKVEETVATSEMDESLECAGAQSLPAEKLSETGGYGTLQHGEDTVPQGPESQAESIPIIVTPAPESILHSDLQREVSASQKQRSDEDNKPDAGPDAAGKESAAREKILRAEPEILELESKSNKIVQSVIQTAVDQFARTETAPETHASDLQNQVPVMQADSQGAQQMLDKDESDLQVSPQDGTLSAVAQEGLAVSDSSEGMSKASEMITTLAVESASVKESVEKLPLQCKDEKEHAADGPQHQSLAKAEADASGNLTKESPDTNGPKLTEEGDALKEEMNKAQTEEDDLQEPKGDLTES

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGAGSSTEQ ------CCCCCCCCC	50.37	-
11	Phosphorylation	GSSTEQRSPEQPAES CCCCCCCCCCCCCCC	32.27	9570427
18	Phosphorylation	SPEQPAESDTPSELE CCCCCCCCCCCCHHH	49.22	26824392
20	Phosphorylation	EQPAESDTPSELELS CCCCCCCCCCHHHCC	37.68	26824392
22	Phosphorylation	PAESDTPSELELSGH CCCCCCCCHHHCCCC	57.83	26824392
27	Phosphorylation	TPSELELSGHGPAAE CCCHHHCCCCCHHHH	21.26	26824392
36	Phosphorylation	HGPAAEASGAAGDPA CCHHHHHCCCCCCCC	22.07	9570451
49	Phosphorylation	PADADPATKLPQKNG CCCCCCCCCCCCCCC	38.20	26643407
59	Phosphorylation	PQKNGQLSAVNGVAE CCCCCCEEEECCCCC	23.45	25293948
76	Phosphorylation	DVHVQEESQDGQEEE CEEECCCCCCCCEEE	32.58	25293948
100	Ubiquitination	ESEDVKEKDRAKEMA CCCCHHHHHHHHHHH	46.96	-
109	Phosphorylation	RAKEMAASSTVVEDI HHHHHHHHHCEEEHH	19.60	28973931
110	Phosphorylation	AKEMAASSTVVEDIT HHHHHHHHCEEEHHC	22.09	28973931
136	Phosphorylation	EQIPASESNVEEMAQ HHCCCCCCCHHHHHH	43.62	-
159	Ubiquitination	VGFKKVFKFVGFKFT CCHHHHHHCCEEEEE	41.97	-
166	Phosphorylation	KFVGFKFTVKKDKNE HCCEEEEEECCCCCC	31.82	26824392
171	Acetylation	KFTVKKDKNEKSDTV EEEECCCCCCCCCEE	75.72	7844549
174	Ubiquitination	VKKDKNEKSDTVQLL ECCCCCCCCCEEEEE	64.13	-
194	Phosphorylation	EGEGAEASVGAGDHQ CCCCCCCCCCCCCCC	16.76	26824392
207	Phosphorylation	HQEPGVETVGESASK CCCCCCCCCCCCCCC	31.25	25293948
211	Phosphorylation	GVETVGESASKESEL CCCCCCCCCCCHHHH	31.73	25293948
213	Phosphorylation	ETVGESASKESELKQ CCCCCCCCCHHHHHH	46.35	25293948
216	Phosphorylation	GESASKESELKQSTE CCCCCCHHHHHHHHH	52.55	25293948
221	Phosphorylation	KESELKQSTEKQEGT CHHHHHHHHHHHCCC	36.63	20139300
222	Phosphorylation	ESELKQSTEKQEGTL HHHHHHHHHHHCCCH	44.71	26824392
228	Phosphorylation	STEKQEGTLKQAQSS HHHHHCCCHHHHHHC	29.99	26824392
234	Phosphorylation	GTLKQAQSSTEIPLQ CCHHHHHHCCCCCCE	42.09	25521595
235	Phosphorylation	TLKQAQSSTEIPLQA CHHHHHHCCCCCCEE	20.27	25521595
236	Phosphorylation	LKQAQSSTEIPLQAE HHHHHHCCCCCCEEC	43.09	25521595
244	Phosphorylation	EIPLQAESGQGTEEE CCCCEECCCCCCHHH	39.16	20415495
248	Phosphorylation	QAESGQGTEEEAAKD EECCCCCCHHHHHHC	32.13	20415495
265	Phosphorylation	ENREKEPTKPLESPT HCCCCCCCCCCCCCC	46.52	24925903
270	Phosphorylation	EPTKPLESPTSPVSN CCCCCCCCCCCCCCC	40.95	25521595
272	Phosphorylation	TKPLESPTSPVSNET CCCCCCCCCCCCCCC	55.75	25521595
273	Phosphorylation	KPLESPTSPVSNETT CCCCCCCCCCCCCCC	27.04	25521595
276	Phosphorylation	ESPTSPVSNETTSSF CCCCCCCCCCCCHHH	32.12	21149613
279	Phosphorylation	TSPVSNETTSSFKKF CCCCCCCCCHHHHHH	35.91	23429704
280	Phosphorylation	SPVSNETTSSFKKFF CCCCCCCCHHHHHHH	19.05	23429704
281	Phosphorylation	PVSNETTSSFKKFFT CCCCCCCHHHHHHHH	40.99	21149613
282	Phosphorylation	VSNETTSSFKKFFTH CCCCCCHHHHHHHHC	38.71	24925903
299	Phosphorylation	AGWRKKTSFKKPKED CCCCCCCCCCCCCHH	43.90	7785621
304	Ubiquitination	KTSFKKPKEDDLETS CCCCCCCCHHCCHHH	80.70	-
311	Phosphorylation	KEDDLETSEKRKEQE CHHCCHHHHHHHHHH	31.57	26824392
330	Phosphorylation	DEEEGEKTEPAPAEE CHHCCCCCCCCCHHH	42.79	27087446
344	Phosphorylation	EQEPAEGTDQARLSA HCCCCCCCCCHHCCC	19.22	25521595
350	Phosphorylation	GTDQARLSADYEKVE CCCCHHCCCCCEEEE	17.34	25521595
353	Phosphorylation	QARLSADYEKVELPL CHHCCCCCEEEECCH	19.84	24925903
371	Phosphorylation	VGDLEALSEKCAPLA CCCHHHHHHHHHHHH	41.90	25521595
422	Phosphorylation	GDVVVEGSGESLPPE CCEEEECCCCCCCHH	26.36	22817900
425	Phosphorylation	VVEGSGESLPPEKLA EEECCCCCCCHHHHH	50.10	22817900
449	Ubiquitination	EPVEELMKTKEVCVS CCHHHHHCCCEEEEC	69.90	-
451	Ubiquitination	VEELMKTKEVCVSGG HHHHHCCCEEEECCC	42.50	-
456	Phosphorylation	KTKEVCVSGGDHTQL CCCEEEECCCCCCCC	31.75	26824392
461	Phosphorylation	CVSGGDHTQLTDLSP EECCCCCCCCCCCCH	29.98	24925903
464	Phosphorylation	GGDHTQLTDLSPEEK CCCCCCCCCCCHHHH	25.69	28464351
467	Phosphorylation	HTQLTDLSPEEKMLP CCCCCCCCHHHHCCC	32.83	25521595
482	Phosphorylation	KHPEGIVSEVEMLSS CCCCCCHHHHHHHCC	33.72	25293948
488	Phosphorylation	VSEVEMLSSQERIKV HHHHHHHCCCCCCCC	28.76	26824392
489	Phosphorylation	SEVEMLSSQERIKVQ HHHHHHCCCCCCCCC	31.90	26824392
494	Ubiquitination	LSSQERIKVQGSPLK HCCCCCCCCCCCHHH	34.42	-
498	Phosphorylation	ERIKVQGSPLKKLFS CCCCCCCCHHHHHHC	15.23	26824392
501	Ubiquitination	KVQGSPLKKLFSSSG CCCCCHHHHHHCCCC	51.30	-
505	Phosphorylation	SPLKKLFSSSGLKKL CHHHHHHCCCCHHHH	33.75	26824392
506	Phosphorylation	PLKKLFSSSGLKKLS HHHHHHCCCCHHHHC	22.53	21082442
507	Phosphorylation	LKKLFSSSGLKKLSG HHHHHCCCCHHHHCC	47.12	26824392
533	Phosphorylation	GDEEPGEYQHIQTES CCCCCCCCCEEECCC	16.00	25293948
538	Phosphorylation	GEYQHIQTESPESAD CCCCEEECCCCCCHH	37.52	21149613
540	Phosphorylation	YQHIQTESPESADEQ CCEEECCCCCCHHHH	37.04	25521595
543	Phosphorylation	IQTESPESADEQKGE EECCCCCCHHHHCCC	44.39	25521595
551	Phosphorylation	ADEQKGESSASSPEE HHHHCCCCCCCCCCC	39.61	26239621
552	Phosphorylation	DEQKGESSASSPEEP HHHCCCCCCCCCCCH	28.06	26239621
554	Phosphorylation	QKGESSASSPEEPEE HCCCCCCCCCCCHHH	48.66	26239621
555	Phosphorylation	KGESSASSPEEPEEI CCCCCCCCCCCHHHH	35.73	26239621
570	Phosphorylation	ACLEKGPSEAPQEAE HHHCCCCCCCCCHHH	55.87	25619855
583	Phosphorylation	AEAEEGATSDGEKKR HHHHCCCCCCCHHHC	37.90	25521595
584	Phosphorylation	EAEEGATSDGEKKRE HHHCCCCCCCHHHCC	42.98	25521595
594	Phosphorylation	EKKREGITPWASFKK HHHCCCCCCHHHHHH	24.51	8066229
598	Phosphorylation	EGITPWASFKKMVTP CCCCCHHHHHHCCCC	33.46	25521595
604	Phosphorylation	ASFKKMVTPKKRVRR HHHHHCCCCCCCCCC	26.37	24719451
613	Phosphorylation	KKRVRRPSESDKEEE CCCCCCCCCCCCHHH	48.17	25521595
615	Phosphorylation	RVRRPSESDKEEELD CCCCCCCCCCHHHHH	59.32	25521595
626	Phosphorylation	EELDKVKSATLSSTE HHHHHHHHCCCCCCC	29.49	24925903
628	Phosphorylation	LDKVKSATLSSTEST HHHHHHCCCCCCCHH	33.97	25521595
630	Phosphorylation	KVKSATLSSTESTAS HHHHCCCCCCCHHHH	30.75	25521595
631	Phosphorylation	VKSATLSSTESTASG HHHCCCCCCCHHHHC	39.03	25521595
632	Phosphorylation	KSATLSSTESTASGM HHCCCCCCCHHHHCC	30.49	24925903
634	Phosphorylation	ATLSSTESTASGMQD CCCCCCCHHHHCCHH	29.39	24925903
635	Phosphorylation	TLSSTESTASGMQDE CCCCCCHHHHCCHHH	20.71	24925903
637	Phosphorylation	SSTESTASGMQDEVR CCCCHHHHCCHHHHH	34.58	25521595
652	Phosphorylation	AVGEEQRSEEPKRRV HHCHHHCCCCCCCCC	46.11	26824392
682	Phosphorylation	KKRARKASSSDDEGG HHHHHHCCCCCCCCC	33.15	25521595
683	Phosphorylation	KRARKASSSDDEGGP HHHHHCCCCCCCCCC	42.52	25521595
684	Phosphorylation	RARKASSSDDEGGPR HHHHCCCCCCCCCCC	46.73	25521595
715	Phosphorylation	EADALPASTQEQDQA CCCCCCCCHHHHHHC	28.78	26239621
716	Phosphorylation	ADALPASTQEQDQAH CCCCCCCHHHHHHCC	37.93	26239621
725	Phosphorylation	EQDQAHGSSSPEPAG HHHHCCCCCCCCCCC	20.13	24925903
726	Phosphorylation	QDQAHGSSSPEPAGS HHHCCCCCCCCCCCC	55.28	26239621
727	Phosphorylation	DQAHGSSSPEPAGSP HHCCCCCCCCCCCCC	34.67	26239621
733	Phosphorylation	SSPEPAGSPSEGEGV CCCCCCCCCCCCCCC	27.62	24925903
735	Phosphorylation	PEPAGSPSEGEGVST CCCCCCCCCCCCCCH	60.99	26239621
741	Phosphorylation	PSEGEGVSTWESFKR CCCCCCCCHHHHHHH	38.36	25293948
742	Phosphorylation	SEGEGVSTWESFKRL CCCCCCCHHHHHHHH	30.74	25293948
745	Phosphorylation	EGVSTWESFKRLVTP CCCCHHHHHHHHCCC	27.85	24925903
751	Phosphorylation	ESFKRLVTPRKKSKS HHHHHHCCCCCCCHH	23.20	27149854
758	Phosphorylation	TPRKKSKSKLEERAE CCCCCCHHHHHHHHH	49.95	26824392
767	Phosphorylation	LEERAEDSGAEQLAS HHHHHHHCHHHHHHH	31.26	26824392
774	Phosphorylation	SGAEQLASEIEPSRE CHHHHHHHHCCCCCH	47.93	26239621
779	Phosphorylation	LASEIEPSREESWVS HHHHCCCCCHHHCEE	39.26	21659605
783	Phosphorylation	IEPSREESWVSIKKF CCCCCHHHCEEHHHH	28.20	26643407
786	Phosphorylation	SREESWVSIKKFIPG CCHHHCEEHHHHCCC	23.56	25521595
811	Phosphorylation	EQAAVEDSGPGEINE HHHHHHCCCCCCCCC	33.12	22006019
832	Phosphorylation	AVVPLSEYDAVEREK CEEEHHHHCHHHHHH	13.06	24008265
855	Ubiquitination	NVELPQLKGAVYVSE HCCCCHHCCCEEECH	39.31	-
859	Phosphorylation	PQLKGAVYVSEELSK CHHCCCEEECHHHHH	9.57	29514104
861	Phosphorylation	LKGAVYVSEELSKTL HCCCEEECHHHHHHH	13.99	26824392
867	Phosphorylation	VSEELSKTLVHTVSV ECHHHHHHHEEEEEE	30.54	19060867
871	Phosphorylation	LSKTLVHTVSVAVID HHHHHEEEEEEEEEC	13.65	22817900
873	Phosphorylation	KTLVHTVSVAVIDGT HHHEEEEEEEEECCC	12.91	26824392
884	Phosphorylation	IDGTRAVTSAEERSP ECCCCCCCCHHHCCC	22.64	26239621
885	Phosphorylation	DGTRAVTSAEERSPS CCCCCCCCHHHCCCC	27.38	26239621
890	Phosphorylation	VTSAEERSPSWISAS CCCHHHCCCCCCCCC	26.94	26824392
892	Phosphorylation	SAEERSPSWISASMT CHHHCCCCCCCCCCC	37.98	25521595
895	Phosphorylation	ERSPSWISASMTEPL HCCCCCCCCCCCCCC	14.18	26239621
897	Phosphorylation	SPSWISASMTEPLEH CCCCCCCCCCCCCCC	21.32	26239621
899	Phosphorylation	SWISASMTEPLEHAE CCCCCCCCCCCCCCC	31.77	25293948
910	Phosphorylation	EHAEGVATPPVGEVT CCCCCCCCCCCCCCC	26.22	26239621
917	Phosphorylation	TPPVGEVTEKDITAE CCCCCCCCHHHCCCC	32.77	26643407
922	Phosphorylation	EVTEKDITAEATPAL CCCHHHCCCCCCHHH	28.69	25293948
926	Phosphorylation	KDITAEATPALAQTL HHCCCCCCHHHHHHC	10.70	28066266
932	Phosphorylation	ATPALAQTLPGGKDA CCHHHHHHCCCCCCC	29.34	29514104
1038	Phosphorylation	EDSQVPATQTLQRAG HCCCCCHHHHHHHHC	18.93	28066266
1040	Phosphorylation	SQVPATQTLQRAGPK CCCCHHHHHHHHCHH	22.09	26824392
1059	Phosphorylation	VEEVEEDSEVLATEK HHHHHHHCCEEECHH	32.65	26824392
1094	Phosphorylation	GSETVQATPESLEVP CCCCEECCHHHCCCC	15.53	29899451
1135	Phosphorylation	PESSETLTDSETNGS CCCCCCCCCCCCCCC	44.92	25338131
1174	Phosphorylation	AIAAVKQSQVTEEEA HHHHHHHHHCCHHHH	22.39	25777480
1177	Phosphorylation	AVKQSQVTEEEAAAA HHHHHHCCHHHHHHH	30.00	25777480
1186	Phosphorylation	EEAAAAQTEGPSTPS HHHHHHHCCCCCCCC	37.88	26160508
1190	Phosphorylation	AAQTEGPSTPSSFPA HHHCCCCCCCCCCCC	64.90	26160508
1191	Phosphorylation	AQTEGPSTPSSFPAQ HHCCCCCCCCCCCCH	30.26	11937285
1193	Phosphorylation	TEGPSTPSSFPAQEE CCCCCCCCCCCCHHH	44.70	25521595
1194	Phosphorylation	EGPSTPSSFPAQEEH CCCCCCCCCCCHHHH	36.13	51459077
1262	Phosphorylation	PVHTGPNSQKTADLT CCCCCCCCHHCCCCC	35.87	25338131
1272	Phosphorylation	TADLTRDSEVMEVAR CCCCCCCHHHHHHHH	28.88	25338131
1283	Phosphorylation	EVARCQETESNEEQS HHHHCCCCCCCCCCC	20.87	23684622
1285	Phosphorylation	ARCQETESNEEQSIS HHCCCCCCCCCCCCC	57.89	24068923
1290	Phosphorylation	TESNEEQSISPEKRE CCCCCCCCCCHHHHH	28.45	24068923
1292	Phosphorylation	SNEEQSISPEKREMG CCCCCCCCHHHHHHC	32.05	25521595
1351	Phosphorylation	ERGKALGSLEGSPSL HCCCCCCCCCCCCCC	24.89	25521595
1355	Phosphorylation	ALGSLEGSPSLPDQD CCCCCCCCCCCCCCC	11.26	25521595
1357	Phosphorylation	GSLEGSPSLPDQDKA CCCCCCCCCCCCCCC	54.99	25521595
1391	Phosphorylation	AVKKVEETVATSEMD HHHHHHHHHCCCCCC	11.26	28973931
1394	Phosphorylation	KVEETVATSEMDESL HHHHHHCCCCCCHHH	22.38	21149613
1395	Phosphorylation	VEETVATSEMDESLE HHHHHCCCCCCHHHH	22.61	28066266
1400	Phosphorylation	ATSEMDESLECAGAQ CCCCCCHHHHHCCCC	25.79	21149613
1408	Phosphorylation	LECAGAQSLPAEKLS HHHCCCCCCCHHHHH	35.47	21149613
1422	Phosphorylation	SETGGYGTLQHGEDT HHCCCCCCCCCCCCC	18.11	51459093
1462	Phosphorylation	SDLQREVSASQKQRS HHHHHHHCHHHHHCC	19.90	25338131
1464	Phosphorylation	LQREVSASQKQRSDE HHHHHCHHHHHCCCC	30.33	25338131
1469	Phosphorylation	SASQKQRSDEDNKPD CHHHHHCCCCCCCCC	42.74	26824392
1508	Ubiquitination	ELESKSNKIVQSVIQ HHHHHCCHHHHHHHH	51.88	-
1512	Phosphorylation	KSNKIVQSVIQTAVD HCCHHHHHHHHHHHH	15.42	22006019
1546	Phosphorylation	VPVMQADSQGAQQML CCCCHHCCHHHHHHH	33.26	-
1594	Phosphorylation	SKASEMITTLAVESA HHHHHHHHHHHHHCC	17.91	25195567
1595	Phosphorylation	KASEMITTLAVESAS HHHHHHHHHHHHCCC	11.20	25195567
1606	Phosphorylation	ESASVKESVEKLPLQ HCCCHHHHHHHCCCC	29.83	28973931
1638	Phosphorylation	AKAEADASGNLTKES HHHHHHCCCCCCCCC	28.85	28066266
1642	Phosphorylation	ADASGNLTKESPDTN HHCCCCCCCCCCCCC	36.44	24925903
1643	Ubiquitination	DASGNLTKESPDTNG HCCCCCCCCCCCCCC	60.40	-
1645	Phosphorylation	SGNLTKESPDTNGPK CCCCCCCCCCCCCCC	29.63	25521595
1648	Phosphorylation	LTKESPDTNGPKLTE CCCCCCCCCCCCCCH	45.52	20139300
1654	Phosphorylation	DTNGPKLTEEGDALK CCCCCCCCHHHHHHH	37.81	29899451
1669	Phosphorylation	EEMNKAQTEEDDLQE HHHHHHHCCHHHCCC	46.32	29550500

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
273	S	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AKA12_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AKA12_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRFE_HUMAN	TF	physical	20360068
AKA12_HUMAN	AKAP12	physical	20360068
PPIA_HUMAN	PPIA	physical	20360068
PROF1_HUMAN	PFN1	physical	20360068
POF1B_HUMAN	POF1B	physical	20360068
SPR2E_HUMAN	SPRR2E	physical	20360068
TERA_HUMAN	VCP	physical	20360068
KPYM_HUMAN	PKM	physical	20360068

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AKA12_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-543; SER-598; SER-613;SER-615; SER-682; SER-683 AND SER-684, AND MASS SPECTROMETRY.	19367708 [Abstract]
"A differential phosphoproteomic analysis of retinoic acid-treated P19cells."; Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.; J. Proteome Res. 6:3174-3186(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631; THR-632; SER-634;SER-682; SER-683 AND SER-684, AND MASS SPECTROMETRY.	17622165 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-467, AND MASSSPECTROMETRY.	16452087 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-22 AND SER-584,AND MASS SPECTROMETRY.	15345747 [Abstract]
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-353, AND MASSSPECTROMETRY.	19131326 [Abstract]