NOL9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOL9_MOUSE
• UniProt AC: Q3TZX8
• Protein Name: Polynucleotide 5'-hydroxyl-kinase NOL9
• Gene Name: Nol9 {ECO:0000312|MGI:MGI:1921285}
• Organism: Mus musculus (Mouse).
• Sequence Length: 714
• Subcellular Localization: Nucleus, nucleolus . Nucleus . Colocalizes with pre-60S rRNP particles..
• Protein Description: Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA (By similarity)..
• Protein Sequence: MAESEVLHRRAPSRSSWLRVRKARPHLLLSRRGRRRFGVLTRVELRRLRRRLLRAHALGGDWKQVAPAGAHVAVKCKLRARSRPAPRSPPTPSVPPAPCTASATCSLLNPRNHSTPQSRAGRPVRKVSPNVTQPVRDLGSGRVLMMLPPGEGFTFSGICRVTCVYGQLEVYGHIINQGQPPQDVFSVYTHSYLTINGVPYAEPEKSEKAIRREIRALLKPYTKLDDRNWVVRYFPPLGSIMILERMQSRFVDFLKTYKCSSYVLLQENAPVRVNSEFTTLKKIGIRRQKRKKAICLSESGLCALEELVSVSCDGCPVILLCGACDIGKSTFNRILINQLLNSIPGVDYLECDLGQTEFTPPGCVALLTITEPLLGPPYTHQRKPQRMVYYGKMNCYNDYENYIDIVKYVFRDYKREFPLIINTMGWVSDNGLRLLVDLIRVLSPNYVVQLYSDRCKFTPTLTSEYVELTDGLYTKSKIKRYRGFEIPEFGDNLEFTYEEKESSPLPVFTGHVLLSVHSEFLSSKNEKNRAKYNRIFRDLAVLGYLSQLMLPVPESLSPLHSLTPYQVPFSAVAIRVLHADVAPTHILYAVNASWVGLCRIVDDMKGYTRGPILLAQNPICDCLGFGICRGIDMDKRTYHILTPLPPEELKTVNCLLVGSISIPHCIFQNQPGPEGSVPYVTTDYNLNIPGATEKIGEREYGKAFPRHKLRQRRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAESEVLHR ------CCCHHHHHH	29.08	-
4	Phosphorylation	----MAESEVLHRRA ----CCCHHHHHHCC	24.38	29176673
16	Phosphorylation	RRAPSRSSWLRVRKA HCCCCCCHHHHHHHC	29.08	24719451
82	Phosphorylation	KCKLRARSRPAPRSP EEEHHCCCCCCCCCC	41.45	25619855
88	Phosphorylation	RSRPAPRSPPTPSVP CCCCCCCCCCCCCCC	33.88	26824392
91	Phosphorylation	PAPRSPPTPSVPPAP CCCCCCCCCCCCCCC	31.42	22942356
93	Phosphorylation	PRSPPTPSVPPAPCT CCCCCCCCCCCCCCC	50.13	22942356
100	Phosphorylation	SVPPAPCTASATCSL CCCCCCCCCCCEEEC	23.69	25619855
102	Phosphorylation	PPAPCTASATCSLLN CCCCCCCCCEEECCC	13.12	25619855
104	Phosphorylation	APCTASATCSLLNPR CCCCCCCEEECCCCC	10.51	25619855
106	Phosphorylation	CTASATCSLLNPRNH CCCCCEEECCCCCCC	31.38	25619855
128	Phosphorylation	GRPVRKVSPNVTQPV CCCCCCCCCCCCCCC	17.50	26824392
132	Phosphorylation	RKVSPNVTQPVRDLG CCCCCCCCCCCEECC	33.52	25266776
496	Phosphorylation	FGDNLEFTYEEKESS CCCCCEEEEEECCCC	22.20	26643407
497	Phosphorylation	GDNLEFTYEEKESSP CCCCEEEEEECCCCC	27.67	26643407
502	Phosphorylation	FTYEEKESSPLPVFT EEEEECCCCCCCEEC	48.61	26745281
503	Phosphorylation	TYEEKESSPLPVFTG EEEECCCCCCCEECC	31.39	27600695
509	Phosphorylation	SSPLPVFTGHVLLSV CCCCCEECCEEEHHH	26.98	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOL9_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOL9_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOL9_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NOL9_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.