TBCD5_MOUSE - dbPTM
TBCD5_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TBCD5_MOUSE
UniProt AC Q80XQ2
Protein Name TBC1 domain family member 5
Gene Name Tbc1d5
Organism Mus musculus (Mouse).
Sequence Length 815
Subcellular Localization Endosome membrane . Cytoplasmic vesicle, autophagosome . During starvation induced autophagy is relocalized from endosomal localization to LC3-positive autophagosomes (By similarity).
Protein Description May act as a GTPase-activating protein for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (By similarity)..
Protein Sequence MYKSVSETRHPLQSEEQEVGIDPLFSYSNKTRGDLSQNGRGSNSTLDTEGTFNSYMKEWEELFVNNNYLATVRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISKIKELRAWYSSIKEIHITNPRKAAGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIIFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMAPIPFARPQDLGPTVAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADSLNLSLVDYVFTAMLLYIRDALISSNYQTCLGLLMHYPIIGDIHSLILKALFLRDPKRNPRPATYQFHPNLDYYKARGADLMNKSRTNARGAPLNIHKVSNSLINFGRKLISPASAPGSMGGPVPGNNSSSSFSAAIPTRTSTEAPRHHLLQQQQQQQHQQQQQQQPQQQQQQHQQQQQQQRLMKSESMPVQLNKGQSSKTISSSPSIESLPGGREFTGSPPPSATKKDSFFSNIARSRSHSKTMGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDMHLVNIQDVVLQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAGENEQITIADDHYCSSGQDQGSQVPRAAKQASSEMPGCTGGTTPDDFILVSKEDEGHRARGAFSGQAQPLLTLRSTSGKSRAPACSPLLFSDPLMGPASASASSSNPSSSPDDDSSKESGFTIVSPLDI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MYKSVSETRHP
----CCCCHHCCCCC		17.2529899451
42PhosphorylationLSQNGRGSNSTLDTE
CCCCCCCCCCCCCCC		26.6727742792
44PhosphorylationQNGRGSNSTLDTEGT
CCCCCCCCCCCCCCC		31.8525293948
45PhosphorylationNGRGSNSTLDTEGTF
CCCCCCCCCCCCCCH		32.6725293948
75AcetylationYLATVRQKGINGQLR
EEHHHHHCCCCCCCC		51.71164885
168UbiquitinationSMIEQDVKRTFPEMQ
HHHHHHHHHHCCHHH		54.75-
431PhosphorylationQFHPNLDYYKARGAD
CCCCCHHHHHHHCHH		15.2729514104
443PhosphorylationGADLMNKSRTNARGA
CHHHCCHHCCCCCCC		39.0625619855
445PhosphorylationDLMNKSRTNARGAPL
HHCCHHCCCCCCCCC		40.0825619855
448Asymmetric dimethylarginineNKSRTNARGAPLNIH
CHHCCCCCCCCCCHH		43.82-
448MethylationNKSRTNARGAPLNIH
CHHCCCCCCCCCCHH		43.8224129315
458PhosphorylationPLNIHKVSNSLINFG
CCCHHHHHHHHHHCC		26.0425338131
460PhosphorylationNIHKVSNSLINFGRK
CHHHHHHHHHHCCCC		24.1028066266
470PhosphorylationNFGRKLISPASAPGS
HCCCCCCCCCCCCCC		25.5025293948
473PhosphorylationRKLISPASAPGSMGG
CCCCCCCCCCCCCCC		38.0825293948
477PhosphorylationSPASAPGSMGGPVPG
CCCCCCCCCCCCCCC		17.1325293948
487PhosphorylationGPVPGNNSSSSFSAA
CCCCCCCCCCCCEEC		35.2826643407
488PhosphorylationPVPGNNSSSSFSAAI
CCCCCCCCCCCEECC		31.9326643407
489PhosphorylationVPGNNSSSSFSAAIP
CCCCCCCCCCEECCC		34.9126643407
490PhosphorylationPGNNSSSSFSAAIPT
CCCCCCCCCEECCCC		25.7626643407
492PhosphorylationNNSSSSFSAAIPTRT
CCCCCCCEECCCCCC		20.8126643407
497PhosphorylationSFSAAIPTRTSTEAP
CCEECCCCCCCCCCH		40.2326643407
544PhosphorylationQQQRLMKSESMPVQL
HHHHHHHHCCCCCCC		22.4225619855
546PhosphorylationQRLMKSESMPVQLNK
HHHHHHCCCCCCCCC		35.1625521595
559PhosphorylationNKGQSSKTISSSPSI
CCCCCCCCCCCCCCC		28.2125619855
561PhosphorylationGQSSKTISSSPSIES
CCCCCCCCCCCCCCC		29.9627742792
562PhosphorylationQSSKTISSSPSIESL
CCCCCCCCCCCCCCC		42.2827742792
563PhosphorylationSSKTISSSPSIESLP
CCCCCCCCCCCCCCC		18.8425521595
565PhosphorylationKTISSSPSIESLPGG
CCCCCCCCCCCCCCC		40.7225521595
568PhosphorylationSSSPSIESLPGGREF
CCCCCCCCCCCCCCC		37.8925521595
576PhosphorylationLPGGREFTGSPPPSA
CCCCCCCCCCCCCCC		31.8125521595
578PhosphorylationGGREFTGSPPPSATK
CCCCCCCCCCCCCCC		31.0425521595
582PhosphorylationFTGSPPPSATKKDSF
CCCCCCCCCCCCCCH		55.1127087446
584PhosphorylationGSPPPSATKKDSFFS
CCCCCCCCCCCCHHH		42.8627087446
588PhosphorylationPSATKKDSFFSNIAR
CCCCCCCCHHHHHHH		36.7526643407
591PhosphorylationTKKDSFFSNIARSRS
CCCCCHHHHHHHHHC		25.8923375375
596PhosphorylationFFSNIARSRSHSKTM
HHHHHHHHHCCCCCC		29.1623375375
598PhosphorylationSNIARSRSHSKTMGR
HHHHHHHCCCCCCCC		33.1023375375
600PhosphorylationIARSRSHSKTMGRKE
HHHHHCCCCCCCCCC		30.9423375375
608PhosphorylationKTMGRKESEEELEAQ
CCCCCCCCHHHHHHH		54.0319060867
718PhosphorylationPRAAKQASSEMPGCT
HHHHHHHHCCCCCCC		25.0829514104
719PhosphorylationRAAKQASSEMPGCTG
HHHHHHHCCCCCCCC		40.7129899451
750PhosphorylationHRARGAFSGQAQPLL
CCCCCCCCCCCCCEE		29.4828059163
758PhosphorylationGQAQPLLTLRSTSGK
CCCCCEEEEECCCCC		28.0123984901
761PhosphorylationQPLLTLRSTSGKSRA
CCEEEEECCCCCCCC		30.0023984901
762PhosphorylationPLLTLRSTSGKSRAP
CEEEEECCCCCCCCC		34.7623984901
763PhosphorylationLLTLRSTSGKSRAPA
EEEEECCCCCCCCCC		45.5323984901
766PhosphorylationLRSTSGKSRAPACSP
EECCCCCCCCCCCCC		36.8826643407
772PhosphorylationKSRAPACSPLLFSDP
CCCCCCCCCCCCCCC		22.2326643407
777PhosphorylationACSPLLFSDPLMGPA
CCCCCCCCCCCCCCC		37.9826643407
785PhosphorylationDPLMGPASASASSSN
CCCCCCCCCCCCCCC		26.3723984901
787PhosphorylationLMGPASASASSSNPS
CCCCCCCCCCCCCCC		26.6223984901
789PhosphorylationGPASASASSSNPSSS
CCCCCCCCCCCCCCC		31.6323984901
790PhosphorylationPASASASSSNPSSSP
CCCCCCCCCCCCCCC		33.5723984901
791PhosphorylationASASASSSNPSSSPD
CCCCCCCCCCCCCCC		50.7123984901
794PhosphorylationSASSSNPSSSPDDDS
CCCCCCCCCCCCCCC		47.9323984901
795PhosphorylationASSSNPSSSPDDDSS
CCCCCCCCCCCCCCC		47.3426643407
796PhosphorylationSSSNPSSSPDDDSSK
CCCCCCCCCCCCCCC		36.3629514104
801PhosphorylationSSSPDDDSSKESGFT
CCCCCCCCCCCCCCE		50.7523984901
802PhosphorylationSSPDDDSSKESGFTI
CCCCCCCCCCCCCEE		47.6523984901
811PhosphorylationESGFTIVSPLDI---
CCCCEEECCCCC---		18.8526745281
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TBCD5_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TBCD5_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TBCD5_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TBCD5_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TBCD5_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-546; SER-565 ANDSER-568, AND MASS SPECTROMETRY.

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