CE162_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CE162_MOUSE
• UniProt AC: Q6ZQ06
• Protein Name: Centrosomal protein of 162 kDa
• Gene Name: Cep162
• Organism: Mus musculus (Mouse).
• Sequence Length: 1403
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Nucleus. Localizes to the distal end of centrioles throughout the cell cycle. During ciliogenesis, found at the cilia base. Localizes to
• Protein Description: Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules (By similarity)..
• Protein Sequence: MAHYFKVDLDEEFERFMKELSDDSFENSNKTPRQPNEDNKEMKKKDPVPWWIAEDDFEDDGLLGTNVSYLKTKKTYQPVMDTEEESAEKVQFLKSSGTSILSVDSLEANELVVSEPHHSTLGLGLDTLEEQEEKEQFFARLEKGLTSSIDYSKLNQELDSDDSAQLKALHRYPRNTEPAEDGCENESEQEELPETYSDDFEDAEDADDPLITKDEETHPKENSESGKDSFPKQEEEKTGMLANVVLLDSFDSVEDVGLSSQEKATPKAKAPPEITDDGPAETGVPYGQSSGDTEALHQAYCHVAHSLGDTGEPRIEASTVQTVRSSIKDGLQENEESSKNVSTTESDLPTVEELMQPIRIDSYGIRAFDLQPISLKKATDSKEAESVGSLPLKTNTNTVSQDTRHAIQFPHKHDESVVLHRTADEGMGSSCPATEEHLDKMYLEILKKKTSVNPSLLPQDDKMNQTSRSQLGAGEEVPVIGKQVPCKKARSTPSLPKRKPQSGLYASARSSGYGKPSSPLQLFSALEKKTSKDNTKTKSVRSIPTSNQFRKREILSGTKLIKPAASNKPSPHREGSPATPKRPEDPSDDSFVQLQTEPLGSYGGNREKELLMLKRAQDAEEKWTGAQALMEQMKMTFCEKEKELENTVESLKRQQERELFRLNQENYILQAKLSSFEETSRKQRWLQFGETSDPLTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQNLFSELASLKEQMHKNHFLSQAVENTEPTKNQSFTDLLAELRAAQKEKNHLMEDIKRLKQDKQALEVDLEKVKRERDQAKDQIAYATGEKLYEIKILEETHKQEVSRLQKRLQWYAENQELLDRDAARLREANEETEKLRLEIEKLKTESGSPATQQRLRSKERALDAKRIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDSVDRNTVEFMERRIKKLEADLEGKDEEAKKSLRTMEQQFQKMKIQYEQRLEEQEQLLAHRQKEAPQSQRNSSSRLKALETELGDIKEAHQITVRKLEAEIDVLKHQNADLEHKKNDKGDQGLQSIEFQVEQAQARAKLARLNEELAAKGREIQDLTKTVERLQKERRMMLSRQIPRSREETAAKRLKKDPNRGHGNAFPETLDGKLYHPHTFTDSHISEVLEENYRLRSELEGLILERSKLKMESEAAVCQLENSMKRVKDDAAAHIASLKASHEREIEKLLCQNAIENSSSKVAELNRKIATQEVLLKHFQGQVNELQGKQESLAVSQVREEILQKQITKLLEELKEAKENHTPEMKHFMGLERKIKQMEMRHRQREQELQQIIQQTRQVVETEQNKEVEKWKRLAQLKNRELDKFRTELDSILDVLRELHRQGVVVPMALAGEENTAEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
148	Phosphorylation	LEKGLTSSIDYSKLN HHHHCCCCCCHHHHH		29514104
160	Phosphorylation	KLNQELDSDDSAQLK HHHHHCCCCCHHHHH		27149854
163	Phosphorylation	QELDSDDSAQLKALH HHCCCCCHHHHHHHH		27149854
223	Phosphorylation	ETHPKENSESGKDSF CCCCCCCCCCCCCCC		-
225	Phosphorylation	HPKENSESGKDSFPK CCCCCCCCCCCCCCC		-
229	Phosphorylation	NSESGKDSFPKQEEE CCCCCCCCCCCHHHH		-
260	Phosphorylation	VEDVGLSSQEKATPK HHHCCCCCCCCCCCC		27149854
346	Phosphorylation	KNVSTTESDLPTVEE CCCCCCHHHCCCHHH		-
350	Phosphorylation	TTESDLPTVEELMQP CCHHHCCCHHHHHCC		-
451	Phosphorylation	EILKKKTSVNPSLLP HHHHHCCCCCHHHCC		21659604
466	Phosphorylation	QDDKMNQTSRSQLGA CCCCCCCCCHHHCCC		29899451
467	Phosphorylation	DDKMNQTSRSQLGAG CCCCCCCCHHHCCCC		29899451
502	Phosphorylation	LPKRKPQSGLYASAR CCCCCCCCCCCCCHH		29109428
510	Phosphorylation	GLYASARSSGYGKPS CCCCCHHCCCCCCCC		23984901
511	Phosphorylation	LYASARSSGYGKPSS CCCCHHCCCCCCCCC		23984901
513	Phosphorylation	ASARSSGYGKPSSPL CCHHCCCCCCCCCHH		23984901
517	Phosphorylation	SSGYGKPSSPLQLFS CCCCCCCCCHHHHHH		26745281
518	Phosphorylation	SGYGKPSSPLQLFSA CCCCCCCCHHHHHHH		23984901
558	Phosphorylation	KREILSGTKLIKPAA CCHHHCCCCCCCCHH		22871156
566	Phosphorylation	KLIKPAASNKPSPHR CCCCCHHCCCCCCCC		28066266
570	Phosphorylation	PAASNKPSPHREGSP CHHCCCCCCCCCCCC		28066266
576	Phosphorylation	PSPHREGSPATPKRP CCCCCCCCCCCCCCC		27149854
579	Phosphorylation	HREGSPATPKRPEDP CCCCCCCCCCCCCCC		20415495
647	Phosphorylation	KEKELENTVESLKRQ HHHHHHHHHHHHHHH		25266776
650	Phosphorylation	ELENTVESLKRQQER HHHHHHHHHHHHHHH		25266776
667	Phosphorylation	FRLNQENYILQAKLS HHHCHHHHHHHHHHH		26060331
712	Phosphorylation	KEIQEQETLLQGYQQ HHHHHHHHHHHHHHH		30635358
717	Phosphorylation	QETLLQGYQQENERL HHHHHHHHHHHHHHH		30635358
897	Phosphorylation	IEKLKTESGSPATQQ HHHHHCCCCCHHHHH		25338131
899	Phosphorylation	KLKTESGSPATQQRL HHHCCCCCHHHHHHH		26824392
1181	Phosphorylation	EENYRLRSELEGLIL HHHHHHHHHHHHHHH		23737553

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CE162_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CE162_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CE162_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPNE4_HUMAN	CPNE4	physical	12522145

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.