DC1I1_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DC1I1_BOVIN
• UniProt AC: Q29RQ3
• Protein Name: Cytoplasmic dynein 1 intermediate chain 1
• Gene Name: DYNC1I1
• Organism: Bos taurus (Bovine).
• Sequence Length: 608
• Subcellular Localization: Cytoplasm . Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.
• Protein Description: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores (By similarity)..
• Protein Sequence: MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVPDDSDLDRKRRETEALLQSIGISPEPPLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRRRLHKLGVSKITQVDFLPREVVSYSKETQTPLATHQSEEDEDDEEMVEPKGDQDSEQENEDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNRVRWAQGGKEVAVGDSEGRIWIYDVGELAVPHNDEWTRFARTLVEIRANRADSEEEGAVELSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDKSDLKA ------CCCHHHHHH	54.46	-
50	Phosphorylation	KEPVPDDSDLDRKRR CCCCCCCHHHHHHHH	47.67	-
83	Phosphorylation	PTPMSPSSKSVSTPS CCCCCCCCCCCCCCC	32.13	-
88	Phosphorylation	PSSKSVSTPSEAGSQ CCCCCCCCCCCCCCC	28.78	-
90	Phosphorylation	SKSVSTPSEAGSQDS CCCCCCCCCCCCCCC	39.92	-
94	Phosphorylation	STPSEAGSQDSGDLG CCCCCCCCCCCCCCC	37.55	-
97	Phosphorylation	SEAGSQDSGDLGPLT CCCCCCCCCCCCHHH	26.94	-
139	Phosphorylation	ETQTPLATHQSEEDE CCCCCCCCCCCCCCC	28.29	-
142	Phosphorylation	TPLATHQSEEDEDDE CCCCCCCCCCCCCCC	35.04	-
160	Phosphorylation	EPKGDQDSEQENEDK CCCCCCCCHHCCHHH	35.23	-
598	Phosphorylation	IRANRADSEEEGAVE HHHHCCCCCCCCCEE	46.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DC1I1_BOVIN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DC1I1_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DC1I1_BOVIN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.