IRGM1_MOUSE - dbPTM
IRGM1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IRGM1_MOUSE
UniProt AC Q60766
Protein Name Immunity-related GTPase family M protein 1
Gene Name Irgm1
Organism Mus musculus (Mouse).
Sequence Length 409
Subcellular Localization Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Late endosome membrane. Cell projection, phagocytic cup. Behaves like an integral membrane protein. Recr
Protein Description Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion..
Protein Sequence MKPSHSSCEAAPLLPNMAETHYAPLSSAFPFVTSYQTGSSRLPEVSRSTERALREGKLLELVYGIKETVATLSQIPVSIFVTGDSGNGMSSFINALRVIGHDEDASAPTGVVRTTKTRTEYSSSHFPNVVLWDLPGLGATAQTVEDYVEEMKFSTCDLFIIIASEQFSSNHVKLSKIIQSMGKRFYIVWTKLDRDLSTSVLSEVRLLQNIQENIRENLQKEKVKYPPVFLVSSLDPLLYDFPKLRDTLHKDLSNIRCCEPLKTLYGTYEKIVGDKVAVWKQRIANESLKNSLGVRDDDNMGECLKVYRLIFGVDDESVQQVAQSMGTVVMEYKDNMKSQNFYTLRREDWKLRLMTCAIVNAFFRLLRFLPCVCCCLRRLRHKRMLFLVAQDTKNILEKILRDSIFPPQI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MKPSHSSCEAA
----CCCCCCCCCCC		30.4023984901
6 (in isoform 2)Phosphorylation-40.8129514104
6Phosphorylation--MKPSHSSCEAAPL
--CCCCCCCCCCCCC		40.8123984901
7Phosphorylation-MKPSHSSCEAAPLL
-CCCCCCCCCCCCCC		15.5623984901
20PhosphorylationLLPNMAETHYAPLSS
CCCCCCCCCCCCHHH		15.6223984901
22PhosphorylationPNMAETHYAPLSSAF
CCCCCCCCCCHHHCC		19.8223984901
26PhosphorylationETHYAPLSSAFPFVT
CCCCCCHHHCCCCEE		20.6823984901
27PhosphorylationTHYAPLSSAFPFVTS
CCCCCHHHCCCCEEC		41.4323984901
33PhosphorylationSSAFPFVTSYQTGSS
HHCCCCEECCCCCCC		23.3029472430
34PhosphorylationSAFPFVTSYQTGSSR
HCCCCEECCCCCCCC		15.2229472430
35PhosphorylationAFPFVTSYQTGSSRL
CCCCEECCCCCCCCC		10.7529472430
37PhosphorylationPFVTSYQTGSSRLPE
CCEECCCCCCCCCCC		30.6929472430
39PhosphorylationVTSYQTGSSRLPEVS
EECCCCCCCCCCCCC		18.7029472430
40PhosphorylationTSYQTGSSRLPEVSR
ECCCCCCCCCCCCCH		38.9029472430
48PhosphorylationRLPEVSRSTERALRE
CCCCCCHHHHHHHHH		27.4126824392
57UbiquitinationERALREGKLLELVYG
HHHHHHCCHHHHHHC		45.1822790023
199PhosphorylationLDRDLSTSVLSEVRL
CCCCCCHHHHHHHHH		20.0621743459
202PhosphorylationDLSTSVLSEVRLLQN
CCCHHHHHHHHHHHH		31.7126824392
250UbiquitinationKLRDTLHKDLSNIRC
HHHHHHCHHHHCCCC		64.5722790023
262AcetylationIRCCEPLKTLYGTYE
CCCCCCHHHHHHHHH		47.39-
270UbiquitinationTLYGTYEKIVGDKVA
HHHHHHHHHHCCHHH		32.0722790023
275UbiquitinationYEKIVGDKVAVWKQR
HHHHHCCHHHHHHHH		26.6022790023
280MalonylationGDKVAVWKQRIANES
CCHHHHHHHHHHCHH		24.0926320211
280UbiquitinationGDKVAVWKQRIANES
CCHHHHHHHHHHCHH		24.09-
289UbiquitinationRIANESLKNSLGVRD
HHHCHHHHHCCCCCC		54.4922790023
305UbiquitinationDNMGECLKVYRLIFG
CCHHHHHHHHHHHHC		49.2122790023
327PhosphorylationQVAQSMGTVVMEYKD
HHHHHHCCEEEEEHH		10.9822871156
332PhosphorylationMGTVVMEYKDNMKSQ
HCCEEEEEHHHCCCC		12.9222871156
342PhosphorylationNMKSQNFYTLRREDW
HCCCCCEEEEEHHHH		16.65-
356S-palmitoylationWKLRLMTCAIVNAFF
HHHHHHHHHHHHHHH		1.1928526873
371S-palmitoylationRLLRFLPCVCCCLRR
HHHHHHHHHHHHHHH		3.8824751652
373S-palmitoylationLRFLPCVCCCLRRLR
HHHHHHHHHHHHHHC		1.4024751652
374S-palmitoylationRFLPCVCCCLRRLRH
HHHHHHHHHHHHHCH		0.9124751652
375S-palmitoylationFLPCVCCCLRRLRHK
HHHHHHHHHHHHCHH		2.5424751652
393UbiquitinationFLVAQDTKNILEKIL
HEEECCHHHHHHHHH		50.7222790023
398UbiquitinationDTKNILEKILRDSIF
CHHHHHHHHHHHCCC		43.5322790023
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IRGM1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IRGM1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IRGM1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of IRGM1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IRGM1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, AND MASSSPECTROMETRY.

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