VAC14_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VAC14_MOUSE
• UniProt AC: Q80WQ2
• Protein Name: Protein VAC14 homolog
• Gene Name: Vac14
• Organism: Mus musculus (Mouse).
• Sequence Length: 782
• Subcellular Localization: Endosome membrane . Microsome membrane. Mainly associated with membranes of the late endocytic pathway.
• Protein Description: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes..
• Protein Sequence: MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVRDFVAQNNTMQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESSKFDLVSFIPLLRERIYSNNQYARQFIISWILVLVSVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTTDDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDEPDEPKSVAQKQTEPNPEDSLPKQEGTASGGPGSCDSSFGSGINVFTSANTDRAPVTLHLDGIVQVLNCHLSDTTIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQTLSDESDEVVLKDLEVLAEIASSPAGQTDDPGAPDGPDLRVNHSELQVPTSGRANLLNPPSTKGLEGSPSTPTMNSYFYKFMINLLQTFSSERKLLEARGPFIIRQLCLLLNAENIFHSMADILLREEDLKFASTMVHTLNTILLTSTELFQLRNQLKDLQTPESQNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKNNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEDCLKAAPKSQKGDSPSIDYTELLQHFEKVQKQHLEVRHQRSGRGDHLDRRVIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNPEKDFA -------CCHHHHCC	19.94	-
11	Phosphorylation	EKDFAPLTPNIVRAL HHHCCCCCHHHHHHH	17.15	26643407
23	Phosphorylation	RALNDKLYEKRKVAA HHHHHHHHHHHHHHH	25.74	-
90	Phosphorylation	LGKDSGLYLKELIEP HCCCCCCHHHHHHHH	21.18	23882026
170	Ubiquitination	DIVTESSKFDLVSFI HHHCCCCCCCHHHHH	52.77	22790023
296	Phosphorylation	AGRVMLPYSSGILTA HCCHHCCCCCCHHHH	16.11	27357545
297	Phosphorylation	GRVMLPYSSGILTAV CCHHCCCCCCHHHHH	21.83	27357545
310	Phosphorylation	AVLPCLAYDDRKKSI HHHHHHHCHHHHHHH	12.86	27357545
324	Glutathionylation	IKEVANVCNQSLMKL HHHHHHHHCHHHHHH	3.73	24333276
348	Ubiquitination	EPKSVAQKQTEPNPE CCCCHHCCCCCCCHH	49.83	27667366
493	Phosphorylation	PDLRVNHSELQVPTS CCCCCCCCCEECCCC	34.49	30352176
499	Phosphorylation	HSELQVPTSGRANLL CCCEECCCCCCCCCC	44.98	-
517	Phosphorylation	STKGLEGSPSTPTMN CCCCCCCCCCCCCHH	13.30	26643407
519	Phosphorylation	KGLEGSPSTPTMNSY CCCCCCCCCCCHHHH	49.03	26643407
520	Phosphorylation	GLEGSPSTPTMNSYF CCCCCCCCCCHHHHH	26.60	26643407
522	Phosphorylation	EGSPSTPTMNSYFYK CCCCCCCCHHHHHHH	29.13	26643407
525	Phosphorylation	PSTPTMNSYFYKFMI CCCCCHHHHHHHHHH	13.04	26643407
526	Phosphorylation	STPTMNSYFYKFMIN CCCCHHHHHHHHHHH	13.11	26643407
743	Phosphorylation	PKSQKGDSPSIDYTE CCCCCCCCCCCCHHH	29.25	27180971
748	Phosphorylation	GDSPSIDYTELLQHF CCCCCCCHHHHHHHH	10.63	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VAC14_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VAC14_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VAC14_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of VAC14_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.