TRPC6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRPC6_MOUSE
• UniProt AC: Q61143
• Protein Name: Short transient receptor potential channel 6 {ECO:0000250|UniProtKB:Q9Y210}
• Gene Name: Trpc6 {ECO:0000303|PubMed:14761972, ECO:0000312|MGI:MGI:109523}
• Organism: Mus musculus (Mouse).
• Sequence Length: 930
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion..
• Protein Sequence: MSQSPRFVTRRGGSLKAAPGAGTRRNESQDYLLMDELGDDGYPQLPLPPYGYYPSFRGNENRLTHRRQTILREKGRRLANRGPAYMFNDHSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQCKDFVVGLLDLCRNTEEVEAILNGDAETRQPGDFGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNARQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLLYLLLKFKKWMCELIQGQKQGFQEDAEMNKRNEEKKFGISGSHEDLSKFSLDKNQLAHNKQSSTRSSEDYHLNSFSNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRKLGERLSLEPKLEESRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	FVTRRGGSLKAAPGA EECCCCCCCCCCCCC	29.53	22001259
28	Phosphorylation	AGTRRNESQDYLLMD CCCCCCCCCCEEEEC	31.72	22001259
69	Phosphorylation	RLTHRRQTILREKGR CCHHHHHHHHHHHHH	21.84	21487005
281	Phosphorylation	NAYKGLASPAYLSLS HHHCCCCCCHHHHCC	18.33	21487005
321	Phosphorylation	KNDYRKLSMQCKDFV HHHHHHHHHHHHHHH	15.16	21487005
448	Phosphorylation	KFVAHAASFTIFLGL HHHHHHHHHHHHHHH	24.57	22817900
487	Phosphorylation	RQLFRMKTSCFSWME HHHHHHHHHHHHHHH	22.76	-
560	N-linked_Glycosylation	AQSIIDANDTLKDLT HHHHHCCCCHHHHHC	38.77	-
812	Phosphorylation	EEKKFGISGSHEDLS HHHHCCCCCCHHHHH	34.32	22817900
814	Phosphorylation	KKFGISGSHEDLSKF HHCCCCCCHHHHHHH	19.53	27742792
819	Phosphorylation	SGSHEDLSKFSLDKN CCCHHHHHHHCCCHH	43.93	29472430
834	Phosphorylation	QLAHNKQSSTRSSED HHHCCCCCCCCCCCC	34.97	-
835	Phosphorylation	LAHNKQSSTRSSEDY HHCCCCCCCCCCCCC	25.91	-
891	Phosphorylation	KEIKQDISSLRYELL HHHHHHHHHHHHHHH	31.45	25159016
892	Phosphorylation	EIKQDISSLRYELLE HHHHHHHHHHHHHHH	19.73	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
28	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
28	S	Phosphorylation	Kinase	PKACA	P05132	PSP
69	T	Phosphorylation	Kinase	PKACA	P17612	PSP
69	T	Phosphorylation	Kinase	PKG1	Q13976	PSP
69	T	Phosphorylation	Kinase	PRKG1	P0C605	GPS
194	S	Phosphorylation	Kinase	MAPK1	P63085	GPS
194	S	Phosphorylation	Kinase	MAPK3	Q63844	GPS
220	T	Phosphorylation	Kinase	MAPK1	P63085	GPS
220	T	Phosphorylation	Kinase	MAPK3	Q63844	GPS
281	S	Phosphorylation	Kinase	MAPK1	P63085	GPS
281	S	Phosphorylation	Kinase	MAPK3	Q63844	GPS
448	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
487	T	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
768	S	Phosphorylation	Kinase	MAPK1	P63085	GPS
768	S	Phosphorylation	Kinase	MAPK3	Q63844	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRPC6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRPC6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PODO_MOUSE	Nphs2	physical	23657570

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.