STEA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STEA2_MOUSE
• UniProt AC: Q8BWB6
• Protein Name: Metalloreductase STEAP2
• Gene Name: Steap2
• Organism: Mus musculus (Mouse).
• Sequence Length: 489
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Endosome membrane ; Multi-pass membrane protein .
• Protein Description: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor..
• Protein Sequence: MESISMMGSPKSLETFLPNGINGIKDARQVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMRVNQYPESNAEYLASLFPDSLIVKGFNVISAWALQLGPKDASRQVYICSNNIQARQQVIELARQLNFIPVDLGSLSSAKEIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLDTWLQCRKQLGLLSFFFAVVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENAWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLITTFHVLIYGWKRAFAEEYYRFYTPPNFVLALVLPSIVILGKMILLLPCISRKLKRIKKGWEKSQFLDEGMGGAVPHLSPERVTVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESISMMGSP -----CCCCCCCCCC	20.75	26160508
5	Phosphorylation	---MESISMMGSPKS ---CCCCCCCCCCHH	16.40	26160508
9	Phosphorylation	ESISMMGSPKSLETF CCCCCCCCCHHHHHH	15.97	26160508
12	Phosphorylation	SMMGSPKSLETFLPN CCCCCCHHHHHHCCC	34.52	25263469
15	Phosphorylation	GSPKSLETFLPNGIN CCCHHHHHHCCCCCC	35.45	29899451
25	Ubiquitination	PNGINGIKDARQVTV CCCCCCCCCCCEEEE	46.89	-
98	Phosphorylation	AIHREHYTSLWDLRH EECHHHHCCHHHHHH	21.17	25338131
165	Phosphorylation	KDASRQVYICSNNIQ CCCCCCEEEECCCHH	6.46	29514104
193	Phosphorylation	FIPVDLGSLSSAKEI CCCCCCCCCCCCHHH	32.16	25338131
195	Phosphorylation	PVDLGSLSSAKEIEN CCCCCCCCCCHHHHC	29.91	25338131
198	Ubiquitination	LGSLSSAKEIENLPL CCCCCCCHHHHCCCC	62.26	-
209	Phosphorylation	NLPLRLFTLWRGPVV CCCCHHHHCCCCHHH	29.97	26643407
220	Phosphorylation	GPVVVAISLATFFFL CHHHHHHHHHHHHHH	11.38	26643407
223	Phosphorylation	VVAISLATFFFLYSF HHHHHHHHHHHHHHH	26.69	26643407
228	Phosphorylation	LATFFFLYSFVRDVI HHHHHHHHHHHHHHH	8.56	26643407
229	Phosphorylation	ATFFFLYSFVRDVIH HHHHHHHHHHHHHHC	21.29	26643407
467	Phosphorylation	IKKGWEKSQFLDEGM HHCCHHHHHHCCCCC	18.04	24925903
482	Phosphorylation	GGAVPHLSPERVTVM CCCCCCCCHHHCCCC	22.98	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STEA2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STEA2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STEA2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of STEA2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.