PTPRK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTPRK_MOUSE
• UniProt AC: P35822
• Protein Name: Receptor-type tyrosine-protein phosphatase kappa
• Gene Name: Ptprk
• Organism: Mus musculus (Mouse).
• Sequence Length: 1457
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa..
• Protein Sequence: MDVAAAALPAFVALWLLYPWPLLGSALGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMVVDSSNHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESRADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLEPNGIITQYEVSYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPSLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEQLHPHRTKREAGAMECYQVPVTYQNALSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYKGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVIVIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSLTFMDQHNFSPRLPNDPLVPTAVLDENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMVWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	N-linked_Glycosylation	QLPTMKENDTHCIDF CCCCCCCCCCEEEEH	54.70	-
139	N-linked_Glycosylation	PLANPIWNVTGFTGR CCCCCEEEECCCCCH	23.38	19349973
210	N-linked_Glycosylation	VEVNAGQNATFQCIA EEECCCCCCEEEEEE	39.78	-
332	Phosphorylation	KEVEYRMTSGSWTET EEEEEEECCCCCCEE	22.42	-
333	Phosphorylation	EVEYRMTSGSWTETH EEEEEECCCCCCEEE	22.83	-
415	N-linked_Glycosylation	DWESLGYNITRCHTF CHHHHCCEEEECEEE	27.62	19349973
423	N-linked_Glycosylation	ITRCHTFNVTICYHY EEECEEEEEEEEEEH	31.04	-
435	N-linked_Glycosylation	YHYFRGHNESRADCL EEHHCCCCCCHHHHC	52.33	-
461	N-linked_Glycosylation	NHLPPYTNVSLKMIL HCCCCCCCEEEEEEE	18.61	19349973
551	N-linked_Glycosylation	QTVSNLWNSTHHVFM CCHHHHHHCCCEEEE	39.95	-
585	N-linked_Glycosylation	FGPATAINVTTNISA CCCCEEEEEECCCCC	23.71	-
589	N-linked_Glycosylation	TAINVTTNISAPSLP EEEEEECCCCCCCCC	19.49	-
606	N-linked_Glycosylation	EGVDASLNETATTIT CCCCCCCCCCCCEEE	41.92	-
689	N-linked_Glycosylation	APFTVGDNRTYKGFW CCCCCCCCCCCCCCC	32.06	-
790	Phosphorylation	RKDAMGNTRQEMTHM HHHCCCCHHHHHHHH	28.18	28059163
810	Phosphorylation	RSYADQSTLHAEDPL CHHCCCCCCCCCCCC	19.55	25338131
820	Phosphorylation	AEDPLSLTFMDQHNF CCCCCCCEEECCCCC	17.34	21082442
828	Phosphorylation	FMDQHNFSPRLPNDP EECCCCCCCCCCCCC	17.90	19060867
847	Phosphorylation	AVLDENHSATAESSR EEECCCCCCCHHHHH	38.61	25338131
861	Phosphorylation	RLLDVPRYLCEGTES HHHCCCCHHCCCCCC	15.05	25619855
866	Phosphorylation	PRYLCEGTESPYQTG CCHHCCCCCCCCCCC	15.82	25619855
868	Phosphorylation	YLCEGTESPYQTGQL HHCCCCCCCCCCCCC	28.84	27087446
870	Phosphorylation	CEGTESPYQTGQLHP CCCCCCCCCCCCCCH	28.17	25619855
872	Phosphorylation	GTESPYQTGQLHPAI CCCCCCCCCCCCHHH	22.50	27087446
893	Phosphorylation	QHINLMKTSDSYGFK HHHHCCCCCCCCCCH	24.65	-
928	Phosphorylation	QNRAKNRYGNIIAYD HHHHHHCCCCEEEEC	24.74	22499769
934	Phosphorylation	RYGNIIAYDHSRVIL CCCCEEEECCCEEEE	12.09	29514104
1080	Phosphorylation	YHATGLLSFIRRVKL CCHHHHHHHHHHHCC	24.54	-
1378	Ubiquitination	KLILQVEKWQEECEE HHHHHHHHHHHHHHC	56.15	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTPRK_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTPRK_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTPRK_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PTPRK_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-139; ASN-415 AND ASN-461,AND MASS SPECTROMETRY.
PubMed: 19349973