NPHN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPHN_MOUSE
• UniProt AC: Q9QZS7
• Protein Name: Nephrin
• Gene Name: Nphs1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1256
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Located at podocyte slit diaphragm between podocyte foot processes.
• Protein Description: Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion..
• Protein Sequence: MGAKEATVRGPGASPVHRTCHLIPLLLAGMLTTGLAQSPVPTSAPRGFWALSENLTVVEGSTVKLWCGVRAPGSVVQWAKDGLLLGPNPKIPGFPRYSLEGDSAKGEFHLLIEACDLSDDAEYECQVGRSELGPELVSPSVILSILVSPKVLQLTPEAGSTVTWVAGQEYVVTCVSGDAKPAPDIIFIQGGRTVEDVSSSVNEGSEEKLFFTEAEARVTPQSSDNGQLLVCEGSNPALATPIKASFTMNILFPPGPPVIDWPGLNEGHVRAGENLELPCIARGGNPPATLQWLKNGKPVSIAWGTEHAQAVAHSVLVMTVRPEDHGARLSCQSYNSVSAETQERSITLQVTFPPSAVTILGSTSQSENKNVTLCCLTKSSRPRVLLRWWLGGRQLLPTDETVMDGLHGGHISMSNLTLLVKREDNGLSLTCEAFSDAFSKETFKKSLTLNVKYPAQKLWIEGPPEGQSIRTGTRVRLVCLAIGGNPEPSLTWLKDSRPVNDPRQSQEPRRVQLGSVEKSGSTFSRELVLIIGPPDNLAKFSCKAGQLSASTQLVVQFPPTNLTILANSSALRPGDALNLTCVSISSNPPVNLSLDKEGERLDDVAAKPQSAPFKGSAASRSVFLRVSSRDHGHRVTCRAHSEALRETVSSFYRLNVLYPPEFLGEQVRAVTVVEQGQALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSGGALQLWNVTRADDGFYQLHCQNSEGTAEALLKLDVHYAPTIRALKDPTEVNVGGSVDIVCTVDANPILPEMFSWERLGEDEEELNLDDMEKMSKGSTGRLRIRQAKLSQAGAYQCIVDNGVAPAARGLVRLVVRFAPQVDHPTPLTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHKYHQGVVHSSLLTIANVSAAQDYALFKCTATNALGSDHTNIQLVSISRPDPPLGLKVVSVSPHSVGLEWKPGFDGGLPQRFQIRYEALESPGFLYMDVLPAQATTFTLTGLKPSTRYRIWLLASNALGDSGLTDKGIQVSITTPGLDQAPEDTDQPLPTEQPPGPPRLPLLPVLFAVGGLLLLSNASCVGGLLWRRRLRRLAEEISEKTEAGSEEDRIRNEYEESQWTGDRDTRSSTVSTAEVDPHYYSMRDFSPQLPPTLEEVSYRQAFTGIEDEDMAFPGHLYDEVERVYGPPGVWGPLYDEVQMDPYDLRWPEVKYEDPRGIYDQVAADMDAGEPGSLPFELRGHLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	N-linked_Glycosylation	GFWALSENLTVVEGS CEEEECCCEEEEECC	37.32	-
370	N-linked_Glycosylation	TSQSENKNVTLCCLT CCCCCCCCEEEEEEE	43.52	-
415	N-linked_Glycosylation	GGHISMSNLTLLVKR CCCEECCCEEEEEEE	28.53	-
446	Phosphorylation	SKETFKKSLTLNVKY CHHHHHHHEEEEEEC	27.46	-
515	Phosphorylation	PRRVQLGSVEKSGST CCEECCCCEECCCCC	35.38	20139300
561	N-linked_Glycosylation	VVQFPPTNLTILANS EEECCCCCEEEEECC	40.75	-
578	N-linked_Glycosylation	LRPGDALNLTCVSIS CCCCCCEEEEEEECC	34.72	-
591	N-linked_Glycosylation	ISSNPPVNLSLDKEG CCCCCCCCCCCCCCC	29.68	-
722	N-linked_Glycosylation	GGALQLWNVTRADDG CCCEEEEEEEECCCC	33.60	-
1112	Phosphorylation	RRLAEEISEKTEAGS HHHHHHHHHHHCCCC	36.00	-
1115	Phosphorylation	AEEISEKTEAGSEED HHHHHHHHCCCCHHH	27.32	-
1119	Phosphorylation	SEKTEAGSEEDRIRN HHHHCCCCHHHHHHH	44.88	-
1191	Phosphorylation	MAFPGHLYDEVERVY CCCCCHHHHHHHHHH	12.37	18212058
1208	Phosphorylation	PGVWGPLYDEVQMDP CCCCCCCCCCCCCCC	17.12	18212058
1232	Phosphorylation	YEDPRGIYDQVAADM CCCCCCHHHHEECCC	11.80	18212058

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1208	Y	Phosphorylation	Kinase	FYN	P39688	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NPHN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPHN_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NPHN_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.