MAAI_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAAI_MOUSE
• UniProt AC: Q9WVL0
• Protein Name: Maleylacetoacetate isomerase
• Gene Name: Gstz1
• Organism: Mus musculus (Mouse).
• Sequence Length: 216
• Subcellular Localization: Cytoplasm.
• Protein Description: Probable bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with t-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid (By similarity)..
• Protein Sequence: MQAGKPILYSYFRSSCSWRVRIALALKGIDYEIVPINLIKDGGQQFTEEFQTLNPMKQVPALKIDGITIVQSLAIMEYLEETRPIPRLLPQDPQKRAIVRMISDLIASGIQPLQNLSVLKQVGQENQMQWAQKVITSGFNALEKILQSTAGKYCVGDEVSMADVCLVPQVANAERFKVDLSPYPTISHINKELLALEVFQVSHPRRQPDTPAELRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MQAGKPIL -------CCCCCCCC	5.78	-
5	Succinylation	---MQAGKPILYSYF ---CCCCCCCCHHHH	31.72	23954790
11	Phosphorylation	GKPILYSYFRSSCSW CCCCCHHHHHHHCCH	6.88	-
16	S-nitrosylation	YSYFRSSCSWRVRIA HHHHHHHCCHHHHHH	4.82	21278135
16	S-nitrosocysteine	YSYFRSSCSWRVRIA HHHHHHHCCHHHHHH	4.82	-
27	Acetylation	VRIALALKGIDYEIV HHHHHHHCCCCEEEE	48.49	23954790
31	Phosphorylation	LALKGIDYEIVPINL HHHCCCCEEEEECEE	12.97	29472430
40	Acetylation	IVPINLIKDGGQQFT EEECEEEEECCCCCH	54.19	23954790
40	Malonylation	IVPINLIKDGGQQFT EEECEEEEECCCCCH	54.19	26073543
57	Succinylation	FQTLNPMKQVPALKI HHHCCCCCCCCCEEE	49.77	-
57	Acetylation	FQTLNPMKQVPALKI HHHCCCCCCCCCEEE	49.77	23806337
57	Succinylation	FQTLNPMKQVPALKI HHHCCCCCCCCCEEE	49.77	23806337
57	Malonylation	FQTLNPMKQVPALKI HHHCCCCCCCCCEEE	49.77	26320211
95	Malonylation	LLPQDPQKRAIVRMI CCCCCHHHHHHHHHH	49.54	26320211
95	Ubiquitination	LLPQDPQKRAIVRMI CCCCCHHHHHHHHHH	49.54	-
103	Phosphorylation	RAIVRMISDLIASGI HHHHHHHHHHHHCCC	19.61	23984901
108	Phosphorylation	MISDLIASGIQPLQN HHHHHHHCCCHHHCC	29.45	21149613
120	Acetylation	LQNLSVLKQVGQENQ HCCHHHHHHHCCHHH	40.56	23954790
133	Succinylation	NQMQWAQKVITSGFN HHHHHHHHHHHHHHH	28.05	23954790
133	Malonylation	NQMQWAQKVITSGFN HHHHHHHHHHHHHHH	28.05	26073543
133	Acetylation	NQMQWAQKVITSGFN HHHHHHHHHHHHHHH	28.05	22733758
136	Phosphorylation	QWAQKVITSGFNALE HHHHHHHHHHHHHHH	26.28	25521595
137	Phosphorylation	WAQKVITSGFNALEK HHHHHHHHHHHHHHH	30.20	25521595
144	Ubiquitination	SGFNALEKILQSTAG HHHHHHHHHHHHCCC	49.95	22790023
144	Acetylation	SGFNALEKILQSTAG HHHHHHHHHHHHCCC	49.95	22733758
154	S-palmitoylation	QSTAGKYCVGDEVSM HHCCCCCCCCCCCCH	2.92	28526873
165	S-palmitoylation	EVSMADVCLVPQVAN CCCHHHEEEHHHCCC	3.05	28526873
177	Ubiquitination	VANAERFKVDLSPYP CCCCHHCCCCCCCCC	40.85	-
177	Succinylation	VANAERFKVDLSPYP CCCCHHCCCCCCCCC	40.85	23806337
177	Succinylation	VANAERFKVDLSPYP CCCCHHCCCCCCCCC	40.85	-
177	Malonylation	VANAERFKVDLSPYP CCCCHHCCCCCCCCC	40.85	26320211
177	Acetylation	VANAERFKVDLSPYP CCCCHHCCCCCCCCC	40.85	23864654
181	Phosphorylation	ERFKVDLSPYPTISH HHCCCCCCCCCCHHH	20.23	25521595
183	Phosphorylation	FKVDLSPYPTISHIN CCCCCCCCCCHHHHC	15.05	25521595
185	Phosphorylation	VDLSPYPTISHINKE CCCCCCCCHHHHCHH	29.30	23140645
187	Phosphorylation	LSPYPTISHINKELL CCCCCCHHHHCHHHH	22.31	23984901
191	Malonylation	PTISHINKELLALEV CCHHHHCHHHHHHEE	49.49	26073543
191	Acetylation	PTISHINKELLALEV CCHHHHCHHHHHHEE	49.49	23864654
210	Phosphorylation	HPRRQPDTPAELRT- CCCCCCCCCHHHCC-	30.95	-
216	Phosphorylation	DTPAELRT------- CCCHHHCC-------	56.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAAI_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAAI_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAAI_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MAAI_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.