DNJB6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNJB6_MOUSE
• UniProt AC: O54946
• Protein Name: DnaJ homolog subfamily B member 6
• Gene Name: Dnajb6
• Organism: Mus musculus (Mouse).
• Sequence Length: 365
• Subcellular Localization: Cytoplasm, perinuclear region . Nucleus . Cytoplasm, myofibril, sarcomere, Z line .
• Protein Description: Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity)..
• Protein Sequence: MVDYYEVLGVQRHASPEDIKKAYRKQALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGGIHFDSPFEFGFTFRNPDDVFREFFGGRDPFSFDFFEDPFDDFFGNRRGPRGNRSRGAGSFFSTFSGFPSFGSGFPAFDTGFTPFGSLGHGGLTSFSSTSFGGSGMGNFKSISTSTKIVNGKKITTKRIVENGQERVEVEEDGQLKSLTINGVADENALAEECQRRGQPTPALAPGPAPAPVRVPSQARPLAPTPAPTPAPTPAPAPAQTPAPSVSTRPQKPPRPAPTAKLGSKSNWEDDEQDRQRVPGNWDAPMTSAGLKEGGKRKKQKQKEDLKKKKSTKGNH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	LGVQRHASPEDIKKA HCCCCCCCHHHHHHH	23.77	30635358
20	Ubiquitination	HASPEDIKKAYRKQA CCCHHHHHHHHHHHH	43.61	22790023
20 (in isoform 2)	Ubiquitination	-	43.61	22790023
34	Ubiquitination	ALKWHPDKNPENKEE HHHHCCCCCCCCHHH	78.01	22790023
34 (in isoform 2)	Ubiquitination	-	78.01	22790023
60	Ubiquitination	YEVLSDAKKRDIYDK HHHHHHHHHCCHHHH	54.02	22790023
60 (in isoform 2)	Ubiquitination	-	54.02	22790023
61	Ubiquitination	EVLSDAKKRDIYDKY HHHHHHHHCCHHHHH	57.96	-
67	Ubiquitination	KKRDIYDKYGKEGLN HHCCHHHHHCCCCCC	38.64	-
136	Methylation	GPRGNRSRGAGSFFS CCCCCCCCCCCCCCH	35.43	24129315
193	Phosphorylation	MGNFKSISTSTKIVN CCCCCEEECCCEEEC	24.32	30635358
194	Phosphorylation	GNFKSISTSTKIVNG CCCCEEECCCEEECC	38.45	30635358
195	Phosphorylation	NFKSISTSTKIVNGK CCCEEECCCEEECCE	22.40	30635358
196	Phosphorylation	FKSISTSTKIVNGKK CCEEECCCEEECCEE	25.52	30635358
197	Ubiquitination	KSISTSTKIVNGKKI CEEECCCEEECCEEC	44.41	22790023
197 (in isoform 2)	Ubiquitination	-	44.41	22790023
226	Ubiquitination	VEEDGQLKSLTINGV EECCCCEEEEEECCC	35.22	22790023
226 (in isoform 2)	Ubiquitination	-	35.22	22790023
233 (in isoform 2)	Ubiquitination	-	5.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNJB6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNJB6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNJB6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HS71B_MOUSE	Hspa1b	physical	16260608
HDAC4_MOUSE	Hdac4	physical	16260608
HDAC7_MOUSE	Hdac7	physical	16260608

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.