TRAK1_HUMAN - dbPTM
TRAK1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRAK1_HUMAN
UniProt AC Q9UPV9
Protein Name Trafficking kinesin-binding protein 1
Gene Name TRAK1
Organism Homo sapiens (Human).
Sequence Length 953
Subcellular Localization Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome. Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HRS. Colocalizes with MGARP at the mitochondria.
Protein Description Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors..
Protein Sequence MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADTIYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDERSKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSAHHPGKCMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVATPCTPRRLSLAESFTNTRESTTTMSTSLGLVWLLKERGISAAVYDPQSWDRAGRGSLLHSYTPKMAVIPSTPPNSPMQTPTSSPPSFEFKCTSPPYDNFLASKPASSILREVREKNVRSSESQTDVSVSNLNLVDKVRRFGVAKVVNSGRAHVPTLTEEQGPLLCGPPGPAPALVPRGLVPEGLPLRCPTVTSAIGGLQLNSGIRRNRSFPTMVGSSMQMKAPVTLTSGILMGAKLSKQTSLR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
106PhosphorylationAERVGQMTKTYNDID
HHHHHHHHHHHHHHH		16.61-
108PhosphorylationRVGQMTKTYNDIDAV
HHHHHHHHHHHHHHH		20.56-
135PhosphorylationLAARIGQSLLKKNKT
HHHHHHHHHHHHCCC		30.3824719451
162PhosphorylationEHIREEVSQLRHELS
HHHHHHHHHHHHHHH		27.1222985185
169PhosphorylationSQLRHELSMKDELLQ
HHHHHHHHCHHHHHH		22.3222985185
200PhosphorylationTPLKRNESSSSVQNY
CCCCCCCCCCHHHHH		38.7823401153
201PhosphorylationPLKRNESSSSVQNYF
CCCCCCCCCHHHHHH		22.0630108239
202PhosphorylationLKRNESSSSVQNYFH
CCCCCCCCHHHHHHH		43.7528450419
203PhosphorylationKRNESSSSVQNYFHL
CCCCCCCHHHHHHHH		29.6628450419
207PhosphorylationSSSSVQNYFHLDSLQ
CCCHHHHHHHHHHHH		3.8528450419
212PhosphorylationQNYFHLDSLQKKLKD
HHHHHHHHHHHHHHH		38.7727732954
265PhosphorylationDANVQIASISEELAK
HCCCHHHHHCHHHHH		28.4222673903
267PhosphorylationNVQIASISEELAKKT
CCHHHHHCHHHHHHH		23.6322673903
285PhosphorylationARQQEEITHLLSQIV
HHHHHHHHHHHHHHH		15.1129083192
289PhosphorylationEEITHLLSQIVDLQK
HHHHHHHHHHHHHHH		24.9918669648
360PhosphorylationKTMPNTTSRRYHSLG
CCCCCCCCHHHHHCC		16.8424425749
384UbiquitinationEIEGTMRKELQLEEA
HHCHHHHHHHCCHHC		52.53-
393PhosphorylationLQLEEAESPDITHQK
HCCHHCCCCCCCHHH		34.6126657352
397PhosphorylationEAESPDITHQKRVFE
HCCCCCCCHHHHHHH		26.1530266825
447O-linked_GlycosylationSCVSTPRSSFYGSDI
HHCCCCCHHCCCCCC		26.4624995978
452PhosphorylationPRSSFYGSDIGNVVL
CCHHCCCCCCCCEEE		18.0629507054
463PhosphorylationNVVLDNKTNSIILET
CEEEECCCCEEEEEE		40.2230108239
465PhosphorylationVLDNKTNSIILETEA
EEECCCCEEEEEECH		19.0830108239
486PhosphorylationERSKKPGTPGTPGSH
CCCCCCCCCCCCCCC		27.3728985074
489PhosphorylationKKPGTPGTPGSHDLE
CCCCCCCCCCCCCHH		26.1928985074
503PhosphorylationETALRRLSLRRENYL
HHHHHHHHHHHHHHH		20.3023532336
535PhosphorylationAEKGELRSGSLTPTE
HHCCCCCCCCCCCCH		45.4123403867
537PhosphorylationKGELRSGSLTPTESI
CCCCCCCCCCCCHHH		30.2523403867
539PhosphorylationELRSGSLTPTESIMS
CCCCCCCCCCHHHHH		29.8422617229
541PhosphorylationRSGSLTPTESIMSLG
CCCCCCCCHHHHHCC		36.8122115753
543PhosphorylationGSLTPTESIMSLGTH
CCCCCCHHHHHCCCC		26.5223403867
546PhosphorylationTPTESIMSLGTHSRF
CCCHHHHHCCCCCCC		23.2123403867
549PhosphorylationESIMSLGTHSRFSEF
HHHHHCCCCCCCCCC		23.2123403867
551PhosphorylationIMSLGTHSRFSEFTG
HHHCCCCCCCCCCCC		34.5523403867
586 (in isoform 2)Phosphorylation-2.5322199227
587 (in isoform 2)Phosphorylation-18.7822199227
588 (in isoform 2)Phosphorylation-27.4425850435
607 (in isoform 2)Phosphorylation-5.68-
611 (in isoform 2)Phosphorylation-14.11-
623PhosphorylationDVDLDEVYCLNDFEE
CCCCCCEEECCCCCC		6.8127642862
638PhosphorylationDDTGDHISLPRLATS
CCCCCCCCCCCCCCC		28.9724719451
644PhosphorylationISLPRLATSTPVQHP
CCCCCCCCCCCCCCC		37.41-
646PhosphorylationLPRLATSTPVQHPET
CCCCCCCCCCCCCCC		24.1127251275
672PhosphorylationTNSTFTFTTCRILHP
CCCCEEEEEEEEECC		23.17-
673PhosphorylationNSTFTFTTCRILHPS
CCCEEEEEEEEECCC		8.80-
676 (in isoform 2)Phosphorylation-4.5128348404
680O-linked_GlycosylationTCRILHPSDELTRVT
EEEEECCCHHHCCCC		32.7324995978
701PhosphorylationPTPACGSTSHLKSTP
CCCCCCCCCCCCCCC		12.88-
707PhosphorylationSTSHLKSTPVATPCT
CCCCCCCCCCCCCCC		21.86-
711PhosphorylationLKSTPVATPCTPRRL
CCCCCCCCCCCCCCC		21.0928348404
714PhosphorylationTPVATPCTPRRLSLA
CCCCCCCCCCCCCHH		22.4928348404
719O-linked_GlycosylationPCTPRRLSLAESFTN
CCCCCCCCHHHHHCC		24.5824995978
719PhosphorylationPCTPRRLSLAESFTN
CCCCCCCCHHHHHCC		24.5822617229
723PhosphorylationRRLSLAESFTNTRES
CCCCHHHHHCCCCCC		31.5923403867
725PhosphorylationLSLAESFTNTRESTT
CCHHHHHCCCCCCCC		44.9823403867
727PhosphorylationLAESFTNTRESTTTM
HHHHHCCCCCCCCCC		32.5323403867
728MethylationAESFTNTRESTTTMS
HHHHCCCCCCCCCCC		37.63115918893
734PhosphorylationTRESTTTMSTSLGLV
CCCCCCCCCHHHHHH		3.7527251275
750PhosphorylationLLKERGISAAVYDPQ
HHHHCCCCEEEECHH		17.01-
754PhosphorylationRGISAAVYDPQSWDR
CCCCEEEECHHHCCC		19.72-
764MethylationQSWDRAGRGSLLHSY
HHCCCCCCCCCCCCC		30.46115918897
766PhosphorylationWDRAGRGSLLHSYTP
CCCCCCCCCCCCCCC		26.7928555341
771PhosphorylationRGSLLHSYTPKMAVI
CCCCCCCCCCCEEEE		19.1328555341
780PhosphorylationPKMAVIPSTPPNSPM
CCEEEECCCCCCCCC		42.2827732954
781PhosphorylationKMAVIPSTPPNSPMQ
CEEEECCCCCCCCCC		37.0927732954
785PhosphorylationIPSTPPNSPMQTPTS
ECCCCCCCCCCCCCC		27.7627732954
789PhosphorylationPPNSPMQTPTSSPPS
CCCCCCCCCCCCCCC		23.4527732954
802PhosphorylationPSFEFKCTSPPYDNF
CCEECEECCCCCCCC		44.8728348404
803PhosphorylationSFEFKCTSPPYDNFL
CEECEECCCCCCCCC		33.0928348404
806PhosphorylationFKCTSPPYDNFLASK
CEECCCCCCCCCCCC		27.2323312004
817PhosphorylationLASKPASSILREVRE
CCCCCHHHHHHHHHH		27.9624719451
829O-linked_GlycosylationVREKNVRSSESQTDV
HHHHCCCCCCCCCCC		33.8924995978
830O-linked_GlycosylationREKNVRSSESQTDVS
HHHCCCCCCCCCCCC		30.6124995978
846UbiquitinationSNLNLVDKVRRFGVA
CHHHHHHHHHHHCCE		30.11-
903O-linked_GlycosylationLRCPTVTSAIGGLQL
CCCCCCHHCCCCEEC		17.3524995978
919PhosphorylationSGIRRNRSFPTMVGS
CCCCCCCCCCCCCCC		38.8422617229
922PhosphorylationRRNRSFPTMVGSSMQ
CCCCCCCCCCCCCCC		23.6028450419
926PhosphorylationSFPTMVGSSMQMKAP
CCCCCCCCCCCCCCC		15.9522210691
927PhosphorylationFPTMVGSSMQMKAPV
CCCCCCCCCCCCCCE		13.7022210691
935O-linked_GlycosylationMQMKAPVTLTSGILM
CCCCCCEEECCCHHH		24.2224995978
935PhosphorylationMQMKAPVTLTSGILM
CCCCCCEEECCCHHH		24.2226074081
937PhosphorylationMKAPVTLTSGILMGA
CCCCEEECCCHHHCC		18.6224719451
938PhosphorylationKAPVTLTSGILMGAK
CCCEEECCCHHHCCC		27.2726074081
938O-linked_GlycosylationKAPVTLTSGILMGAK
CCCEEECCCHHHCCC		27.2724995978
947PhosphorylationILMGAKLSKQTSLR-
HHHCCCCCCCCCCC-		23.2422210691
950PhosphorylationGAKLSKQTSLR----
CCCCCCCCCCC----		33.2026074081
951PhosphorylationAKLSKQTSLR-----
CCCCCCCCCC-----		21.4726074081
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TRAK1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRAK1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRAK1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HGS_HUMANHGSphysical
18675823
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRAK1_HUMAN

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Related Literatures of Post-Translational Modification

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