| UniProt ID | NID1_HUMAN | |
|---|---|---|
| UniProt AC | P14543 | |
| Protein Name | Nidogen-1 | |
| Gene Name | NID1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1247 | |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix, basement membrane. | |
| Protein Description | Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.. | |
| Protein Sequence | MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELSGALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFANDRESVENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDYDLATTRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETFHQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 100 | Phosphorylation | HPGLFPPTFGAVAPF CCCCCCCCCCCCHHH | 34.63 | - | |
| 113 | Phosphorylation | PFLADLDTTDGLGKV HHHHCCCCCCCCCCE | 33.80 | - | |
| 114 | Phosphorylation | FLADLDTTDGLGKVY HHHCCCCCCCCCCEE | 27.95 | - | |
| 127 | Phosphorylation | VYYREDLSPSITQRA EEEECCCCHHHHHHH | 28.99 | 21406692 | |
| 129 | Phosphorylation | YREDLSPSITQRAAE EECCCCHHHHHHHHH | 34.59 | 21406692 | |
| 131 | Phosphorylation | EDLSPSITQRAAECV CCCCHHHHHHHHHHH | 19.15 | 21406692 | |
| 289 | Sulfation | GTEDGAEYDDEDEDY ECCCCCCCCCCCCCC | 28.32 | - | |
| 289 | Sulfation | GTEDGAEYDDEDEDY ECCCCCCCCCCCCCC | 28.32 | - | |
| 296 | Sulfation | YDDEDEDYDLATTRL CCCCCCCCCCCCCCC | 15.71 | - | |
| 296 | Sulfation | YDDEDEDYDLATTRL CCCCCCCCCCCCCCC | 15.71 | - | |
| 300 | Phosphorylation | DEDYDLATTRLGLED CCCCCCCCCCCCCCC | 21.53 | 26657352 | |
| 310 | O-linked_Glycosylation | LGLEDVGTTPFSYKA CCCCCCCCCCCCHHH | 31.01 | 55825527 | |
| 311 | O-linked_Glycosylation | GLEDVGTTPFSYKAL CCCCCCCCCCCHHHH | 19.19 | 55825533 | |
| 314 | O-linked_Glycosylation | DVGTTPFSYKALRRG CCCCCCCCHHHHHCC | 27.25 | OGP | |
| 320 | Methylation | FSYKALRRGGADTYS CCHHHHHCCCCCCCC | 49.07 | 115484997 | |
| 325 | Phosphorylation | LRRGGADTYSVPSVL HHCCCCCCCCCCCCC | 19.70 | 28348404 | |
| 325 | O-linked_Glycosylation | LRRGGADTYSVPSVL HHCCCCCCCCCCCCC | 19.70 | OGP | |
| 326 | Phosphorylation | RRGGADTYSVPSVLS HCCCCCCCCCCCCCC | 14.28 | - | |
| 327 | Phosphorylation | RGGADTYSVPSVLSP CCCCCCCCCCCCCCC | 29.64 | 27251275 | |
| 327 | O-linked_Glycosylation | RGGADTYSVPSVLSP CCCCCCCCCCCCCCC | 29.64 | 46509307 | |
| 330 | O-linked_Glycosylation | ADTYSVPSVLSPRRA CCCCCCCCCCCCCCC | 33.27 | 55831621 | |
| 330 | Phosphorylation | ADTYSVPSVLSPRRA CCCCCCCCCCCCCCC | 33.27 | 28348404 | |
| 333 | O-linked_Glycosylation | YSVPSVLSPRRAATE CCCCCCCCCCCCCCC | 17.76 | 51560317 | |
| 333 | Phosphorylation | YSVPSVLSPRRAATE CCCCCCCCCCCCCCC | 17.76 | 28857561 | |
| 339 | O-linked_Glycosylation | LSPRRAATERPLGPP CCCCCCCCCCCCCCC | 31.38 | 55826141 | |
| 347 | O-linked_Glycosylation | ERPLGPPTERTRSFQ CCCCCCCCHHHHHHH | 41.03 | 55826147 | |
| 350 | O-linked_Glycosylation | LGPPTERTRSFQLAV CCCCCHHHHHHHHHH | 25.16 | 55830513 | |
| 359 | O-linked_Glycosylation | SFQLAVETFHQQHPQ HHHHHHHHHHHHCCE | 21.59 | OGP | |
| 423 | Methylation | AGYTGNGRQCVAEGS EECCCCCCEEEECCC | 30.63 | 115384315 | |
| 517 | Phosphorylation | SITGGEFTRQAEVTF EECCCEEEEEEEEEE | 19.98 | - | |
| 600 | Phosphorylation | EPERDGASPSRIYTY CCCCCCCCCCCEEEE | 29.01 | 30242111 | |
| 602 | Phosphorylation | ERDGASPSRIYTYQW CCCCCCCCCEEEEEE | 28.90 | 30242111 | |
| 614 | Phosphorylation | YQWRQTITFQECVHD EEEEEEEEHHHCCCC | 23.74 | 25690035 | |
| 623 | Phosphorylation | QECVHDDSRPALPST HHCCCCCCCCCCCCC | 46.34 | 25690035 | |
| 832 | Phosphorylation | TCQCKPGYQGDGFRC EEEECCCCCCCCEEE | 20.18 | - | |
| 887 | O-linked_Glycosylation | AHGHYAPTQCHGSTG CCCCCCCCCCCCCCC | 35.34 | OGP | |
| 909 | Phosphorylation | DGREVEGTRTRPGMT CCCEEECCCCCCCCC | 18.50 | - | |
| 921 | O-linked_Glycosylation | GMTPPCLSTVAPPIH CCCCCCCCCCCCCCC | 27.79 | OGP | |
| 922 | O-linked_Glycosylation | MTPPCLSTVAPPIHQ CCCCCCCCCCCCCCC | 14.03 | 55823697 | |
| 935 | O-linked_Glycosylation | HQGPAVPTAVIPLPP CCCCCCCEEEEECCC | 27.27 | 55823703 | |
| 1013 | O-linked_Glycosylation | SLHGGEPTTIIRQDL ECCCCCCCEEEECCC | 26.73 | OGP | |
| 1014 | O-linked_Glycosylation | LHGGEPTTIIRQDLG CCCCCCCEEEECCCC | 25.73 | OGP | |
| 1053 | Phosphorylation | EVAKLDGTQRRVLFE EEEECCCCCCEEEEE | 20.69 | 24719451 | |
| 1073 | Phosphorylation | PRGIVTDSVRGNLYW CCCEECCCCCCCEEE | 12.35 | 24719451 | |
| 1092 | Phosphorylation | RDNPKIETSYMDGTN CCCCCEEEEEECCCC | 28.73 | 24505115 | |
| 1098 | Phosphorylation | ETSYMDGTNRRILVQ EEEEECCCCCEEEEE | 22.68 | - | |
| 1137 | N-linked_Glycosylation | TNRAECLNPSQPSRR CCHHHHCCCCCHHHH | 45.92 | UniProtKB CARBOHYD | |
| 1181 | Phosphorylation | VALDLAISKETDAFQ EHHEEEECCCCCCCC | 20.87 | 27251275 | |
| 1184 | Phosphorylation | DLAISKETDAFQPHK EEEECCCCCCCCCCC | 36.04 | - | |
| 1193 | Phosphorylation | AFQPHKQTRLYGITT CCCCCCCHHHHCHHH | 27.69 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NID1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NID1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NID1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| FIBA_HUMAN | FGA | physical | 1680863 | |
| FIBB_HUMAN | FGB | physical | 1680863 | |
| NID1_HUMAN | NID1 | physical | 9278415 | |
| NID1_HUMAN | NID1 | physical | 8354280 | |
| FBLN1_HUMAN | FBLN1 | physical | 8354280 | |
| PTPRF_HUMAN | PTPRF | physical | 9647658 | |
| FBLN2_HUMAN | FBLN2 | physical | 7500359 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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