SVEP1_HUMAN - dbPTM
SVEP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SVEP1_HUMAN
UniProt AC Q4LDE5
Protein Name Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
Gene Name SVEP1
Organism Homo sapiens (Human).
Sequence Length 3571
Subcellular Localization Secreted . Cytoplasm . Membrane
Peripheral membrane protein .
Protein Description May play a role in the cell attachment process..
Protein Sequence MWPRLAFCCWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRVERLGQAFRRRVRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVDYISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPIAASLRDSGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVHVHPAFTPPYLFPIGDVAIVYTATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWDEPQFSDNSGAELVITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHIVIKGSPCEIPFTPVNGDFICTPDNTGVNCTLTCLEGYDFTEGSTDKYYCAYEDGVWKPTYTTEWPDCAKKRFANHGFKSFEMFYKAARCDDTDLMKKFSEAFETTLGKMVPSFCSDAEDIDCRLEENLTKKYCLEYNYDYENGFAIGPGGWGAANRLDYSYDDFLDTVQETATSIGNAKSSRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKLKRTLNKDPMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIGSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDGMLPSLHALTCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGREKITNCPSVNDGRWHHIAITWTSANGIWKVYIDGKLSDGGAGLSVGLPIPGGGALVLGQEQDKKGEGFSPAESFVGSISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRPNRCHCLSSWTGHNCSRKRRTGF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
31PhosphorylationMSPSRNFSFRLFPET
CCCCCCEEEEECCCC		17.0124719451
126PhosphorylationATRVAIVTFSSKNYV
CCEEEEEEECCCCCE		16.2225022875
128PhosphorylationRVAIVTFSSKNYVVP
EEEEEEECCCCCEEE		30.9125022875
129PhosphorylationVAIVTFSSKNYVVPR
EEEEEECCCCCEEEC		22.2625022875
132PhosphorylationVTFSSKNYVVPRVDY
EEECCCCCEEECCEE		13.4225022875
139PhosphorylationYVVPRVDYISTRRAR
CEEECCEECCCHHHH		8.2326852163
141PhosphorylationVPRVDYISTRRARQH
EECCEECCCHHHHHH		15.0524114839
142PhosphorylationPRVDYISTRRARQHK
ECCEECCCHHHHHHH		18.0224114839
161PhosphorylationLQEIPAISYRGGGTY
HEECCCEEECCCCCC		15.7526330541
162PhosphorylationQEIPAISYRGGGTYT
EECCCEEECCCCCCC		13.7326330541
186N-linked_GlycosylationILLHARENSTKVVFL
HHHHHHCCCCEEEEE		49.80UniProtKB CARBOHYD
415PhosphorylationPGFDLVGSSIILCLP
CCCCCCCCEEEEECC		15.75-
416PhosphorylationGFDLVGSSIILCLPN
CCCCCCCEEEEECCC		14.02-
477UbiquitinationYRLEGSDKLTCQGNS
CCCCCCCCEEECCCC		47.60-
516UbiquitinationISPHNCGKQPAKFGT
ECCCCCCCCCCCCCC		56.14-
545PhosphorylationVKEMLRCTTSGKWNV
HHHHHCCCCCCCCCE		19.98-
546PhosphorylationKEMLRCTTSGKWNVG
HHHHCCCCCCCCCEE		38.82-
547PhosphorylationEMLRCTTSGKWNVGV
HHHCCCCCCCCCEEE		21.88-
571UbiquitinationAPQINCPKDIEAKTL
CCCCCCCCCCCCCCC		73.81-
592PhosphorylationNVTWQIPTAKDNSGE
CEEEEECCCCCCCCC		48.2224719451
777UbiquitinationAYEDGVWKPTYTTEW
EEECCCCCCCCCCCC		25.69-
789UbiquitinationTEWPDCAKKRFANHG
CCCCHHHHHHHHCCC		51.30-
799PhosphorylationFANHGFKSFEMFYKA
HHCCCCCHHHHHHHH		24.9523322592
805UbiquitinationKSFEMFYKAARCDDT
CHHHHHHHHHCCCCH		25.06-
824PhosphorylationKFSEAFETTLGKMVP
HHHHHHHHHHHHHCC		22.3727794612
825PhosphorylationFSEAFETTLGKMVPS
HHHHHHHHHHHHCCC		26.7327794612
847N-linked_GlycosylationIDCRLEENLTKKYCL
CCHHHHHHCCHHHEE		43.57UniProtKB CARBOHYD
849PhosphorylationCRLEENLTKKYCLEY
HHHHHHCCHHHEEEC		36.7520068230
901PhosphorylationSIGNAKSSRIKRSAP
HHHCCCCCCCCCCCC		37.00-
913UbiquitinationSAPLSDYKIKLIFNI
CCCCCCCEEEEEEEE		38.05-
952UbiquitinationTLETITNKLKRTLNK
HHHHHHHHHHHHHCC		46.89-
981PhosphorylationADSNSLETKKASPFC
ECCCCCCCCCCCCCC		43.04-
1060PhosphorylationKAQCKQGTYSYSGLE
HHHHCCCCCCCCCCC		13.5524043423
1061PhosphorylationAQCKQGTYSYSGLET
HHHCCCCCCCCCCCC		16.6724043423
1062PhosphorylationQCKQGTYSYSGLETC
HHCCCCCCCCCCCCC		16.8024043423
1063PhosphorylationCKQGTYSYSGLETCE
HCCCCCCCCCCCCCC		9.0624043423
1064PhosphorylationKQGTYSYSGLETCES
CCCCCCCCCCCCCCC		30.8424043423
1068PhosphorylationYSYSGLETCESCPLG
CCCCCCCCCCCCCCC		26.9824043423
1071PhosphorylationSGLETCESCPLGTYQ
CCCCCCCCCCCCCCC		24.1524043423
1076PhosphorylationCESCPLGTYQPKFGS
CCCCCCCCCCCCCCC		27.0224043423
1077PhosphorylationESCPLGTYQPKFGSR
CCCCCCCCCCCCCCC		22.4824043423
1097UbiquitinationPENTSTVKRGAVNIS
CCCCCCCCCCCEEEE		45.24-
1102N-linked_GlycosylationTVKRGAVNISACGVP
CCCCCCEEEEECCCC		23.20UniProtKB CARBOHYD
1215PhosphorylationCQQLGRGYVCLCPLG
CCCCCCEEEEECCCC		6.14-
1223PhosphorylationVCLCPLGYTGLKCET
EEECCCCCCCCEEEC		12.81-
1224PhosphorylationCLCPLGYTGLKCETD
EECCCCCCCCEEECC		33.9524719451
1224O-linked_GlycosylationCLCPLGYTGLKCETD
EECCCCCCCCEEECC		33.9528657654
1397PhosphorylationNPCRNQATCVDELNS
CCCCCCCCHHHHHHH		11.87-
1477PhosphorylationSYAVDNGSDNTLLLT
EEEEECCCCCCEEEE		33.66-
1645PhosphorylationVPHLRTASEDLKPGS
CCCCCCCCCCCCCCC		30.9126437602
1805PhosphorylationGHSSGEIYTVGAEVT
CCCCCCEEEECEEEE		7.3523403867
1814PhosphorylationVGAEVTFSCQEGYQL
ECEEEEEECCCCCEE		12.9123403867
1819PhosphorylationTFSCQEGYQLMGVTK
EEECCCCCEEECEEE		9.5623403867
1825PhosphorylationGYQLMGVTKITCLES
CCEEECEEEEEEECC		15.8223403867
1875UbiquitinationKVTYRCNKGYTLAGD
EEEEECCCCEEECCC		57.85-
2160PhosphorylationMNGYASGSNYSFGAM
CCCCCCCCCCCCCEE		30.05-
2179UbiquitinationCNKGFYIKGEKKSTC
CCCCEEEECCCCCCC		50.03-
2225PhosphorylationTTGRIFESEVRYQCN
CCCCEEECEEEEECC		30.5525159151
2229PhosphorylationIFESEVRYQCNPGYK
EEECEEEEECCCCCC		23.6925627689
2235PhosphorylationRYQCNPGYKSVGSPV
EEECCCCCCCCCCCE		11.0125627689
2237PhosphorylationQCNPGYKSVGSPVFV
ECCCCCCCCCCCEEE		24.1922617229
2240PhosphorylationPGYKSVGSPVFVCQA
CCCCCCCCCEEEEEC		18.7422617229
2523PhosphorylationYGQTVTYSCNRGFRL
CCCEEEEECCCCCCC		8.7822210691
2647O-linked_GlycosylationMMEVPYVTPHPPYHL
CEECCCCCCCCCCCH		15.27OGP
2731PhosphorylationENGFLRFTETSMGSA
CCCCEEEEECCCCCC		31.7426074081
2733PhosphorylationGFLRFTETSMGSAVQ
CCEEEEECCCCCCEE		22.4326074081
2734PhosphorylationFLRFTETSMGSAVQY
CEEEEECCCCCCEEE		18.2126074081
2737PhosphorylationFTETSMGSAVQYSCK
EEECCCCCCEEEECC		19.3426074081
2741PhosphorylationSMGSAVQYSCKPGHI
CCCCCEEEECCCCCE		14.9426074081
2902PhosphorylationPQLANGVTEGLDYGF
HHHCCCCCCCCCCCC		26.2427251275
2907PhosphorylationGVTEGLDYGFMKEVT
CCCCCCCCCCEEEEE		19.8027251275
2921PhosphorylationTFHCHEGYILHGAPK
EEEEECCEEECCCCC		9.4227251275
3018N-linked_GlycosylationVIEYGTVNGTDFDCG
EEEEEEECCCCCCCC		47.70UniProtKB CARBOHYD
3088PhosphorylationWKENVITYSCRSGYV
CCCCEEEEECCCCEE		8.4722468782
3092PhosphorylationVITYSCRSGYVIQGS
EEEEECCCCEEEECC		38.5122468782
3186N-linked_GlycosylationKKCPLPENITHILVH
CCCCCCCCCEEEEEE		42.38UniProtKB CARBOHYD
3370PhosphorylationIPENALLSEKEFYVD
CCCCCCCCCCEEECC		47.6924719451
3415PhosphorylationSAKCEKISCGPPAHV
CCEEEECCCCCCHHH		24.88-
3432PhosphorylationAIARGVHYQYGDMIT
HHHCCCCCCCCCEEE		10.8724043423
3434PhosphorylationARGVHYQYGDMITYS
HCCCCCCCCCEEEEE		14.1324043423
3439PhosphorylationYQYGDMITYSCYSGY
CCCCCEEEEEECCCC		11.6224043423
3440PhosphorylationQYGDMITYSCYSGYM
CCCCEEEEEECCCCC		5.9424043423
3441PhosphorylationYGDMITYSCYSGYML
CCCEEEEEECCCCCH		9.6424043423
3443PhosphorylationDMITYSCYSGYMLEG
CEEEEEECCCCCHHH		10.1324043423
3444PhosphorylationMITYSCYSGYMLEGF
EEEEEECCCCCHHHH		27.9824043423
3446PhosphorylationTYSCYSGYMLEGFLR
EEEECCCCCHHHHHH		7.8124043423
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SVEP1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SVEP1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SVEP1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SVEP1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SVEP1_HUMAN

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Related Literatures of Post-Translational Modification

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