HEYL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEYL_HUMAN
• UniProt AC: Q9NQ87
• Protein Name: Hairy/enhancer-of-split related with YRPW motif-like protein
• Gene Name: HEYL
• Organism: Homo sapiens (Human).
• Sequence Length: 328
• Subcellular Localization: Nucleus .
• Protein Description: Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6..
• Protein Sequence: MKRPKEPSGSDGESDGPIDVGQEGQLSQMARPLSTPSSSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFFHSCPGLPALSNQLAILGRVPSPVLPGVSSPAYPIPALRTAPLRRATGIILPARRNVLPSRGASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTPPGPTGSAAYVAVPTPNSSSPGPAGRPAGAMLYHSWVSEITEIGAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Ubiquitination	MQARKKHRGIIEKRR HHHHHHHHCHHHHHH	47.05	22817900
53	Acetylation	KHRGIIEKRRRDRIN HHHCHHHHHHHHHHH	40.57	30589159
53	Ubiquitination	KHRGIIEKRRRDRIN HHHCHHHHHHHHHHH	40.57	22817900
61	Phosphorylation	RRRDRINSSLSELRR HHHHHHHHHHHHHHH	30.22	26699800
62	Phosphorylation	RRDRINSSLSELRRL HHHHHHHHHHHHHHH	31.27	26699800
64	Phosphorylation	DRINSSLSELRRLVP HHHHHHHHHHHHHHH	36.21	26699800
76	Ubiquitination	LVPTAFEKQGSSKLE HHHHHHHHHCCCHHH	54.21	22817900
81	Ubiquitination	FEKQGSSKLEKAEVL HHHHCCCHHHHHHHH	63.46	22817900
84	Ubiquitination	QGSSKLEKAEVLQMT HCCCHHHHHHHHHHH	61.35	-
201	Phosphorylation	AILGRVPSPVLPGVS HHCCCCCCCCCCCCC	25.45	27251275
219	Phosphorylation	YPIPALRTAPLRRAT CCCCHHHCCCCHHCC	33.21	30631047
239	Phosphorylation	ARRNVLPSRGASSTR CHHCCCCCCCCCCCC	38.90	-
240	Methylation	RRNVLPSRGASSTRR HHCCCCCCCCCCCCC	42.64	115478473
256	Phosphorylation	RPLERPATPVPVAPS CCCCCCCCCCCCCCC	27.74	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEYL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEYL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEYL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SP8_HUMAN	SP8	physical	20211142
A4_HUMAN	APP	physical	21832049
RPGR1_HUMAN	RPGRIP1	physical	25416956
ARL10_HUMAN	ARL10	physical	26186194
FNTA_HUMAN	FNTA	physical	26186194
PGTB1_HUMAN	PGGT1B	physical	26186194
MDFI_HUMAN	MDFI	physical	21516116
FBSP1_HUMAN	FBXO45	physical	26068074
PGTB1_HUMAN	PGGT1B	physical	28514442
ARL10_HUMAN	ARL10	physical	28514442
FNTA_HUMAN	FNTA	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.