SP8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SP8_HUMAN
• UniProt AC: Q8IXZ3
• Protein Name: Transcription factor Sp8
• Gene Name: SP8
• Organism: Homo sapiens (Human).
• Sequence Length: 490
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity)..
• Protein Sequence: MLAATCNKIGSPSPSPSSLSDSSSSFGKGFHPWKRSSSSSSASCNVVGSSLSSFGVSGASRNGGSSSAAAAAAAAAAAAAALVSDSFSCGGSPGSSAFSLTSSSAAAAAAAAAAAASSSPFANDYSVFQAPGVSGGSGGGGGGGGGGSSAHSQDGSHQPVFISKVHTSVDGLQGIYPRVGMAHPYESWFKPSHPGLGAAGEVGSAGASSWWDVGAGWIDVQNPNSAAALPGSLHPAAGGLQTSLHSPLGGYNSDYSGLSHSAFSSGASSHLLSPAGQHLMDGFKPVLPGSYPDSAPSPLAGAGGSMLSAGPSAPLGGSPRSSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHVKTHSGGGGGGGSAGSGSGGKKGSDTDSEHSAAGSPPCHSPELLQPPEPGHRNGLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	ATCNKIGSPSPSPSS CCCCCCCCCCCCCCC	26.19	22617229
13	Phosphorylation	CNKIGSPSPSPSSLS CCCCCCCCCCCCCCC	39.44	22617229
15	Phosphorylation	KIGSPSPSPSSLSDS CCCCCCCCCCCCCCC	41.57	22617229
22	Phosphorylation	SPSSLSDSSSSFGKG CCCCCCCCCCCCCCC	28.83	-
23	Phosphorylation	PSSLSDSSSSFGKGF CCCCCCCCCCCCCCC	34.68	-
25	Phosphorylation	SLSDSSSSFGKGFHP CCCCCCCCCCCCCCC	39.71	-
36	Phosphorylation	GFHPWKRSSSSSSAS CCCCCCCCCCCCCCC	30.74	23186163
37	Phosphorylation	FHPWKRSSSSSSASC CCCCCCCCCCCCCCC	37.97	23186163
38	Phosphorylation	HPWKRSSSSSSASCN CCCCCCCCCCCCCCC	35.17	23186163
39	Phosphorylation	PWKRSSSSSSASCNV CCCCCCCCCCCCCCE	30.20	23186163
40	Phosphorylation	WKRSSSSSSASCNVV CCCCCCCCCCCCCEE	31.69	23186163
41	Phosphorylation	KRSSSSSSASCNVVG CCCCCCCCCCCCEEC	26.58	23186163
290	Phosphorylation	FKPVLPGSYPDSAPS CCCCCCCCCCCCCCC	31.39	20562096
291	Phosphorylation	KPVLPGSYPDSAPSP CCCCCCCCCCCCCCC	19.58	20562096
305	Phosphorylation	PLAGAGGSMLSAGPS CCCCCCCCCCCCCCC	18.68	20562096
308	Phosphorylation	GAGGSMLSAGPSAPL CCCCCCCCCCCCCCC	23.65	20562096
312	Phosphorylation	SMLSAGPSAPLGGSP CCCCCCCCCCCCCCC	41.42	20562096
318	Phosphorylation	PSAPLGGSPRSSARR CCCCCCCCCCCCCCH	18.49	20562096
349	Phosphorylation	RLGPAGASLRRKGLH HHCCCCHHHHHCCCC	22.84	26437602
381	Phosphorylation	KAHLRWHTGERPFVC HHHHHHCCCCCCEEE	33.50	-
398	Phosphorylation	LFCGKRFTRSDELQR EECCCCCCCCHHHHH	33.04	30108239
400	Phosphorylation	CGKRFTRSDELQRHL CCCCCCCCHHHHHHH	32.17	29496963
409	Phosphorylation	ELQRHLRTHTGEKRF HHHHHHHHHCCCCEE	30.10	-
411	Phosphorylation	QRHLRTHTGEKRFAC HHHHHHHCCCCEECC	46.56	-
428	Phosphorylation	CNKRFMRSDHLSKHV CCCHHHCCHHHHHCC	20.00	28555341
437	Phosphorylation	HLSKHVKTHSGGGGG HHHHCCCCCCCCCCC	21.86	22210691
439	Phosphorylation	SKHVKTHSGGGGGGG HHCCCCCCCCCCCCC	44.35	22210691
452	Phosphorylation	GGSAGSGSGGKKGSD CCCCCCCCCCCCCCC	46.17	22210691
460	Phosphorylation	GGKKGSDTDSEHSAA CCCCCCCCCCCCCCC	43.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SP8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SP8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SP8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SP8_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.