KRT81_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KRT81_HUMAN
• UniProt AC: Q14533
• Protein Name: Keratin, type II cuticular Hb1
• Gene Name: KRT81
• Organism: Homo sapiens (Human).
• Sequence Length: 505
• Protein Sequence: MTCGSGFGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEILILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGIGAVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCNGNVAVSTGLCAPCGQLNTTCGGGSCGVGSCGISSLGVGSCGSSCRKC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	ISCYRGLTGGFGSHS CCCCCCCCCCCCCCC	37.78	20068231
47	Phosphorylation	GLTGGFGSHSVCGGF CCCCCCCCCCCCCCC	15.44	20068231
49	Phosphorylation	TGGFGSHSVCGGFRA CCCCCCCCCCCCCCC	22.32	26657352
62	Phosphorylation	RAGSCGRSFGYRSGG CCCCCCCCCCCCCCC	14.33	24719451
132	Ubiquitination	RFLEQQNKLLETKLQ HHHHHHHHHHHHHHH	50.54	22817900
137	Ubiquitination	QNKLLETKLQFYQNR HHHHHHHHHHHHHCH	30.80	22817900
203	Phosphorylation	EEVSLRATAENEFVA HHHCHHEEECCCEEE	28.24	20068231
252	Phosphorylation	EEILILQSHISDTSV HHHHEEECCCCCCEE	21.24	20860994
257	Phosphorylation	LQSHISDTSVVVKLD EECCCCCCEEEEEEC	19.34	20860994
258	Phosphorylation	QSHISDTSVVVKLDN ECCCCCCEEEEEECC	20.22	20068231
279	Ubiquitination	DCIIAEIKAQYDDIV CEEEEEHHHHHCHHH	22.42	33845483
282	Phosphorylation	IAEIKAQYDDIVTRS EEEHHHHHCHHHHHH	22.05	22461510
289	Phosphorylation	YDDIVTRSRAEAESW HCHHHHHHHHHHHHH	26.86	28348404
295	Phosphorylation	RSRAEAESWYRSKCE HHHHHHHHHHHHHHH	36.13	28348404
297	Phosphorylation	RAEAESWYRSKCEEM HHHHHHHHHHHHHHH	17.81	-
300	Ubiquitination	AESWYRSKCEEMKAT HHHHHHHHHHHHHHH	36.35	33845483
305	Ubiquitination	RSKCEEMKATVIRHG HHHHHHHHHHHHHCC	44.15	33845483
307	Phosphorylation	KCEEMKATVIRHGET HHHHHHHHHHHCCHH	15.79	24719451
314	Phosphorylation	TVIRHGETLRRTKEE HHHHCCHHHHHHHHH	30.11	24719451
318	Phosphorylation	HGETLRRTKEEINEL CCHHHHHHHHHHHHH	36.05	24719451
319	Ubiquitination	GETLRRTKEEINELN CHHHHHHHHHHHHHH	52.09	24816145
340	Ubiquitination	TAEVENAKCQNSKLE HHHHHHHHHHCHHHH	48.19	33845483
345	Ubiquitination	NAKCQNSKLEAAVAQ HHHHHCHHHHHHHHC	58.87	33845483
362	Phosphorylation	QQGEAALSDARCKLA HHHHHHHHHHHHHHH	25.21	28348404
367	Ubiquitination	ALSDARCKLAELEGA HHHHHHHHHHHHHHH	45.22	-
377	Ubiquitination	ELEGALQKAKQDMAC HHHHHHHHHHHHHHH	59.40	33845483
379	Ubiquitination	EGALQKAKQDMACLI HHHHHHHHHHHHHHH	54.59	33845483
395	Phosphorylation	EYQEVMNSKLGLDIE HHHHHHHHCCCCCEE	15.91	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KRT81_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KRT81_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KRT81_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KXDL1_HUMAN	KXD1	physical	16189514
OTX1_HUMAN	OTX1	physical	25416956
KRT38_HUMAN	KRT38	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
OTX1_HUMAN	OTX1	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 158000: Monilethrix (MNLIX)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.