dbPTM

SPRL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPRL1_HUMAN
UniProt AC	Q14515
Protein Name	SPARC-like protein 1
Gene Name	SPARCL1
Organism	Homo sapiens (Human).
Sequence Length	664
Subcellular Localization	Secreted, extracellular space, extracellular matrix.
Protein Description
Protein Sequence	MKTGLFFLCLLGTAAAIPTNARLLSDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETSSEGNMRVHAVDSCMSFQCKRGHICKADQQGKPHCVCQDPVTCPPTKPLDQVCGTDNQTYASSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPTCTDFEVIQFPLRMRDWLKNILMQLYEANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHPIDLLLRDFKKNYHMYVYPVHWQFSELDQHPMDRVLTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGHCFGIKEEDIDENLLF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	PTNARLLSDHSKPTA CCCHHHCCCCCCCCC	37.56	24719451
28	Phosphorylation	ARLLSDHSKPTAETV HHHCCCCCCCCCCCC	45.37	24719451
31	Phosphorylation	LSDHSKPTAETVAPD CCCCCCCCCCCCCCC	40.64	24719451
31	O-linked_Glycosylation	LSDHSKPTAETVAPD CCCCCCCCCCCCCCC	40.64	23234360
34	O-linked_Glycosylation	HSKPTAETVAPDNTA CCCCCCCCCCCCCCC	21.36	OGP
40	O-linked_Glycosylation	ETVAPDNTAIPSLRA CCCCCCCCCCCHHHH	33.09	23234360
44	Phosphorylation	PDNTAIPSLRAEAEE CCCCCCCHHHHHHHH	25.11	24719451
44	O-linked_Glycosylation	PDNTAIPSLRAEAEE CCCCCCCHHHHHHHH	25.11	23234360
56	Phosphorylation	AEENEKETAVSTEDD HHHHHHCCCCCCCCC	43.35	24702127
59	Phosphorylation	NEKETAVSTEDDSHH HHHCCCCCCCCCHHC	24.50	27130503
60	Phosphorylation	EKETAVSTEDDSHHK HHCCCCCCCCCHHCH	36.51	27130503
64	Phosphorylation	AVSTEDDSHHKAEKS CCCCCCCHHCHHHHH	39.55	29759185
76	Phosphorylation	EKSSVLKSKEESHEQ HHHHHHHHHHHHHHH	40.93	29759185
80	Phosphorylation	VLKSKEESHEQSAEQ HHHHHHHHHHHHHHH	33.16	27251275
84	Phosphorylation	KEESHEQSAEQGKSS HHHHHHHHHHHHCCH	30.68	25307156
90	Phosphorylation	QSAEQGKSSSQELGL HHHHHHCCHHHHHCC	41.88	29691806
91	Phosphorylation	SAEQGKSSSQELGLK HHHHHCCHHHHHCCC	39.26	26657352
92	Phosphorylation	AEQGKSSSQELGLKD HHHHCCHHHHHCCCC	34.46	20886841
116	O-linked_Glycosylation	VNLEYAPTEGTLDIK EEEEECCCCCEECHH	38.58	23234360
127	Phosphorylation	LDIKEDMSEPQEKKL ECHHHCCCCHHHHHH	59.45	-
135	Phosphorylation	EPQEKKLSENTDFLA CHHHHHHHCCCCCCC	37.37	29978859
138	Phosphorylation	EKKLSENTDFLAPGV HHHHHCCCCCCCCCH	24.87	29978859
146	Phosphorylation	DFLAPGVSSFTDSNQ CCCCCCHHHCCCCCC	26.16	29978859
147	Phosphorylation	FLAPGVSSFTDSNQQ CCCCCHHHCCCCCCH	29.74	29978859
149	Phosphorylation	APGVSSFTDSNQQES CCCHHHCCCCCCHHH	40.23	29978859
149	O-linked_Glycosylation	APGVSSFTDSNQQES CCCHHHCCCCCCHHH	40.23	OGP
151	Phosphorylation	GVSSFTDSNQQESIT CHHHCCCCCCHHHCH	33.22	26657352
156	Phosphorylation	TDSNQQESITKREEN CCCCCHHHCHHHHHH	31.08	29978859
158	Phosphorylation	SNQQESITKREENQE CCCHHHCHHHHHHCC	33.07	29978859
169	N-linked_Glycosylation	ENQEQPRNYSHHQLN HHCCCCCCCCHHHCC	49.71	UniProtKB CARBOHYD
170	Phosphorylation	NQEQPRNYSHHQLNR HCCCCCCCCHHHCCH	15.62	21955146
171	Phosphorylation	QEQPRNYSHHQLNRS CCCCCCCCHHHCCHH	20.31	21955146
176	N-linked_Glycosylation	NYSHHQLNRSSKHSQ CCCHHHCCHHHHHHH	34.91	UniProtKB CARBOHYD
178	Phosphorylation	SHHQLNRSSKHSQGL CHHHCCHHHHHHHCC	42.54	21955146
179	Phosphorylation	HHQLNRSSKHSQGLR HHHCCHHHHHHHCCC	31.02	21955146
182	Phosphorylation	LNRSSKHSQGLRDQG CCHHHHHHHCCCCCC	29.67	-
196	N-linked_Glycosylation	GNQEQDPNISNGEEE CCCCCCCCCCCCCCH	59.62	UniProtKB CARBOHYD
198	Phosphorylation	QEQDPNISNGEEEEE CCCCCCCCCCCCHHC	45.48	24702127
213	Phosphorylation	KEPGEVGTHNDNQER CCCCCCCCCCCCHHH	23.76	24702127
231	Phosphorylation	LPREHANSKQEEDNT CCHHHHCCCHHCCCC	36.18	26657352
238	Phosphorylation	SKQEEDNTQSDDILE CCHHCCCCCCCHHHH	41.60	28857561
240	Phosphorylation	QEEDNTQSDDILEES HHCCCCCCCHHHHHC	34.90	24702127
254	Phosphorylation	SDQPTQVSKMQEDEF CCCCCHHHHHHHHCC	16.76	29759185
272	Phosphorylation	NQEQEDNSNAEMEEE CHHCHHCCHHHHHHH	50.14	18702456
280	N-linked_Glycosylation	NAEMEEENASNVNKH HHHHHHHHHHHHHHH	52.53	UniProtKB CARBOHYD
291	Phosphorylation	VNKHIQETEWQSQEG HHHHHHHHHHHHHCC	26.58	28270605
295	Phosphorylation	IQETEWQSQEGKTGL HHHHHHHHHCCCCHH	31.13	28348404
315	O-linked_Glycosylation	HKETEEKTVSEALLM CCCCCCEEHHHHHHC	32.32	OGP
331	O-linked_Glycosylation	PTDDGNTTPRNHGVD CCCCCCCCCCCCCCC	25.01	UniProtKB CARBOHYD
356	O-linked_Glycosylation	GTDGPRHSASDDYFI CCCCCCCCCCCCCCC	30.65	OGP
358	Phosphorylation	DGPRHSASDDYFIPS CCCCCCCCCCCCCCH	33.75	-
365	O-linked_Glycosylation	SDDYFIPSQAFLEAE CCCCCCCHHHHHHHH	29.35	OGP
365	Phosphorylation	SDDYFIPSQAFLEAE CCCCCCCHHHHHHHH	29.35	-
398	O-linked_Glycosylation	HENENIGTTEPGEHQ HCCCCCCCCCCCHHH	24.96	19838169
412	N-linked_Glycosylation	QEAKKAENSSNEEET HHHHHHCCCCCCCCC	56.44	16335952
413	Phosphorylation	EAKKAENSSNEEETS HHHHHCCCCCCCCCC	26.50	24719451
414	Phosphorylation	AKKAENSSNEEETSS HHHHCCCCCCCCCCC	60.90	26657352
419	Phosphorylation	NSSNEEETSSEGNMR CCCCCCCCCCCCCCE	40.61	-
420	Phosphorylation	SSNEEETSSEGNMRV CCCCCCCCCCCCCEE	29.67	22210691
421	Phosphorylation	SNEEETSSEGNMRVH CCCCCCCCCCCCEEE	57.87	23911959
435	Phosphorylation	HAVDSCMSFQCKRGH EEECCCEECEECCCC	19.25	22210691
476	N-linked_Glycosylation	DQVCGTDNQTYASSC HHCCCCCCCCCHHHH	35.61	UniProtKB CARBOHYD
645	Ubiquitination	KDKHITLKEWGHCFG CCCCEEHHHHHHCCC	42.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPRL1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPRL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPRL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SPRL1_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPRL1_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-412, AND MASSSPECTROMETRY.	16335952 [Abstract]