NXF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NXF3_HUMAN
• UniProt AC: Q9H4D5
• Protein Name: Nuclear RNA export factor 3
• Gene Name: NXF3
• Organism: Homo sapiens (Human).
• Sequence Length: 531
• Subcellular Localization: Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm.
• Protein Description: May function as a tissue-specific nuclear mRNA export factor..
• Protein Sequence: MSLPSGHTTGHTDQVVQRRARCWDIYQRRFSSRSEPVNPGMHSSSHQQQDGDAAMHGAHMDSPVRYTPYTISPYNRKGSFRKQDQTHVNMEREQKPPERRMEGNMPDGTLGSWFKITVPFGIKYNEKWLLNLIQNECSVPFVPVEFHYENMHASFFVENASIAYALKNVSGKIWDEDNEKISIFVNPAGIPHFVHRELKSEKVEQIKLAMNQQCDVSQEALDIQRLPFYPDMVNRDTKMASNPRKCMAASLDVHEENIPTVMSAGEMDKWKGIEPGEKCADRSPVCTTFSDTSSNINSILELFPKLLCLDGQQSPRATLCGTEAHKRLPTCKGSFFGSEMLKNLVLQFLQQYYLIYDSGDRQGLLSAYHDEACFSLSIPFNPEDSAPSSFCKFFKDSRNIKILKDPYLRGELLKHTKLDIVDSLSALPKTQHDLSSFLVDMWYQTEWMLCFSVNGVFKEVEGQSQGSVLAFTRTFIATPGSSSSLCIVNDKLFVRDTSHQGTQSALFTLVPTAFSSSVPAFSQEQQKMLPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLPSGHTT ------CCCCCCCCC	49.33	25002506
5	Phosphorylation	---MSLPSGHTTGHT ---CCCCCCCCCCCH	48.80	25002506
8	Phosphorylation	MSLPSGHTTGHTDQV CCCCCCCCCCCHHHH	37.69	25002506
9	Phosphorylation	SLPSGHTTGHTDQVV CCCCCCCCCCHHHHH	22.69	25002506
12	Phosphorylation	SGHTTGHTDQVVQRR CCCCCCCHHHHHHHH	29.48	25002506
66	Phosphorylation	HMDSPVRYTPYTISP CCCCCCCCCCCCCCC	16.58	24043423
67	Phosphorylation	MDSPVRYTPYTISPY CCCCCCCCCCCCCCC	10.15	24043423
69	Phosphorylation	SPVRYTPYTISPYNR CCCCCCCCCCCCCCC	14.65	24043423
70	Phosphorylation	PVRYTPYTISPYNRK CCCCCCCCCCCCCCC	19.04	24043423
72	Phosphorylation	RYTPYTISPYNRKGS CCCCCCCCCCCCCCC	17.33	24043423
74	Phosphorylation	TPYTISPYNRKGSFR CCCCCCCCCCCCCCC	22.32	24043423
86	Phosphorylation	SFRKQDQTHVNMERE CCCCCCCCCCCCCCC	35.76	22210691
124	Phosphorylation	TVPFGIKYNEKWLLN EEECCCCCCHHHHHH	27.00	20736484
241	Phosphorylation	NRDTKMASNPRKCMA CCCCCCCCCHHHHHH	43.82	24719451
283	Phosphorylation	GEKCADRSPVCTTFS CCCCCCCCCCCCCCC	23.41	28450419
287	Phosphorylation	ADRSPVCTTFSDTSS CCCCCCCCCCCCCCC	30.98	28450419
288	Phosphorylation	DRSPVCTTFSDTSSN CCCCCCCCCCCCCCC	18.93	28450419
290	Phosphorylation	SPVCTTFSDTSSNIN CCCCCCCCCCCCCHH	37.58	28450419
292	Phosphorylation	VCTTFSDTSSNINSI CCCCCCCCCCCHHHH	32.62	28450419
293	Phosphorylation	CTTFSDTSSNINSIL CCCCCCCCCCHHHHH	26.78	28450419
294	Phosphorylation	TTFSDTSSNINSILE CCCCCCCCCHHHHHH	43.77	28450419
314	Phosphorylation	LCLDGQQSPRATLCG HHCCCCCCCCCEECC	14.41	28450419
407	Phosphorylation	IKILKDPYLRGELLK CEECCCHHHHCHHHH	21.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NXF3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NXF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NXF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XPO1_HUMAN	XPO1	physical	11545741
NXT1_HUMAN	NXT1	physical	19060904

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.