| UniProt ID | BRMS1_HUMAN | |
|---|---|---|
| UniProt AC | Q9HCU9 | |
| Protein Name | Breast cancer metastasis-suppressor 1 | |
| Gene Name | BRMS1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 246 | |
| Subcellular Localization | Nucleus. Cytoplasm. Predominantly nuclear. | |
| Protein Description | Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.. | |
| Protein Sequence | MPVQPPSKDTEEMEAEGDSAAEMNGEEEESEEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPEYTEPLGGLQRSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKLLLYDTLQGELQERIQRLEEDRQSLDLSSEWWDDKLHARGSSRSWDSLPPSKRKKAPLVSGPYIVYMLQEIDILEDWTAIKKARAAVSPQKRKSDGP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 30 | Phosphorylation | MNGEEEESEEERSGS HCCCHHHCHHHHCCC | 54.29 | - | |
| 58 | Phosphorylation | EDYERRRSECVSEML HHHHHHHHHHHHHHH | 33.27 | 30108239 | |
| 62 | Phosphorylation | RRRSECVSEMLDLEK HHHHHHHHHHHHHHH | 29.02 | 30108239 | |
| 75 | Ubiquitination | EKQFSELKEKLFRER HHHHHHHHHHHHHHH | 49.07 | 21906983 | |
| 133 | Acetylation | CLDVIRNKYECELQG HHHHHCHHHHHHHHH | 32.36 | 27452117 | |
| 133 | Ubiquitination | CLDVIRNKYECELQG HHHHHCHHHHHHHHH | 32.36 | - | |
| 142 | Ubiquitination | ECELQGAKQHLESEK HHHHHHHHHHHHHHH | 45.11 | - | |
| 149 | Ubiquitination | KQHLESEKLLLYDTL HHHHHHHHHHHHHHH | 54.43 | 21906983 | |
| 173 | Phosphorylation | RLEEDRQSLDLSSEW HHHHHHHHCCCCHHH | 25.41 | 30266825 | |
| 177 | Phosphorylation | DRQSLDLSSEWWDDK HHHHCCCCHHHHHHH | 26.36 | 30266825 | |
| 178 | Phosphorylation | RQSLDLSSEWWDDKL HHHCCCCHHHHHHHH | 44.53 | 30266825 | |
| 184 | Sumoylation | SSEWWDDKLHARGSS CHHHHHHHHHHCCCC | 39.43 | 28112733 | |
| 184 | Ubiquitination | SSEWWDDKLHARGSS CHHHHHHHHHHCCCC | 39.43 | 2190698 | |
| 209 | Phosphorylation | RKKAPLVSGPYIVYM CCCCCCCCCCCHHEE | 41.56 | 20068231 | |
| 212 | Phosphorylation | APLVSGPYIVYMLQE CCCCCCCCHHEEEHH | 13.42 | 20068231 | |
| 215 | Phosphorylation | VSGPYIVYMLQEIDI CCCCCHHEEEHHHCC | 5.20 | 20068231 | |
| 227 | Phosphorylation | IDILEDWTAIKKARA HCCHHCHHHHHHHHH | 30.72 | 20068231 | |
| 237 | Phosphorylation | KKARAAVSPQKRKSD HHHHHCCCCCHHCCC | 19.52 | 30266825 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BRMS1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BRMS1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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