ANGL4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANGL4_HUMAN
• UniProt AC: Q9BY76
• Protein Name: Angiopoietin-related protein 4
• Gene Name: ANGPTL4
• Organism: Homo sapiens (Human).
• Sequence Length: 406
• Subcellular Localization: Secreted . Secreted, extracellular space, extracellular matrix. The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity)..
• Protein Description: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity)..
• Protein Sequence: MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAERTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSRLHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAYSLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLNGQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAAEAAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSGAPTAGAALML --CCCCCHHHHHHHH	36.87	22468782
17	Phosphorylation	ALMLCAATAVLLSAQ HHHHHHHHHHHHHCC	9.97	22468782
30	Phosphorylation	AQGGPVQSKSPRFAS CCCCCCCCCCCCCCC	35.02	46163247
87	O-linked_Glycosylation	CQGTEGSTDLPLAPE HCCCCCCCCCCCCCH	53.03	OGP
164	Methylation	AKPARRKRLPEMAQP HHHHHHCCCHHHCCC	54.38	-
177	N-linked_Glycosylation	QPVDPAHNVSRLHRL CCCCCCCCHHHHHCC	35.25	UniProtKB CARBOHYD
180	Methylation	DPAHNVSRLHRLPRD CCCCCHHHHHCCCHH	30.17	-
219	Phosphorylation	FLVNCKMTSDGGWTV EEEEEEEECCCCEEE	14.79	22210691
220	Phosphorylation	LVNCKMTSDGGWTVI EEEEEEECCCCEEEE	30.66	22210691
234	Phosphorylation	IQRRHDGSVDFNRPW EEECCCCCCCCCCCH	25.27	22210691
244	Phosphorylation	FNRPWEAYKAGFGDP CCCCHHHHHCCCCCC	7.00	22210691
315	O-linked_Glycosylation	VAGQLGATTVPPSGL CCCCCCCEECCCCCC	26.91	OGP
316	O-linked_Glycosylation	AGQLGATTVPPSGLS CCCCCCEECCCCCCC	30.40	OGP
382	Phosphorylation	KKGIFWKTWRGRYYP HCCCCCHHCCCCCCC	15.81	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANGL4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANGL4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANGL4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTB_HUMAN	ACTB	physical	22573825
WDR47_HUMAN	WDR47	physical	28514442
NMT2_HUMAN	NMT2	physical	28514442
P20D2_HUMAN	PM20D2	physical	28514442
ADPPT_HUMAN	AASDHPPT	physical	28514442
NMT1_HUMAN	NMT1	physical	28514442
ITIH2_HUMAN	ITIH2	physical	28514442
ARMC8_HUMAN	ARMC8	physical	28514442
DNJB4_HUMAN	DNAJB4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.