dbPTM

SMTN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SMTN_HUMAN
UniProt AC	P53814
Protein Name	Smoothelin
Gene Name	SMTN
Organism	Homo sapiens (Human).
Sequence Length	917
Subcellular Localization	Cytoplasm, cytoskeleton. Exhibits a filamentous organization.
Protein Description	Structural protein of the cytoskeleton..
Protein Sequence	MADEALAGLDEGALRKLLEVTADLAERRRIRSAIRELQRQELEREEEALASKRFRAERQDNKENWLHSQQREAEQRAALARLAGQLESMNDVEELTALLRSAGEYEERKLIRAAIRRVRAQEIEAATLAGRLYSGRPNSGSREDSKGLAAHRLEQCEVPEREEQEQQAEVSKPTPTPEGTSQDVTTVTLLLRAPPGSTSSSPASPSSSPTPASPEPPLEPAEAQCLTAEVPGSPEPPPSPPKTTSPEPQESPTLPSTEGQVVNKLLSGPKETPAAQSPTRGPSDTKRADVAGPRPCQRSLSVLSPRQPAQNRESTPLASGPSSFQRAGSVRDRVHKFTSDSPMAARLQDGTPQAALSPLTPARLLGPSLTSTTPASSSSGSSSRGPSDTSSRFSKEQRGVAQPLAQLRSCPQEEGPRGRGLAARPLENRAGGPVARSEEPGAPLPVAVGTAEPGGSMKTTFTIEIKDGRGQASTGRVLLPTGNQRAELTLGLRAPPTLLSTSSGGKSTITRVNSPGTLARLGSVTHVTSFSHAPPSSRGGCSIKMEAEPAEPLAAAVEAANGAEQTRVNKAPEGRSPLSAEELMTIEDEGVLDKMLDQSTDFEERKLIRAALRELRQRKRDQRDKERERRLQEARGRPGEGRGNTATETTTRHSQRAADGSAVSTVTKTERLVHSNDGTRTARTTTVESSFVRRSENGSGSTMMQTKTFSSSSSSKKMGSIFDREDQASPRAGSLAALEKRQAEKKKELMKAQSLPKTSASQARKAMIEKLEKEGAAGSPGGPRAAVQRSTSFGVPNANSIKQMLLDWCRAKTRGYEHVDIQNFSSSWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQNFEVAFSSAEMLVDCVPLVEVDDMMIMGKKPDPKCVFTYVQSLYNHLRRHELRLRGKNV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADEALAGL ------CHHHHHHCC	24.29	22814378
16	Ubiquitination	LDEGALRKLLEVTAD CCHHHHHHHHHHHHH	59.27	-
21	Phosphorylation	LRKLLEVTADLAERR HHHHHHHHHHHHHHH	12.70	28509920
32	Phosphorylation	AERRRIRSAIRELQR HHHHHHHHHHHHHHH	26.19	23532336
88	Phosphorylation	RLAGQLESMNDVEEL HHHHHHHCCCCHHHH	31.32	-
133	Phosphorylation	ATLAGRLYSGRPNSG HHHHHHHHCCCCCCC	14.02	23312004
134	Phosphorylation	TLAGRLYSGRPNSGS HHHHHHHCCCCCCCC	32.68	28270605
139	Phosphorylation	LYSGRPNSGSREDSK HHCCCCCCCCCCCCC	40.61	26055452
141	Phosphorylation	SGRPNSGSREDSKGL CCCCCCCCCCCCCCH	32.11	28270605
145	Phosphorylation	NSGSREDSKGLAAHR CCCCCCCCCCHHHHH	24.70	28270605
193	Phosphorylation	TVTLLLRAPPGSTSS EEEEEEECCCCCCCC	18.01	27251275
233	Phosphorylation	LTAEVPGSPEPPPSP EEEECCCCCCCCCCC	21.74	26657352
239	Phosphorylation	GSPEPPPSPPKTTSP CCCCCCCCCCCCCCC	60.66	26657352
243	Phosphorylation	PPPSPPKTTSPEPQE CCCCCCCCCCCCCCC	37.98	29255136
244	Phosphorylation	PPSPPKTTSPEPQES CCCCCCCCCCCCCCC	48.70	29255136
245	Phosphorylation	PSPPKTTSPEPQESP CCCCCCCCCCCCCCC	32.28	29255136
251	Phosphorylation	TSPEPQESPTLPSTE CCCCCCCCCCCCCCC	20.24	29255136
253	Phosphorylation	PEPQESPTLPSTEGQ CCCCCCCCCCCCCHH	61.66	25159151
256	Phosphorylation	QESPTLPSTEGQVVN CCCCCCCCCCHHHHH	42.05	25850435
257	Phosphorylation	ESPTLPSTEGQVVNK CCCCCCCCCHHHHHH	42.04	28060719
267	O-linked_Glycosylation	QVVNKLLSGPKETPA HHHHHHHCCCCCCCC	64.58	30379171
267	Phosphorylation	QVVNKLLSGPKETPA HHHHHHHCCCCCCCC	64.58	24732914
272	Phosphorylation	LLSGPKETPAAQSPT HHCCCCCCCCCCCCC	25.10	29255136
277	Phosphorylation	KETPAAQSPTRGPSD CCCCCCCCCCCCCCC	24.42	29255136
279	Phosphorylation	TPAAQSPTRGPSDTK CCCCCCCCCCCCCCC	54.21	29255136
283	Phosphorylation	QSPTRGPSDTKRADV CCCCCCCCCCCCCCC	61.82	23403867
285	Phosphorylation	PTRGPSDTKRADVAG CCCCCCCCCCCCCCC	27.11	23403867
297	Phosphorylation	VAGPRPCQRSLSVLS CCCCCCCCCCCCCCC	40.45	24719451
299	Phosphorylation	GPRPCQRSLSVLSPR CCCCCCCCCCCCCCC	10.10	30266825
301	Phosphorylation	RPCQRSLSVLSPRQP CCCCCCCCCCCCCCC	23.43	23401153
304	Phosphorylation	QRSLSVLSPRQPAQN CCCCCCCCCCCCCCC	18.84	30266825
307	Phosphorylation	LSVLSPRQPAQNRES CCCCCCCCCCCCCCC	40.85	27251275
314	Phosphorylation	QPAQNRESTPLASGP CCCCCCCCCCCCCCC	31.89	21815630
315	Phosphorylation	PAQNRESTPLASGPS CCCCCCCCCCCCCCC	19.98	25159151
319	Phosphorylation	RESTPLASGPSSFQR CCCCCCCCCCCHHHC	59.94	22199227
322	Phosphorylation	TPLASGPSSFQRAGS CCCCCCCCHHHCCCC	47.51	22199227
323	Phosphorylation	PLASGPSSFQRAGSV CCCCCCCHHHCCCCH	28.65	22199227
331	Phosphorylation	FQRAGSVRDRVHKFT HHCCCCHHHHHHHCC	27.93	24719451
336	Methylation	SVRDRVHKFTSDSPM CHHHHHHHCCCCCHH	47.70	115980829
338	Phosphorylation	RDRVHKFTSDSPMAA HHHHHHCCCCCHHHH	36.11	24732914
339	Phosphorylation	DRVHKFTSDSPMAAR HHHHHCCCCCHHHHH	38.94	29255136
341	Phosphorylation	VHKFTSDSPMAARLQ HHHCCCCCHHHHHCC	19.15	29255136
351	Phosphorylation	AARLQDGTPQAALSP HHHCCCCCCCHHCCC	22.10	30266825
355	Phosphorylation	QDGTPQAALSPLTPA CCCCCCHHCCCCCHH	11.88	24719451
357	Phosphorylation	GTPQAALSPLTPARL CCCCHHCCCCCHHHH	17.09	30266825
358	Phosphorylation	TPQAALSPLTPARLL CCCHHCCCCCHHHHH	40.89	24719451
360	Phosphorylation	QAALSPLTPARLLGP CHHCCCCCHHHHHCC	20.49	30266825
368	Phosphorylation	PARLLGPSLTSTTPA HHHHHCCCCCCCCCC	42.34	21712546
369	Phosphorylation	ARLLGPSLTSTTPAS HHHHCCCCCCCCCCC	5.02	27251275
370	Phosphorylation	RLLGPSLTSTTPASS HHHCCCCCCCCCCCC	28.50	22199227
371	Phosphorylation	LLGPSLTSTTPASSS HHCCCCCCCCCCCCC	35.26	21815630
372	Phosphorylation	LGPSLTSTTPASSSS HCCCCCCCCCCCCCC	31.40	30576142
373	Phosphorylation	GPSLTSTTPASSSSG CCCCCCCCCCCCCCC	19.34	25159151
376	Phosphorylation	LTSTTPASSSSGSSS CCCCCCCCCCCCCCC	31.77	25159151
377	Phosphorylation	TSTTPASSSSGSSSR CCCCCCCCCCCCCCC	30.54	22199227
378	Phosphorylation	STTPASSSSGSSSRG CCCCCCCCCCCCCCC	35.90	22199227
379	Phosphorylation	TTPASSSSGSSSRGP CCCCCCCCCCCCCCC	44.64	26462736
381	Phosphorylation	PASSSSGSSSRGPSD CCCCCCCCCCCCCCC	27.39	22199227
382	Phosphorylation	ASSSSGSSSRGPSDT CCCCCCCCCCCCCCC	27.81	22199227
383	Phosphorylation	SSSSGSSSRGPSDTS CCCCCCCCCCCCCCH	42.84	25627689
384	Methylation	SSSGSSSRGPSDTSS CCCCCCCCCCCCCHH	64.09	115917293
387	Phosphorylation	GSSSRGPSDTSSRFS CCCCCCCCCCHHCCC	57.24	22199227
389	Phosphorylation	SSRGPSDTSSRFSKE CCCCCCCCHHCCCHH	32.70	22199227
391	Phosphorylation	RGPSDTSSRFSKEQR CCCCCCHHCCCHHHH	39.16	-
394	Phosphorylation	SDTSSRFSKEQRGVA CCCHHCCCHHHHCCC	33.89	25159151
395	Phosphorylation	DTSSRFSKEQRGVAQ CCHHCCCHHHHCCCH	55.97	24719451
409	Phosphorylation	QPLAQLRSCPQEEGP HHHHHHHCCCCCCCC	38.45	28674419
411	Phosphorylation	LAQLRSCPQEEGPRG HHHHHCCCCCCCCCC	45.95	24719451
414	Phosphorylation	LRSCPQEEGPRGRGL HHCCCCCCCCCCCCC	70.06	24719451
419	Methylation	QEEGPRGRGLAARPL CCCCCCCCCCCCCCC	37.93	54559457
424	Methylation	RGRGLAARPLENRAG CCCCCCCCCCCCCCC	30.63	115917297
426	Phosphorylation	RGLAARPLENRAGGP CCCCCCCCCCCCCCC	8.31	24719451
436	Methylation	RAGGPVARSEEPGAP CCCCCCCCCCCCCCC	44.85	24387877
456	Phosphorylation	GTAEPGGSMKTTFTI EECCCCCCCEEEEEE	24.03	28555341
459	Phosphorylation	EPGGSMKTTFTIEIK CCCCCCEEEEEEEEE	20.64	29396449
460	Phosphorylation	PGGSMKTTFTIEIKD CCCCCEEEEEEEEEC	17.17	29396449
462	Phosphorylation	GSMKTTFTIEIKDGR CCCEEEEEEEEECCC	18.66	29396449
481	Phosphorylation	TGRVLLPTGNQRAEL EEEEEEECCCCCEEE	49.05	-
497	Phosphorylation	LGLRAPPTLLSTSSG EECCCCCEEEECCCC	38.99	25867546
500	Phosphorylation	RAPPTLLSTSSGGKS CCCCEEEECCCCCCC	29.38	20068231
501	Phosphorylation	APPTLLSTSSGGKST CCCEEEECCCCCCCE	27.21	20068231
502	Phosphorylation	PPTLLSTSSGGKSTI CCEEEECCCCCCCEE	24.49	22199227
503	Phosphorylation	PTLLSTSSGGKSTIT CEEEECCCCCCCEEE	52.21	26055452
506	Ubiquitination	LSTSSGGKSTITRVN EECCCCCCCEEEEEC	48.20	-
507	Phosphorylation	STSSGGKSTITRVNS ECCCCCCCEEEEECC	28.46	24732914
508	Phosphorylation	TSSGGKSTITRVNSP CCCCCCCEEEEECCC	29.83	24732914
510	Phosphorylation	SGGKSTITRVNSPGT CCCCCEEEEECCCCC	28.75	24732914
514	Phosphorylation	STITRVNSPGTLARL CEEEEECCCCCEEEC	23.11	30266825
517	Phosphorylation	TRVNSPGTLARLGSV EEECCCCCEEECCCE	22.19	30266825
523	Phosphorylation	GTLARLGSVTHVTSF CCEEECCCEEEEEEE	28.56	22617229
525	Phosphorylation	LARLGSVTHVTSFSH EEECCCEEEEEEECC	16.60	26657352
528	Phosphorylation	LGSVTHVTSFSHAPP CCCEEEEEEECCCCC	19.22	23312004
529	Phosphorylation	GSVTHVTSFSHAPPS CCEEEEEEECCCCCC	24.54	26657352
531	Phosphorylation	VTHVTSFSHAPPSSR EEEEEEECCCCCCCC	20.64	23312004
536	Phosphorylation	SFSHAPPSSRGGCSI EECCCCCCCCCCEEE	31.44	23312004
537	Phosphorylation	FSHAPPSSRGGCSIK ECCCCCCCCCCEEEE	40.49	23312004
538	Methylation	SHAPPSSRGGCSIKM CCCCCCCCCCEEEEE	50.27	115917301
556	Phosphorylation	PAEPLAAAVEAANGA CCHHHHHHHHHHCCC	8.28	24719451
568	Phosphorylation	NGAEQTRVNKAPEGR CCCHHHCCCCCCCCC	11.07	24719451
576	Phosphorylation	NKAPEGRSPLSAEEL CCCCCCCCCCCHHHH	40.84	25159151
577	Phosphorylation	KAPEGRSPLSAEELM CCCCCCCCCCHHHHC	29.04	24719451
579	Phosphorylation	PEGRSPLSAEELMTI CCCCCCCCHHHHCCC	36.70	22617229
585	Phosphorylation	LSAEELMTIEDEGVL CCHHHHCCCCCHHHH	33.56	29396449
599	Phosphorylation	LDKMLDQSTDFEERK HHHHHHCCCCHHHHH	29.61	28555341
628	Phosphorylation	DQRDKERERRLQEAR HHHHHHHHHHHHHHH	43.15	27251275
645	Phosphorylation	PGEGRGNTATETTTR CCCCCCCCCCCCCCH	37.47	28348404
647	Phosphorylation	EGRGNTATETTTRHS CCCCCCCCCCCCHHH	31.65	28348404
649	Phosphorylation	RGNTATETTTRHSQR CCCCCCCCCCHHHHH	29.16	28348404
650	Phosphorylation	GNTATETTTRHSQRA CCCCCCCCCHHHHHC	18.66	28348404
651	Phosphorylation	NTATETTTRHSQRAA CCCCCCCCHHHHHCC	33.53	28348404
654	Phosphorylation	TETTTRHSQRAADGS CCCCCHHHHHCCCCC	20.33	28348404
661	Phosphorylation	SQRAADGSAVSTVTK HHHCCCCCCEEEEEE	26.50	27499020
664	Phosphorylation	AADGSAVSTVTKTER CCCCCCEEEEEECEE	19.51	28348404
665	Phosphorylation	ADGSAVSTVTKTERL CCCCCEEEEEECEEE	26.12	28348404
667	Phosphorylation	GSAVSTVTKTERLVH CCCEEEEEECEEEEE	32.13	28348404
668	Sumoylation	SAVSTVTKTERLVHS CCEEEEEECEEEEEC	44.01	-
668	Sumoylation	SAVSTVTKTERLVHS CCEEEEEECEEEEEC	44.01	-
684	Phosphorylation	DGTRTARTTTVESSF CCCCEEEEEEEEECE	25.10	20068231
685	Phosphorylation	GTRTARTTTVESSFV CCCEEEEEEEEECEE	24.24	20068231
686	Phosphorylation	TRTARTTTVESSFVR CCEEEEEEEEECEEE	22.97	20068231
689	Phosphorylation	ARTTTVESSFVRRSE EEEEEEEECEEECCC	25.41	26657352
690	Phosphorylation	RTTTVESSFVRRSEN EEEEEEECEEECCCC	17.79	20068231
695	Phosphorylation	ESSFVRRSENGSGST EECEEECCCCCCCCE	25.50	20068231
699	Phosphorylation	VRRSENGSGSTMMQT EECCCCCCCCEEEEE	40.95	20068231
701	Phosphorylation	RSENGSGSTMMQTKT CCCCCCCCEEEEEEE	18.15	20068231
702	Phosphorylation	SENGSGSTMMQTKTF CCCCCCCEEEEEEEE	21.86	20068231
706	Phosphorylation	SGSTMMQTKTFSSSS CCCEEEEEEEECCCC	17.73	20068231
708	Phosphorylation	STMMQTKTFSSSSSS CEEEEEEEECCCCCC	31.94	26437602
710	Phosphorylation	MMQTKTFSSSSSSKK EEEEEEECCCCCCCC	34.24	20068231
711	Phosphorylation	MQTKTFSSSSSSKKM EEEEEECCCCCCCCC	30.01	20068231
712	Phosphorylation	QTKTFSSSSSSKKMG EEEEECCCCCCCCCC	32.80	20068231
713	Phosphorylation	TKTFSSSSSSKKMGS EEEECCCCCCCCCCC	40.35	26657352
714	Phosphorylation	KTFSSSSSSKKMGSI EEECCCCCCCCCCCC	48.39	26437602
715	Phosphorylation	TFSSSSSSKKMGSIF EECCCCCCCCCCCCC	37.94	26657352
716	Acetylation	FSSSSSSKKMGSIFD ECCCCCCCCCCCCCC	49.04	7672263
720	Phosphorylation	SSSKKMGSIFDREDQ CCCCCCCCCCCCCHH	19.31	26657352
729	Phosphorylation	FDREDQASPRAGSLA CCCCHHCCCCHHHHH	14.86	29255136
734	Phosphorylation	QASPRAGSLAALEKR HCCCCHHHHHHHHHH	17.53	26657352
739	Phosphorylation	AGSLAALEKRQAEKK HHHHHHHHHHHHHHH	41.27	27251275
740	Ubiquitination	GSLAALEKRQAEKKK HHHHHHHHHHHHHHH	51.14	-
750	Phosphorylation	AEKKKELMKAQSLPK HHHHHHHHHHHCCCC	3.38	27251275
754	Phosphorylation	KELMKAQSLPKTSAS HHHHHHHCCCCCCHH	52.04	20068231
757	Acetylation	MKAQSLPKTSASQAR HHHHCCCCCCHHHHH	61.48	7972615
761	Phosphorylation	SLPKTSASQARKAMI CCCCCCHHHHHHHHH	24.92	23532336
765	Acetylation	TSASQARKAMIEKLE CCHHHHHHHHHHHHH	45.37	7972631
765	Methylation	TSASQARKAMIEKLE CCHHHHHHHHHHHHH	45.37	7972631
779	Phosphorylation	EKEGAAGSPGGPRAA HHCCCCCCCCCHHHH	18.69	29255136
790	Phosphorylation	PRAAVQRSTSFGVPN HHHHHHHCCCCCCCC	16.00	30266825
791	Phosphorylation	RAAVQRSTSFGVPNA HHHHHHCCCCCCCCH	30.20	30266825
792	Phosphorylation	AAVQRSTSFGVPNAN HHHHHCCCCCCCCHH	22.65	30266825
800	Phosphorylation	FGVPNANSIKQMLLD CCCCCHHHHHHHHHH	28.84	24702127
814	Phosphorylation	DWCRAKTRGYEHVDI HHHHHHCCCCCCEEC	45.01	24719451
819	Phosphorylation	KTRGYEHVDIQNFSS HCCCCCCEECCCCCC	4.66	27251275
839	Phosphorylation	MAFCALVHNFFPEAF HHHHHHHHHHCHHHH	26.65	24719451
848	Phosphorylation	FFPEAFDYGQLSPQN HCHHHHHCCCCCCCH	10.58	26657352
852	Phosphorylation	AFDYGQLSPQNRRQN HHHCCCCCCCHHHHC	19.29	26657352
864	Phosphorylation	RQNFEVAFSSAEMLV HHCCEEEECCHHHHH	7.77	24719451
877	Phosphorylation	LVDCVPLVEVDDMMI HHCCEEEEEECCEEE	5.73	24719451
885	Phosphorylation	EVDDMMIMGKKPDPK EECCEEECCCCCCCC	3.32	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SMTN_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SMTN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SMTN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SMTN_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SMTN_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-357 AND THR-360, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-514, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301; SER-304; SER-341;THR-351; SER-357; THR-360; SER-503; SER-514; SER-576 AND SER-729,PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-373 (ISOFORMS B AND B2),AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, AND MASSSPECTROMETRY.	15302935 [Abstract]