dbPTM

LYPD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LYPD3_HUMAN
UniProt AC	O95274
Protein Name	Ly6/PLAUR domain-containing protein 3
Gene Name	LYPD3
Organism	Homo sapiens (Human).
Sequence Length	346
Subcellular Localization	Cell membrane Lipid-anchor, GPI-anchor.
Protein Description	Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression..
Protein Sequence	MDPARKAGAQAMIWTAGWLLLLLLRGGAQALECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLTSRALDPAGNESAYPPNGVECYSCVGLSREACQGTSPPVVSCYNASDHVYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGSCCQGSRCNSDLRNKTYFSPRIPPLVRLPPPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPTSQTPRQGVEHEASRDEEPRLTGGAAGHQDRSNSGQYPAKGGPQQPHNKGCVAPTAGLAALLLAVAAGVLL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
118	N-linked_Glycosylation	DRCNAKLNLTSRALD HHHHCCCCCCCCCCC	40.33	UniProtKB CARBOHYD
163	N-linked_Glycosylation	PPVVSCYNASDHVYK CCEEEEEECCCCCCC	36.98	UniProtKB CARBOHYD
163	N-linked_Glycosylation	PPVVSCYNASDHVYK CCEEEEEECCCCCCC	36.98	17623646
176	N-linked_Glycosylation	YKGCFDGNVTLTAAN CCCCCCCCEEEEEEE	25.99	UniProtKB CARBOHYD
183	N-linked_Glycosylation	NVTLTAANVTVSLPV CEEEEEEEEEEEECC	27.77	UniProtKB CARBOHYD
205	Phosphorylation	FCTRDGVTGPGFTLS EECCCCCCCCCEEEC	43.09	-
232	Phosphorylation	LRNKTYFSPRIPPLV HCCCCCCCCCCCCCC	11.67	-
277	Phosphorylation	KPMPAPTSQTPRQGV CCCCCCCCCCCCCCC	30.88	27050516
289	Phosphorylation	QGVEHEASRDEEPRL CCCCCCCCCCCCCCC	36.96	20068231
289	O-linked_Glycosylation	QGVEHEASRDEEPRL CCCCCCCCCCCCCCC	36.96	36023823
297	O-linked_Glycosylation	RDEEPRLTGGAAGHQ CCCCCCCCCCCCCCC	34.54	55826595
326	GPI-anchor	QQPHNKGCVAPTAGL CCCCCCCCCCCHHHH	2.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LYPD3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LYPD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LYPD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VDAC3_HUMAN	VDAC3	physical	26186194
XPO7_HUMAN	XPO7	physical	26186194
TTI2_HUMAN	TTI2	physical	26186194
AT2B4_HUMAN	ATP2B4	physical	26186194
BZW2_HUMAN	BZW2	physical	26186194
BZW1_HUMAN	BZW1	physical	26186194
SL9A1_HUMAN	SLC9A1	physical	26186194
FLVC1_HUMAN	FLVCR1	physical	26186194
TNPO2_HUMAN	TNPO2	physical	26186194
SYMPK_HUMAN	SYMPK	physical	26186194
RBM26_HUMAN	RBM26	physical	26186194
PHTF2_HUMAN	PHTF2	physical	26186194
TM214_HUMAN	TMEM214	physical	26186194
GPAA1_HUMAN	GPAA1	physical	26186194
TARB1_HUMAN	TARBP1	physical	26186194
GBF1_HUMAN	GBF1	physical	26186194
SCAM1_HUMAN	SCAMP1	physical	26186194
S35B2_HUMAN	SLC35B2	physical	26186194
WFS1_HUMAN	WFS1	physical	26186194
TMM94_HUMAN	KIAA0195	physical	26186194
CKAP4_HUMAN	CKAP4	physical	26186194
GHITM_HUMAN	GHITM	physical	26186194
BTAF1_HUMAN	BTAF1	physical	26186194
HSDL1_HUMAN	HSDL1	physical	26186194
SLMAP_HUMAN	SLMAP	physical	26186194
PIGS_HUMAN	PIGS	physical	26186194
PIGU_HUMAN	PIGU	physical	26186194
PDS5B_HUMAN	PDS5B	physical	26186194
PDS5A_HUMAN	PDS5A	physical	26186194
FAKD2_HUMAN	FASTKD2	physical	26186194
DAAF5_HUMAN	DNAAF5	physical	26186194
HEAT3_HUMAN	HEATR3	physical	26186194
D19L1_HUMAN	DPY19L1	physical	26186194
TBRG4_HUMAN	TBRG4	physical	26186194
STRN_HUMAN	STRN	physical	26186194
PLAP_HUMAN	PLAA	physical	26186194
QSOX2_HUMAN	QSOX2	physical	26186194
AT11C_HUMAN	ATP11C	physical	26186194
ECM29_HUMAN	KIAA0368	physical	26186194
RFT1_HUMAN	RFT1	physical	26186194
TOM40_HUMAN	TOMM40	physical	26186194
PTN1_HUMAN	PTPN1	physical	26186194
LAP4B_HUMAN	LAPTM4B	physical	26186194
ATR_HUMAN	ATR	physical	26186194
GNPAT_HUMAN	GNPAT	physical	26186194
RUS1_HUMAN	C16orf58	physical	26186194
COMD9_HUMAN	COMMD9	physical	26186194
TNPO3_HUMAN	TNPO3	physical	26186194
DYN3_HUMAN	DNM3	physical	26186194
MTCH2_HUMAN	MTCH2	physical	26186194
AAAS_HUMAN	AAAS	physical	26186194
K1161_HUMAN	KIAA1161	physical	26186194
TPPC5_HUMAN	TRAPPC5	physical	26186194
THADA_HUMAN	THADA	physical	26186194
MKS3_HUMAN	TMEM67	physical	26186194
UBP22_HUMAN	USP22	physical	26186194
CLDN1_HUMAN	CLDND1	physical	26186194
TPPC3_HUMAN	TRAPPC3	physical	26186194
GLT10_HUMAN	GALNT10	physical	26186194
UBP24_HUMAN	USP24	physical	26186194
S41A1_HUMAN	SLC41A1	physical	26186194
UB2Q1_HUMAN	UBE2Q1	physical	26186194
ASPH2_HUMAN	ASPHD2	physical	26186194
LPAR1_HUMAN	LPAR1	physical	26186194
BRAT1_HUMAN	BRAT1	physical	26186194
ENDD1_HUMAN	ENDOD1	physical	26186194
MTOR_HUMAN	MTOR	physical	26186194
MTX1_HUMAN	MTX1	physical	26186194
CTL1_HUMAN	SLC44A1	physical	26186194
NDC1_HUMAN	NDC1	physical	26186194
HELLS_HUMAN	HELLS	physical	26186194
ZNT7_HUMAN	SLC30A7	physical	26186194
GPI8_HUMAN	PIGK	physical	26186194
CND1_HUMAN	NCAPD2	physical	26186194
NEMP1_HUMAN	TMEM194A	physical	26186194
CKAP5_HUMAN	CKAP5	physical	26186194
NCEH1_HUMAN	NCEH1	physical	26186194
TM245_HUMAN	TMEM245	physical	26186194
LMBR1_HUMAN	LMBR1	physical	26186194
CLAP2_HUMAN	CLASP2	physical	26186194
C2CD5_HUMAN	C2CD5	physical	26186194
ARFP2_HUMAN	ARFIP2	physical	26186194
XPO6_HUMAN	XPO6	physical	26186194
ELOV4_HUMAN	ELOVL4	physical	26186194
COT2_HUMAN	NR2F2	physical	26186194
ORC5_HUMAN	ORC5	physical	26186194
CLCN7_HUMAN	CLCN7	physical	26186194
PIGA_HUMAN	PIGA	physical	26186194
SPCS1_HUMAN	SPCS1	physical	26186194
BOD1_HUMAN	BOD1	physical	26186194
CLCN3_HUMAN	CLCN3	physical	26186194
HIP1R_HUMAN	HIP1R	physical	26186194
QSOX1_HUMAN	QSOX1	physical	26186194
DCNL5_HUMAN	DCUN1D5	physical	26186194
GDPD5_HUMAN	GDPD5	physical	26186194
LNP_HUMAN	KIAA1715	physical	26186194
GLT10_HUMAN	GALNT10	physical	28514442
S41A1_HUMAN	SLC41A1	physical	28514442
PHTF2_HUMAN	PHTF2	physical	28514442
D19L1_HUMAN	DPY19L1	physical	28514442
TM245_HUMAN	TMEM245	physical	28514442
TMM94_HUMAN	KIAA0195	physical	28514442
CLDN1_HUMAN	CLDND1	physical	28514442
REEP1_HUMAN	REEP1	physical	28514442
SCAM1_HUMAN	SCAMP1	physical	28514442
BOD1_HUMAN	BOD1	physical	28514442
UBP24_HUMAN	USP24	physical	28514442
SLMAP_HUMAN	SLMAP	physical	28514442
ARFP2_HUMAN	ARFIP2	physical	28514442
CTL1_HUMAN	SLC44A1	physical	28514442
PDS5B_HUMAN	PDS5B	physical	28514442
UB2Q1_HUMAN	UBE2Q1	physical	28514442
ENDD1_HUMAN	ENDOD1	physical	28514442
ORC5_HUMAN	ORC5	physical	28514442
GHITM_HUMAN	GHITM	physical	28514442
HELLS_HUMAN	HELLS	physical	28514442
CLAP2_HUMAN	CLASP2	physical	28514442
ASPH2_HUMAN	ASPHD2	physical	28514442
SYMPK_HUMAN	SYMPK	physical	28514442
TM214_HUMAN	TMEM214	physical	28514442
XPO7_HUMAN	XPO7	physical	28514442
TARB1_HUMAN	TARBP1	physical	28514442
XPO6_HUMAN	XPO6	physical	28514442
CLCN7_HUMAN	CLCN7	physical	28514442
PDS5A_HUMAN	PDS5A	physical	28514442
GPAA1_HUMAN	GPAA1	physical	28514442
FLVC1_HUMAN	FLVCR1	physical	28514442
COMD9_HUMAN	COMMD9	physical	28514442
AT2B4_HUMAN	ATP2B4	physical	28514442
PLAP_HUMAN	PLAA	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442
MTOR_HUMAN	MTOR	physical	28514442
SL9A1_HUMAN	SLC9A1	physical	28514442
STRN_HUMAN	STRN	physical	28514442
C2CD5_HUMAN	C2CD5	physical	28514442
DYN3_HUMAN	DNM3	physical	28514442
SPCS1_HUMAN	SPCS1	physical	28514442
LPAR1_HUMAN	LPAR1	physical	28514442
DCNL5_HUMAN	DCUN1D5	physical	28514442
GNPAT_HUMAN	GNPAT	physical	28514442
TNPO3_HUMAN	TNPO3	physical	28514442
K1161_HUMAN	KIAA1161	physical	28514442
COT2_HUMAN	NR2F2	physical	28514442
TBRG4_HUMAN	TBRG4	physical	28514442
NCEH1_HUMAN	NCEH1	physical	28514442
ATR_HUMAN	ATR	physical	28514442
LAP4B_HUMAN	LAPTM4B	physical	28514442
PIGU_HUMAN	PIGU	physical	28514442
MKS3_HUMAN	TMEM67	physical	28514442
PHTF1_HUMAN	PHTF1	physical	28514442
LNP_HUMAN	KIAA1715	physical	28514442
LMBR1_HUMAN	LMBR1	physical	28514442
UBP22_HUMAN	USP22	physical	28514442
HEAT3_HUMAN	HEATR3	physical	28514442
RFT1_HUMAN	RFT1	physical	28514442
GBF1_HUMAN	GBF1	physical	28514442
PX11B_HUMAN	PEX11B	physical	28514442
ECM29_HUMAN	KIAA0368	physical	28514442
BZW2_HUMAN	BZW2	physical	28514442
TPPC5_HUMAN	TRAPPC5	physical	28514442
HIP1R_HUMAN	HIP1R	physical	28514442
MTX1_HUMAN	MTX1	physical	28514442
EBP_HUMAN	EBP	physical	28514442
QSOX1_HUMAN	QSOX1	physical	28514442
MTCH2_HUMAN	MTCH2	physical	28514442
TNPO2_HUMAN	TNPO2	physical	28514442
HSDL1_HUMAN	HSDL1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LYPD3_HUMAN

Related Literatures of Post-Translational Modification