REEP1_HUMAN - dbPTM
REEP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID REEP1_HUMAN
UniProt AC Q9H902
Protein Name Receptor expression-enhancing protein 1
Gene Name REEP1
Organism Homo sapiens (Human).
Sequence Length 201
Subcellular Localization Membrane . Mitochondrion membrane
Multi-pass membrane protein . Endoplasmic reticulum . Localizes to endoplasmic reticulum tubular network.
Protein Description Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors. [PubMed: 20200447 May play a role in long-term axonal maintenance]
Protein Sequence MVSWIISRLVVLIFGTLYPAYYSYKAVKSKDIKEYVKWMMYWIIFALFTTAETFTDIFLCWFPFYYELKIAFVAWLLSPYTKGSSLLYRKFVHPTLSSKEKEIDDCLVQAKDRSYDALVHFGKRGLNVAATAAVMAASKGQGALSERLRSFSMQDLTTIRGDGAPAPSGPPPPGSGRASGKHGQPKMSRSASESASSSGTA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MVSWIISRLV
-----CHHHHHHHHH		15.9729507054
15 (in isoform 3)Phosphorylation-14.0723663014
17 (in isoform 3)Phosphorylation-5.0223663014
18PhosphorylationVLIFGTLYPAYYSYK
HHHHHCHHHHHHHHH		5.9023663014
21PhosphorylationFGTLYPAYYSYKAVK
HHCHHHHHHHHHHHH		6.6123663014
23 (in isoform 3)Phosphorylation-13.8923663014
24PhosphorylationLYPAYYSYKAVKSKD
HHHHHHHHHHHHCCC		6.1923663014
25 (in isoform 3)Phosphorylation-40.5423663014
28 (in isoform 3)Phosphorylation-57.5623663014
29 (in isoform 3)Phosphorylation-29.0323663014
30 (in isoform 3)Phosphorylation-58.7323663014
31 (in isoform 3)Phosphorylation-65.3723663014
72UbiquitinationYYELKIAFVAWLLSP
HHHHHHHHHHHHHCC		4.3629967540
73 (in isoform 4)Phosphorylation-2.49-
84UbiquitinationLSPYTKGSSLLYRKF
HCCCCCCCHHHHHHH		21.2629967540
84 (in isoform 4)Phosphorylation-21.26-
84PhosphorylationLSPYTKGSSLLYRKF
HCCCCCCCHHHHHHH		21.2618491316
85PhosphorylationSPYTKGSSLLYRKFV
CCCCCCCHHHHHHHC		30.9418491316
99UbiquitinationVHPTLSSKEKEIDDC
CCCCCCCCCCCHHHH		70.2329967540
106UbiquitinationKEKEIDDCLVQAKDR
CCCCHHHHHHHHCCC		3.3929967540
111UbiquitinationDDCLVQAKDRSYDAL
HHHHHHHCCCCHHHH		36.2629967540
114PhosphorylationLVQAKDRSYDALVHF
HHHHCCCCHHHHHHH		37.1827251275
115PhosphorylationVQAKDRSYDALVHFG
HHHCCCCHHHHHHHH		13.2127251275
118UbiquitinationKDRSYDALVHFGKRG
CCCCHHHHHHHHHHC		2.5529967540
125PhosphorylationLVHFGKRGLNVAATA
HHHHHHHCHHHHHHH		25.7032142685
134 (in isoform 4)Phosphorylation-2.1926437602
138PhosphorylationTAAVMAASKGQGALS
HHHHHHHHCCCCHHH		27.99-
150PhosphorylationALSERLRSFSMQDLT
HHHHHHHHCCHHHCC		26.6830266825
152PhosphorylationSERLRSFSMQDLTTI
HHHHHHCCHHHCCEE		19.4430266825
157PhosphorylationSFSMQDLTTIRGDGA
HCCHHHCCEECCCCC		28.5930266825
158PhosphorylationFSMQDLTTIRGDGAP
CCHHHCCEECCCCCC		18.9030266825
159PhosphorylationSMQDLTTIRGDGAPA
CHHHCCEECCCCCCC		3.7932142685
175PhosphorylationSGPPPPGSGRASGKH
CCCCCCCCCCCCCCC		30.7728674419
198PhosphorylationASESASSSGTA----
HHHHHHCCCCC----		37.3523532336
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
152SPhosphorylationKinaseAMPKA2P54646
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of REEP1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of REEP1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PLS1_HUMANPLSCR1physical
28514442
REEP4_HUMANREEP4physical
28514442
NCAM1_HUMANNCAM1physical
28514442
1433Z_HUMANYWHAZphysical
28514442
REEP2_HUMANREEP2physical
28514442
1433G_HUMANYWHAGphysical
28514442
Drug and Disease Associations
Kegg Disease
H00266 Hereditary spastic paraplegia (SPG)
OMIM Disease
610250Spastic paraplegia 31, autosomal dominant (SPG31)
614751Neuronopathy, distal hereditary motor, 5B (HMN5B)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of REEP1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, AND MASSSPECTROMETRY.

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