REEP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: REEP2_HUMAN
• UniProt AC: Q9BRK0
• Protein Name: Receptor expression-enhancing protein 2
• Gene Name: REEP2
• Organism: Homo sapiens (Human).
• Sequence Length: 252
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity)..
• Protein Sequence: MVSWIISRLVVLIFGTLYPAYSSYKAVKTKNVKEYVKWMMYWIVFAFFTTAETLTDIVLSWFPFYFELKIAFVIWLLSPYTKGSSVLYRKFVHPTLSNKEKEIDEYITQARDKSYETMMRVGKRGLNLAANAAVTAAAKGVLSEKLRSFSMQDLTLIRDEDALPLQRPDGRLRPSPGSLLDTIEDLGDDPALSLRSSTNPADSRTEASEDDMGDKAPKRAKPIKKAPKAEPLASKTLKTRPKKKTSGGGDSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MVSWIISRLV -----CHHHHHHHHH	15.97	29507054
16	Phosphorylation	LVVLIFGTLYPAYSS HHHHHHHCHHHHHHC	16.63	23607784
18	Phosphorylation	VLIFGTLYPAYSSYK HHHHHCHHHHHHCHH	5.90	23607784
21	Phosphorylation	FGTLYPAYSSYKAVK HHCHHHHHHCHHHHH	8.14	23607784
22	Phosphorylation	GTLYPAYSSYKAVKT HCHHHHHHCHHHHHC	29.33	23607784
23	Phosphorylation	TLYPAYSSYKAVKTK CHHHHHHCHHHHHCC	20.27	23607784
24	Phosphorylation	LYPAYSSYKAVKTKN HHHHHHCHHHHHCCC	9.31	23607784
97	Phosphorylation	KFVHPTLSNKEKEID HHCCCCCCCCHHHHH	48.62	22496350
101	Ubiquitination	PTLSNKEKEIDEYIT CCCCCCHHHHHHHHH	62.67	-
106	Phosphorylation	KEKEIDEYITQARDK CHHHHHHHHHHHHHH	12.91	22673903
108	Phosphorylation	KEIDEYITQARDKSY HHHHHHHHHHHHHHH	18.44	22673903
113	Ubiquitination	YITQARDKSYETMMR HHHHHHHHHHHHHHH	49.75	-
145	Ubiquitination	AKGVLSEKLRSFSMQ HHCHHHHHHHHCCCC	45.91	-
148	Phosphorylation	VLSEKLRSFSMQDLT HHHHHHHHCCCCCCE	31.91	30266825
150	Phosphorylation	SEKLRSFSMQDLTLI HHHHHHCCCCCCEEE	19.44	30266825
155	Phosphorylation	SFSMQDLTLIRDEDA HCCCCCCEEECCCCC	28.55	30266825
175	Phosphorylation	PDGRLRPSPGSLLDT CCCCCCCCCCCHHHH	35.14	22496350
178	Phosphorylation	RLRPSPGSLLDTIED CCCCCCCCHHHHHHH	29.19	27732954
182	Phosphorylation	SPGSLLDTIEDLGDD CCCCHHHHHHHHCCC	26.66	27732954
193	Phosphorylation	LGDDPALSLRSSTNP HCCCCCHHHCCCCCC	24.68	24719451
205	Phosphorylation	TNPADSRTEASEDDM CCCCCCCCCCCCCCC	39.59	28122231
208	Phosphorylation	ADSRTEASEDDMGDK CCCCCCCCCCCCCCC	35.01	22617229
242	Acetylation	KTLKTRPKKKTSGGG CCCCCCCCCCCCCCC	64.71	7667095
243	Acetylation	TLKTRPKKKTSGGGD CCCCCCCCCCCCCCC	65.06	7667105
244	Acetylation	LKTRPKKKTSGGGDS CCCCCCCCCCCCCCC	54.79	7667115

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
150	S	Phosphorylation	Kinase	AMPKA2	P54646	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of REEP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of REEP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCIP2_HUMAN	KCNIP2	physical	28514442
DSG4_HUMAN	DSG4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.