TMM94_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMM94_HUMAN
• UniProt AC: Q12767
• Protein Name: Transmembrane protein 94 {ECO:0000312|HGNC:HGNC:28983}
• Gene Name: TMEM94 {ECO:0000312|HGNC:HGNC:28983}
• Organism: Homo sapiens (Human).
• Sequence Length: 1356
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MDLKEKHLGEPPSALGLSTRKALSVLKEQLEAVLEGHLRERKKCLTWKEVWRSSFLHHSNRCSCFHWPGASLMLLAVLLLLGCCGGQPAGSRGVGLVNASALFLLLLLNLVLIGRQDRLKRREVERRLRGIIDQIQDALRDGREIQWPSAMYPDLHMPFAPSWSLHWAYRDGHLVNLPVSLLVEGDIIALRPGQESFASLRGIKDDEHIVLEPGDLFPPFSPPPSPRGEVERGPQSPQQHRLFRVLETPVIDNIRWCLDMALSRPVTALDNERFTVQSVMLHYAVPVVLAGFLITNALRFIFSAPGVTSWQYTLLQLQVNGVLPILPLLFPVLWVLATACGEARVLAQMSKASPSSLLAKFSEDTLSSYTEAVSSQEMLRCIWGHFLRVLGGTSPTLSHSSSLLHSLGSVTVLCCVDKQGILSWPNPSPETVLFFSGKVEPPHSSHEDLTDGLSTRSFCHPEPHERDALLAGSLNNTLHLSNEQERGDWPGEAPKPPEPYSHHKAHGRSKHPSGSNVSFSRDTEGGEEEPSKTQPGMESDPYEAEDFVCDYHLEMLSLSQDQQNPSCIQFDDSNWQLHLTSLKPLGLNVLLNLCDASVTERLCRFSDHLCNIALQESHSAVLPVHVPWGLCELARLIGFTPGAKELFKQENHLALYRLPSAETMKETSLGRLSCVTKRRPPLSHMISLFIKDTTTSTEQMLSHGTADVVLEACTDFWDGADIYPLSGSDRKKVLDFYQRACLSGYCSAFAYKPMNCALSSQLNGKCIELVQVPGQSSIFTMCELPSTIPIKQNARRSSWSSDEGIGEVLEKEDCMQALSGQIFMGMVSSQYQARLDIVRLIDGLVNACIRFVYFSLEDELKSKVFAEKMGLETGWNCHISLTPNGDMPGSEIPPSSPSHAGSLHDDLNQVSRDDAEGLLLMEEEGHSDLISFQPTDSDIPSFLEDSNRAKLPRGIHQVRPHLQNIDNVPLLVPLFTDCTPETMCEMIKIMQEYGEVTCCLGSSANLRNSCLFLQSDISIALDPLYPSRCSWETFGYATSISMAQASDGLSPLQLSGQLNSLPCSLTFRQEETISIIRLIEQARHATYGIRKCFLFLLQCQLTLVVIQFLSCLVQLPPLLSTTDILWLSCFCYPLLSISLLGKPPHSSIMSMATGKNLQSIPKKTQHYFLLCFLLKFSLTISSCLICFGFTLQSFCDSSRDRNLTNCSSVMLPSNDDRAPAWFEDFANGLLSAQKLTAALIVLHTVFISITHVHRTKPLWRKSPLTNLWWAVTVPVVLLGQVVQTAVDLQLWTHRDSHVHFGLEDVPLLTWLLGCLSLVLVVVTNEIVKLHEIRVRVRYQKRQKLQFETKLGMNSPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MDLKEKHLGEPPS --CCCCHHHCCCCCH		-
6 (in isoform 1)	Ubiquitination	-		21890473
6 (in isoform 2)	Ubiquitination	-		21890473
6	Acetylation	--MDLKEKHLGEPPS --CCCCHHHCCCCCH		11792051
13	Phosphorylation	KHLGEPPSALGLSTR HHCCCCCHHHCCCHH		24719451
19	Phosphorylation	PSALGLSTRKALSVL CHHHCCCHHHHHHHH		24719451
24	Phosphorylation	LSTRKALSVLKEQLE CCHHHHHHHHHHHHH		-
27	Ubiquitination	RKALSVLKEQLEAVL HHHHHHHHHHHHHHH		-
28	Phosphorylation	KALSVLKEQLEAVLE HHHHHHHHHHHHHHH		30257219
29	Phosphorylation	ALSVLKEQLEAVLEG HHHHHHHHHHHHHHH		30257219
221	Phosphorylation	GDLFPPFSPPPSPRG CCCCCCCCCCCCCCC		30266825
225	Phosphorylation	PPFSPPPSPRGEVER CCCCCCCCCCCCCCC		30266825
236	Phosphorylation	EVERGPQSPQQHRLF CCCCCCCCHHHHHHH		-
351	Ubiquitination	RVLAQMSKASPSSLL HHHHHHHCCCHHHHH		-
362	Phosphorylation	SSLLAKFSEDTLSSY HHHHHHCCHHHHHHH		19369195
365	Phosphorylation	LAKFSEDTLSSYTEA HHHCCHHHHHHHHHH		27080861
367	Phosphorylation	KFSEDTLSSYTEAVS HCCHHHHHHHHHHCC		19060867
368	Phosphorylation	FSEDTLSSYTEAVSS CCHHHHHHHHHHCCC		18691976
369	Phosphorylation	SEDTLSSYTEAVSSQ CHHHHHHHHHHCCCH		18691976
370	Phosphorylation	EDTLSSYTEAVSSQE HHHHHHHHHHCCCHH		18691976
374	Phosphorylation	SSYTEAVSSQEMLRC HHHHHHCCCHHHHHH		22468782
444	Phosphorylation	GKVEPPHSSHEDLTD CCCCCCCCCCCCCCC		29255136
445	Phosphorylation	KVEPPHSSHEDLTDG CCCCCCCCCCCCCCC		29255136
450	Phosphorylation	HSSHEDLTDGLSTRS CCCCCCCCCCCCCCC		30266825
454	Phosphorylation	EDLTDGLSTRSFCHP CCCCCCCCCCCCCCC		23401153
455	Phosphorylation	DLTDGLSTRSFCHPE CCCCCCCCCCCCCCC		30266825
457 (in isoform 2)	Phosphorylation	-		18220336
457	Phosphorylation	TDGLSTRSFCHPEPH CCCCCCCCCCCCCCC		23401153
473	Phosphorylation	RDALLAGSLNNTLHL CHHHHHHHCCCCEEC		28348404
475	N-linked_Glycosylation	ALLAGSLNNTLHLSN HHHHHHCCCCEECCC		UniProtKB CARBOHYD
477	Phosphorylation	LAGSLNNTLHLSNEQ HHHHCCCCEECCCCH		28348404
509	Phosphorylation	HHKAHGRSKHPSGSN CCCCCCCCCCCCCCC		30108239
513	Phosphorylation	HGRSKHPSGSNVSFS CCCCCCCCCCCCCCC		23927012
515	Phosphorylation	RSKHPSGSNVSFSRD CCCCCCCCCCCCCCC		25159151
516	N-linked_Glycosylation	SKHPSGSNVSFSRDT CCCCCCCCCCCCCCC		UniProtKB CARBOHYD
518	Phosphorylation	HPSGSNVSFSRDTEG CCCCCCCCCCCCCCC		25159151
520	Phosphorylation	SGSNVSFSRDTEGGE CCCCCCCCCCCCCCC		23927012
523	Phosphorylation	NVSFSRDTEGGEEEP CCCCCCCCCCCCCCC		28270605
531	Phosphorylation	EGGEEEPSKTQPGME CCCCCCCCCCCCCCC		28270605
640	Phosphorylation	LARLIGFTPGAKELF HHHHHCCCCCHHHHH		17192257
644	Ubiquitination	IGFTPGAKELFKQEN HCCCCCHHHHHHHCC		21890473
648	Ubiquitination	PGAKELFKQENHLAL CCHHHHHHHCCCEEE		2189047
650 (in isoform 2)	Ubiquitination	-		21890473
654	Ubiquitination	FKQENHLALYRLPSA HHHCCCEEEEECCCH		21890473
654 (in isoform 2)	Ubiquitination	-		21890473
658	Ubiquitination	NHLALYRLPSAETMK CCEEEEECCCHHHHH		-
660	Phosphorylation	LALYRLPSAETMKET EEEEECCCHHHHHHC		24719451
665	Ubiquitination	LPSAETMKETSLGRL CCCHHHHHHCCCCCC		-
668	Phosphorylation	AETMKETSLGRLSCV HHHHHHCCCCCCCCC		19369195
683	Phosphorylation	TKRRPPLSHMISLFI CCCCCCHHHHHHHEE		21406692
687	Phosphorylation	PPLSHMISLFIKDTT CCHHHHHHHEEECCC		21406692
743	Phosphorylation	FYQRACLSGYCSAFA HHHHHHHHCCCHHHC		-
787	Phosphorylation	TMCELPSTIPIKQNA EECCCCCCCCCCCCC		24719451
797	Phosphorylation	IKQNARRSSWSSDEG CCCCCCCCCCCCCCC		25159151
798	Phosphorylation	KQNARRSSWSSDEGI CCCCCCCCCCCCCCH		25159151
800	Phosphorylation	NARRSSWSSDEGIGE CCCCCCCCCCCCHHH		25159151
801	Phosphorylation	ARRSSWSSDEGIGEV CCCCCCCCCCCHHHH		25159151
890	Phosphorylation	PNGDMPGSEIPPSSP CCCCCCCCCCCCCCC		26471730
895	Phosphorylation	PGSEIPPSSPSHAGS CCCCCCCCCCCCCCC		26471730
896	Phosphorylation	GSEIPPSSPSHAGSL CCCCCCCCCCCCCCC		26471730
898	Phosphorylation	EIPPSSPSHAGSLHD CCCCCCCCCCCCCCC		26471730
902	Phosphorylation	SSPSHAGSLHDDLNQ CCCCCCCCCCCCHHH		26471730
911	Phosphorylation	HDDLNQVSRDDAEGL CCCHHHCCCCCHHCE		26471730
927	Phosphorylation	LMEEEGHSDLISFQP EEEECCCCCCEEECC		18691976
935	Phosphorylation	DLISFQPTDSDIPSF CCEEECCCCCCCCHH		19369195
941	Phosphorylation	PTDSDIPSFLEDSNR CCCCCCCHHHHCCCC		19369195
1155	Ubiquitination	IMSMATGKNLQSIPK HHHHHCCCCHHHCCH		-
1159	Phosphorylation	ATGKNLQSIPKKTQH HCCCCHHHCCHHHHH		23401153
1202	N-linked_Glycosylation	CDSSRDRNLTNCSSV HCCCCCCCCCCCCCE		UniProtKB CARBOHYD
1205	N-linked_Glycosylation	SRDRNLTNCSSVMLP CCCCCCCCCCCEECC		UniProtKB CARBOHYD
1265 (in isoform 2)	Phosphorylation	-		18491316
1354	Phosphorylation	ETKLGMNSPF----- CCCCCCCCCC-----		28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMM94_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMM94_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMM94_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMM94_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.