TTI2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TTI2_HUMAN
• UniProt AC: Q6NXR4
• Protein Name: TELO2-interacting protein 2
• Gene Name: TTI2
• Organism: Homo sapiens (Human).
• Sequence Length: 508
• Protein Description: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs..
• Protein Sequence: MELDSALEAPSQEDSNLSEELSHSAFGQAFSKILHCLARPEARRGNVKDAVLKDLGDLIEATEFDRLFEGTGARLRGMPETLGQVAKALEKYAAPSKEEEGGGDGHSEAAEKAAQVGLLFLKLLGKVETAKNSLVGPAWQTGLHHLAGPVYIFAITHSLEQPWTTPRSREVAREVLTSLLQVTECGSVAGFLHGENEDEKGRLSVILGLLKPDLYKESWKNNPAIKHVFSWTLQQVTRPWLSQHLERVLPASLVISDDYQTENKILGVHCLHHIVLNVPAADLLQYNRAQVLYHAISNHLYTPEHHLIQAVLLCLLDLFPILEKTLHWKGDGARPTTHCDEVLRLILTHMEPEHRLLLRRTYARNLPAFVNRLGILTVRHLKRLERVIIGYLEVYDGPEEEARLKILETLKLLMQHTWPRVSCRLVVLLKALLKLICDVARDPNLTPESVKSALLQEATDCLILLDRCSQGRVKGLLAKIPQSCEDRKVVNYIRKVQQVSEGAPYNGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MELDSALEAPSQ ---CCHHHHCCCCCC	47.59	24043423
11	Phosphorylation	DSALEAPSQEDSNLS HHHCCCCCCCCCCCC	53.93	24043423
15	Phosphorylation	EAPSQEDSNLSEELS CCCCCCCCCCCHHHH	38.63	29759185
18	Phosphorylation	SQEDSNLSEELSHSA CCCCCCCCHHHHHHH	33.02	29759185
22	Phosphorylation	SNLSEELSHSAFGQA CCCCHHHHHHHHHHH	20.76	24043423
24	Phosphorylation	LSEELSHSAFGQAFS CCHHHHHHHHHHHHH	23.16	24043423
31	Phosphorylation	SAFGQAFSKILHCLA HHHHHHHHHHHHHHH	23.08	24043423
48	Ubiquitination	EARRGNVKDAVLKDL HHHCCCHHHHHHHHH	43.92	-
53	Ubiquitination	NVKDAVLKDLGDLIE CHHHHHHHHHHHHHH	44.29	-
87	Ubiquitination	ETLGQVAKALEKYAA HHHHHHHHHHHHHCC	55.43	-
91	Ubiquitination	QVAKALEKYAAPSKE HHHHHHHHHCCCCCC	40.83	21906983
97	Ubiquitination	EKYAAPSKEEEGGGD HHHCCCCCCCCCCCC	69.00	21906983
112	Ubiquitination	GHSEAAEKAAQVGLL CCHHHHHHHHHHHHH	44.27	-
126	Ubiquitination	LFLKLLGKVETAKNS HHHHHHCCHHHHHCC	36.55	-
200	Ubiquitination	HGENEDEKGRLSVIL CCCCCCCCCCHHHHH	62.75	-
211	Ubiquitination	SVILGLLKPDLYKES HHHHHHCCHHHHHHH	41.34	-
220	Ubiquitination	DLYKESWKNNPAIKH HHHHHHHHCCHHHHH	57.01	-
293	Phosphorylation	YNRAQVLYHAISNHL CCHHHHHHHHHHCCC	7.14	24043423
297	Phosphorylation	QVLYHAISNHLYTPE HHHHHHHHCCCCCCH	20.98	24043423
301	Phosphorylation	HAISNHLYTPEHHLI HHHHCCCCCCHHHHH	16.82	24043423
302	Phosphorylation	AISNHLYTPEHHLIQ HHHCCCCCCHHHHHH	28.67	24043423
329	Ubiquitination	LEKTLHWKGDGARPT HHHHCCCCCCCCCCC	36.05	-
377	Phosphorylation	VNRLGILTVRHLKRL HHHHCHHHHHHHHHH	17.36	-
474	Ubiquitination	RCSQGRVKGLLAKIP HHCCCCCCHHHHHCC	42.34	-
479	Ubiquitination	RVKGLLAKIPQSCED CCCHHHHHCCCCCCC	55.69	-
488	Ubiquitination	PQSCEDRKVVNYIRK CCCCCCHHHHHHHHH	63.96	-
495	Ubiquitination	KVVNYIRKVQQVSEG HHHHHHHHHHHHHCC	34.53	2190698
505	Phosphorylation	QVSEGAPYNGT---- HHHCCCCCCCC----	26.20	25839225
508	Phosphorylation	EGAPYNGT------- CCCCCCCC-------	31.62	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TTI2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TTI2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TTI2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RUVB1_HUMAN	RUVBL1	physical	20801936
PRKDC_HUMAN	PRKDC	physical	20801936
RUVB2_HUMAN	RUVBL2	physical	20801936
HS90A_HUMAN	HSP90AA1	physical	20801936
PIHD1_HUMAN	PIH1D1	physical	20801936
TELO2_HUMAN	TELO2	physical	20801936
TTI1_HUMAN	TTI1	physical	20801936
RPAP3_HUMAN	RPAP3	physical	20801936
HSP74_HUMAN	HSPA4	physical	20801936
TELO2_HUMAN	TELO2	physical	20810650
TTI1_HUMAN	TTI1	physical	20810650
OSBL3_HUMAN	OSBPL3	physical	26186194
OSBL3_HUMAN	OSBPL3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615541: Mental retardation, autosomal recessive 39 (MRT39)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.