CTL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTL1_HUMAN
• UniProt AC: Q8WWI5
• Protein Name: Choline transporter-like protein 1
• Gene Name: SLC44A1
• Organism: Homo sapiens (Human).
• Sequence Length: 657
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Mitochondrion outer membrane ; Multi-pass membrane protein .
• Protein Description: Choline transporter. May be involved in membrane synthesis and myelin production..
• Protein Sequence: MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRKYVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSPKETVTPEQLQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALVLFWVYWIMTLLFLGTTGSPVQNEQGFVEFKISGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDKRNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGKENACARCVLKSCICCLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRVATINTVGDFMLFLGKVLIVCSTGLAGIMLLNYQQDYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKGGVADSRELKPMASGASSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGCCSSASS ------CCCCCCHHH	22.57	22223895
75	Ubiquitination	ICGQKNTKLEAIPNS CCCCCCCCEEECCCC	54.44	-
98	S-palmitoylation	YVFFLDPCNLDLINR EEEEECCCCHHHHCH	8.68	29575903
123	Ubiquitination	ACPRQELKTLSDVQK HCCHHHHCCHHHHHH	46.82	-
167	Phosphorylation	PKLPVPASAPIPFFH CCCCCCCCCCCCCCC	28.62	-
180	N-linked_Glycosylation	FHRCAPVNISCYAKF CCCCCCCCHHHHHHH	21.28	17660510
263	Phosphorylation	TGVLWWLYAKQRRSP HHHHHHHHHCCCCCC	9.68	22817900
447	Phosphorylation	LGTVAKGSFIITLVK HCCCCCCCEEEEEEH	16.74	26503514
462	Phosphorylation	IPRMILMYIHSQLKG HHHHHHHHHHHHHCC	7.64	26503514
465	Phosphorylation	MILMYIHSQLKGKEN HHHHHHHHHHCCCCC	27.87	26503514
468	Acetylation	MYIHSQLKGKENACA HHHHHHHCCCCCHHH	61.37	11688447
611	Phosphorylation	DTKYNDGSPGREFYM CCCCCCCCCCHHCHH	27.35	25159151
638	Ubiquitination	KAMKEAGKGGVADSR HHHHHHCCCCCCCCH	60.58	-
644	Phosphorylation	GKGGVADSRELKPMA CCCCCCCCHHHCCCC	20.23	23401153
648	Ubiquitination	VADSRELKPMASGAS CCCCHHHCCCCCCCC	28.17	21906983
648 (in isoform 1)	Ubiquitination	-	28.17	21906983
652	Phosphorylation	RELKPMASGASSA-- HHHCCCCCCCCCC--	28.74	11698453
652	O-linked_Glycosylation	RELKPMASGASSA-- HHHCCCCCCCCCC--	28.74	28657654
655	Phosphorylation	KPMASGASSA----- CCCCCCCCCC-----	30.26	29255136
656	Phosphorylation	PMASGASSA------ CCCCCCCCC------	37.15	29255136

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CTL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CTL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTL1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CTL1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-652 AND SER-655, ANDMASS SPECTROMETRY.
PubMed: 18669648