BOD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BOD1_HUMAN
• UniProt AC: Q96IK1
• Protein Name: Biorientation of chromosomes in cell division protein 1
• Gene Name: BOD1
• Organism: Homo sapiens (Human).
• Sequence Length: 185
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase un
• Protein Description: Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles..
• Protein Sequence: MADGGGGGGTGAVGGGGTSQASAGAATGATGASGGGGPINPASLPPGDPQLIALIVEQLKSRGLFDSFRRDCLADVDTKPAYQNLRQKVDNFVSTHLDKQEWNPTMNKNQLRNGLRQSVVQSGMLEAGVDRIISQVVDPKLNHIFRPQIERAIHEFLAAQKKAAVPAPPPEPEGQDPPAPSQDTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Methylation	IVEQLKSRGLFDSFR HHHHHHHCCCHHHHH	44.22	-
67	Phosphorylation	KSRGLFDSFRRDCLA HHCCCHHHHHHHHHH	17.20	28348404
78	Phosphorylation	DCLADVDTKPAYQNL HHHHCCCCCHHHHHH	38.48	29978859
79	Ubiquitination	CLADVDTKPAYQNLR HHHCCCCCHHHHHHH	24.16	23000965
79	Acetylation	CLADVDTKPAYQNLR HHHCCCCCHHHHHHH	24.16	72601091
82	Phosphorylation	DVDTKPAYQNLRQKV CCCCCHHHHHHHHHH	13.37	29978859
88	Ubiquitination	AYQNLRQKVDNFVST HHHHHHHHHHHHHHH	45.16	29967540
95	Phosphorylation	KVDNFVSTHLDKQEW HHHHHHHHHCCHHHC	22.58	-
99	Ubiquitination	FVSTHLDKQEWNPTM HHHHHCCHHHCCCCC	57.38	29967540
108	Ubiquitination	EWNPTMNKNQLRNGL HCCCCCCHHHHHHHH	34.94	21906983
108 (in isoform 2)	Ubiquitination	-	34.94	21906983
108 (in isoform 1)	Ubiquitination	-	34.94	21890473
140	Ubiquitination	ISQVVDPKLNHIFRP HHHHHCCCCCCCCHH	58.41	22817900
140 (in isoform 1)	Ubiquitination	-	58.41	21890473
161	Ubiquitination	HEFLAAQKKAAVPAP HHHHHHHHHHCCCCC	39.39	32015554
161	Acetylation	HEFLAAQKKAAVPAP HHHHHHHHHHCCCCC	39.39	26051181
162	Ubiquitination	EFLAAQKKAAVPAPP HHHHHHHHHCCCCCC	29.51	29967540
181	Phosphorylation	GQDPPAPSQDTS--- CCCCCCCCCCCC---	42.68	25627689

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BOD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BOD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BOD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
BD1L2_HUMAN	BOD1L2	physical	26186194
MS3L1_HUMAN	MSL3	physical	26186194
DCP1B_HUMAN	DCP1B	physical	26186194
FMN2_HUMAN	FMN2	physical	26186194
BD1L2_HUMAN	BOD1L2	physical	28514442
MS3L1_HUMAN	MSL3	physical	28514442
FMN2_HUMAN	FMN2	physical	28514442
ATG4A_HUMAN	ATG4A	physical	28514442
DCP1B_HUMAN	DCP1B	physical	28514442
PMGE_HUMAN	BPGM	physical	28514442
BTBD1_HUMAN	BTBD1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.