PHTF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHTF1_HUMAN
• UniProt AC: Q9UMS5
• Protein Name: Putative homeodomain transcription factor 1
• Gene Name: PHTF1
• Organism: Homo sapiens (Human).
• Sequence Length: 762
• Subcellular Localization: Nucleus .
• Protein Description: May play a role in transcription regulation..
• Protein Sequence: MASNERDAISWYQKKIGAYDQQIWEKSIEQTQIKGLKNKPKKMGHIKPDLIDVDLIRGSTFAKAKPEIPWTSLTRKGLVRVVFFPLFSNWWIQVTSLRIFVWLLLLYFMQVIAIVLYLMMPIVNISEVLGPLCLMLLMGTVHCQIVSTQITRPSGNNGNRRRRKLRKTVNGDGSRENGNNSSDKVRGIETLESVPIIGGFWETIFGNRIKRVKLISNKGTETDNDPSCVHPIIKRRQCRPEIRMWQTREKAKFSDGEKCRREAFRRLGNGVSDDLSSEEDGEARTQMILLRRSVEGASSDNGCEVKNRKSILSRHLNSQVKKTTTRWCHIVRDSDSLAESEFESAAFSQGSRSGVSGGSRSLNMSRRDSESTRHDSETEDMLWDDLLHGPECRSSVTSDSEGAHVNTLHSGTKRDPKEDVFQQNHLFWLQNSSPSSDRVSAIIWEGNECKKMDMSVLEISGIIMSRVNAYQQGVGYQMLGNVVTIGLAFFPFLHRLFREKSLDQLKSISAEEILTLFCGAPPVTPIIVLSIINFFERLCLTWMFFFMMCVAERTYKQRFLFAKLFSHITSARKARKYEIPHFRLKKVENIKIWLSLRSYLKRRGPQRSVDVVVSSVFLLTLSIAFICCAQVLQGHKTFLNDAYNWEFLIWETALLLFLLRLASLGSETNKKYSNVSILLTEQINLYLKMEKKPNKKEQLTLVNNVLKLSTKLLKELDTPFRLYGLTMNPLIYNITRVVILSAVSGVISDLLGFNIRLWKIKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	O-linked_Glycosylation	EIPWTSLTRKGLVRV CCCCCCCCCCCCEEE	30.06	30379171
168	O-linked_Glycosylation	RRRKLRKTVNGDGSR HHHHCCCHHCCCCCC	16.87	30379171
174	Phosphorylation	KTVNGDGSRENGNNS CHHCCCCCCCCCCCC	40.95	22210691
174	O-linked_Glycosylation	KTVNGDGSRENGNNS CHHCCCCCCCCCCCC	40.95	30379171
179	N-linked_Glycosylation	DGSRENGNNSSDKVR CCCCCCCCCCCCCCC	57.71	-
180	N-linked_Glycosylation	GSRENGNNSSDKVRG CCCCCCCCCCCCCCC	44.27	-
190	Phosphorylation	DKVRGIETLESVPII CCCCCCCCHHCCCEE	33.63	-
193	Phosphorylation	RGIETLESVPIIGGF CCCCCHHCCCEECCH	35.98	-
203	Phosphorylation	IIGGFWETIFGNRIK EECCHHHHHHCCEEE	16.53	27422710
220	Phosphorylation	KLISNKGTETDNDPS EEECCCCCCCCCCCC	37.00	29255136
222	Phosphorylation	ISNKGTETDNDPSCV ECCCCCCCCCCCCHH	39.68	29255136
243	Methylation	RQCRPEIRMWQTREK CCCCCCCCCCHHHHH	20.73	54561629
243	Dimethylation	RQCRPEIRMWQTREK CCCCCCCCCCHHHHH	20.73	-
250	Ubiquitination	RMWQTREKAKFSDGE CCCHHHHHCCCCCHH	54.29	-
254	Phosphorylation	TREKAKFSDGEKCRR HHHHCCCCCHHHHHH	43.96	24719451
272	Phosphorylation	RRLGNGVSDDLSSEE HHHCCCCCCCCCCCC	27.14	20363803
276	Phosphorylation	NGVSDDLSSEEDGEA CCCCCCCCCCCCCCH	42.57	20363803
277	Phosphorylation	GVSDDLSSEEDGEAR CCCCCCCCCCCCCHH	52.91	20363803
293	Phosphorylation	QMILLRRSVEGASSD HHEEEEHHCCCCCCC	20.34	30177828
298	Phosphorylation	RRSVEGASSDNGCEV EHHCCCCCCCCCCEE	49.43	30177828
299	Phosphorylation	RSVEGASSDNGCEVK HHCCCCCCCCCCEEC	34.26	27966365
310	Phosphorylation	CEVKNRKSILSRHLN CEECCHHHHHHHHHH	26.06	24719451
313	Phosphorylation	KNRKSILSRHLNSQV CCHHHHHHHHHHHHC	18.91	24719451
334	Phosphorylation	WCHIVRDSDSLAESE CEEEECCCCHHCHHH	20.66	-
336	Phosphorylation	HIVRDSDSLAESEFE EEECCCCHHCHHHHH	33.17	-
353	Phosphorylation	AFSQGSRSGVSGGSR HHCCCCCCCCCCCCC	45.29	22210691
356	Phosphorylation	QGSRSGVSGGSRSLN CCCCCCCCCCCCCCC	40.75	29759185
359	Phosphorylation	RSGVSGGSRSLNMSR CCCCCCCCCCCCCCC	23.40	22210691
361	Phosphorylation	GVSGGSRSLNMSRRD CCCCCCCCCCCCCCC	26.28	29759185
363	N-linked_Glycosylation	SGGSRSLNMSRRDSE CCCCCCCCCCCCCCC	27.85	-
365	Phosphorylation	GSRSLNMSRRDSEST CCCCCCCCCCCCCCC	24.08	29759185
398	Phosphorylation	ECRSSVTSDSEGAHV CHHCCCCCCCCCCCE	36.66	25849741
400	Phosphorylation	RSSVTSDSEGAHVNT HCCCCCCCCCCCEEC	37.38	-
431	N-linked_Glycosylation	NHLFWLQNSSPSSDR CCEEEECCCCCCCCC	42.14	-
455	Phosphorylation	ECKKMDMSVLEISGI HHCCCCCHHHHHHHH	21.20	25690035
465	Phosphorylation	EISGIIMSRVNAYQQ HHHHHHHHHHCHHHC	23.75	25690035
586	Acetylation	IPHFRLKKVENIKIW CCCCEEECHHCCHHH	60.41	7683511
666	Phosphorylation	LRLASLGSETNKKYS HHHHHCCCCCCCCCC	46.68	-
668	Phosphorylation	LASLGSETNKKYSNV HHHCCCCCCCCCCCC	54.77	22817900
674	N-linked_Glycosylation	ETNKKYSNVSILLTE CCCCCCCCCEEEEHH	28.59	-
723	Phosphorylation	LDTPFRLYGLTMNPL CCCCHHHCCCCCCHH	13.06	24043423
726	Phosphorylation	PFRLYGLTMNPLIYN CHHHCCCCCCHHHHH	15.56	24043423
732	Phosphorylation	LTMNPLIYNITRVVI CCCCHHHHHHHHHHH	14.27	24043423
733	N-linked_Glycosylation	TMNPLIYNITRVVIL CCCHHHHHHHHHHHH	23.35	-
735	Phosphorylation	NPLIYNITRVVILSA CHHHHHHHHHHHHHH	17.49	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHTF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHTF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHTF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAN5_HUMAN	CAPN5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.