UniProt ID | CAN5_HUMAN | |
---|---|---|
UniProt AC | O15484 | |
Protein Name | Calpain-5 | |
Gene Name | CAPN5 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 640 | |
Subcellular Localization | ||
Protein Description | Calcium-regulated non-lysosomal thiol-protease.. | |
Protein Sequence | MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
8 | Phosphorylation | MFSCVKPYEDQNYSA CCCCCCCCCCCCHHH | 26.81 | 27732954 | |
13 | Phosphorylation | KPYEDQNYSALRRDC CCCCCCCHHHHHHHH | 6.95 | 27732954 | |
14 | Phosphorylation | PYEDQNYSALRRDCR CCCCCCHHHHHHHHH | 28.51 | 27732954 | |
24 | Ubiquitination | RRDCRRRKVLFEDPL HHHHHHCCCCCCCCC | 41.29 | - | |
35 | Phosphorylation | EDPLFPATDDSLYYK CCCCCCCCCCCCCCC | 40.34 | 24719451 | |
38 | Phosphorylation | LFPATDDSLYYKGTP CCCCCCCCCCCCCCC | 22.53 | 28857561 | |
41 | Phosphorylation | ATDDSLYYKGTPGPA CCCCCCCCCCCCCCC | 14.29 | 28857561 | |
42 | Ubiquitination | TDDSLYYKGTPGPAV CCCCCCCCCCCCCCC | 42.63 | 21906983 | |
44 | Phosphorylation | DSLYYKGTPGPAVRW CCCCCCCCCCCCCCC | 22.41 | 26657352 | |
223 | Phosphorylation | ERMLKVHSRGGLISA HHHHHHHHCCCHHHC | 35.29 | 27251275 | |
229 | Phosphorylation | HSRGGLISASIKAVT HHCCCHHHCEEEHHH | 22.47 | 27251275 | |
231 | Phosphorylation | RGGLISASIKAVTAA CCCHHHCEEEHHHHH | 20.17 | 27251275 | |
236 | Phosphorylation | SASIKAVTAADMEAR HCEEEHHHHHCHHHH | 22.46 | 27251275 | |
254 | Phosphorylation | GLVKGHAYAVTDVRK HCCCCCEEEEEEHEE | 8.91 | 24719451 | |
257 | Phosphorylation | KGHAYAVTDVRKVRL CCCEEEEEEHEEEEC | 22.17 | 24719451 | |
273 | Ubiquitination | HGLLAFFKSEKLDMI CCHHHHHHHCCCCEE | 51.78 | - | |
381 | Ubiquitination | GGGCINHKDTFFQNP CCCCCCCCCCCCCCC | 54.71 | - | |
449 | Phosphorylation | LQHKAASSIYINSRS HCHHHCCEEEECCEE | 18.06 | 24670416 | |
454 | Phosphorylation | ASSIYINSRSVFLRT CCEEEECCEEEEEEC | 19.17 | 24670416 | |
555 | Ubiquitination | KVRSAVQKGTSTPEY HHHHHHHCCCCCCCC | 58.52 | - | |
562 | Phosphorylation | KGTSTPEYNVKGIFY CCCCCCCCCEEEEEE | 26.85 | 24719451 | |
565 | Ubiquitination | STPEYNVKGIFYRKK CCCCCCEEEEEEEEC | 42.52 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CAN5_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CAN5_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CAN5_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
STIP1_HUMAN | STIP1 | physical | 28514442 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
193235 | Vitreoretinopathy, neovascular inflammatory (VRNI) | |||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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