CAN5_HUMAN - dbPTM
CAN5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CAN5_HUMAN
UniProt AC O15484
Protein Name Calpain-5
Gene Name CAPN5
Organism Homo sapiens (Human).
Sequence Length 640
Subcellular Localization
Protein Description Calcium-regulated non-lysosomal thiol-protease..
Protein Sequence MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMFSCVKPYEDQNYSA
CCCCCCCCCCCCHHH
26.8127732954
13PhosphorylationKPYEDQNYSALRRDC
CCCCCCCHHHHHHHH
6.9527732954
14PhosphorylationPYEDQNYSALRRDCR
CCCCCCHHHHHHHHH
28.5127732954
24UbiquitinationRRDCRRRKVLFEDPL
HHHHHHCCCCCCCCC
41.29-
35PhosphorylationEDPLFPATDDSLYYK
CCCCCCCCCCCCCCC
40.3424719451
38PhosphorylationLFPATDDSLYYKGTP
CCCCCCCCCCCCCCC
22.5328857561
41PhosphorylationATDDSLYYKGTPGPA
CCCCCCCCCCCCCCC
14.2928857561
42UbiquitinationTDDSLYYKGTPGPAV
CCCCCCCCCCCCCCC
42.6321906983
44PhosphorylationDSLYYKGTPGPAVRW
CCCCCCCCCCCCCCC
22.4126657352
223PhosphorylationERMLKVHSRGGLISA
HHHHHHHHCCCHHHC
35.2927251275
229PhosphorylationHSRGGLISASIKAVT
HHCCCHHHCEEEHHH
22.4727251275
231PhosphorylationRGGLISASIKAVTAA
CCCHHHCEEEHHHHH
20.1727251275
236PhosphorylationSASIKAVTAADMEAR
HCEEEHHHHHCHHHH
22.4627251275
254PhosphorylationGLVKGHAYAVTDVRK
HCCCCCEEEEEEHEE
8.9124719451
257PhosphorylationKGHAYAVTDVRKVRL
CCCEEEEEEHEEEEC
22.1724719451
273UbiquitinationHGLLAFFKSEKLDMI
CCHHHHHHHCCCCEE
51.78-
381UbiquitinationGGGCINHKDTFFQNP
CCCCCCCCCCCCCCC
54.71-
449PhosphorylationLQHKAASSIYINSRS
HCHHHCCEEEECCEE
18.0624670416
454PhosphorylationASSIYINSRSVFLRT
CCEEEECCEEEEEEC
19.1724670416
555UbiquitinationKVRSAVQKGTSTPEY
HHHHHHHCCCCCCCC
58.52-
562PhosphorylationKGTSTPEYNVKGIFY
CCCCCCCCCEEEEEE
26.8524719451
565UbiquitinationSTPEYNVKGIFYRKK
CCCCCCEEEEEEEEC
42.52-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CAN5_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CAN5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CAN5_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STIP1_HUMANSTIP1physical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
193235Vitreoretinopathy, neovascular inflammatory (VRNI)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CAN5_HUMAN

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Related Literatures of Post-Translational Modification

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