CAN5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAN5_HUMAN
• UniProt AC: O15484
• Protein Name: Calpain-5
• Gene Name: CAPN5
• Organism: Homo sapiens (Human).
• Sequence Length: 640
• Protein Description: Calcium-regulated non-lysosomal thiol-protease..
• Protein Sequence: MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MFSCVKPYEDQNYSA CCCCCCCCCCCCHHH	26.81	27732954
13	Phosphorylation	KPYEDQNYSALRRDC CCCCCCCHHHHHHHH	6.95	27732954
14	Phosphorylation	PYEDQNYSALRRDCR CCCCCCHHHHHHHHH	28.51	27732954
24	Ubiquitination	RRDCRRRKVLFEDPL HHHHHHCCCCCCCCC	41.29	-
35	Phosphorylation	EDPLFPATDDSLYYK CCCCCCCCCCCCCCC	40.34	24719451
38	Phosphorylation	LFPATDDSLYYKGTP CCCCCCCCCCCCCCC	22.53	28857561
41	Phosphorylation	ATDDSLYYKGTPGPA CCCCCCCCCCCCCCC	14.29	28857561
42	Ubiquitination	TDDSLYYKGTPGPAV CCCCCCCCCCCCCCC	42.63	21906983
44	Phosphorylation	DSLYYKGTPGPAVRW CCCCCCCCCCCCCCC	22.41	26657352
223	Phosphorylation	ERMLKVHSRGGLISA HHHHHHHHCCCHHHC	35.29	27251275
229	Phosphorylation	HSRGGLISASIKAVT HHCCCHHHCEEEHHH	22.47	27251275
231	Phosphorylation	RGGLISASIKAVTAA CCCHHHCEEEHHHHH	20.17	27251275
236	Phosphorylation	SASIKAVTAADMEAR HCEEEHHHHHCHHHH	22.46	27251275
254	Phosphorylation	GLVKGHAYAVTDVRK HCCCCCEEEEEEHEE	8.91	24719451
257	Phosphorylation	KGHAYAVTDVRKVRL CCCEEEEEEHEEEEC	22.17	24719451
273	Ubiquitination	HGLLAFFKSEKLDMI CCHHHHHHHCCCCEE	51.78	-
381	Ubiquitination	GGGCINHKDTFFQNP CCCCCCCCCCCCCCC	54.71	-
449	Phosphorylation	LQHKAASSIYINSRS HCHHHCCEEEECCEE	18.06	24670416
454	Phosphorylation	ASSIYINSRSVFLRT CCEEEECCEEEEEEC	19.17	24670416
555	Ubiquitination	KVRSAVQKGTSTPEY HHHHHHHCCCCCCCC	58.52	-
562	Phosphorylation	KGTSTPEYNVKGIFY CCCCCCCCCEEEEEE	26.85	24719451
565	Ubiquitination	STPEYNVKGIFYRKK CCCCCCEEEEEEEEC	42.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAN5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAN5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAN5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STIP1_HUMAN	STIP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 193235: Vitreoretinopathy, neovascular inflammatory (VRNI)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.