CLDN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLDN1_HUMAN
• UniProt AC: Q9NY35
• Protein Name: Claudin domain-containing protein 1
• Gene Name: CLDND1
• Organism: Homo sapiens (Human).
• Sequence Length: 253
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQENSSDLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCITIPKNMHWYSPPERTESFDVVTKCVSFTLTEQFMEKFVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLCACICRSLYPTIATGILHLLAGLCTLGSVSCYVAGIELLHQKLELPDNVSGEFGWSFCLACVSAPLQFMASALFIWAAHTNRKEYTLMKAYRVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 3)	Phosphorylation	-	20.50	22115753
42	N-linked_Glycosylation	YRSPVQENSSDLNKS CCCCCCCCCCHHCHH	29.71	17660510
43	Phosphorylation	RSPVQENSSDLNKSI CCCCCCCCCHHCHHH	25.20	24114839
48	Ubiquitination	ENSSDLNKSIWDEFI CCCCHHCHHHHHHHC	51.09	21906983
48 (in isoform 1)	Ubiquitination	-	51.09	21890473
48 (in isoform 2)	Ubiquitination	-	51.09	21906983
49	Phosphorylation	NSSDLNKSIWDEFIS CCCHHCHHHHHHHCC	28.04	27794612
56	Phosphorylation	SIWDEFISDEADEKT HHHHHHCCCCCCCCH	34.42	27794612
62	Ubiquitination	ISDEADEKTYNDALF CCCCCCCCHHHHHHH	57.78	2190698
62 (in isoform 2)	Ubiquitination	-	57.78	21906983
62 (in isoform 1)	Ubiquitination	-	57.78	21890473
72	N-linked_Glycosylation	NDALFRYNGTVGLWR HHHHHHCCCCEEECH	35.09	19349973
92	Phosphorylation	PKNMHWYSPPERTES CCCCCCCCCCCCCCC	28.87	28348404
97	Phosphorylation	WYSPPERTESFDVVT CCCCCCCCCCCCHHH	34.03	28348404
99	Phosphorylation	SPPERTESFDVVTKC CCCCCCCCCCHHHHH	26.57	28348404
244	Phosphorylation	AHTNRKEYTLMKAYR HHCCCHHHHHHHHHC	14.28	22817900
245	Phosphorylation	HTNRKEYTLMKAYRV HCCCHHHHHHHHHCC	22.82	-
248	Ubiquitination	RKEYTLMKAYRVA-- CHHHHHHHHHCCC--	45.43	21890473
248 (in isoform 1)	Ubiquitination	-	45.43	21890473
250	Phosphorylation	EYTLMKAYRVA---- HHHHHHHHCCC----	10.49	18083107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLDN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLDN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLDN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GOGA7_HUMAN	GOLGA7	physical	26186194
K2013_HUMAN	KIAA2013	physical	26186194
MA1A1_HUMAN	MAN1A1	physical	26186194
MA1A2_HUMAN	MAN1A2	physical	26186194
ZDHC8_HUMAN	ZDHHC8	physical	26186194
ZDHC5_HUMAN	ZDHHC5	physical	26186194
B4GT4_HUMAN	B4GALT4	physical	26186194
BMR1A_HUMAN	BMPR1A	physical	26186194
ALG3_HUMAN	ALG3	physical	26186194
ZDHC5_HUMAN	ZDHHC5	physical	28514442
ZDHC8_HUMAN	ZDHHC8	physical	28514442
GOGA7_HUMAN	GOLGA7	physical	28514442
MA1A1_HUMAN	MAN1A1	physical	28514442
MA1A2_HUMAN	MAN1A2	physical	28514442
CYB_HUMAN	CYTB	physical	28514442
K2013_HUMAN	KIAA2013	physical	28514442
BMR1A_HUMAN	BMPR1A	physical	28514442
B4GT4_HUMAN	B4GALT4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-72, AND MASS SPECTROMETRY.
PubMed: 19349973