dbPTM

GOGA7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GOGA7_HUMAN
UniProt AC	Q7Z5G4
Protein Name	Golgin subfamily A member 7
Gene Name	GOLGA7
Organism	Homo sapiens (Human).
Sequence Length	137
Subcellular Localization	Golgi apparatus membrane Lipid-anchor .
Protein Description	May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS..
Protein Sequence	MRPQQAPVSGKVFIQRDYSSGTRCQFQTKFPAELENRIDRQQFEETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVLKKVSKYIQEQNEKIYAPQGLLLTDPIERGLRVIEITIYEDRGMSSGR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	QQAPVSGKVFIQRDY CCCCCCCEEEEEECC	26.85	29967540
29	Ubiquitination	TRCQFQTKFPAELEN CEEEEEECCCHHHHC	38.27	23000965
37	Methylation	FPAELENRIDRQQFE CCHHHHCCCCHHHHH	23.86	-
54	Phosphorylation	VRTLNNLYAEAEKLG HHHHHHHHHHHHHHC	12.43	29496907
69	S-palmitoylation	GQSYLEGCLACLTAY CCHHHHHHHHHHHHH	1.27	14522980
72	S-palmitoylation	YLEGCLACLTAYTIF HHHHHHHHHHHHHHH	1.93	14522980
76	Phosphorylation	CLACLTAYTIFLCME HHHHHHHHHHHHHHH	8.64	-
91	Ubiquitination	THYEKVLKKVSKYIQ HHHHHHHHHHHHHHH	54.86	23000965
92	Ubiquitination	HYEKVLKKVSKYIQE HHHHHHHHHHHHHHH	47.80	23000965
95	Ubiquitination	KVLKKVSKYIQEQNE HHHHHHHHHHHHHHC	49.73	23000965
103	Ubiquitination	YIQEQNEKIYAPQGL HHHHHHCCCCCCCCE	48.87	23000965
118	Dimethylation	LLTDPIERGLRVIEI EECCHHHHCEEEEEE	50.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GOGA7_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
69	C	Palmitoylation	14522980
Palmitoylated on Cys-69 and Cys-72; which is required for Golgi localization and interaction with GOLGA3.
72	C	Palmitoylation	14522980
Palmitoylated on Cys-69 and Cys-72; which is required for Golgi localization and interaction with GOLGA3.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GOGA7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
GOGA3_HUMAN	GOLGA3	physical	14522980

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GOGA7_HUMAN

Related Literatures of Post-Translational Modification

Palmitoylation
Reference	PubMed
"Identification and characterization of GCP16, a novel acylated Golgiprotein that interacts with GCP170."; Ohta E., Misumi Y., Sohda M., Fujiwara T., Yano A., Ikehara Y.; J. Biol. Chem. 278:51957-51967(2003). Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH GOLGA3, TISSUESPECIFICITY, PALMITOYLATION AT CYS-69 AND CYS-72, MUTAGENESIS OFCYS-24; CYS-69; CYS-72 AND CYS-81, SUBCELLULAR LOCATION, AND FUNCTION.	14522980 [Abstract]