ZDHC8_HUMAN - dbPTM
ZDHC8_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZDHC8_HUMAN
UniProt AC Q9ULC8
Protein Name Probable palmitoyltransferase ZDHHC8
Gene Name ZDHHC8
Organism Homo sapiens (Human).
Sequence Length 765
Subcellular Localization Cytoplasmic vesicle membrane
Multi-pass membrane protein .
Protein Description Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1..
Protein Sequence MPRSPGTRLKPAKYIPVATAAALLVGSSTLFFVFTCPWLTRAVSPAVPVYNGIIFLFVLANFSMATFMDPGVFPRADEDEDKEDDFRAPLYKNVDVRGIQVRMKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVNNCIGRRNYRYFFLFLLSLSAHMVGVVAFGLVYVLNHAEGLGAAHTTITMAVMCVAGLFFIPVIGLTGFHVVLVTRGRTTNEQVTGKFRGGVNPFTRGCCGNVEHVLCSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSSDLQTPRPGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSPPLSASDAFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPYLHPGATGDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPRGPALRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHSPSYAGPKAVAFIHTDLPEPPPSLTVQRDHPQLKTPPSKLNGQSPGLARLGPATGPPGPSASPTRHTLVKKVSGVGGTTYEISV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
91PhosphorylationDDFRAPLYKNVDVRG
CCCCCCCCCCCCCCC		10.23-
224UbiquitinationTNEQVTGKFRGGVNP
CCCCCCCCCCCCCCC		23.6323000965
224 (in isoform 1)Ubiquitination-23.6321890473
224UbiquitinationTNEQVTGKFRGGVNP
CCCCCCCCCCCCCCC		23.6321890473
224 (in isoform 3)Ubiquitination-23.6321890473
246PhosphorylationNVEHVLCSPLAPRYV
CCCEEEECCCCCCEE		20.8428555341
286PhosphorylationAPLKVKLSDNGLKAG
CCCEEEECCCCCCCC		24.2627251275
286 (in isoform 3)Phosphorylation-24.2627251275
299PhosphorylationAGLGRSKSKGSLDRL
CCCCCCCCCCCHHCC		43.4223090842
300MethylationGLGRSKSKGSLDRLD
CCCCCCCCCCHHCCC		57.14117956017
302PhosphorylationGRSKSKGSLDRLDEK
CCCCCCCCHHCCCCC		30.7323090842
325PhosphorylationPPKIEAGTFSSDLQT
CCCCCCCCCCCCCCC		27.6524719451
327PhosphorylationKIEAGTFSSDLQTPR
CCCCCCCCCCCCCCC		23.8423090842
328PhosphorylationIEAGTFSSDLQTPRP
CCCCCCCCCCCCCCC		37.8423090842
332PhosphorylationTFSSDLQTPRPGSAE
CCCCCCCCCCCCCHH		28.6724719451
337PhosphorylationLQTPRPGSAESALSV
CCCCCCCCHHHHHHC		31.3930266825
340PhosphorylationPRPGSAESALSVQRT
CCCCCHHHHHHCCCC		33.9428857561
343PhosphorylationGSAESALSVQRTSPP
CCHHHHHHCCCCCCC		18.8723090842
347PhosphorylationSALSVQRTSPPTPAM
HHHHCCCCCCCCCCH		28.6128985074
351PhosphorylationVQRTSPPTPAMYKFR
CCCCCCCCCCHHEEC		27.3623312004
363PhosphorylationKFRPAFPTGPKVPFC
EECCCCCCCCCCCCC		60.7128555341
391PhosphorylationLGDDSIRSLDFVSEP
CCCCCCCCCCCCCCC		30.5328122231
396PhosphorylationIRSLDFVSEPSLDLP
CCCCCCCCCCCCCCC		43.7328122231
399PhosphorylationLDFVSEPSLDLPDYG
CCCCCCCCCCCCCCC		30.3928122231
405PhosphorylationPSLDLPDYGPGGLHA
CCCCCCCCCCCCCCC		24.2328122231
414PhosphorylationPGGLHAAYPPSPPLS
CCCCCCCCCCCCCCC		19.2328122231
417PhosphorylationLHAAYPPSPPLSASD
CCCCCCCCCCCCHHH		34.3519276368
421PhosphorylationYPPSPPLSASDAFSG
CCCCCCCCHHHHHHH		31.3428122231
423PhosphorylationPSPPLSASDAFSGAL
CCCCCCHHHHHHHHH		26.5428122231
427PhosphorylationLSASDAFSGALRSLS
CCHHHHHHHHHHHHC		25.5228122231
432PhosphorylationAFSGALRSLSLKASS
HHHHHHHHHCHHHHC		24.1424719451
434PhosphorylationSGALRSLSLKASSRR
HHHHHHHCHHHHCCC		29.1323911959
438PhosphorylationRSLSLKASSRRGGDH
HHHCHHHHCCCCCCE		23.8421712546
439PhosphorylationSLSLKASSRRGGDHV
HHCHHHHCCCCCCEE		30.7529449344
441MethylationSLKASSRRGGDHVAL
CHHHHCCCCCCEEEE		56.2358860363
453 (in isoform 3)Phosphorylation-48.5627251275
453PhosphorylationVALQPLRSEGGPPTP
EEEEECCCCCCCCCC		48.5629632367
459PhosphorylationRSEGGPPTPHRSIFA
CCCCCCCCCCCCCCC		34.5628674419
463PhosphorylationGPPTPHRSIFAPHAL
CCCCCCCCCCCCCCC		21.0128857561
479PhosphorylationNRNGSLSYDSLLNPG
CCCCCCCCHHCCCCC		18.16-
524PhosphorylationPPRPLPRSFSPVLGP
CCCCCCCCCCCCCCC		28.3030266825
526 (in isoform 3)Phosphorylation-18.4927251275
526PhosphorylationRPLPRSFSPVLGPRP
CCCCCCCCCCCCCCC		18.4919664994
537PhosphorylationGPRPREPSPVRYDNL
CCCCCCCCCCCCCCH		31.1330266825
541PhosphorylationREPSPVRYDNLSRTI
CCCCCCCCCCHHHHH		14.9328102081
545PhosphorylationPVRYDNLSRTIMASI
CCCCCCHHHHHHHHH		33.3628152594
579PhosphorylationLFGDSGVYDAPSSYS
HHCCCCCCCCCCCCC		15.2027259358
604PhosphorylationPRGPALRYGSRDDLV
CCCCCHHCCCHHHCC		21.9422617229
606PhosphorylationGPALRYGSRDDLVAG
CCCHHCCCHHHCCCC		24.4923401153
606 (in isoform 3)Phosphorylation-24.4927251275
626 (in isoform 3)Phosphorylation-32.2727251275
626PhosphorylationARNPALQTSLSSLSS
CCCHHHHHHHHHHHH		32.2729978859
627PhosphorylationRNPALQTSLSSLSSS
CCHHHHHHHHHHHHH		17.1927050516
629PhosphorylationPALQTSLSSLSSSVS
HHHHHHHHHHHHHHH		29.0623403867
630PhosphorylationALQTSLSSLSSSVSR
HHHHHHHHHHHHHHC		37.2529978859
632PhosphorylationQTSLSSLSSSVSRAP
HHHHHHHHHHHHCCC		23.6329978859
633PhosphorylationTSLSSLSSSVSRAPR
HHHHHHHHHHHCCCC		39.8029978859
634PhosphorylationSLSSLSSSVSRAPRT
HHHHHHHHHHCCCCC		22.2727732954
636PhosphorylationSSLSSSVSRAPRTSS
HHHHHHHHCCCCCCC		25.3623186163
641PhosphorylationSVSRAPRTSSSSLQA
HHHCCCCCCCHHCCH		31.7227732954
642PhosphorylationVSRAPRTSSSSLQAD
HHCCCCCCCHHCCHH		29.5127732954
643PhosphorylationSRAPRTSSSSLQADQ
HCCCCCCCHHCCHHH		24.2727732954
644PhosphorylationRAPRTSSSSLQADQA
CCCCCCCHHCCHHHH		34.5327732954
645PhosphorylationAPRTSSSSLQADQAS
CCCCCCHHCCHHHHH		26.8427732954
652PhosphorylationSLQADQASSNAPGPR
HCCHHHHHCCCCCCC		20.6323312004
653PhosphorylationLQADQASSNAPGPRP
CCHHHHHCCCCCCCC		39.7723312004
661PhosphorylationNAPGPRPSSGSHRSP
CCCCCCCCCCCCCCC		48.9223312004
662PhosphorylationAPGPRPSSGSHRSPA
CCCCCCCCCCCCCCC		47.1723312004
664PhosphorylationGPRPSSGSHRSPARQ
CCCCCCCCCCCCCCC		20.0629214152
667PhosphorylationPSSGSHRSPARQGLP
CCCCCCCCCCCCCCC		19.9323312004
675 (in isoform 3)Phosphorylation-49.0927251275
675PhosphorylationPARQGLPSPPGTPHS
CCCCCCCCCCCCCCC		49.0930266825
679PhosphorylationGLPSPPGTPHSPSYA
CCCCCCCCCCCCCCC		24.4930266825
682 (in isoform 3)Phosphorylation-19.4227251275
682PhosphorylationSPPGTPHSPSYAGPK
CCCCCCCCCCCCCCC		19.4227134283
684PhosphorylationPGTPHSPSYAGPKAV
CCCCCCCCCCCCCEE		30.5422199227
685PhosphorylationGTPHSPSYAGPKAVA
CCCCCCCCCCCCEEE		20.9722199227
704PhosphorylationDLPEPPPSLTVQRDH
CCCCCCCCCCCCCCC		42.3128555341
706PhosphorylationPEPPPSLTVQRDHPQ
CCCCCCCCCCCCCCC		20.9424719451
716PhosphorylationRDHPQLKTPPSKLNG
CCCCCCCCCHHHHCC		49.3729214152
719PhosphorylationPQLKTPPSKLNGQSP
CCCCCCHHHHCCCCC		51.4829214152
720MethylationQLKTPPSKLNGQSPG
CCCCCHHHHCCCCCC		52.31115978321
725PhosphorylationPSKLNGQSPGLARLG
HHHHCCCCCCCCCCC		23.4927422710
735PhosphorylationLARLGPATGPPGPSA
CCCCCCCCCCCCCCC		54.0429255136
741PhosphorylationATGPPGPSASPTRHT
CCCCCCCCCCCCCEE		47.4929255136
743PhosphorylationGPPGPSASPTRHTLV
CCCCCCCCCCCEEEE		31.0129255136
745PhosphorylationPGPSASPTRHTLVKK
CCCCCCCCCEEEEEE		32.3729255136
748PhosphorylationSASPTRHTLVKKVSG
CCCCCCEEEEEEECC		29.9223186163
754PhosphorylationHTLVKKVSGVGGTTY
EEEEEEECCCCCCEE		36.3230266825
759PhosphorylationKVSGVGGTTYEISV-
EECCCCCCEEEEEC-		21.9230266825
760PhosphorylationVSGVGGTTYEISV--
ECCCCCCEEEEEC--		23.5630266825
761PhosphorylationSGVGGTTYEISV---
CCCCCCEEEEEC---		15.8825159151
764PhosphorylationGGTTYEISV------
CCCEEEEEC------		15.1628152594
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZDHC8_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZDHC8_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZDHC8_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZDHC8_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZDHC8_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-741 AND SER-743, ANDMASS SPECTROMETRY.
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438, AND MASSSPECTROMETRY.

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