RFT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RFT1_HUMAN
• UniProt AC: Q96AA3
• Protein Name: Protein RFT1 homolog
• Gene Name: RFT1
• Organism: Homo sapiens (Human).
• Sequence Length: 541
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane..
• Protein Sequence: MGSQEVLGHAARLASSGLLLQVLFRLITFVLNAFILRFLSKEIVGVVNVRLTLLYSTTLFLAREAFRRACLSGGTQRDWSQTLNLLWLTVPLGVFWSLFLGWIWLQLLEVPDPNVVPHYATGVVLFGLSAVVELLGEPFWVLAQAHMFVKLKVIAESLSVILKSVLTAFLVLWLPHWGLYIFSLAQLFYTTVLVLCYVIYFTKLLGSPESTKLQTLPVSRITDLLPNITRNGAFINWKEAKLTWSFFKQSFLKQILTEGERYVMTFLNVLNFGDQGVYDIVNNLGSLVARLIFQPIEESFYIFFAKVLERGKDATLQKQEDVAVAAAVLESLLKLALLAGLTITVFGFAYSQLALDIYGGTMLSSGSGPVLLRSYCLYVLLLAINGVTECFTFAAMSKEEVDRYNFVMLALSSSFLVLSYLLTRWCGSVGFILANCFNMGIRITQSLCFIHRYYRRSPHRPLAGLHLSPVLLGTFALSGGVTAVSEVFLCCEQGWPARLAHIAVGAFCLGATLGTAFLTETKLIHFLRTQLGVPRRTDKMT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGSQEVLGHA -----CCHHHHHHHH	23.13	22985185
19	Ubiquitination	RLASSGLLLQVLFRL HHHHHHHHHHHHHHH	3.42	22817900
22	Ubiquitination	SSGLLLQVLFRLITF HHHHHHHHHHHHHHH	5.71	22817900
29	Ubiquitination	VLFRLITFVLNAFIL HHHHHHHHHHHHHHH	4.70	22817900
34	Ubiquitination	ITFVLNAFILRFLSK HHHHHHHHHHHHHCC	5.42	21963094
52	Phosphorylation	GVVNVRLTLLYSTTL HHHHHHHHHHHHHHH	12.26	27174698
55	Phosphorylation	NVRLTLLYSTTLFLA HHHHHHHHHHHHHHH	13.69	19835603
56	Phosphorylation	VRLTLLYSTTLFLAR HHHHHHHHHHHHHHH	18.19	19835603
57	Phosphorylation	RLTLLYSTTLFLARE HHHHHHHHHHHHHHH	17.60	19835603
58	Phosphorylation	LTLLYSTTLFLAREA HHHHHHHHHHHHHHH	15.01	27174698
93	Ubiquitination	LWLTVPLGVFWSLFL HHHHHHHHHHHHHHH	13.40	27667366
99	Ubiquitination	LGVFWSLFLGWIWLQ HHHHHHHHHHHHHHH	5.04	23503661
207	Phosphorylation	YFTKLLGSPESTKLQ HHHHHHCCCCCCCCC	26.01	21406692
210	Phosphorylation	KLLGSPESTKLQTLP HHHCCCCCCCCCCCC	33.94	21406692
211	Phosphorylation	LLGSPESTKLQTLPV HHCCCCCCCCCCCCH	33.83	21406692
212	Ubiquitination	LGSPESTKLQTLPVS HCCCCCCCCCCCCHH	48.12	21906983
215	Phosphorylation	PESTKLQTLPVSRIT CCCCCCCCCCHHHHH	43.39	21406692
219	Phosphorylation	KLQTLPVSRITDLLP CCCCCCHHHHHHCCC	18.94	21406692
238	Ubiquitination	NGAFINWKEAKLTWS CCCCCCHHHCHHHHH	43.22	21906983
241	Ubiquitination	FINWKEAKLTWSFFK CCCHHHCHHHHHHHH	47.76	22817900
248	Ubiquitination	KLTWSFFKQSFLKQI HHHHHHHHHHHHHHH	42.92	22817900
250	Phosphorylation	TWSFFKQSFLKQILT HHHHHHHHHHHHHCC	32.89	24719451
253	Ubiquitination	FFKQSFLKQILTEGE HHHHHHHHHHCCCCH	33.03	21963094
262	Phosphorylation	ILTEGERYVMTFLNV HCCCCHHHHHHHHHH	7.11	26503514
265	Phosphorylation	EGERYVMTFLNVLNF CCHHHHHHHHHHHCC	18.22	26503514
312	Ubiquitination	AKVLERGKDATLQKQ HHHHHHCCCCCCCCH	50.87	27667366
318	Ubiquitination	GKDATLQKQEDVAVA CCCCCCCCHHHHHHH	59.78	23503661
331	Phosphorylation	VAAAVLESLLKLALL HHHHHHHHHHHHHHH	34.54	21406692
404	Phosphorylation	SKEEVDRYNFVMLAL CHHHHHHHHHHHHHH	14.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RFT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RFT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RFT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STOM_HUMAN	STOM	physical	27173435

Drug and Disease Associations

• Kegg Disease
• H00118: Congenital disorders of glycosylation (CDG) type I
• OMIM Disease
• 612015: Congenital disorder of glycosylation 1N (CDG1N)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.